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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12623

FusionGeneSummary for FAM168A_DNAJB13

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM168A_DNAJB13
Fusion gene ID: 12623
HgeneTgene
Gene symbol

FAM168A

DNAJB13

Gene ID

23201

374407

Gene namefamily with sequence similarity 168 member ADnaJ heat shock protein family (Hsp40) member B13
SynonymsKIAA0280|TCRP1CILD34|RSPH16A|TSARG5|TSARG6
Cytomap

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM168Atongue cancer chemotherapy resistance-associated protein 1dnaJ homolog subfamily B member 13DnaJ (Hsp40) homolog, subfamily B, member 13DnaJ (Hsp40) related, subfamily B, member 13DnaJ-like proteinradial spoke 16 homolog Atestis and spermatogenesis cell-related protein 6testis spermatocyte apoptosis-relate
Modification date2018052320180523
UniProtAcc

Q92567

P59910

Ensembl transtripts involved in fusion geneENST00000064778, ENST00000450446, 
ENST00000356467, 
ENST00000339764, 
ENST00000537753, ENST00000543947, 
Fusion gene scores* DoF score20 X 4 X 10=8001 X 1 X 1=1
# samples 231
** MAII scorelog2(23/800*10)=-1.79836613883035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: FAM168A [Title/Abstract] AND DNAJB13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM168A

GO:1905053

positive regulation of base-excision repair

25260657


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A08I-01AFAM168Achr11

73308968

-DNAJB13chr11

73669362

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000064778ENST00000339764FAM168Achr11

73308968

-DNAJB13chr11

73669362

+
5UTR-intronENST00000064778ENST00000537753FAM168Achr11

73308968

-DNAJB13chr11

73669362

+
5UTR-intronENST00000064778ENST00000543947FAM168Achr11

73308968

-DNAJB13chr11

73669362

+
5UTR-3CDSENST00000450446ENST00000339764FAM168Achr11

73308968

-DNAJB13chr11

73669362

+
5UTR-intronENST00000450446ENST00000537753FAM168Achr11

73308968

-DNAJB13chr11

73669362

+
5UTR-intronENST00000450446ENST00000543947FAM168Achr11

73308968

-DNAJB13chr11

73669362

+
5UTR-3CDSENST00000356467ENST00000339764FAM168Achr11

73308968

-DNAJB13chr11

73669362

+
5UTR-intronENST00000356467ENST00000537753FAM168Achr11

73308968

-DNAJB13chr11

73669362

+
5UTR-intronENST00000356467ENST00000543947FAM168Achr11

73308968

-DNAJB13chr11

73669362

+

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FusionProtFeatures for FAM168A_DNAJB13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM168A

Q92567

DNAJB13

P59910

In cancer context, protects cells from induced-DNAdamage and apoptosis. Acts, at least in part, throughPI3K/AKT/NFKB signaling pathway and by preventing POLBdegradation. Decreases POLB ubiquitation and stabilizes itsprotein levels. {ECO:0000269|PubMed:21334329,ECO:0000269|PubMed:21603883, ECO:0000269|PubMed:23251525,ECO:0000269|PubMed:25260657}. Plays a role in the formation of the central complex ofciliary and flagellar axonemes. {ECO:0000250|UniProtKB:Q80Y75,ECO:0000269|PubMed:27486783}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM168A_DNAJB13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM168A_DNAJB13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM168ABAG3, RBFOX1, DAB1, SNRPC, UBE2V1, SF1, TAX1BP1, DAZAP2, CALCOCO2, TNIP1, RBPMS, R3HDM2, FAM168A, SS18L1, VPS37C, KLHL42, SMAP2, OTUB2, UBASH3B, C1orf94, OTULIN, NAF1, DTX2, PRR20A, MOV10, FBXO6, WWP2, EWSR1, FBXW5, MCM2, TRIM25DNAJB13


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM168A_DNAJB13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM168A_DNAJB13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAM168AC0038356Stomach Neoplasms1CTD_human