FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1259

FusionGeneSummary for AIFM1_AIFM1

check button Fusion gene summary
Fusion gene informationFusion gene name: AIFM1_AIFM1
Fusion gene ID: 1259
HgeneTgene
Gene symbol

AIFM1

AIFM1

Gene ID

9131

9131

Gene nameapoptosis inducing factor mitochondria associated 1apoptosis inducing factor mitochondria associated 1
SynonymsAIF|CMT2D|CMTX4|COWCK|COXPD6|DFNX5|NADMR|NAMSD|PDCD8AIF|CMT2D|CMTX4|COWCK|COXPD6|DFNX5|NADMR|NAMSD|PDCD8
Cytomap

Xq26.1

Xq26.1

Type of geneprotein-codingprotein-coding
Descriptionapoptosis-inducing factor 1, mitochondrialapoptosis-inducing factor, mitochondrion-associated, 1programmed cell death 8 (apoptosis-inducing factor)striatal apoptosis-inducing factortesticular secretory protein Li 4apoptosis-inducing factor 1, mitochondrialapoptosis-inducing factor, mitochondrion-associated, 1programmed cell death 8 (apoptosis-inducing factor)striatal apoptosis-inducing factortesticular secretory protein Li 4
Modification date2018052720180527
UniProtAcc

O95831

O95831

Ensembl transtripts involved in fusion geneENST00000460436, ENST00000440263, 
ENST00000535724, ENST00000346424, 
ENST00000319908, ENST00000287295, 
ENST00000460436, ENST00000440263, 
ENST00000535724, ENST00000346424, 
ENST00000319908, ENST00000287295, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: AIFM1 [Title/Abstract] AND AIFM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAIFM1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17094969

TgeneAIFM1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17094969


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW835589AIFM1chrX

129265750

-AIFM1chrX

129270102

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000460436ENST00000460436AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000460436ENST00000440263AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000460436ENST00000535724AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000460436ENST00000346424AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000460436ENST00000319908AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000460436ENST00000287295AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000440263ENST00000460436AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000440263ENST00000440263AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000440263ENST00000535724AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000440263ENST00000346424AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000440263ENST00000319908AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000440263ENST00000287295AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000535724ENST00000460436AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000535724ENST00000440263AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000535724ENST00000535724AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000535724ENST00000346424AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000535724ENST00000319908AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000535724ENST00000287295AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000346424ENST00000460436AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000346424ENST00000440263AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000346424ENST00000535724AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000346424ENST00000346424AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000346424ENST00000319908AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000346424ENST00000287295AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000319908ENST00000460436AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000319908ENST00000440263AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000319908ENST00000535724AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000319908ENST00000346424AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000319908ENST00000319908AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000319908ENST00000287295AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000287295ENST00000460436AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3CDSENST00000287295ENST00000440263AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000287295ENST00000535724AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000287295ENST00000346424AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000287295ENST00000319908AIFM1chrX

129265750

-AIFM1chrX

129270102

+
intron-3UTRENST00000287295ENST00000287295AIFM1chrX

129265750

-AIFM1chrX

129270102

+

Top

FusionProtFeatures for AIFM1_AIFM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AIFM1

O95831

AIFM1

O95831


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for AIFM1_AIFM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for AIFM1_AIFM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for AIFM1_AIFM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for AIFM1_AIFM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAIFM1C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneAIFM1C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
HgeneAIFM1C0020179Huntington Disease1CTD_human
HgeneAIFM1C0027540Necrosis1CTD_human
HgeneAIFM1C0035305Retinal Detachment1CTD_human
HgeneAIFM1C0795910COWCHOCK SYNDROME1ORPHANET;UNIPROT
HgeneAIFM1C1845095DEAFNESS, X-LINKED 5 (disorder)1ORPHANET;UNIPROT
HgeneAIFM1C3151753COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 61CTD_human;ORPHANET;UNIPROT
HgeneAIFM1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneAIFM1C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneAIFM1C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
TgeneAIFM1C0020179Huntington Disease1CTD_human
TgeneAIFM1C0027540Necrosis1CTD_human
TgeneAIFM1C0035305Retinal Detachment1CTD_human
TgeneAIFM1C0795910COWCHOCK SYNDROME1ORPHANET;UNIPROT
TgeneAIFM1C1845095DEAFNESS, X-LINKED 5 (disorder)1ORPHANET;UNIPROT
TgeneAIFM1C3151753COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 61CTD_human;ORPHANET;UNIPROT
TgeneAIFM1C4277682Chemical and Drug Induced Liver Injury1CTD_human