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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12589

FusionGeneSummary for FAM155A_TUBGCP2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM155A_TUBGCP2
Fusion gene ID: 12589
HgeneTgene
Gene symbol

FAM155A

TUBGCP2

Gene ID

728215

10844

Gene namefamily with sequence similarity 155 member Atubulin gamma complex associated protein 2
Synonyms-ALP4|GCP-2|GCP2|Grip103|SPBC97|SPC97|Spc97p|h103p|hGCP2|hSpc97
Cytomap

13q33.3

10q26.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein FAM155Agamma-tubulin complex component 2gamma-ring complex protein 103 kDahGrip103spindle pole body protein Spc97 homolog
Modification date2018052320180523
UniProtAcc

B1AL88

Q9BSJ2

Ensembl transtripts involved in fusion geneENST00000375915, ENST00000252936, 
ENST00000417178, ENST00000368563, 
ENST00000368562, ENST00000543663, 
ENST00000470829, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 2 X 3=18
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM155A [Title/Abstract] AND TUBGCP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-B0-4688-01AFAM155Achr13

108518030

-TUBGCP2chr10

135116484

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375915ENST00000252936FAM155Achr13

108518030

-TUBGCP2chr10

135116484

-
5CDS-intronENST00000375915ENST00000417178FAM155Achr13

108518030

-TUBGCP2chr10

135116484

-
5CDS-5UTRENST00000375915ENST00000368563FAM155Achr13

108518030

-TUBGCP2chr10

135116484

-
5CDS-intronENST00000375915ENST00000368562FAM155Achr13

108518030

-TUBGCP2chr10

135116484

-
5CDS-intronENST00000375915ENST00000543663FAM155Achr13

108518030

-TUBGCP2chr10

135116484

-
5CDS-5UTRENST00000375915ENST00000470829FAM155Achr13

108518030

-TUBGCP2chr10

135116484

-

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FusionProtFeatures for FAM155A_TUBGCP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM155A

B1AL88

TUBGCP2

Q9BSJ2

Gamma-tubulin complex is necessary for microtubulenucleation at the centrosome.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM155Achr13:108518030chr10:135116484ENST00000375915-13136_145305459Compositional biasNote=Poly-Gly
HgeneFAM155Achr13:108518030chr10:135116484ENST00000375915-1373_95305459Compositional biasNote=Poly-Gln
HgeneFAM155Achr13:108518030chr10:135116484ENST00000375915-1340_60305459TransmembraneHelical
TgeneTUBGCP2chr13:108518030chr10:135116484ENST00000252936--117109_11250903Compositional biasNote=Poly-Ala
TgeneTUBGCP2chr13:108518030chr10:135116484ENST00000368563-018109_112-13903Compositional biasNote=Poly-Ala
TgeneTUBGCP2chr13:108518030chr10:135116484ENST00000417178-017109_112-99773Compositional biasNote=Poly-Ala
TgeneTUBGCP2chr13:108518030chr10:135116484ENST00000543663--118109_11250931Compositional biasNote=Poly-Ala

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM155Achr13:108518030chr10:135116484ENST00000375915-13417_437305459TransmembraneHelical


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FusionGeneSequence for FAM155A_TUBGCP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FAM155A_ENST00000375915_chr13_108518030_-_TUBGCP2_ENST00000252936_chr10_135116484_-_305aa
MTRGAWMCRQTDDGLKIWLAAPRENEKPFIDSERAQKWRLSLASLLFFTVLLSDHLWFCAEAKLTRARDKEHQQQQRQQQQQQQQQRQRQ
QQQQQRRQQEPSWPALLASMGESSPAAQAHRLLSASSSPTLPPSPGDGGGGGGKGNRGKDDRGKALFLGNSAKPVWRLETCYPQGASSGQ
CFTVENADAVCARNWSRGAAGGDGQEVRSKHPTPLWNLSDFYLSFCNSYTLWELFSGLSSPNTLNCSLDVVLKEGGEMTTCRQCVEAYQD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FAM155A_ENST00000375915_chr13_108518030_-_TUBGCP2_ENST00000252936_chr10_135116484_-_915nt
ATGACCAGGGGTGCTTGGATGTGTCGGCAGTATGACGACGGCTTAAAAATCTGGTTGGCAGCACCCCGAGAGAACGAGAAACCGTTCATC
GATTCCGAGAGGGCTCAGAAATGGCGACTGTCTCTGGCATCTCTCTTGTTTTTCACAGTCCTGCTCTCTGATCACTTGTGGTTCTGCGCC
GAGGCCAAGCTGACCCGGGCCCGGGACAAGGAGCACCAGCAGCAGCAGCGGCAGCAGCAGCAGCAGCAGCAGCAGCAGAGGCAGCGGCAG
CAGCAGCAGCAGCAGCGGCGGCAGCAGGAGCCCTCCTGGCCCGCGCTCCTGGCGAGCATGGGGGAGTCCTCGCCCGCCGCCCAGGCACAC
AGACTCCTCTCCGCCTCCTCGTCCCCCACCCTGCCCCCCTCCCCGGGAGACGGCGGCGGCGGCGGCGGCAAGGGCAACCGAGGCAAAGAC
GACCGGGGCAAGGCTCTTTTTCTAGGAAACTCTGCCAAGCCCGTGTGGCGCCTGGAGACTTGTTACCCCCAGGGCGCGTCCTCGGGCCAG
TGCTTCACGGTGGAGAATGCGGACGCGGTGTGCGCCAGGAACTGGAGTCGGGGGGCGGCCGGGGGGGACGGGCAGGAGGTGAGGAGCAAG
CATCCCACTCCGCTCTGGAACTTGTCGGATTTTTACCTTTCGTTTTGTAATTCCTACACACTTTGGGAGTTGTTCTCGGGGTTGTCCAGT
CCCAACACTTTGAACTGCAGTCTGGATGTGGTGCTCAAGGAAGGCGGCGAGATGACCACTTGCAGGCAGTGCGTCGAGGCTTACCAGGAC
TATGACCACCATGCTCAGGAGAAATACGAAGAGTTTGAAAGCGTGCTCCACAAATATTTACAGTCGGAGGAGTACTCGGTGAAATCCTGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_FAM155A_ENST00000375915_chr13_108518030_-_TUBGCP2_ENST00000252936_chr10_135116484_-_3938nt
GAGAGAAAGAGAGAGAGGAGAGAGAAGAAACGGGAGGAGGGGATAAGGAAATTAAACCCTTTAAGTCAATGCATATTGTGGTGACACCGG
CACAGGCGCCCTCACGGTGGAGTCGGCCAGGGCTGTGCGTTCCCAAAATATGACCAGGGGTGCTTGGATGTGTCGGCAGTATGACGACGG
CTTAAAAATCTGGTTGGCAGCACCCCGAGAGAACGAGAAACCGTTCATCGATTCCGAGAGGGCTCAGAAATGGCGACTGTCTCTGGCATC
TCTCTTGTTTTTCACAGTCCTGCTCTCTGATCACTTGTGGTTCTGCGCCGAGGCCAAGCTGACCCGGGCCCGGGACAAGGAGCACCAGCA
GCAGCAGCGGCAGCAGCAGCAGCAGCAGCAGCAGCAGAGGCAGCGGCAGCAGCAGCAGCAGCAGCGGCGGCAGCAGGAGCCCTCCTGGCC
CGCGCTCCTGGCGAGCATGGGGGAGTCCTCGCCCGCCGCCCAGGCACACAGACTCCTCTCCGCCTCCTCGTCCCCCACCCTGCCCCCCTC
CCCGGGAGACGGCGGCGGCGGCGGCGGCAAGGGCAACCGAGGCAAAGACGACCGGGGCAAGGCTCTTTTTCTAGGAAACTCTGCCAAGCC
CGTGTGGCGCCTGGAGACTTGTTACCCCCAGGGCGCGTCCTCGGGCCAGTGCTTCACGGTGGAGAATGCGGACGCGGTGTGCGCCAGGAA
CTGGAGTCGGGGGGCGGCCGGGGGGGACGGGCAGGAGGTGAGGAGCAAGCATCCCACTCCGCTCTGGAACTTGTCGGATTTTTACCTTTC
GTTTTGTAATTCCTACACACTTTGGGAGTTGTTCTCGGGGTTGTCCAGTCCCAACACTTTGAACTGCAGTCTGGATGTGGTGCTCAAGGA
AGGCGGCGAGATGACCACTTGCAGGCAGTGCGTCGAGGCTTACCAGGACTATGACCACCATGCTCAGGAGAAATACGAAGAGTTTGAAAG
CGTGCTCCACAAATATTTACAGTCGGAGGAGTACTCGGTGAAATCCTGTCCTGAAGACTGTAAGGGAGAACATATTGTGATGTTCGTGCC
TCAGAGCTAAAACTATGAGTGAATTTCGGATTCACCATGACGTCAATGAACTGCTTAGCCTGCTGCGTGTCCACGGAGGAGATGGGGCTG
AGGTCTACATTGACCTGCTTCAAAAGAACAGGACCCCGTACGTCACTACCACTGTCTCTGCTCACAGTGCCAAGGTTAAAATTGCAGAGT
TTTCTCGTACTCCAGAAGACTTTCTAAAGAAATATGATGAACTGAAATCTAAAAATACAAGGAACCTTGACCCGCTGGTGTACCTGTTGT
CAAAGCTCACGGAAGACAAAGAGACTCTGCAGTACTTACAACAGAATGCAAAAGAAAGAGCTGAGCTTGCAGCCGCTGCTGTGGGCAGCA
GTACCACCAGCATCAACGTCCCTGCCGCGGCCTCCAAGATCTCCATGCAGGAGCTTGAGGAACTGAGGAAGCAGCTTGGCAGCGTGGCCA
CAGGCTCCACGCTGCAGCAGTCTCTGGAACTTAAAAGAAAGATGCTTCGAGACAAGCAGAACAAAAAAAATTCAGGCCAGCACCTCCCCA
TCTTCCCAGCATGGGTGTATGAGAGACCTGCCCTGATCGGGGATTTCCTGATTGGTGCTGGCATCAGCACAGACACCGCTTTGCCGATAG
GCACGTTGCCCCTGGCCTCGCAGGAGTCGGCCGTGGTGGAGGACCTGCTGTACGTGCTGGTGGGCGTGGACGGGAGGTACGTCAGTGCTC
AGCCCCTGGCTGGGAGGCAGAGCCGGACCTTCCTCGTGGACCCCAACCTGGACCTGTCCATCAGGGAGCTGGTGCACAGGATCCTCCCAG
TGGCCGCCAGCTACTCCGCTGTGACCAGGTTCATTGAAGAGAAGTCTTCCTTCGAGTACGGGCAGGTGAACCACGCCCTGGCGGCCGCCA
TGCGCACCCTGGTGAAGGAGCACCTGATTCTGGTGTCACAGCTGGAGCAGCTGCACAGGCAGGGCCTCCTTTCGCTGCAGAAGCTCTGGT
TCTACATCCAGCCAGCCATGCGCACCATGGACATCCTGGCCTCCCTCGCCACCTCGGTGGACAAAGGCGAATGTCTTGGGGGGTCCACGC
TGAGCCTGCTCCACGACAGGAGCTTCAGCTACACAGGGGACAGCCAGGCGCAGGAGCTATGCCTGTACCTAACCAAGGCGGCCAGTGCTC
CCTACTTCGAGGTTCTGGAGAAGTGGATCTACAGGGGCATCATCCACGACCCATACAGTGAGTTTATGGTCGAGGAGCACGAGCTGCGGA
AGGAGAGGATCCAGGAGGATTACAACGACAAGTACTGGGACCAGCGGTACACCATCGTCCAGCAGCAGATCCCGTCCTTCCTGCAGAAAA
TGGCGGACAAGATCCTCAGCACAGGAAAATATCTAAATGTGGTCAGAGAGTGTGGCCATGACGTCACCTGCCCGGTGGCTAAAGAGATCA
TCTACACGTTAAAAGAGCGGGCGTATGTGGAGCAGATCGAGAAGGCGTTTAACTACGCCAGCAAGGTGCTGCTGGACTTCCTGATGGAGG
AGAAGGAGCTGGTGGCTCACCTCAGGTCCATCAAGCGCTACTTCCTCATGGACCAGGGCGACTTCTTCGTGCACTTCATGGACCTCGCGG
AGGAGGAGCTCCGGAAGCCGGTGGAGGACATCACGCCCCCTCGCCTGGAAGCGCTCCTGGAGCTGGCGCTGCGCATGAGCACGGCCAACA
CTGACCCCTTCAAGGACGACCTCAAGATCGACCTGATGCCCCATGACCTCATCACTCAGCTCTTGCGCGTCCTGGCCATCGAGACCAAGC
AGGAGAAGGCGATGGCGCACGCCGACCCCACGGAGCTGGCGCTGAGCGGCCTGGAGGCCTTCTCTTTCGACTACATCGTCAAGTGGCCCC
TTTCGCTCATCATCAACAGGAAAGCCCTCACTCGCTACCAGATGCTCTTCAGGCACATGTTCTACTGCAAGCACGTGGAGCGGCAGCTCT
GCAGCGTCTGGATCAGCAACAAAACCGCCAAGCAGCACTCGCTGCACTCCGCCCAGTGGTTTGCTGGGGCTTTCACTCTGCGGCAGCGAA
TGCTCAACTTCGTCCAGAATATTCAATACTACATGATGTTTGAAGTGATGGAACCGACCTGGCACATCCTGGAGAAAAACCTGAAATCCG
CCTCCAACATTGACGACGTCCTTGGCCACCACACAGGCTTCCTGGACACCTGCCTGAAGGACTGCATGCTCACCAACCCCGAGCTGCTGA
AGGTCTTCTCCAAGCTCATGTCTGTGTGCGTCATGTTCACCAACTGCATGCAGAAATTTACACAGAGCATGAAATTAGATGGCGAGCTGG
GCGGGCAGACGCTGGAGCACAGCACCGTCCTGGGGCTGCCCGCAGGGGCCGAGGAGCGGGCCCGGAAGGAGCTCGCCAGGAAGCACCTGG
CTGAGCACGCAGACACTGTGCAGCTGGTGTCCGGCTTCGAGGCCACCATCAACAAGTTTGACAAGAACTTCTCAGCCCACCTGCTGGACC
TCCTGGCCCGGCTGAGCATCTATAGCACCAGTGACTGTGAGCACGGCATGGCCAGCGTCATCTCCAGGCTTGACTTCAATGGTTTCTACA
CGGAGCGCCTGGAGCGCCTGTCTGCAGAGAGGAGCCAGAAGGCCACCCCCCAAGTGCCTGTCCTGCGGGGGCCCCCGGCTCCTGCACCCA
GGGTCGCAGTCACCGCACAGTGAGCCCTGGCTGTGACAGGAAGGAAGGGTGTGGGGTCAGCAGGGACTGGTGCAAATGGGTCCAGAATTT


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FusionGenePPI for FAM155A_TUBGCP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM155ATUBGCP2PCNT, BTRC, MYC, MINOS1, SH3KBP1, CDK5RAP2, UBC, VCP, METTL18, METTL21C, TUBGCP3, SAV1, HECW2, ACTB, ATAD3A, BAG2, MZT1, UQCC2, CAPNS1, TUBB, HSPA1A, DDB1, EEF1A1, EMD, TUBB4A, MZT2A, MZT2B, HAX1, HSP90AB1, HSPA5, HSPA8, HSPA9, IGF2BP1, LOC400682, NME7, PHKA1, PHKA2, PRPF4, RARS, RPL11, RPLP2, RPS19, RPS20, RPS3, SCO2, TUBA1A, TUBA1B, TUBA4A, TUBB2A, TUBB4B, TUBG1, TUBGCP4, TUBGCP5, TUBGCP6, UBB, ALK, EGFR, SPINT2, HLA-B, PTGER3, NTRK1, CEP152, CNTRL, NINL, LGALS3BP, RAD51, XPO1, SRSF10, SCAF11, NEDD1, LRWD1, WWP2, SNW1, CDC5L, PCGF1, DPPA4, ZNF746, TXNDC12, TUBG2, OPRM1, C5AR2, NPY2R, MAS1, SLC37A3, VIPR2, TMEM206, CHRM4, PTGIR, KIF14, CD2BP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM155A_TUBGCP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM155A_TUBGCP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource