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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12585

FusionGeneSummary for FAM155A_ADIPOR1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM155A_ADIPOR1
Fusion gene ID: 12585
HgeneTgene
Gene symbol

FAM155A

ADIPOR1

Gene ID

728215

51094

Gene namefamily with sequence similarity 155 member Aadiponectin receptor 1
Synonyms-ACDCR1|CGI-45|CGI45|PAQR1|TESBP1A
Cytomap

13q33.3

1q32.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein FAM155Aadiponectin receptor protein 1progestin and adipoQ receptor family member 1progestin and adipoQ receptor family member I
Modification date2018052320180523
UniProtAcc

B1AL88

Q96A54

Ensembl transtripts involved in fusion geneENST00000375915, ENST00000340990, 
ENST00000436244, ENST00000367254, 
Fusion gene scores* DoF score5 X 4 X 3=602 X 2 X 1=4
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: FAM155A [Title/Abstract] AND ADIPOR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADIPOR1

GO:0009755

hormone-mediated signaling pathway

12802337

TgeneADIPOR1

GO:0019395

fatty acid oxidation

12802337

TgeneADIPOR1

GO:0033211

adiponectin-activated signaling pathway

12802337


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF961218FAM155Achr13

108372496

+ADIPOR1chr1

202911318

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000375915ENST00000340990FAM155Achr13

108372496

+ADIPOR1chr1

202911318

+
intron-3CDSENST00000375915ENST00000436244FAM155Achr13

108372496

+ADIPOR1chr1

202911318

+
intron-intronENST00000375915ENST00000367254FAM155Achr13

108372496

+ADIPOR1chr1

202911318

+

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FusionProtFeatures for FAM155A_ADIPOR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM155A

B1AL88

ADIPOR1

Q96A54

Receptor for ADIPOQ, an essential hormone secreted byadipocytes that regulates glucose and lipid metabolism(PubMed:25855295, PubMed:12802337). Required for normal glucoseand fat homeostasis and for maintaining a normal body weight.ADIPOQ-binding activates a signaling cascade that leads toincreased AMPK activity, and ultimately to increased fatty acidoxidation, increased glucose uptake and decreased gluconeogenesis.Has high affinity for globular adiponectin and low affinity forfull-length adiponectin (By similarity).{ECO:0000250|UniProtKB:Q91VH1, ECO:0000269|PubMed:12802337,ECO:0000269|PubMed:25855295}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM155A_ADIPOR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM155A_ADIPOR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM155A_ADIPOR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM155A_ADIPOR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADIPOR1C0021361Female infertility1CTD_human
TgeneADIPOR1C0022661Kidney Failure, Chronic1CTD_human