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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12581

FusionGeneSummary for FAM13C_ZNF365

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM13C_ZNF365
Fusion gene ID: 12581
HgeneTgene
Gene symbol

FAM13C

ZNF365

Gene ID

220965

22891

Gene namefamily with sequence similarity 13 member Czinc finger protein 365
SynonymsFAM13C1Su48|UAN|ZNF365D
Cytomap

10q21.1

10q21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM13Cfamily with sequence similarity 13, member C1protein ZNF365DISC1-binding zinc-finger proteinprotein su48talanin
Modification date2018051920180519
UniProtAcc

Q8NE31

Q70YC5

Ensembl transtripts involved in fusion geneENST00000373867, ENST00000373868, 
ENST00000442566, ENST00000277705, 
ENST00000419214, ENST00000468840, 
ENST00000435852, ENST00000422313, 
ENST00000510215, 
ENST00000395255, 
ENST00000410046, ENST00000395251, 
ENST00000395254, ENST00000466727, 
ENST00000395249, 
Fusion gene scores* DoF score3 X 2 X 4=244 X 4 X 4=64
# samples 44
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM13C [Title/Abstract] AND ZNF365 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZNF365

GO:0010977

negative regulation of neuron projection development

17389905


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-BT-A2LA-01AFAM13Cchr10

61011335

-ZNF365chr10

64382863

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373867ENST00000395255FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373867ENST00000410046FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373867ENST00000395251FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373867ENST00000395254FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373867ENST00000466727FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373867ENST00000395249FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373868ENST00000395255FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373868ENST00000410046FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373868ENST00000395251FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373868ENST00000395254FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373868ENST00000466727FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000373868ENST00000395249FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000442566ENST00000395255FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000442566ENST00000410046FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000442566ENST00000395251FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000442566ENST00000395254FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000442566ENST00000466727FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000442566ENST00000395249FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000277705ENST00000395255FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000277705ENST00000410046FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000277705ENST00000395251FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000277705ENST00000395254FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000277705ENST00000466727FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000277705ENST00000395249FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000419214ENST00000395255FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000419214ENST00000410046FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000419214ENST00000395251FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000419214ENST00000395254FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000419214ENST00000466727FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000419214ENST00000395249FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000468840ENST00000395255FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000468840ENST00000410046FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000468840ENST00000395251FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000468840ENST00000395254FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000468840ENST00000466727FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
5CDS-intronENST00000468840ENST00000395249FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000435852ENST00000395255FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000435852ENST00000410046FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000435852ENST00000395251FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000435852ENST00000395254FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000435852ENST00000466727FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000435852ENST00000395249FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000422313ENST00000395255FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000422313ENST00000410046FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000422313ENST00000395251FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000422313ENST00000395254FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000422313ENST00000466727FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000422313ENST00000395249FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000510215ENST00000395255FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000510215ENST00000410046FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000510215ENST00000395251FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000510215ENST00000395254FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000510215ENST00000466727FAM13Cchr10

61011335

-ZNF365chr10

64382863

+
intron-intronENST00000510215ENST00000395249FAM13Cchr10

61011335

-ZNF365chr10

64382863

+

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FusionProtFeatures for FAM13C_ZNF365


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM13C

Q8NE31

ZNF365

Q70YC5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM13C_ZNF365


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAM13C_ZNF365


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM13CCCDC85B, DVL3, PHC2, KIF2A, MEOX2, MTUS2, TFIP11, SDCBP2, MED4, HMBOX1, CEP70, FAM13C, CCDC172, TUBA3C, AHCYL2, AHCYL1, PDZRN3ZNF365DISC1, APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM13C_ZNF365


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAM13C_ZNF365


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZNF365C0011615Dermatitis, Atopic1CTD_human
TgeneZNF365C1458155Mammary Neoplasms1CTD_human