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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12569

FusionGeneSummary for FAM135A_NACA

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM135A_NACA
Fusion gene ID: 12569
HgeneTgene
Gene symbol

FAM135A

NACA

Gene ID

57579

4666

Gene namefamily with sequence similarity 135 member Anascent polypeptide associated complex subunit alpha
SynonymsKIAA1411HSD48|NAC-alpha|NACA1|skNAC
Cytomap

6q13

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM135Anascent polypeptide-associated complex subunit alphaalpha-NAC, muscle-specific formnascent polypeptide-associated complex alpha subunitnascent-polypeptide-associated complex alpha polypeptide
Modification date2018052320180519
UniProtAcc

Q9P2D6

Q13765

Ensembl transtripts involved in fusion geneENST00000418814, ENST00000370479, 
ENST00000505769, ENST00000457062, 
ENST00000361499, ENST00000505868, 
ENST00000508844, 
ENST00000454682, 
ENST00000550952, ENST00000356769, 
ENST00000552540, ENST00000393891, 
ENST00000548563, ENST00000546392, 
ENST00000551793, 
Fusion gene scores* DoF score7 X 5 X 6=2109 X 9 X 5=405
# samples 710
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM135A [Title/Abstract] AND NACA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN271038FAM135Achr6

71263512

+NACAchr12

57106653

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000418814ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000418814ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000370479ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000505769ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000457062ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000361499ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000505868ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000508844ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-

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FusionProtFeatures for FAM135A_NACA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM135A

Q9P2D6

NACA

Q13765

Prevents inappropriate targeting of non-secretorypolypeptides to the endoplasmic reticulum (ER). Binds to nascentpolypeptide chains as they emerge from the ribosome and blockstheir interaction with the signal recognition particle (SRP),which normally targets nascent secretory peptides to the ER. Alsoreduces the inherent affinity of ribosomes for proteintranslocation sites in the ER membrane (M sites). May act as aspecific coactivator for JUN, binding to DNA and stabilizing theinteraction of JUN homodimers with target gene promoters.{ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678,ECO:0000269|PubMed:9877153}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM135A_NACA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM135A_NACA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM135A_NACA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM135A_NACA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource