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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12568

FusionGeneSummary for FAM135A_LMO3

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM135A_LMO3
Fusion gene ID: 12568
HgeneTgene
Gene symbol

FAM135A

LMO3

Gene ID

57579

55885

Gene namefamily with sequence similarity 135 member ALIM domain only 3
SynonymsKIAA1411RBTN3|RBTNL2|RHOM3|Rhom-3
Cytomap

6q13

12p12.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM135ALIM domain only protein 3LIM domain only 3 (rhombotin-like 2)neuronal-specific transcription factor DAT1rhombotin-3
Modification date2018052320180519
UniProtAcc

Q9P2D6

Q8TAP4

Ensembl transtripts involved in fusion geneENST00000418814, ENST00000370479, 
ENST00000505769, ENST00000457062, 
ENST00000361499, ENST00000505868, 
ENST00000508844, 		ENST00000354662, 
ENST00000441439, ENST00000447609, 
ENST00000320122, ENST00000261169, 
ENST00000540848, ENST00000535535, 
ENST00000537304, ENST00000541295, 
ENST00000534946, ENST00000540445, 
ENST00000541846, ENST00000537568, 
Fusion gene scores* DoF score7 X 5 X 6=2104 X 3 X 4=48
# samples 74
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM135A [Title/Abstract] AND LMO3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLMO3

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

23823477

TgeneLMO3

GO:0070373

negative regulation of ERK1 and ERK2 cascade

23823477

TgeneLMO3

GO:2000324

positive regulation of glucocorticoid receptor signaling pathway

23823477


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-2102-01AFAM135Achr6

71212494

+LMO3chr12

16713472

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000418814ENST00000354662FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000441439FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000447609FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000320122FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000261169FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000540848FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000535535FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000537304FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000541295FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000534946FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000540445FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000418814ENST00000541846FAM135Achr6

71212494

+LMO3chr12

16713472

-
5CDS-intronENST00000418814ENST00000537568FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000354662FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000441439FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000447609FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000320122FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000261169FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000540848FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000535535FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000537304FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000541295FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000534946FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000540445FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000370479ENST00000541846FAM135Achr6

71212494

+LMO3chr12

16713472

-
5CDS-intronENST00000370479ENST00000537568FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000354662FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000441439FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000447609FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000320122FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000261169FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000540848FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000535535FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000537304FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000541295FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000534946FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000540445FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505769ENST00000541846FAM135Achr6

71212494

+LMO3chr12

16713472

-
5CDS-intronENST00000505769ENST00000537568FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000354662FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000441439FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000447609FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000320122FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000261169FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000540848FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000535535FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000537304FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000541295FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000534946FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000540445FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000457062ENST00000541846FAM135Achr6

71212494

+LMO3chr12

16713472

-
5CDS-intronENST00000457062ENST00000537568FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000354662FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000441439FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000447609FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000320122FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000261169FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000540848FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000535535FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000537304FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000541295FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000534946FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000540445FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000361499ENST00000541846FAM135Achr6

71212494

+LMO3chr12

16713472

-
5CDS-intronENST00000361499ENST00000537568FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000354662FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000441439FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000447609FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000320122FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000261169FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000540848FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000535535FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000537304FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000541295FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000534946FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000540445FAM135Achr6

71212494

+LMO3chr12

16713472

-
Frame-shiftENST00000505868ENST00000541846FAM135Achr6

71212494

+LMO3chr12

16713472

-
5CDS-intronENST00000505868ENST00000537568FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000354662FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000441439FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000447609FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000320122FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000261169FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000540848FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000535535FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000537304FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000541295FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000534946FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000540445FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-3CDSENST00000508844ENST00000541846FAM135Achr6

71212494

+LMO3chr12

16713472

-
intron-intronENST00000508844ENST00000537568FAM135Achr6

71212494

+LMO3chr12

16713472

-

Top

FusionProtFeatures for FAM135A_LMO3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM135A

Q9P2D6

LMO3

Q8TAP4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM135A_LMO3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM135A_LMO3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM135ALMO3RALYL, CARF, ZBTB43, GABPB1, AIMP2, KXD1, LDB1, CCDC85B, PHC2, RFX6, MDFI, HNRNPM, HNRNPC, MBIP, ZBTB8A, CEP170P1, RORA, LDB2, FOS, SP4, TAX1BP1, IKZF1, FBLIM1, BANP, CCDC33, SAMD3, SPERT, NUTM1, KCTD1, NBPF22P, CEP57L1, FAM131C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM135A_LMO3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAM135A_LMO3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource