FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12566

FusionGeneSummary for FAM135A_GRM1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM135A_GRM1
Fusion gene ID: 12566
HgeneTgene
Gene symbol

FAM135A

GRM1

Gene ID

57579

2911

Gene namefamily with sequence similarity 135 member Aglutamate metabotropic receptor 1
SynonymsKIAA1411GPRC1A|MGLU1|MGLUR1|PPP1R85|SCA44|SCAR13
Cytomap

6q13

6q24.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM135Ametabotropic glutamate receptor 1glutamate receptor, metabotropic 1protein phosphatase 1, regulatory subunit 85
Modification date2018052320180523
UniProtAcc

Q9P2D6

Q13255

Ensembl transtripts involved in fusion geneENST00000418814, ENST00000370479, 
ENST00000505769, ENST00000457062, 
ENST00000361499, ENST00000505868, 
ENST00000508844, 		ENST00000361719, 
ENST00000392299, ENST00000492807, 
ENST00000355289, ENST00000282753, 
ENST00000507907, 
Fusion gene scores* DoF score7 X 5 X 6=2103 X 2 X 2=12
# samples 73
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM135A [Title/Abstract] AND GRM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRM1

GO:0007186

G-protein coupled receptor signaling pathway

24603153

TgeneGRM1

GO:0038042

dimeric G-protein coupled receptor signaling pathway

24603153


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-AATS-01AFAM135Achr6

71212494

+GRM1chr6

146348784

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000418814ENST00000361719FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000418814ENST00000392299FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000418814ENST00000492807FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000418814ENST00000355289FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000418814ENST00000282753FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000418814ENST00000507907FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000370479ENST00000361719FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000370479ENST00000392299FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000370479ENST00000492807FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000370479ENST00000355289FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000370479ENST00000282753FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000370479ENST00000507907FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000505769ENST00000361719FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000505769ENST00000392299FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000505769ENST00000492807FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000505769ENST00000355289FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000505769ENST00000282753FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000505769ENST00000507907FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000457062ENST00000361719FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000457062ENST00000392299FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000457062ENST00000492807FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000457062ENST00000355289FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000457062ENST00000282753FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000457062ENST00000507907FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000361499ENST00000361719FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000361499ENST00000392299FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000361499ENST00000492807FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000361499ENST00000355289FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000361499ENST00000282753FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000361499ENST00000507907FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000505868ENST00000361719FAM135Achr6

71212494

+GRM1chr6

146348784

+
Frame-shiftENST00000505868ENST00000392299FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000505868ENST00000492807FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000505868ENST00000355289FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000505868ENST00000282753FAM135Achr6

71212494

+GRM1chr6

146348784

+
5CDS-intronENST00000505868ENST00000507907FAM135Achr6

71212494

+GRM1chr6

146348784

+
intron-3CDSENST00000508844ENST00000361719FAM135Achr6

71212494

+GRM1chr6

146348784

+
intron-3CDSENST00000508844ENST00000392299FAM135Achr6

71212494

+GRM1chr6

146348784

+
intron-intronENST00000508844ENST00000492807FAM135Achr6

71212494

+GRM1chr6

146348784

+
intron-intronENST00000508844ENST00000355289FAM135Achr6

71212494

+GRM1chr6

146348784

+
intron-intronENST00000508844ENST00000282753FAM135Achr6

71212494

+GRM1chr6

146348784

+
intron-intronENST00000508844ENST00000507907FAM135Achr6

71212494

+GRM1chr6

146348784

+

Top

FusionProtFeatures for FAM135A_GRM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM135A

Q9P2D6

GRM1

Q13255


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FAM135A_GRM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAM135A_GRM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM135AGRM1TRPC1, GRM1, ADORA1, OPTN, ADRBK1, HTT, HOMER1, GRASP, SRC, FYN, SYK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM135A_GRM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGRM1Q13255DB00142Glutamic AcidMetabotropic glutamate receptor 1small moleculeapproved|nutraceutical

Top

RelatedDiseases for FAM135A_GRM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGRM1C0011570Mental Depression5PSYGENET
TgeneGRM1C0011581Depressive disorder5PSYGENET
TgeneGRM1C0036341Schizophrenia2PSYGENET
TgeneGRM1C0038220Status Epilepticus2CTD_human
TgeneGRM1C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGRM1C0014544Epilepsy1CTD_human
TgeneGRM1C0014556Epilepsy, Temporal Lobe1CTD_human
TgeneGRM1C0016045fibroma1CTD_human
TgeneGRM1C0041696Unipolar Depression1PSYGENET
TgeneGRM1C0206639Neoplasms, Bone Tissue1CTD_human
TgeneGRM1C1263846Attention deficit hyperactivity disorder1CTD_human