FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12559

FusionGeneSummary for FAM134C_AP2B1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM134C_AP2B1
Fusion gene ID: 12559
HgeneTgene
Gene symbol

FAM134C

AP2B1

Gene ID

163

Gene nameadaptor related protein complex 2 subunit beta 1
SynonymsADTB2|AP105B|AP2-BETA|CLAPB1
Cytomap

17q12

Type of geneprotein-coding
DescriptionAP-2 complex subunit betaadapter-related protein complex 2 beta subunitadapter-related protein complex 2 subunit betaadaptin, beta 2 (beta)adaptor protein complex AP-2 subunit betaadaptor related protein complex 2 beta 1 subunitadaptor-related prote
Modification date20180522
UniProtAcc

P63010

Ensembl transtripts involved in fusion geneENST00000309428, ENST00000585894, 
ENST00000543197, 
ENST00000262325, 
ENST00000592545, ENST00000538556, 
ENST00000312678, ENST00000589344, 
ENST00000537622, ENST00000545922, 
Fusion gene scores* DoF score4 X 4 X 3=489 X 10 X 7=630
# samples 410
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM134C [Title/Abstract] AND AP2B1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-L5-A8NH-01AFAM134Cchr17

40738783

-AP2B1chr17

34001195

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000309428ENST00000262325FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
In-frameENST00000309428ENST00000592545FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
In-frameENST00000309428ENST00000538556FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
In-frameENST00000309428ENST00000312678FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
In-frameENST00000309428ENST00000589344FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
In-frameENST00000309428ENST00000537622FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
5CDS-3UTRENST00000309428ENST00000545922FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
Frame-shiftENST00000585894ENST00000262325FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
Frame-shiftENST00000585894ENST00000592545FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
Frame-shiftENST00000585894ENST00000538556FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
Frame-shiftENST00000585894ENST00000312678FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
Frame-shiftENST00000585894ENST00000589344FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
Frame-shiftENST00000585894ENST00000537622FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
5CDS-3UTRENST00000585894ENST00000545922FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
5UTR-3CDSENST00000543197ENST00000262325FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
5UTR-3CDSENST00000543197ENST00000592545FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
5UTR-3CDSENST00000543197ENST00000538556FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
5UTR-3CDSENST00000543197ENST00000312678FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
5UTR-3CDSENST00000543197ENST00000589344FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
5UTR-3CDSENST00000543197ENST00000537622FAM134Cchr17

40738783

-AP2B1chr17

34001195

+
5UTR-3UTRENST00000543197ENST00000545922FAM134Cchr17

40738783

-AP2B1chr17

34001195

+

Top

FusionProtFeatures for FAM134C_AP2B1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM134C

AP2B1

P63010

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Component of the adaptor protein complex 2 (AP-2).Adaptor protein complexes function in protein transport viatransport vesicles in different membrane traffic pathways. Adaptorprotein complexes are vesicle coat components and appear to beinvolved in cargo selection and vesicle formation. AP-2 isinvolved in clathrin-dependent endocytosis in which cargo proteinsare incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with theearly endosome. The clathrin lattice serves as a mechanicalscaffold but is itself unable to bind directly to membranecomponents. Clathrin-associated adaptor protein (AP) complexeswhich can bind directly to both the clathrin lattice and to thelipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 alsoserves as a cargo receptor to selectively sort the membraneproteins involved in receptor-mediated endocytosis. AP-2 seems toplay a role in the recycling of synaptic vesicle membranes fromthe presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi)and [ED]-X-X-X-L-[LI] endocytosis signal motifs within thecytosolic tails of transmembrane cargo molecules. AP-2 may alsoplay a role in maintaining normal post-endocytic traffickingthrough the ARF6-regulated, non-clathrin pathway. The AP-2 betasubunit acts via its C-terminal appendage domain as a scaffoldingplatform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds toclathrin heavy chain, promoting clathrin lattice assembly;clathrin displaces at least some CLASPs from AP2B1 which probablythen can be positioned for further coat assembly.{ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334,ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM134Cchr17:40738783chr17:34001195ENST00000309428-4981_101168467TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM134Cchr17:40738783chr17:34001195ENST00000309428-49445_450168467MotifLIR motif
HgeneFAM134Cchr17:40738783chr17:34001195ENST00000309428-49164_184168467TransmembraneHelical
HgeneFAM134Cchr17:40738783chr17:34001195ENST00000309428-49187_207168467TransmembraneHelical
TgeneAP2B1chr17:40738783chr17:34001195ENST00000262325+1421576_716712938Compositional biasNote=Pro-rich (stalk region)
TgeneAP2B1chr17:40738783chr17:34001195ENST00000312678+1522576_716726952Compositional biasNote=Pro-rich (stalk region)
TgeneAP2B1chr17:40738783chr17:34001195ENST00000537622+1522576_716726952Compositional biasNote=Pro-rich (stalk region)
TgeneAP2B1chr17:40738783chr17:34001195ENST00000538556+1522576_716655881Compositional biasNote=Pro-rich (stalk region)
TgeneAP2B1chr17:40738783chr17:34001195ENST00000589344+1522576_716726952Compositional biasNote=Pro-rich (stalk region)


Top

FusionGeneSequence for FAM134C_AP2B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000262325_chr17_34001195_+_394aa
MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLV
FLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKVWLPAVKAKGLE
ISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVF
YFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELR

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000592545_chr17_34001195_+_394aa
MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLV
FLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKVWLPAVKAKGLE
ISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVF
YFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELR

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000538556_chr17_34001195_+_394aa
MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLV
FLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKVWLPAVKAKGLE
ISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVF
YFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELR

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000312678_chr17_34001195_+_394aa
MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLV
FLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKVWLPAVKAKGLE
ISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVF
YFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELR

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000589344_chr17_34001195_+_394aa
MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLV
FLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKVWLPAVKAKGLE
ISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVF
YFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELR

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000537622_chr17_34001195_+_394aa
MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLV
FLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKVWLPAVKAKGLE
ISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVF
YFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000262325_chr17_34001195_+_1182nt
ATGGCTGAGGCCGAAGGGGTTCCCACGACCCCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAG
CGGGACCAGCAGGTTGAGGCGGCGCAGCGGGCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTG
GTGTGGGAGCGGCCAGCTAGGAGCGCTCTGTGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTG
TTTTTACTTGCATTTGGCTTGATGATCATTGTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGAC
GCATTAGACAATGAGAGCTGGGGCTTTGTGCACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGT
GGGACCATTTTCATAAGGAATGTTTTGCTTTTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAG
ATTTCCGGAACATTTACTCACCGCCAAGGGCACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCA
ATCCAGTTTAACAAAAATAGCTTTGGTGTCATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTC
TCCCTGCCTCTCAATACCTTGGGCCCAGTCATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTC
TACTTCAGCTGCCTCATCCCACTCAATGTGCTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATT
CCCAATGAAAATGAACTTCAGTTTCAGATTAAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTAT
ACTATTGCCAAGAGGAATGTGGAAGGGCAGGACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGT
ATCCAGCCAGGAAACCCCAATTACACGCTGTCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATT

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000592545_chr17_34001195_+_1182nt
ATGGCTGAGGCCGAAGGGGTTCCCACGACCCCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAG
CGGGACCAGCAGGTTGAGGCGGCGCAGCGGGCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTG
GTGTGGGAGCGGCCAGCTAGGAGCGCTCTGTGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTG
TTTTTACTTGCATTTGGCTTGATGATCATTGTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGAC
GCATTAGACAATGAGAGCTGGGGCTTTGTGCACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGT
GGGACCATTTTCATAAGGAATGTTTTGCTTTTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAG
ATTTCCGGAACATTTACTCACCGCCAAGGGCACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCA
ATCCAGTTTAACAAAAATAGCTTTGGTGTCATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTC
TCCCTGCCTCTCAATACCTTGGGCCCAGTCATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTC
TACTTCAGCTGCCTCATCCCACTCAATGTGCTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATT
CCCAATGAAAATGAACTTCAGTTTCAGATTAAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTAT
ACTATTGCCAAGAGGAATGTGGAAGGGCAGGACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGT
ATCCAGCCAGGAAACCCCAATTACACGCTGTCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATT

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000538556_chr17_34001195_+_1182nt
ATGGCTGAGGCCGAAGGGGTTCCCACGACCCCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAG
CGGGACCAGCAGGTTGAGGCGGCGCAGCGGGCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTG
GTGTGGGAGCGGCCAGCTAGGAGCGCTCTGTGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTG
TTTTTACTTGCATTTGGCTTGATGATCATTGTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGAC
GCATTAGACAATGAGAGCTGGGGCTTTGTGCACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGT
GGGACCATTTTCATAAGGAATGTTTTGCTTTTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAG
ATTTCCGGAACATTTACTCACCGCCAAGGGCACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCA
ATCCAGTTTAACAAAAATAGCTTTGGTGTCATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTC
TCCCTGCCTCTCAATACCTTGGGCCCAGTCATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTC
TACTTCAGCTGCCTCATCCCACTCAATGTGCTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATT
CCCAATGAAAATGAACTTCAGTTTCAGATTAAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTAT
ACTATTGCCAAGAGGAATGTGGAAGGGCAGGACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGT
ATCCAGCCAGGAAACCCCAATTACACGCTGTCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATT

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000312678_chr17_34001195_+_1182nt
ATGGCTGAGGCCGAAGGGGTTCCCACGACCCCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAG
CGGGACCAGCAGGTTGAGGCGGCGCAGCGGGCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTG
GTGTGGGAGCGGCCAGCTAGGAGCGCTCTGTGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTG
TTTTTACTTGCATTTGGCTTGATGATCATTGTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGAC
GCATTAGACAATGAGAGCTGGGGCTTTGTGCACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGT
GGGACCATTTTCATAAGGAATGTTTTGCTTTTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAG
ATTTCCGGAACATTTACTCACCGCCAAGGGCACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCA
ATCCAGTTTAACAAAAATAGCTTTGGTGTCATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTC
TCCCTGCCTCTCAATACCTTGGGCCCAGTCATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTC
TACTTCAGCTGCCTCATCCCACTCAATGTGCTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATT
CCCAATGAAAATGAACTTCAGTTTCAGATTAAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTAT
ACTATTGCCAAGAGGAATGTGGAAGGGCAGGACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGT
ATCCAGCCAGGAAACCCCAATTACACGCTGTCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATT

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000589344_chr17_34001195_+_1182nt
ATGGCTGAGGCCGAAGGGGTTCCCACGACCCCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAG
CGGGACCAGCAGGTTGAGGCGGCGCAGCGGGCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTG
GTGTGGGAGCGGCCAGCTAGGAGCGCTCTGTGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTG
TTTTTACTTGCATTTGGCTTGATGATCATTGTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGAC
GCATTAGACAATGAGAGCTGGGGCTTTGTGCACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGT
GGGACCATTTTCATAAGGAATGTTTTGCTTTTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAG
ATTTCCGGAACATTTACTCACCGCCAAGGGCACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCA
ATCCAGTTTAACAAAAATAGCTTTGGTGTCATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTC
TCCCTGCCTCTCAATACCTTGGGCCCAGTCATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTC
TACTTCAGCTGCCTCATCCCACTCAATGTGCTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATT
CCCAATGAAAATGAACTTCAGTTTCAGATTAAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTAT
ACTATTGCCAAGAGGAATGTGGAAGGGCAGGACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGT
ATCCAGCCAGGAAACCCCAATTACACGCTGTCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATT

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000537622_chr17_34001195_+_1182nt
ATGGCTGAGGCCGAAGGGGTTCCCACGACCCCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAG
CGGGACCAGCAGGTTGAGGCGGCGCAGCGGGCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTG
GTGTGGGAGCGGCCAGCTAGGAGCGCTCTGTGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTG
TTTTTACTTGCATTTGGCTTGATGATCATTGTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGAC
GCATTAGACAATGAGAGCTGGGGCTTTGTGCACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGT
GGGACCATTTTCATAAGGAATGTTTTGCTTTTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAG
ATTTCCGGAACATTTACTCACCGCCAAGGGCACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCA
ATCCAGTTTAACAAAAATAGCTTTGGTGTCATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTC
TCCCTGCCTCTCAATACCTTGGGCCCAGTCATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTC
TACTTCAGCTGCCTCATCCCACTCAATGTGCTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATT
CCCAATGAAAATGAACTTCAGTTTCAGATTAAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTAT
ACTATTGCCAAGAGGAATGTGGAAGGGCAGGACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGT
ATCCAGCCAGGAAACCCCAATTACACGCTGTCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000262325_chr17_34001195_+_3960nt
AGTTGCTGTTATTGTGACTTGTCGGGCCACGGCCCCGGATGTTGTGGCTGCCGCGGGGAGATGGCTGAGGCCGAAGGGGTTCCCACGACC
CCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAGCGGGACCAGCAGGTTGAGGCGGCGCAGCGG
GCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTGGTGTGGGAGCGGCCAGCTAGGAGCGCTCTG
TGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTGTTTTTACTTGCATTTGGCTTGATGATCATT
GTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGACGCATTAGACAATGAGAGCTGGGGCTTTGTG
CACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGTGGGACCATTTTCATAAGGAATGTTTTGCTT
TTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAGATTTCCGGAACATTTACTCACCGCCAAGGG
CACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCAATCCAGTTTAACAAAAATAGCTTTGGTGTC
ATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTCTCCCTGCCTCTCAATACCTTGGGCCCAGTC
ATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTCTACTTCAGCTGCCTCATCCCACTCAATGTG
CTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATTCCCAATGAAAATGAACTTCAGTTTCAGATT
AAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTATACTATTGCCAAGAGGAATGTGGAAGGGCAG
GACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGTATCCAGCCAGGAAACCCCAATTACACGCTG
TCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATTTTGAAAAACTAACAAGACTGGTCCAGTACC
CTTCAACCATGCTGTGATCGGTGCAAGTCAAGAACTCTTAACTGGAAGAAATTGTATTGCTGCGTAGAATCTGAACACACTGAGGCCACC
TAGCAAGGTAGTAACTAGTCTAACCTGTGCTAACATTAGGGCACAACCTGTTGGATAGTTTTAGCTTCCTGTGAACATTTGTAACCACTG
CTTCAGTCACCTCCCACCTCTTGCCACCTGCTGCTGCTATCTGTCCTTACTTGTGGGCTTCTCCATGCTGTGCCAATGGCTGGCTTTTTC
TACACCCTCTTTTGAGTGTAGTTTGGTATTTTGTAATTGAGAGCTCATTTCAAAAGCAGAAAAAGACAACAAATATTAAAGCAAGGAAAA
GTGTAACTGAAACACTGCACTTTACTGTTTTATACTTTTGTACATATGAGAAATCAAGGGATTAGTGCAACCAGTAGAAAGCATTGAAAT
GACTGTCATTAACCACACAGTCCTGGAGGCAGAGATGCAGTTACCTACCCTAGCTTTTGATGGGTTCTCTTACCTGTAGTAGCCTTATCC
CTGGTCATTTGGATTTTCAGTTTGCTTTTTTCTTTTTTTCCCCTCCAAACTCCTTTTCCTTGGCCAAGCCTTCATGCTTCCCCCTTTCCA
TATTATAATCTCATTTGATTGCTCTGCAGTTGGGAACGGTGATCTTCTTGAATGATGTTTCAGTGTGCAAAAACTATAGAGCCTGTCAGC
ACCAAAGCTGACAGAAGTTATACCTTACTCCTTTCCTTTCCCCTGAACAAACCTGCTAATCCCACTAATTCAGGAATTTGAGTAGAGATG
GGGAACAAGAACCCAGATGCTGTCCCCTCACCCCCTCTCCTGTATTTCTCAGGTCCAGTTCAAATCTAAAATTCTACTTTTAGAGTTGAA
ACAGAGTAATAACTTATCTAACCCTCTTTTCCTACAAAGGAGAAAGATAAAAGGCACAAAGGTTACCGCCAAGGCCCGTCAGCTGTGTAG
TGGCAAAGCCGAGACCGAGTCTCCTAAGTCCCCGTCAGTGTGGTTTTCACCACAGGACTGTCTCTTGTCGTTTTCCCCTAATGCCTTCTC
CTGCCTTTTCTGTGCCTAGTTTTTGGCTCTTCACATATTCCATATTGATTTTGACGCTCTGTATATTGGCATCAGGTGGCAGCTGAATAT
CTTTTGAATTACTCGAAGGTAAAGCCAGATGCCAGAATGAAGGTGTAGCCAGTGTTTCCCATATGCCCCTGGAGCCCCACTTATTGAGGC
CAGCAGAATAGGTGCAGAGATGAAGTGAGCTTAGAGATGTTGCAAATGCTCTTTATCCCTTCAGCTCTCTGATCTGCTCTTTCTTCATGA
TACTTAGTCTGCAGGGCATATTAAGATCATCCCAGAGGTTCAGGCAGTTCCTGTCATCTCTGAAAAGACTGGGGGATATGAAATCTTCCC
CCTACCCCACTTAATGCGTTGGATATGATTTTTCAAAGAATGCTTCATGCCCAAAATACCAGCCTGTTTAGCAGTGTTACACTGTTTGAT
CTGCGGGCACTTGTTGCATTGCCTGGCACCCAATATTCAGGGTCCATGACTAAGACTGGTCTTCTCAGATGCCCTGCTTAAATCAGGGGC
ACTTCAGGCTCCACAGGCGTCATGTTGGACTGAGACCTAACTCACTGGACTCAGAGGAGGAATCGTGGAAAACAAGAGCAAAACTACCCC
ACACCCCTATTTCATGTCTGAAATAACCCTGTTTCATACCAGTTGCAAAGCTTGTGGGGAGCGGTCCCACAAAGCACTTTCTTAAACCTT
GAGAATCTCCAAGAGAAAAATATTTGGGGAAGGAGGGAGGAAATATGTCCCTTGCACACCACCCCTGAAGCACATGGCAGTAGGAAACAG
CATAGGATTGTATGTGGGAGGTGGATAGGTCGGTGATGTGTGGAGCGGAAAAGCAGGTTGGTAAAGTTCCCTTCTTGGGACTTATTCCTG
GAGTCAGTGGATACAAGTAGTGCAGAAGGTTCACACTGCAAATAGTGTTCTCATCTCAAAGCAAACTATCATTCCAGAAGGAAAAGTGTG
TCAGGGCAAGCAGACAACACAATTTCCTATCAGAATATGTCCCTCAACCCCCGAAACAAGGCTTCTCTCAGCCTCCCCACCAGTGATGGA
TAACAGCTCCTATTCTCAGCTGACCTGACTGAGCCAACCCATGAACTCTTCACTCCTTGGGGAAGCCACCTCCCATCACACCCCTGAGCA
GAGTTAGGGAGGAATTCTACTTCCCATAAAAGGACCTCTCCTGAGAGGCAAAACCTGTTGCCTCCACCACGGCTTCCCTCTTGGCTCATT
CCAAGCTTGGCCAAATTGGGGAAGTGGGATGGAGGTTGCCCTGCATCCCCCCTCCTCTGCCTGAGTGTGTCTTTGTAATGTCAGCTGGCA
TCATACAAAGAGCAGGAGAAGCAAACACCCAGAACTCTTTTGCTGGTCAGAGATTCCCTGAGTGTCTGTCCTCACCCAAGCCTGCTCTGT
GTCTGTGTTGTGAAGCTTGAGACTCTGGAAAGAAATGGGGAGGGGGGGCAGGGGAAATGTTGCCCTAAGAATGCTTCTCATTCCTCTGTT
CTTATTGGGTCCTGTTTTTCGGGAGGGTGGGGGTTGGGGGAAGCTTGACCTTGTGTCTTCGTCAATAAACTCACATTTACACAAAATGAA

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000592545_chr17_34001195_+_1629nt
AGTTGCTGTTATTGTGACTTGTCGGGCCACGGCCCCGGATGTTGTGGCTGCCGCGGGGAGATGGCTGAGGCCGAAGGGGTTCCCACGACC
CCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAGCGGGACCAGCAGGTTGAGGCGGCGCAGCGG
GCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTGGTGTGGGAGCGGCCAGCTAGGAGCGCTCTG
TGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTGTTTTTACTTGCATTTGGCTTGATGATCATT
GTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGACGCATTAGACAATGAGAGCTGGGGCTTTGTG
CACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGTGGGACCATTTTCATAAGGAATGTTTTGCTT
TTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAGATTTCCGGAACATTTACTCACCGCCAAGGG
CACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCAATCCAGTTTAACAAAAATAGCTTTGGTGTC
ATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTCTCCCTGCCTCTCAATACCTTGGGCCCAGTC
ATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTCTACTTCAGCTGCCTCATCCCACTCAATGTG
CTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATTCCCAATGAAAATGAACTTCAGTTTCAGATT
AAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTATACTATTGCCAAGAGGAATGTGGAAGGGCAG
GACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGTATCCAGCCAGGAAACCCCAATTACACGCTG
TCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATTTTGAAAAACTAACAAGACTGGTCCAGTACC
CTTCAACCATGCTGTGATCGGTGCAAGTCAAGAACTCTTAACTGGAAGAAATTGTATTGCTGCGTAGAATCTGAACACACTGAGGCCACC
TAGCAAGGTAGTAACTAGTCTAACCTGTGCTAACATTAGGGCACAACCTGTTGGATAGTTTTAGCTTCCTGTGAACATTTGTAACCACTG
CTTCAGTCACCTCCCACCTCTTGCCACCTGCTGCTGCTATCTGTCCTTACTTGTGGGCTTCTCCATGCTGTGCCAATGGCTGGCTTTTTC
TACACCCTCTTTTGAGTGTAGTTTGGTATTTTGTAATTGAGAGCTCATTTCAAAAGCAGAAAAAGACAACAAATATTAAAGCAAGGAAAA

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000538556_chr17_34001195_+_1629nt
AGTTGCTGTTATTGTGACTTGTCGGGCCACGGCCCCGGATGTTGTGGCTGCCGCGGGGAGATGGCTGAGGCCGAAGGGGTTCCCACGACC
CCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAGCGGGACCAGCAGGTTGAGGCGGCGCAGCGG
GCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTGGTGTGGGAGCGGCCAGCTAGGAGCGCTCTG
TGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTGTTTTTACTTGCATTTGGCTTGATGATCATT
GTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGACGCATTAGACAATGAGAGCTGGGGCTTTGTG
CACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGTGGGACCATTTTCATAAGGAATGTTTTGCTT
TTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAGATTTCCGGAACATTTACTCACCGCCAAGGG
CACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCAATCCAGTTTAACAAAAATAGCTTTGGTGTC
ATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTCTCCCTGCCTCTCAATACCTTGGGCCCAGTC
ATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTCTACTTCAGCTGCCTCATCCCACTCAATGTG
CTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATTCCCAATGAAAATGAACTTCAGTTTCAGATT
AAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTATACTATTGCCAAGAGGAATGTGGAAGGGCAG
GACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGTATCCAGCCAGGAAACCCCAATTACACGCTG
TCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATTTTGAAAAACTAACAAGACTGGTCCAGTACC
CTTCAACCATGCTGTGATCGGTGCAAGTCAAGAACTCTTAACTGGAAGAAATTGTATTGCTGCGTAGAATCTGAACACACTGAGGCCACC
TAGCAAGGTAGTAACTAGTCTAACCTGTGCTAACATTAGGGCACAACCTGTTGGATAGTTTTAGCTTCCTGTGAACATTTGTAACCACTG
CTTCAGTCACCTCCCACCTCTTGCCACCTGCTGCTGCTATCTGTCCTTACTTGTGGGCTTCTCCATGCTGTGCCAATGGCTGGCTTTTTC
TACACCCTCTTTTGAGTGTAGTTTGGTATTTTGTAATTGAGAGCTCATTTCAAAAGCAGAAAAAGACAACAAATATTAAAGCAAGGAAAA

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000312678_chr17_34001195_+_1918nt
AGTTGCTGTTATTGTGACTTGTCGGGCCACGGCCCCGGATGTTGTGGCTGCCGCGGGGAGATGGCTGAGGCCGAAGGGGTTCCCACGACC
CCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAGCGGGACCAGCAGGTTGAGGCGGCGCAGCGG
GCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTGGTGTGGGAGCGGCCAGCTAGGAGCGCTCTG
TGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTGTTTTTACTTGCATTTGGCTTGATGATCATT
GTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGACGCATTAGACAATGAGAGCTGGGGCTTTGTG
CACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGTGGGACCATTTTCATAAGGAATGTTTTGCTT
TTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAGATTTCCGGAACATTTACTCACCGCCAAGGG
CACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCAATCCAGTTTAACAAAAATAGCTTTGGTGTC
ATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTCTCCCTGCCTCTCAATACCTTGGGCCCAGTC
ATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTCTACTTCAGCTGCCTCATCCCACTCAATGTG
CTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATTCCCAATGAAAATGAACTTCAGTTTCAGATT
AAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTATACTATTGCCAAGAGGAATGTGGAAGGGCAG
GACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGTATCCAGCCAGGAAACCCCAATTACACGCTG
TCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATTTTGAAAAACTAACAAGACTGGTCCAGTACC
CTTCAACCATGCTGTGATCGGTGCAAGTCAAGAACTCTTAACTGGAAGAAATTGTATTGCTGCGTAGAATCTGAACACACTGAGGCCACC
TAGCAAGGTAGTAACTAGTCTAACCTGTGCTAACATTAGGGCACAACCTGTTGGATAGTTTTAGCTTCCTGTGAACATTTGTAACCACTG
CTTCAGTCACCTCCCACCTCTTGCCACCTGCTGCTGCTATCTGTCCTTACTTGTGGGCTTCTCCATGCTGTGCCAATGGCTGGCTTTTTC
TACACCCTCTTTTGAGTGTAGTTTGGTATTTTGTAATTGAGAGCTCATTTCAAAAGCAGAAAAAGACAACAAATATTAAAGCAAGGAAAA
GTGTAACTGAAACACTGCACTTTACTGTTTTATACTTTTGTACATATGAGAAATCAAGGGATTAGTGCAACCAGTAGAAAGCATTGAAAT
GACTGTCATTAACCACACAGTCCTGGAGGCAGAGATGCAGTTACCTACCCTAGCTTTTGATGGGTTCTCTTACCTGTAGTAGCCTTATCC
CTGGTCATTTGGATTTTCAGTTTGCTTTTTTCTTTTTTTCCCCTCCAAACTCCTTTTCCTTGGCCAAGCCTTCATGCTTCCCCCTTTCCA

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000589344_chr17_34001195_+_1308nt
AGTTGCTGTTATTGTGACTTGTCGGGCCACGGCCCCGGATGTTGTGGCTGCCGCGGGGAGATGGCTGAGGCCGAAGGGGTTCCCACGACC
CCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAGCGGGACCAGCAGGTTGAGGCGGCGCAGCGG
GCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTGGTGTGGGAGCGGCCAGCTAGGAGCGCTCTG
TGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTGTTTTTACTTGCATTTGGCTTGATGATCATT
GTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGACGCATTAGACAATGAGAGCTGGGGCTTTGTG
CACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGTGGGACCATTTTCATAAGGAATGTTTTGCTT
TTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAGATTTCCGGAACATTTACTCACCGCCAAGGG
CACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCAATCCAGTTTAACAAAAATAGCTTTGGTGTC
ATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTCTCCCTGCCTCTCAATACCTTGGGCCCAGTC
ATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTCTACTTCAGCTGCCTCATCCCACTCAATGTG
CTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATTCCCAATGAAAATGAACTTCAGTTTCAGATT
AAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTATACTATTGCCAAGAGGAATGTGGAAGGGCAG
GACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGTATCCAGCCAGGAAACCCCAATTACACGCTG
TCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATTTTGAAAAACTAACAAGACTGGTCCAGTACC

>In-frame_FAM134C_ENST00000309428_chr17_40738783_-_AP2B1_ENST00000537622_chr17_34001195_+_1632nt
AGTTGCTGTTATTGTGACTTGTCGGGCCACGGCCCCGGATGTTGTGGCTGCCGCGGGGAGATGGCTGAGGCCGAAGGGGTTCCCACGACC
CCAGGCCCGGCTTCGGGGTCGACTTTCAGGGGCCGCCGAGATGTGTCAGGCTCCTGGGAGCGGGACCAGCAGGTTGAGGCGGCGCAGCGG
GCCCTGGTGGAGGTGCTGGGGCCTTACGAGCCTCTGCTGAGTCGGGTGCAGGCAGCCCTGGTGTGGGAGCGGCCAGCTAGGAGCGCTCTG
TGGTGCCTGGGGCTGAACGCGGCTTTCTGGTTTTTTGCCCTGACATCTCTTCGTCTTGTGTTTTTACTTGCATTTGGCTTGATGATCATT
GTGTGTATTGATCAATGGAAGAACAAAATCTGGCCTGAAATAAAAGTGCCAAGACCCGACGCATTAGACAATGAGAGCTGGGGCTTTGTG
CACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGTGGGACCATTTTCATAAGGAATGTTTTGCTT
TTCAAAAAGCAAAACCCAGGCAAGGTCTGGCTACCTGCAGTAAAGGCTAAAGGCTTGGAGATTTCCGGAACATTTACTCACCGCCAAGGG
CACATCTATATGGAAATGAACTTCACCAATAAAGCTCTGCAGCACATGACAGATTTTGCAATCCAGTTTAACAAAAATAGCTTTGGTGTC
ATCCCCAGCACTCCTCTGGCCATCCATACACCACTGATGCCAAACCAGAGCATTGATGTCTCCCTGCCTCTCAATACCTTGGGCCCAGTC
ATGAAGATGGAACCTCTGAATAACCTCCAGGTGGCTGTGAAAAACAATATCGATGTCTTCTACTTCAGCTGCCTCATCCCACTCAATGTG
CTTTTTGTAGAAGATGGCAAAATGGAGCGCCAGGTCTTCCTTGCAACATGGAAGGATATTCCCAATGAAAATGAACTTCAGTTTCAGATT
AAGGAATGTCATTTAAATGCTGACACTGTTTCCAGCAAGTTGCAAAACAACAATGTTTATACTATTGCCAAGAGGAATGTGGAAGGGCAG
GACATGCTGTACCAATCCCTGAAGCTCACTAATGGCATTTGGATTTTGGCCGAACTACGTATCCAGCCAGGAAACCCCAATTACACGCTG
TCACTGAAGTGTAGAGCTCCTGAAGTCTCTCAATACATCTATCAGGTCTACGACAGCATTTTGAAAAACTAACAAGACTGGTCCAGTACC
CTTCAACCATGCTGTGATCGGTGCAAGTCAAGAACTCTTAACTGGAAGAAATTGTATTGCTGCGTAGAATCTGAACACACTGAGGCCACC
TAGCAAGGTAGTAACTAGTCTAACCTGTGCTAACATTAGGGCACAACCTGTTGGATAGTTTTAGCTTCCTGTGAACATTTGTAACCACTG
CTTCAGTCACCTCCCACCTCTTGCCACCTGCTGCTGCTATCTGTCCTTACTTGTGGGCTTCTCCATGCTGTGCCAATGGCTGGCTTTTTC
TACACCCTCTTTTGAGTGTAGTTTGGTATTTTGTAATTGAGAGCTCATTTCAAAAGCAGAAAAAGACAACAAATATTAAAGCAAGGAAAA


Top

FusionGenePPI for FAM134C_AP2B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM134CELAVL1, ABHD16A, ARL6IP1, GABARAPL1, STAP1, MAP1LC3A, MOV10, NXF1, ATP5F1, TSPAN5, TSPAN17, POMK, LPAR1, SCN2B, JPH1, ATP12A, NCAM1, KTN1, NDUFAF1, SLC4A2, TTYH3, REEP5, GNPTAB, TUBA3C, POMGNT1, RMND1, YIPF4, PLSCR1, CD47, SEC62, SLC35F2, ARL6IP5, CD63, GNPTG, ATP9A, CERS6, COX1, RNF170, XYLT2, TSPAN15, GPR89B, LCLAT1, UBE2A, HTR2C, IPPK, RTN4, TMEM208, GPR21, DAZAP2, MAS1, ATP5B, SLC6A5, TPTEAP2B1KIAA0408, DHX58, MLH1, AP1M1, MEA1, TUBGCP4, LDLRAP1, THAP1, POM121, NECAP2, ATP6V1G1, NUP54, TERF2IP, FAM46C, RIBC2, AP1M2, AP2M1, RNPS1, TGFBR1, TGFBR2, BUB1B, CLINT1, ARRB2, OSBPL10, APC, ITSN1, SIRT7, CLTC, AMPH, CUL3, ABL1, SHC1, CRK, EPS15, ERBB2, FN1, VCAM1, DAB2, ITGA4, MMS19, RNF11, EGFR, GRB2, PLOD2, EPN1, LNPEP, NUSAP1, SEC24C, XPO7, RPA3, RPA2, RPA1, EPHA2, GTF2I, PIP5K1C, SLC25A6, KPNA2, U2AF1, RAPGEF3, TXN2, AFF4, XRCC6BP1, NEU4, AAK1, HSPB1, AP1S1, AP1S2, AP1G1, AP2A1, AP2A2, CAB39, AP2S1, COX5B, NUP50, TOMM40, VAPA, NTRK1, CEP128, ODF2, XPO1, CLTB, DBN1, FLNA, GAK, MYH9, PICALM, LIMA1, GTSE1, ANLN, MYO19, TFRC, MCM2, MEX3C, TFAP2A, DIEXF, MYO6, ARFGAP1, RUNDC3A, SNX9, UBC, OCRL, TRIM25, BRCA1, SLC2A8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAP2B1chr17:40738783chr17:34001195ENST00000262325+1421841_937712938ARRB1
TgeneAP2B1chr17:40738783chr17:34001195ENST00000312678+1522841_937726952ARRB1
TgeneAP2B1chr17:40738783chr17:34001195ENST00000537622+1522841_937726952ARRB1
TgeneAP2B1chr17:40738783chr17:34001195ENST00000538556+1522841_937655881ARRB1
TgeneAP2B1chr17:40738783chr17:34001195ENST00000589344+1522841_937726952ARRB1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM134C_AP2B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAM134C_AP2B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAP2B1C0086132Depressive Symptoms1PSYGENET