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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12546

FusionGeneSummary for FAM131A_HTR3D

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM131A_HTR3D
Fusion gene ID: 12546
HgeneTgene
Gene symbol

FAM131A

HTR3D

Gene ID

131408

200909

Gene namefamily with sequence similarity 131 member A5-hydroxytryptamine receptor 3D
SynonymsC3orf40|FLAT715|PRO13785HT3D
Cytomap

3q27.1

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM131A5-hydroxytryptamine receptor 3D5-hydroxytryptamine (serotonin) receptor 3 family member D5-hydroxytryptamine (serotonin) receptor 3D, ionotropic5-hydroxytryptamine receptor 3 subunit Dserotonin 5-HT-3D receptorserotonin receptor 3D
Modification date2018051920180523
UniProtAcc

Q6UXB0

Q70Z44

Ensembl transtripts involved in fusion geneENST00000450976, ENST00000418281, 
ENST00000340957, ENST00000383847, 
ENST00000497070, ENST00000453072, 
ENST00000310585, 
ENST00000334128, 
ENST00000428798, ENST00000382489, 
ENST00000453435, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 2=8
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: FAM131A [Title/Abstract] AND HTR3D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-CD-8535-01AFAM131Achr3

184055159

+HTR3Dchr3

183752845

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000450976ENST00000334128FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-intronENST00000450976ENST00000428798FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-intronENST00000450976ENST00000382489FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-intronENST00000450976ENST00000453435FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-5UTRENST00000418281ENST00000334128FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-intronENST00000418281ENST00000428798FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-intronENST00000418281ENST00000382489FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-intronENST00000418281ENST00000453435FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-5UTRENST00000340957ENST00000334128FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-intronENST00000340957ENST00000428798FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-intronENST00000340957ENST00000382489FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
5UTR-intronENST00000340957ENST00000453435FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-5UTRENST00000383847ENST00000334128FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000383847ENST00000428798FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000383847ENST00000382489FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000383847ENST00000453435FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-5UTRENST00000497070ENST00000334128FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000497070ENST00000428798FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000497070ENST00000382489FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000497070ENST00000453435FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-5UTRENST00000453072ENST00000334128FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000453072ENST00000428798FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000453072ENST00000382489FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000453072ENST00000453435FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-5UTRENST00000310585ENST00000334128FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000310585ENST00000428798FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000310585ENST00000382489FAM131Achr3

184055159

+HTR3Dchr3

183752845

+
intron-intronENST00000310585ENST00000453435FAM131Achr3

184055159

+HTR3Dchr3

183752845

+

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FusionProtFeatures for FAM131A_HTR3D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM131A

Q6UXB0

HTR3D

Q70Z44

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functionsas a neurotransmitter, a hormone, and a mitogen. This receptor isa ligand-gated ion channel, which when activated causes fast,depolarizing responses. It is a cation-specific, but otherwiserelatively nonselective, ion channel.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM131A_HTR3D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM131A_HTR3D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM131APHYHIP, ELAVL1, TRIM25, IDH1HTR3DLRFN4, RSPRY1, HSDL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM131A_HTR3D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHTR3DQ70Z44DB00898Ethanol5-hydroxytryptamine receptor 3Dsmall moleculeapproved

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RelatedDiseases for FAM131A_HTR3D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHTR3DC0036341Schizophrenia1PSYGENET