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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12540

FusionGeneSummary for FAM129B_OLFM1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM129B_OLFM1
Fusion gene ID: 12540
HgeneTgene
Gene symbol

FAM129B

OLFM1

Gene ID

64855

10439

Gene namefamily with sequence similarity 129 member Bolfactomedin 1
SynonymsC9orf88|MEG-3|MINERVA|OC58|bA356B19.6AMY|NOE1|NOELIN1|OlfA
Cytomap

9q34.11

9q34.3

Type of geneprotein-codingprotein-coding
Descriptionniban-like protein 1melanoma invasion by ERKnoelinneuroblastoma proteinneuronal olfactomedin-related ER localized proteinolfactomedin related ER localized proteinpancortin 1
Modification date2018052220180519
UniProtAcc

Q96TA1

Q99784

Ensembl transtripts involved in fusion geneENST00000373314, ENST00000373312, 
ENST00000468379, 		ENST00000371799, 
ENST00000277415, ENST00000252854, 
ENST00000371801, ENST00000371796, 
ENST00000392991, ENST00000371793, 
Fusion gene scores* DoF score14 X 9 X 9=11345 X 5 X 3=75
# samples 135
** MAII scorelog2(13/1134*10)=-3.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM129B [Title/Abstract] AND OLFM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM129B

GO:0008285

negative regulation of cell proliferation

14602737|17569660|20032057|20179190

HgeneFAM129B

GO:0045892

negative regulation of transcription, DNA-templated

17569660

HgeneFAM129B

GO:0045893

positive regulation of transcription, DNA-templated

17569660|20032057|20179190

HgeneFAM129B

GO:2000279

negative regulation of DNA biosynthetic process

14602737|17569660|20032057

HgeneFAM129B

GO:2000679

positive regulation of transcription regulatory region DNA binding

17569660


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A08X-01AFAM129Bchr9

130331099

-OLFM1chr9

137982041

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000373314ENST00000371799FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
intron-intronENST00000373314ENST00000277415FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
intron-intronENST00000373314ENST00000252854FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
intron-intronENST00000373314ENST00000371801FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
intron-intronENST00000373314ENST00000371796FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
intron-intronENST00000373314ENST00000392991FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
intron-intronENST00000373314ENST00000371793FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5CDS-intronENST00000373312ENST00000371799FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5CDS-intronENST00000373312ENST00000277415FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5CDS-intronENST00000373312ENST00000252854FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5CDS-intronENST00000373312ENST00000371801FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5CDS-intronENST00000373312ENST00000371796FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5CDS-intronENST00000373312ENST00000392991FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5CDS-intronENST00000373312ENST00000371793FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5UTR-intronENST00000468379ENST00000371799FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5UTR-intronENST00000468379ENST00000277415FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5UTR-intronENST00000468379ENST00000252854FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5UTR-intronENST00000468379ENST00000371801FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5UTR-intronENST00000468379ENST00000371796FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5UTR-intronENST00000468379ENST00000392991FAM129Bchr9

130331099

-OLFM1chr9

137982041

+
5UTR-intronENST00000468379ENST00000371793FAM129Bchr9

130331099

-OLFM1chr9

137982041

+

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FusionProtFeatures for FAM129B_OLFM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM129B

Q96TA1

OLFM1

Q99784

May play a role in apoptosis suppression. May promotemelanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540,ECO:0000269|PubMed:21148485}. Contributes to the regulation of axonal growth in theembryonic and adult central nervous system by inhibitinginteractions between RTN4R and LINGO1. Inhibits RTN4R-mediatedaxon growth cone collapse (By similarity). May play an importantrole in regulating the production of neural crest cells by theneural tube (By similarity). May be required for normal responsesto olfactory stimuli (By similarity).{ECO:0000250|UniProtKB:O88998, ECO:0000250|UniProtKB:Q9IAK4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM129B_OLFM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM129B_OLFM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM129BKEAP1, HTATSF1, ZNF512B, DDI2, CORO1C, DNM1L, GLUL, PAWR, PUF60, SHMT1, TARS, VPS26A, VPS29, VPS35, ZYX, GTF2A1, H3F3A, NUDC, PAPOLA, SNX2, SNX6, TSN, NTRK1, TMEM17, SNW1, CDC5L, EGFR, HRAS, KRAS, CDH1, CTDSPL, PTPRG, CDK15, PDE4DIP, TRIM25OLFM1EGFR, DISC1, TRAF3IP1, APP, ASPH, TUBA3C, PCOLCE2, OLFM2, TXNDC11, MANEA, EDEM2, ARNTL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM129B_OLFM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM129B_OLFM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneOLFM1C0033578Prostatic Neoplasms1CTD_human