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Fusion gene ID: 1253 |
FusionGeneSummary for AHSG_TF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AHSG_TF | Fusion gene ID: 1253 | Hgene | Tgene | Gene symbol | AHSG | TF | Gene ID | 197 | 7018 |
| Gene name | alpha 2-HS glycoprotein | transferrin | |
| Synonyms | A2HS|AHS|APMR1|FETUA|HSGA | HEL-S-71p|PRO1557|PRO2086|TFQTL1 | |
| Cytomap | 3q27.3 | 3q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-2-HS-glycoproteinalpha-2-Z-globulinba-alpha-2-glycoproteinfetuin-A | serotransferrinbeta-1 metal-binding globulinepididymis secretory sperm binding protein Li 71psiderophilin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P02765 | P02787 | |
| Ensembl transtripts involved in fusion gene | ENST00000411641, ENST00000273784, | ENST00000402696, ENST00000264998, ENST00000475382, | |
| Fusion gene scores | * DoF score | 4 X 3 X 2=24 | 8 X 7 X 3=168 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AHSG [Title/Abstract] AND TF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AHSG | GO:0006953 | acute-phase response | 12153747 |
| Hgene | AHSG | GO:0050766 | positive regulation of phagocytosis | 12725640 |
| Tgene | TF | GO:0048260 | positive regulation of receptor-mediated endocytosis | 12704209 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-CC-A9FW-01A | AHSG | chr3 | 186331143 | + | TF | chr3 | 133483026 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000411641 | ENST00000402696 | AHSG | chr3 | 186331143 | + | TF | chr3 | 133483026 | + |
| In-frame | ENST00000411641 | ENST00000264998 | AHSG | chr3 | 186331143 | + | TF | chr3 | 133483026 | + |
| 5CDS-intron | ENST00000411641 | ENST00000475382 | AHSG | chr3 | 186331143 | + | TF | chr3 | 133483026 | + |
| In-frame | ENST00000273784 | ENST00000402696 | AHSG | chr3 | 186331143 | + | TF | chr3 | 133483026 | + |
| In-frame | ENST00000273784 | ENST00000264998 | AHSG | chr3 | 186331143 | + | TF | chr3 | 133483026 | + |
| 5CDS-intron | ENST00000273784 | ENST00000475382 | AHSG | chr3 | 186331143 | + | TF | chr3 | 133483026 | + |
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FusionProtFeatures for AHSG_TF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AHSG | TF |
| Promotes endocytosis, possesses opsonic properties andinfluences the mineral phase of bone. Shows affinity for calciumand barium ions. | Transferrins are iron binding transport proteins whichcan bind two Fe(3+) ions in association with the binding of ananion, usually bicarbonate. It is responsible for the transport ofiron from sites of absorption and heme degradation to those ofstorage and utilization. Serum transferrin may also have a furtherrole in stimulating cell proliferation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >AHSG | chr3:186331143 | chr3:133483026 | ENST00000411641 | + | 1 | 7 | 144_255 | 71 | 368 | Domain | Cystatin fetuin-A-type 2 |
| Hgene | >AHSG | chr3:186331143 | chr3:133483026 | ENST00000411641 | + | 1 | 7 | 27_133 | 71 | 368 | Domain | Cystatin fetuin-A-type 1 |
| Tgene | TF | chr3:186331143 | chr3:133483026 | ENST00000402696 | + | 8 | 17 | 25_347 | 401 | 699 | Domain | Transferrin-like 1 |
| Tgene | TF | chr3:186331143 | chr3:133483026 | ENST00000402696 | + | 8 | 17 | 361_683 | 401 | 699 | Domain | Transferrin-like 2 |
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FusionGeneSequence for AHSG_TF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AHSG_ENST00000411641_chr3_186331143_+_TF_ENST00000402696_chr3_133483026_+_369aa MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQNGEADAMSLDGGFVYIAGK CGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKD SSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLAR APNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLL >In-frame_AHSG_ENST00000411641_chr3_186331143_+_TF_ENST00000264998_chr3_133483026_+_369aa MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQNGEADAMSLDGGFVYIAGK CGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKD SSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLAR APNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLL >In-frame_AHSG_ENST00000273784_chr3_186331143_+_TF_ENST00000402696_chr3_133483026_+_369aa MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQNGEADAMSLDGGFVYIAGK CGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKD SSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLAR APNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLL >In-frame_AHSG_ENST00000273784_chr3_186331143_+_TF_ENST00000264998_chr3_133483026_+_369aa MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQNGEADAMSLDGGFVYIAGK CGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKD SSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLAR APNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AHSG_ENST00000411641_chr3_186331143_+_TF_ENST00000402696_chr3_133483026_+_1107nt ATGAAGTCCCTCGTCCTGCTCCTTTGTCTTGCTCAGCTCTGGGGCTGCCACTCAGCCCCACATGGCCCAGGGCTGATTTATAGACAACCG AACTGCGATGATCCAGAAACTGAGGAAGCAGCTCTGGTGGCTATAGACTACATCAATCAAAACCTTCCTTGGGGATACAAACACACCTTG AACCAGATTGATGAAGTAAAGGTGTGGCCTCAGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAG TGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACACCAGAGGCAGGGTATTTTGCTATAGCAGTG GTGAAGAAATCAGCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAAC ATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGTGAAGGTTGTGCCCCTGGGTCTAAGAAAGAC TCCAGTCTCTGTAAGCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTC AGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGGAAAAAACCCTGATCCATGGGCT AAGAATCTGAATGAAAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGA GCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTACGTCAACAGCAGCACCTATTTGGAAGCAAC GTAACTGACTGCTCGGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTT CATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAACCTGAGAAAATGCTCCACCTCATCACTCCTG >In-frame_AHSG_ENST00000411641_chr3_186331143_+_TF_ENST00000264998_chr3_133483026_+_1107nt ATGAAGTCCCTCGTCCTGCTCCTTTGTCTTGCTCAGCTCTGGGGCTGCCACTCAGCCCCACATGGCCCAGGGCTGATTTATAGACAACCG AACTGCGATGATCCAGAAACTGAGGAAGCAGCTCTGGTGGCTATAGACTACATCAATCAAAACCTTCCTTGGGGATACAAACACACCTTG AACCAGATTGATGAAGTAAAGGTGTGGCCTCAGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAG TGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACACCAGAGGCAGGGTATTTTGCTATAGCAGTG GTGAAGAAATCAGCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAAC ATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGTGAAGGTTGTGCCCCTGGGTCTAAGAAAGAC TCCAGTCTCTGTAAGCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTC AGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGGAAAAAACCCTGATCCATGGGCT AAGAATCTGAATGAAAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGA GCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTACGTCAACAGCAGCACCTATTTGGAAGCAAC GTAACTGACTGCTCGGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTT CATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAACCTGAGAAAATGCTCCACCTCATCACTCCTG >In-frame_AHSG_ENST00000273784_chr3_186331143_+_TF_ENST00000402696_chr3_133483026_+_1107nt ATGAAGTCCCTCGTCCTGCTCCTTTGTCTTGCTCAGCTCTGGGGCTGCCACTCAGCCCCACATGGCCCAGGGCTGATTTATAGACAACCG AACTGCGATGATCCAGAAACTGAGGAAGCAGCTCTGGTGGCTATAGACTACATCAATCAAAACCTTCCTTGGGGATACAAACACACCTTG AACCAGATTGATGAAGTAAAGGTGTGGCCTCAGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAG TGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACACCAGAGGCAGGGTATTTTGCTATAGCAGTG GTGAAGAAATCAGCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAAC ATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGTGAAGGTTGTGCCCCTGGGTCTAAGAAAGAC TCCAGTCTCTGTAAGCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTC AGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGGAAAAAACCCTGATCCATGGGCT AAGAATCTGAATGAAAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGA GCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTACGTCAACAGCAGCACCTATTTGGAAGCAAC GTAACTGACTGCTCGGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTT CATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAACCTGAGAAAATGCTCCACCTCATCACTCCTG >In-frame_AHSG_ENST00000273784_chr3_186331143_+_TF_ENST00000264998_chr3_133483026_+_1107nt ATGAAGTCCCTCGTCCTGCTCCTTTGTCTTGCTCAGCTCTGGGGCTGCCACTCAGCCCCACATGGCCCAGGGCTGATTTATAGACAACCG AACTGCGATGATCCAGAAACTGAGGAAGCAGCTCTGGTGGCTATAGACTACATCAATCAAAACCTTCCTTGGGGATACAAACACACCTTG AACCAGATTGATGAAGTAAAGGTGTGGCCTCAGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAG TGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACACCAGAGGCAGGGTATTTTGCTATAGCAGTG GTGAAGAAATCAGCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAAC ATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGTGAAGGTTGTGCCCCTGGGTCTAAGAAAGAC TCCAGTCTCTGTAAGCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTC AGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGGAAAAAACCCTGATCCATGGGCT AAGAATCTGAATGAAAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGA GCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTACGTCAACAGCAGCACCTATTTGGAAGCAAC GTAACTGACTGCTCGGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTT CATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAACCTGAGAAAATGCTCCACCTCATCACTCCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AHSG_ENST00000411641_chr3_186331143_+_TF_ENST00000402696_chr3_133483026_+_1712nt TGTTTGCTTTTCCAGGGCTGATGTTTGCAGGGTGTTTTTTTTTTTCTTTTGAACCAAAGCAGAAATCATCCTGTATCCTTATGCAATTCT TCCGGCAGGCTCCAACAGATAAATAAAGCCCACCACCCTCCATGGGTCTACCTTTCCCAGCAGAGCACCTGGGTTGGTCCCGAAGCCTCC AACCACCTGCACGCCTGCCAGGGCCTCTCTGGGGCAGCCATGAAGTCCCTCGTCCTGCTCCTTTGTCTTGCTCAGCTCTGGGGCTGCCAC TCAGCCCCACATGGCCCAGGGCTGATTTATAGACAACCGAACTGCGATGATCCAGAAACTGAGGAAGCAGCTCTGGTGGCTATAGACTAC ATCAATCAAAACCTTCCTTGGGGATACAAACACACCTTGAACCAGATTGATGAAGTAAAGGTGTGGCCTCAGAATGGAGAAGCTGATGCC ATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAGTGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGT GAGGATACACCAGAGGCAGGGTATTTTGCTATAGCAGTGGTGAAGAAATCAGCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAG TCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAACATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAA TTTTTCAGTGAAGGTTGTGCCCCTGGGTCTAAGAAAGACTCCAGTCTCTGTAAGCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCC AACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTCAGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTC CCACAGAACACTGGGGGAAAAAACCCTGATCCATGGGCTAAGAATCTGAATGAAAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGG AAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGAGCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCAC AAGATATTACGTCAACAGCAGCACCTATTTGGAAGCAACGTAACTGACTGCTCGGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGAC CTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTTCATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCT GTTGGTAACCTGAGAAAATGCTCCACCTCATCACTCCTGGAAGCCTGCACTTTCCGTAGACCTTAAAATCTCAGAGGTAGGGCTGCCACC AAGGTGAAGATGGGAACGCAGATGATCCATGAGTTTGCCCTGGTTTCACTGGCCCAAGTGGTTTGTGCTAACCACGTCTGTCTTCACAGC TCTGTGTTGCCATGTGTGCTGAACAAAAAATAAAAATTATTATTGATTTTATATTTCAAAAACTCCATTCTTTCCTAAATATTTTCAACA AAGGATTTCTTTATGCATTCTGCCTAAATACCTATGCAACTGAGCCCTTCCTTCTCAGCTCAAGATTCGTCTGGTCTTTCCCTACAGCTT TGTGTGTGCCATGGCCACATCTCCTGGGTACAGTTCAAGGAGACATCTTTTCTAAAAGGGTCTGCGTGATCATTAAAATATAATCAAATG >In-frame_AHSG_ENST00000411641_chr3_186331143_+_TF_ENST00000264998_chr3_133483026_+_1497nt TGTTTGCTTTTCCAGGGCTGATGTTTGCAGGGTGTTTTTTTTTTTCTTTTGAACCAAAGCAGAAATCATCCTGTATCCTTATGCAATTCT TCCGGCAGGCTCCAACAGATAAATAAAGCCCACCACCCTCCATGGGTCTACCTTTCCCAGCAGAGCACCTGGGTTGGTCCCGAAGCCTCC AACCACCTGCACGCCTGCCAGGGCCTCTCTGGGGCAGCCATGAAGTCCCTCGTCCTGCTCCTTTGTCTTGCTCAGCTCTGGGGCTGCCAC TCAGCCCCACATGGCCCAGGGCTGATTTATAGACAACCGAACTGCGATGATCCAGAAACTGAGGAAGCAGCTCTGGTGGCTATAGACTAC ATCAATCAAAACCTTCCTTGGGGATACAAACACACCTTGAACCAGATTGATGAAGTAAAGGTGTGGCCTCAGAATGGAGAAGCTGATGCC ATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAGTGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGT GAGGATACACCAGAGGCAGGGTATTTTGCTATAGCAGTGGTGAAGAAATCAGCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAG TCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAACATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAA TTTTTCAGTGAAGGTTGTGCCCCTGGGTCTAAGAAAGACTCCAGTCTCTGTAAGCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCC AACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTCAGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTC CCACAGAACACTGGGGGAAAAAACCCTGATCCATGGGCTAAGAATCTGAATGAAAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGG AAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGAGCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCAC AAGATATTACGTCAACAGCAGCACCTATTTGGAAGCAACGTAACTGACTGCTCGGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGAC CTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTTCATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCT GTTGGTAACCTGAGAAAATGCTCCACCTCATCACTCCTGGAAGCCTGCACTTTCCGTAGACCTTAAAATCTCAGAGGTAGGGCTGCCACC AAGGTGAAGATGGGAACGCAGATGATCCATGAGTTTGCCCTGGTTTCACTGGCCCAAGTGGTTTGTGCTAACCACGTCTGTCTTCACAGC >In-frame_AHSG_ENST00000273784_chr3_186331143_+_TF_ENST00000402696_chr3_133483026_+_1569nt TTCCCAGCAGAGCACCTGGGTTGGTCCCGAAGCCTCCAACCACCTGCACGCCTGCCAGGGCCTCTCTGGGGCAGCCATGAAGTCCCTCGT CCTGCTCCTTTGTCTTGCTCAGCTCTGGGGCTGCCACTCAGCCCCACATGGCCCAGGGCTGATTTATAGACAACCGAACTGCGATGATCC AGAAACTGAGGAAGCAGCTCTGGTGGCTATAGACTACATCAATCAAAACCTTCCTTGGGGATACAAACACACCTTGAACCAGATTGATGA AGTAAAGGTGTGGCCTCAGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAGTGTGGTCTGGTGCC TGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACACCAGAGGCAGGGTATTTTGCTATAGCAGTGGTGAAGAAATCAGC TTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAACATCCCCATGGGCCT GCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGTGAAGGTTGTGCCCCTGGGTCTAAGAAAGACTCCAGTCTCTGTAA GCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTCAGGTGTCTGGTTGA GAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGGAAAAAACCCTGATCCATGGGCTAAGAATCTGAATGA AAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGAGCCCCGAATCACGC TGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTACGTCAACAGCAGCACCTATTTGGAAGCAACGTAACTGACTGCTC GGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTTCATGACAGAAACAC ATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAACCTGAGAAAATGCTCCACCTCATCACTCCTGGAAGCCTGCACTTT CCGTAGACCTTAAAATCTCAGAGGTAGGGCTGCCACCAAGGTGAAGATGGGAACGCAGATGATCCATGAGTTTGCCCTGGTTTCACTGGC CCAAGTGGTTTGTGCTAACCACGTCTGTCTTCACAGCTCTGTGTTGCCATGTGTGCTGAACAAAAAATAAAAATTATTATTGATTTTATA TTTCAAAAACTCCATTCTTTCCTAAATATTTTCAACAAAGGATTTCTTTATGCATTCTGCCTAAATACCTATGCAACTGAGCCCTTCCTT CTCAGCTCAAGATTCGTCTGGTCTTTCCCTACAGCTTTGTGTGTGCCATGGCCACATCTCCTGGGTACAGTTCAAGGAGACATCTTTTCT >In-frame_AHSG_ENST00000273784_chr3_186331143_+_TF_ENST00000264998_chr3_133483026_+_1354nt TTCCCAGCAGAGCACCTGGGTTGGTCCCGAAGCCTCCAACCACCTGCACGCCTGCCAGGGCCTCTCTGGGGCAGCCATGAAGTCCCTCGT CCTGCTCCTTTGTCTTGCTCAGCTCTGGGGCTGCCACTCAGCCCCACATGGCCCAGGGCTGATTTATAGACAACCGAACTGCGATGATCC AGAAACTGAGGAAGCAGCTCTGGTGGCTATAGACTACATCAATCAAAACCTTCCTTGGGGATACAAACACACCTTGAACCAGATTGATGA AGTAAAGGTGTGGCCTCAGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAGTGTGGTCTGGTGCC TGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACACCAGAGGCAGGGTATTTTGCTATAGCAGTGGTGAAGAAATCAGC TTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAACATCCCCATGGGCCT GCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGTGAAGGTTGTGCCCCTGGGTCTAAGAAAGACTCCAGTCTCTGTAA GCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTCAGGTGTCTGGTTGA GAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGGAAAAAACCCTGATCCATGGGCTAAGAATCTGAATGA AAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGAGCCCCGAATCACGC TGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTACGTCAACAGCAGCACCTATTTGGAAGCAACGTAACTGACTGCTC GGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTTCATGACAGAAACAC ATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAACCTGAGAAAATGCTCCACCTCATCACTCCTGGAAGCCTGCACTTT CCGTAGACCTTAAAATCTCAGAGGTAGGGCTGCCACCAAGGTGAAGATGGGAACGCAGATGATCCATGAGTTTGCCCTGGTTTCACTGGC CCAAGTGGTTTGTGCTAACCACGTCTGTCTTCACAGCTCTGTGTTGCCATGTGTGCTGAACAAAAAATAAAAATTATTATTGATTTTATA |
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FusionGenePPI for AHSG_TF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AHSG | INSR, FBXO2, DCN, GRB2, CDC42, PSMA3, PPP5C, VKORC1, ALB, ATF2, GDPD1, POTEF, USP38, EGFR, SNX27, MAPK6, CA8, DDX31, SOD1 | TF | FNBP1, TUBB3, IGF1, IGF2, IGFBP3, CALR, CANX, TFRC, TFR2, MIS12, GRB2, PSMA3, RAB5A, TYRP1, ESR1, VKORC1, MYC, FN1, LAMC3, TIMELESS, SMAD3, CA8, GDPD1, DDX19B, GLRA2, MATN3, STPG2, SH2D4A, SLC38A6, SYT17, UTP3, EDIL3, ALDH2, SNX27, DDX31, MAPK6, CCDC82, C3, IGHG4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AHSG_TF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | AHSG | P02765 | DB01593 | Zinc | Alpha-2-HS-glycoprotein | small molecule | approved|investigational |
| Tgene | TF | P02787 | DB00515 | Cisplatin | Serotransferrin | small molecule | approved |
| Tgene | TF | P02787 | DB01592 | Iron | Serotransferrin | small molecule | approved |
| Tgene | TF | P02787 | DB01370 | Aluminium | Serotransferrin | small molecule | approved|investigational |
| Tgene | TF | P02787 | DB01593 | Zinc | Serotransferrin | small molecule | approved|investigational |
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RelatedDiseases for AHSG_TF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AHSG | C0006663 | Calcinosis | 1 | CTD_human |
| Tgene | TF | C0036341 | Schizophrenia | 3 | PSYGENET |
| Tgene | TF | C0521802 | Congenital atransferrinemia | 3 | CTD_human;HPO;ORPHANET;UNIPROT |
| Tgene | TF | C0001973 | Alcoholic Intoxication, Chronic | 2 | CTD_human |
| Tgene | TF | C0002395 | Alzheimer's Disease | 2 | CTD_human |
| Tgene | TF | C0015695 | Fatty Liver | 2 | CTD_human |
| Tgene | TF | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| Tgene | TF | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
| Tgene | TF | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | TF | C0013502 | Echinococcosis | 1 | CTD_human |
| Tgene | TF | C0019158 | Hepatitis | 1 | CTD_human |
| Tgene | TF | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | TF | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | TF | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
| Tgene | TF | C0028754 | Obesity | 1 | CTD_human |
| Tgene | TF | C0030524 | Paratuberculosis | 1 | CTD_human |
| Tgene | TF | C0035258 | Restless Legs Syndrome | 1 | CTD_human |
| Tgene | TF | C0036337 | Schizoaffective Disorder | 1 | PSYGENET |
| Tgene | TF | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | TF | C0271901 | Microcytic hypochromic anemia (disorder) | 1 | CTD_human |
| Tgene | TF | C0282193 | Iron Overload | 1 | CTD_human |
| Tgene | TF | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | TF | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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