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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12509

FusionGeneSummary for FAM120A_MT2A

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM120A_MT2A
Fusion gene ID: 12509
HgeneTgene
Gene symbol

FAM120A

MT2A

Gene ID

23196

4502

Gene namefamily with sequence similarity 120Ametallothionein 2A
SynonymsC9orf10|HBVPTPAP|OSSAMT-2|MT-II|MT2
Cytomap

9q22.31

16q13

Type of geneprotein-codingprotein-coding
Descriptionconstitutive coactivator of PPAR-gamma-like protein 1oxidative stess-associated Src activatoroxidative stress-associated Src activatormetallothionein-2metallothionein-II
Modification date2018052320180523
UniProtAcc

Q9NZB2

P02795

Ensembl transtripts involved in fusion geneENST00000277165, ENST00000375389, 
ENST00000340893, ENST00000333936, 
ENST00000475933, 
ENST00000245185, 
ENST00000563985, ENST00000561491, 
Fusion gene scores* DoF score6 X 6 X 3=1082 X 2 X 2=8
# samples 62
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: FAM120A [Title/Abstract] AND MT2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMT2A

GO:0035690

cellular response to drug

19536566


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU534183FAM120Achr9

96261159

+MT2Achr16

56642493

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000277165ENST00000245185FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-5UTRENST00000277165ENST00000563985FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-intronENST00000277165ENST00000561491FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-5UTRENST00000375389ENST00000245185FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-5UTRENST00000375389ENST00000563985FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-intronENST00000375389ENST00000561491FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-5UTRENST00000340893ENST00000245185FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-5UTRENST00000340893ENST00000563985FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-intronENST00000340893ENST00000561491FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-5UTRENST00000333936ENST00000245185FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-5UTRENST00000333936ENST00000563985FAM120Achr9

96261159

+MT2Achr16

56642493

+
5CDS-intronENST00000333936ENST00000561491FAM120Achr9

96261159

+MT2Achr16

56642493

+
intron-5UTRENST00000475933ENST00000245185FAM120Achr9

96261159

+MT2Achr16

56642493

+
intron-5UTRENST00000475933ENST00000563985FAM120Achr9

96261159

+MT2Achr16

56642493

+
intron-intronENST00000475933ENST00000561491FAM120Achr9

96261159

+MT2Achr16

56642493

+

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FusionProtFeatures for FAM120A_MT2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM120A

Q9NZB2

MT2A

P02795

Metallothioneins have a high content of cysteineresidues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals andglucocorticoids.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM120A_MT2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM120A_MT2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM120A_MT2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMT2AP02795DB01593ZincMetallothionein-2small moleculeapproved|investigational

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RelatedDiseases for FAM120A_MT2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMT2AC0005695Bladder Neoplasm2CTD_human
TgeneMT2AC0033578Prostatic Neoplasms2CTD_human
TgeneMT2AC0011849Diabetes Mellitus1CTD_human
TgeneMT2AC0018799Heart Diseases1CTD_human
TgeneMT2AC0018800Cardiomegaly1CTD_human
TgeneMT2AC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneMT2AC0027626Neoplasm Invasiveness1CTD_human
TgeneMT2AC0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneMT2AC0038356Stomach Neoplasms1CTD_human
TgeneMT2AC0282612Prostatic Intraepithelial Neoplasias1CTD_human
TgeneMT2AC0349218Recurrent depressive disorder, unspecified1PSYGENET
TgeneMT2AC0403447Chronic Kidney Insufficiency1CTD_human
TgeneMT2AC2239176Liver carcinoma1CTD_human