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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12480

FusionGeneSummary for FAM114A1_DAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM114A1_DAB1
Fusion gene ID: 12480
HgeneTgene
Gene symbol

FAM114A1

DAB1

Gene ID

92689

115209

Gene namefamily with sequence similarity 114 member A1OMA1 zinc metallopeptidase
SynonymsNoxp202010001O09Rik|DAB1|MPRP-1|MPRP1|YKR087C|ZMPOMA1|peptidase
Cytomap

4p14

1p32.2-p32.1

Type of geneprotein-codingprotein-coding
Descriptionprotein NOXP20nervous system over-expressed protein 20metalloendopeptidase OMA1, mitochondrialOMA1 homolog, zinc metallopeptidaseOMA1 zinc metallopeptidase homologmetalloprotease-related protein 1overlapping activity with M-AAA proteaseoverlapping with the m-AAA protease 1 homologzinc metallopeptidase
Modification date2018051920180519
UniProtAcc

Q8IWE2

O75553

Ensembl transtripts involved in fusion geneENST00000515037, ENST00000358869, 
ENST00000513966, 
ENST00000485760, 
ENST00000371236, ENST00000371234, 
ENST00000420954, ENST00000439789, 
ENST00000414851, ENST00000371231, 
ENST00000371230, 
Fusion gene scores* DoF score8 X 7 X 6=33610 X 7 X 7=490
# samples 810
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/490*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM114A1 [Title/Abstract] AND DAB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A8E2-01AFAM114A1chr4

38893451

+DAB1chr1

58115337

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000515037ENST00000485760FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5UTR-intronENST00000515037ENST00000371236FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5UTR-5UTRENST00000515037ENST00000371234FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5UTR-intronENST00000515037ENST00000420954FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5UTR-intronENST00000515037ENST00000439789FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5UTR-intronENST00000515037ENST00000414851FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5UTR-intronENST00000515037ENST00000371231FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5UTR-intronENST00000515037ENST00000371230FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5CDS-5UTRENST00000358869ENST00000485760FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5CDS-intronENST00000358869ENST00000371236FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5CDS-5UTRENST00000358869ENST00000371234FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5CDS-intronENST00000358869ENST00000420954FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5CDS-intronENST00000358869ENST00000439789FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5CDS-intronENST00000358869ENST00000414851FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5CDS-intronENST00000358869ENST00000371231FAM114A1chr4

38893451

+DAB1chr1

58115337

-
5CDS-intronENST00000358869ENST00000371230FAM114A1chr4

38893451

+DAB1chr1

58115337

-
intron-5UTRENST00000513966ENST00000485760FAM114A1chr4

38893451

+DAB1chr1

58115337

-
intron-intronENST00000513966ENST00000371236FAM114A1chr4

38893451

+DAB1chr1

58115337

-
intron-5UTRENST00000513966ENST00000371234FAM114A1chr4

38893451

+DAB1chr1

58115337

-
intron-intronENST00000513966ENST00000420954FAM114A1chr4

38893451

+DAB1chr1

58115337

-
intron-intronENST00000513966ENST00000439789FAM114A1chr4

38893451

+DAB1chr1

58115337

-
intron-intronENST00000513966ENST00000414851FAM114A1chr4

38893451

+DAB1chr1

58115337

-
intron-intronENST00000513966ENST00000371231FAM114A1chr4

38893451

+DAB1chr1

58115337

-
intron-intronENST00000513966ENST00000371230FAM114A1chr4

38893451

+DAB1chr1

58115337

-

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FusionProtFeatures for FAM114A1_DAB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM114A1

Q8IWE2

DAB1

O75553

May play a role in neuronal cell development.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM114A1_DAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM114A1_DAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM114A1AKT1S1, FAF1, PPAT, TLN1, HSPA4, N4BP1, RSU1, SEC24D, TARS, THUMPD3, RAB2A, SPG21, AGTRAP, RAB2B, CMTM5, TENC1, MIRLET7A1DAB1APLP1, SIAH1, LRP2, LRP1, LDLR, VLDLR, LRP8, MYO6, APP, APLP2, CDK5, SH3KBP1, SOCS1, SOCS3, ERBB2, ERBB3, INPP5D, RBFOX1, CDK6, MBNL1, ROR2, PIN1, SNRPB, TCEA2, HYAL3, BHLHE40, PPIG, MAGED1, DAZAP2, SERF2, SIRPB1, ARID5A, CLASRP, POGZ, FAM168A, RBFOX2, ZBTB32, VENTX, TOLLIP, USP53, ZCCHC10, WDYHV1, STRBP, MBNL3, SMAP2, HMBOX1, FAM103A1, RHOXF2, LNX1, ZC3H10, C1orf94, NAF1, HNRNPLL, ZNF488, PRR20A, CIART, TMTC3, TCEANC, LGALS9B, KRTAP8-1, KRTAP19-5, KRTAP19-7, LGALS9C, SOCS6, SOCS7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM114A1_DAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM114A1_DAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDAB1C0004352Autistic Disorder1CTD_human