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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12471

FusionGeneSummary for FAM107B_PHF11

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM107B_PHF11
Fusion gene ID: 12471
HgeneTgene
Gene symbol

FAM107B

PHF11

Gene ID

83641

51131

Gene namefamily with sequence similarity 107 member BPHD finger protein 11
SynonymsC10orf45|HITSAPY|BCAP|IGEL|IGER|IGHER|NY-REN-34|NYREN34
Cytomap

10p13

13q14.2

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small proteinPHD finger protein 11BRCA1 C-terminus-associated proteinIgE responsiveness (atopic)renal carcinoma antigen NY-REN-34
Modification date2018051920180527
UniProtAcc

Q9H098

Q9UIL8

Ensembl transtripts involved in fusion geneENST00000181796, ENST00000378470, 
ENST00000468747, ENST00000378467, 
ENST00000378465, ENST00000378458, 
ENST00000478076, ENST00000378462, 
ENST00000496330, ENST00000479731, 
ENST00000471815, 
ENST00000378319, 
ENST00000357596, ENST00000488958, 
ENST00000460489, 
Fusion gene scores* DoF score5 X 5 X 2=502 X 3 X 2=12
# samples 52
** MAII scorelog2(5/50*10)=0log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM107B [Title/Abstract] AND PHF11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE937160FAM107Bchr10

14606556

-PHF11chr13

50096069

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000181796ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000181796ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000181796ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000181796ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378470ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378470ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378470ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378470ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000468747ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000468747ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000468747ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000468747ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378467ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378467ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378467ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378467ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378465ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378465ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378465ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378465ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378458ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378458ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378458ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378458ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000478076ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000478076ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000478076ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000478076ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378462ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378462ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378462ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000378462ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000496330ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000496330ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000496330ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000496330ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000479731ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000479731ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000479731ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000479731ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000471815ENST00000378319FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000471815ENST00000357596FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000471815ENST00000488958FAM107Bchr10

14606556

-PHF11chr13

50096069

+
intron-intronENST00000471815ENST00000460489FAM107Bchr10

14606556

-PHF11chr13

50096069

+

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FusionProtFeatures for FAM107B_PHF11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM107B

Q9H098

PHF11

Q9UIL8

Positive regulator of Th1-type cytokine gene expression.{ECO:0000269|PubMed:18405956}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM107B_PHF11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM107B_PHF11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM107B_PHF11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM107B_PHF11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource