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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12470

FusionGeneSummary for FAM107B_MXI1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM107B_MXI1
Fusion gene ID: 12470
HgeneTgene
Gene symbol

FAM107B

MXI1

Gene ID

83641

4601

Gene namefamily with sequence similarity 107 member BMAX interactor 1, dimerization protein
SynonymsC10orf45|HITSMAD2|MXD2|MXI|bHLHc11
Cytomap

10p13

10q25.2

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small proteinmax-interacting protein 1MAX dimerization protein 2Max-related transcription factorclass C basic helix-loop-helix protein 11
Modification date2018051920180519
UniProtAcc

Q9H098

P50539

Ensembl transtripts involved in fusion geneENST00000181796, ENST00000378470, 
ENST00000468747, ENST00000378467, 
ENST00000378465, ENST00000378458, 
ENST00000478076, ENST00000378462, 
ENST00000496330, ENST00000479731, 
ENST00000471815, 
ENST00000332674, 
ENST00000361248, ENST00000239007, 
ENST00000393134, ENST00000485566, 
ENST00000369612, 
Fusion gene scores* DoF score5 X 5 X 2=505 X 5 X 4=100
# samples 55
** MAII scorelog2(5/50*10)=0log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM107B [Title/Abstract] AND MXI1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMXI1

GO:0000122

negative regulation of transcription by RNA polymerase II

11875718


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB176204FAM107Bchr10

14613762

-MXI1chr10

111987945

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000181796ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000181796ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000181796ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000181796ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3UTRENST00000181796ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000181796ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3CDSENST00000378470ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378470ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378470ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378470ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3UTRENST00000378470ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378470ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3CDSENST00000468747ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000468747ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000468747ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000468747ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3UTRENST00000468747ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000468747ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3CDSENST00000378467ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378467ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378467ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378467ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3UTRENST00000378467ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378467ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3CDSENST00000378465ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378465ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378465ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378465ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3UTRENST00000378465ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378465ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+
5UTR-3CDSENST00000378458ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
5UTR-5UTRENST00000378458ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
5UTR-5UTRENST00000378458ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
5UTR-5UTRENST00000378458ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
5UTR-3UTRENST00000378458ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
5UTR-5UTRENST00000378458ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3CDSENST00000478076ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000478076ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000478076ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000478076ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3UTRENST00000478076ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000478076ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3CDSENST00000378462ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378462ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378462ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378462ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3UTRENST00000378462ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000378462ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3CDSENST00000496330ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000496330ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000496330ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000496330ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3UTRENST00000496330ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000496330ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3CDSENST00000479731ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000479731ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000479731ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000479731ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3UTRENST00000479731ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000479731ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3CDSENST00000471815ENST00000332674FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000471815ENST00000361248FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000471815ENST00000239007FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000471815ENST00000393134FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-3UTRENST00000471815ENST00000485566FAM107Bchr10

14613762

-MXI1chr10

111987945

+
intron-5UTRENST00000471815ENST00000369612FAM107Bchr10

14613762

-MXI1chr10

111987945

+

Top

FusionProtFeatures for FAM107B_MXI1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM107B

Q9H098

MXI1

P50539

Transcriptional repressor. MXI1 binds with MAX to form asequence-specific DNA-binding protein complex which recognizes thecore sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYCtranscriptional activity by competing for MAX.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM107B_MXI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM107B_MXI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM107BELAVL1, BAG3, U2AF2, TRIM25MXI1MAX, SMC3, SIN3B, BUB1B, CDC20, APP, ENTPD5, CALCOCO2, RPL23AP32, KRT40, KRTAP10-7, KRTAP10-9, KRTAP10-5, KRTAP10-8, KRTAP10-3, NOTCH2NL, FBXW11, MXD3, BTRC, SMARCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM107B_MXI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM107B_MXI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMXI1C0022658Kidney Diseases1CTD_human
TgeneMXI1C0376358Malignant neoplasm of prostate1UNIPROT