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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12468

FusionGeneSummary for FAM107B_DGKG

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM107B_DGKG
Fusion gene ID: 12468
HgeneTgene
Gene symbol

FAM107B

DGKG

Gene ID

83641

1608

Gene namefamily with sequence similarity 107 member Bdiacylglycerol kinase gamma
SynonymsC10orf45|HITSDAGK3|DGK-GAMMA
Cytomap

10p13

3q27.2-q27.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small proteindiacylglycerol kinase gammaDAG kinase gammadiacylglycerol kinase, gamma 90kDadiacylglyerol kinase gammadiglyceride kinase gamma
Modification date2018051920180519
UniProtAcc

Q9H098

P49619

Ensembl transtripts involved in fusion geneENST00000181796, ENST00000378470, 
ENST00000468747, ENST00000378467, 
ENST00000378465, ENST00000378458, 
ENST00000478076, ENST00000378462, 
ENST00000496330, ENST00000479731, 
ENST00000471815, 
ENST00000447054, 
ENST00000265022, ENST00000344484, 
ENST00000382164, ENST00000544847, 
Fusion gene scores* DoF score5 X 5 X 2=509 X 7 X 6=378
# samples 59
** MAII scorelog2(5/50*10)=0log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM107B [Title/Abstract] AND DGKG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDGKG

GO:0046486

glycerolipid metabolic process

22627129

TgeneDGKG

GO:0046834

lipid phosphorylation

22627129


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA322377FAM107Bchr10

14717034

+DGKGchr3

185969661

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000181796ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000181796ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000181796ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000181796ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000181796ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378470ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378470ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378470ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378470ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378470ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000468747ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000468747ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000468747ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000468747ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000468747ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378467ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378467ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378467ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378467ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378467ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378465ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378465ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378465ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378465ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378465ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378458ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378458ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378458ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378458ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378458ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000478076ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000478076ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000478076ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000478076ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000478076ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378462ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378462ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378462ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378462ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000378462ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000496330ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000496330ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000496330ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000496330ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000496330ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000479731ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000479731ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000479731ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000479731ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000479731ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000471815ENST00000447054FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000471815ENST00000265022FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000471815ENST00000344484FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000471815ENST00000382164FAM107Bchr10

14717034

+DGKGchr3

185969661

-
intron-intronENST00000471815ENST00000544847FAM107Bchr10

14717034

+DGKGchr3

185969661

-

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FusionProtFeatures for FAM107B_DGKG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM107B

Q9H098

DGKG

P49619

Reverses the normal flow of glycerolipid biosynthesis byphosphorylating diacylglycerol back to phosphatidic acid.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM107B_DGKG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM107B_DGKG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM107B_DGKG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM107B_DGKG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource