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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12446

FusionGeneSummary for FAIM2_FAIM2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAIM2_FAIM2
Fusion gene ID: 12446
HgeneTgene
Gene symbol

FAIM2

FAIM2

Gene ID

23017

23017

Gene nameFas apoptotic inhibitory molecule 2Fas apoptotic inhibitory molecule 2
SynonymsLFG|LFG2|NGP35|NMP35|TMBIM2LFG|LFG2|NGP35|NMP35|TMBIM2
Cytomap

12q13.12

12q13.12

Type of geneprotein-codingprotein-coding
Descriptionprotein lifeguard 2neural membrane protein 35transmembrane BAX inhibitor motif-containing protein 2protein lifeguard 2neural membrane protein 35transmembrane BAX inhibitor motif-containing protein 2
Modification date2018051920180519
UniProtAcc

Q9BWQ8

Q9BWQ8

Ensembl transtripts involved in fusion geneENST00000320634, ENST00000550890, 
ENST00000320634, ENST00000550890, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 2=32
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAIM2 [Title/Abstract] AND FAIM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAIM2

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

26582200

TgeneFAIM2

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

26582200


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA564475FAIM2chr12

50261132

-FAIM2chr12

50260678

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000320634ENST00000320634FAIM2chr12

50261132

-FAIM2chr12

50260678

+
intron-intronENST00000320634ENST00000550890FAIM2chr12

50261132

-FAIM2chr12

50260678

+
intron-intronENST00000550890ENST00000320634FAIM2chr12

50261132

-FAIM2chr12

50260678

+
intron-intronENST00000550890ENST00000550890FAIM2chr12

50261132

-FAIM2chr12

50260678

+

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FusionProtFeatures for FAIM2_FAIM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAIM2

Q9BWQ8

FAIM2

Q9BWQ8

Antiapoptotic protein which protects cells uniquely fromFas-induced apoptosis. Regulates Fas-mediated apoptosis in neuronsby interfering with caspase-8 activation. May play a role incerebellar development by affecting cerebellar size, internalgranular layer (IGL) thickness, and Purkinje cell (PC)development. {ECO:0000269|PubMed:10535980,ECO:0000269|PubMed:17635665}. Antiapoptotic protein which protects cells uniquely fromFas-induced apoptosis. Regulates Fas-mediated apoptosis in neuronsby interfering with caspase-8 activation. May play a role incerebellar development by affecting cerebellar size, internalgranular layer (IGL) thickness, and Purkinje cell (PC)development. {ECO:0000269|PubMed:10535980,ECO:0000269|PubMed:17635665}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAIM2_FAIM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAIM2_FAIM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAIM2_FAIM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAIM2_FAIM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource