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Fusion gene ID: 12440 |
FusionGeneSummary for FAF2_METTL2A |
Fusion gene summary |
Fusion gene information | Fusion gene name: FAF2_METTL2A | Fusion gene ID: 12440 | Hgene | Tgene | Gene symbol | FAF2 | METTL2A | Gene ID | 23197 | 339175 |
Gene name | Fas associated factor family member 2 | methyltransferase like 2A | |
Synonyms | ETEA|UBXD8|UBXN3B | METTL2 | |
Cytomap | 5q35.2 | 17q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | FAS-associated factor 2UBX domain containing 8UBX domain protein 3BUBX domain-containing protein 3BUBX domain-containing protein 8expressed in T-cells and eosinophils in atopic dermatitis | methyltransferase-like protein 2A | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96CS3 | Q96IZ6 | |
Ensembl transtripts involved in fusion gene | ENST00000261942, ENST00000510446, | ENST00000311506, | |
Fusion gene scores | * DoF score | 2 X 1 X 1=2 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/2*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: FAF2 [Title/Abstract] AND METTL2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-13-1497-01A | FAF2 | chr5 | 175875471 | + | METTL2A | chr17 | 60522198 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000261942 | ENST00000311506 | FAF2 | chr5 | 175875471 | + | METTL2A | chr17 | 60522198 | + |
intron-3CDS | ENST00000510446 | ENST00000311506 | FAF2 | chr5 | 175875471 | + | METTL2A | chr17 | 60522198 | + |
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FusionProtFeatures for FAF2_METTL2A |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FAF2 | METTL2A |
Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependentdegradation of misfolded endoplasmic reticulum proteins(PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates theinsulin-like growth factor receptor signaling pathway(PubMed:26692333). Involved in inhibition of lipid dropletdegradation by binding to phospholipase PNPL2 and inhibiting itsactivity by promoting dissociation of PNPL2 from its endogenousactivator, ABHD5 which inhibits the rate of triacylglycerolhydrolysis (PubMed:23297223). {ECO:0000269|PubMed:18711132,ECO:0000269|PubMed:23297223, ECO:0000269|PubMed:24215460,ECO:0000269|PubMed:26692333}. | Probable S-adenosyl-L-methionine-dependentmethyltransferase that mediates 3-methylcytidine modification ofsome tRNAs. {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAF2_METTL2A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAF2_METTL2A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAF2 | RGS20, INSIG1, VCP, AMFR, USP13, VCPIP1, UBL4A, YOD1, NPLOC4, UFD1L, CUL1, CUL2, CUL3, UBR1, HIF1A, ALPP, TCEB1, LGALS3BP, DDB1, WDR26, DCAF7, UBR2, UBR4, PJA2, RNF126, UBR5, UBE3A, HUWE1, INSIG2, PCK1, ELAVL1, UBAC2, AUP1, UBE2J1, SEL1L, DERL1, DERL2, PSMD2, APOB, FAS, UBXN6, CALU, SLC25A22, ERGIC1, MTHFD1, PTPLAD1, GDAP1, TRA2B, HLA-G, TIMM17B, SLC25A24, TOMM40, MRPL37, MRPL21, S100A10, YES1, ECE1, GPD2, OXA1L, TIMM23B, UQCRQ, ACTN1, LPCAT1, BAG6, GET4, PNPLA2, FBXO6, UBQLN2, ZFAND2B, USP19, UBC, FAF2, NF1, UBE2D1, RNF2, EGFR, VIMP, ENO1, VDAC3, OAT, ABCD3, PFKP, ARL6IP1, RAB7A, TOMM22, VAPB, TOMM20, OS9, ERLIN2, TMED9, MCM2, SAE1, LARS, PFKL, ARF5, NPEPPS, GCN1L1, TUBA1A, CSE1L, PEX11B, CAND1, ERLIN1, PEX19, ESYT1, TMEM43, ATP5B, COX2, COX4I1, HSP90B1, KRT18, EMD, RAB9A, SERPINH1, UQCRC2, PRKDC, IPO9, DNAJB1, ARF3, ACTG1, ACTG2, TUBA1B, KRT8, MAP3K1, FUNDC2, SETDB1, CLEC11A, RPTOR, DMXL2, VPS52, C19orf52, SLC25A16, PSEN2, PJA1, ATAD1, ORAI1, ATG9A, ABHD17B, UBB, RRM2, VRK2, VPS13A, KIDINS220, NDUFAF1, TRO, SARAF, ECSIT, INTS4, VPS13C, MFN1, NNT, HMGCR, XPR1, RBM14-RBM4, STOM, VMP1, CAV1, AHCTF1, SQLE, ACAD9, INTS3, EVI5L, INTS7, TMEM159, TARBP1, CCRN4L, SPG7, MCM9, SLC26A6, DAGLB, ARL14EP, CCDC109B, MCUR1, TCTN2, CBR1, HSPA5, RAB5C, SORT1, STK17B, HAUS2, FAM46A, ACTR5, TUBA1C, SYVN1, SLC25A4, ATP4A, UBXN7, MAGED1, PTGS2, NDUFS2, CDKN2AIP, EPB41L3, PNPLA6, EMC1, ATP2B3, TRAM1, VDAC2, ABCB7, ABCF2, ACADM, ACADSB, ALDH1B1, ALDH3A2, ARAF, ATP2C1, ATP6V1H, BCKDHB, TIMMDC1, CDKAL1, ESYT2, GCAT, GCDH, HLA-B, HLA-C, ILVBL, MSH2, MSH6, NUP85, SLC25A10, STT3A, SUCLA2, SUCLG2, TBCD, TIMM23, TM9SF3, TMED2, TMEM55B, TTC27, TUBA4A, TUBB3, TUBG1, UBE3C, UNC45A, YIPF5, POLD3, UBXN1, SMURF1, PTPN5, TRIM25 | METTL2A | MAPK6, ELAVL1, SHMT2, METTL2B, ID4, CPNE7, NDUFAF7, MTIF2, UBR4, NDUFS1, NDUFS6, TOP3A, MCCC1, NDUFAF5, UBR2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAF2_METTL2A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAF2_METTL2A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FAF2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |