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Fusion gene ID: 12430 |
FusionGeneSummary for FAF1_ITGB3BP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAF1_ITGB3BP | Fusion gene ID: 12430 | Hgene | Tgene | Gene symbol | FAF1 | ITGB3BP | Gene ID | 11124 | 23421 |
| Gene name | Fas associated factor 1 | integrin subunit beta 3 binding protein | |
| Synonyms | CGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1 | CENP-R|CENPR|HSU37139|NRIF3|TAP20 | |
| Cytomap | 1p32.3 | 1p31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FAS-associated factor 1Fas (TNFRSF6) associated factor 1TNFRSF6-associated factor 1UBX domain protein 3AUBX domain-containing protein 12UBX domain-containing protein 3A | centromere protein Rbeta 3 endonexinbeta3-endonexinintegrin beta 3 binding protein (beta3-endonexin)integrin beta-3-binding proteinnuclear receptor-interacting factor 3 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q9UNN5 | Q13352 | |
| Ensembl transtripts involved in fusion gene | ENST00000396153, ENST00000371778, ENST00000545823, ENST00000472808, | ENST00000371092, ENST00000271002, ENST00000283568, ENST00000461681, | |
| Fusion gene scores | * DoF score | 15 X 10 X 8=1200 | 4 X 2 X 3=24 |
| # samples | 21 | 3 | |
| ** MAII score | log2(21/1200*10)=-2.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FAF1 [Title/Abstract] AND ITGB3BP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FAF1 | GO:0010942 | positive regulation of cell death | 15596450 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-4Z-AA84-01A | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000396153 | ENST00000371092 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| Frame-shift | ENST00000396153 | ENST00000271002 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| In-frame | ENST00000396153 | ENST00000283568 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| 5CDS-intron | ENST00000396153 | ENST00000461681 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| Frame-shift | ENST00000371778 | ENST00000371092 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| In-frame | ENST00000371778 | ENST00000271002 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| Frame-shift | ENST00000371778 | ENST00000283568 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| 5CDS-intron | ENST00000371778 | ENST00000461681 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| intron-3CDS | ENST00000545823 | ENST00000371092 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| intron-3CDS | ENST00000545823 | ENST00000271002 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| intron-3CDS | ENST00000545823 | ENST00000283568 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| intron-intron | ENST00000545823 | ENST00000461681 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| intron-3CDS | ENST00000472808 | ENST00000371092 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| intron-3CDS | ENST00000472808 | ENST00000271002 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| intron-3CDS | ENST00000472808 | ENST00000283568 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
| intron-intron | ENST00000472808 | ENST00000461681 | FAF1 | chr1 | 51267303 | - | ITGB3BP | chr1 | 63974241 | - |
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FusionProtFeatures for FAF1_ITGB3BP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAF1 | ITGB3BP |
| Ubiquitin-binding protein (PubMed:19722279). Requiredfor the progression of DNA replication forks by targeting DNAreplication licensing factor CDT1 for degradation(PubMed:26842564). Potentiates but cannot initiate FAS-inducedapoptosis (By similarity). {ECO:0000250|UniProtKB:P54731,ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ITGB3BP | chr1:51267303 | chr1:63974241 | ENST00000271002 | - | 0 | 9 | 83_113 | 1 | 262 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >ITGB3BP | chr1:51267303 | chr1:63974241 | ENST00000283568 | - | 0 | 8 | 83_113 | 1 | 171 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >ITGB3BP | chr1:51267303 | chr1:63974241 | ENST00000371092 | - | 1 | 10 | 83_113 | 40 | 283 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >ITGB3BP | chr1:51267303 | chr1:63974241 | ENST00000271002 | - | 0 | 9 | 9_13 | 1 | 262 | Motif | Note=LXXLL motif |
| Tgene | >ITGB3BP | chr1:51267303 | chr1:63974241 | ENST00000283568 | - | 0 | 8 | 9_13 | 1 | 171 | Motif | Note=LXXLL motif |
| Tgene | >ITGB3BP | chr1:51267303 | chr1:63974241 | ENST00000271002 | - | 0 | 9 | 20_50 | 1 | 262 | Region | Note=DD1 |
| Tgene | >ITGB3BP | chr1:51267303 | chr1:63974241 | ENST00000283568 | - | 0 | 8 | 20_50 | 1 | 171 | Region | Note=DD1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FAF1 | chr1:51267303 | chr1:63974241 | ENST00000371778 | - | 4 | 20 | 1_57 | 53 | 651 | Domain | UBA |
| Hgene | >FAF1 | chr1:51267303 | chr1:63974241 | ENST00000371778 | - | 4 | 20 | 569_646 | 53 | 651 | Domain | UBX |
| Hgene | >FAF1 | chr1:51267303 | chr1:63974241 | ENST00000396153 | - | 3 | 19 | 1_57 | 53 | 651 | Domain | UBA |
| Hgene | >FAF1 | chr1:51267303 | chr1:63974241 | ENST00000396153 | - | 3 | 19 | 569_646 | 53 | 651 | Domain | UBX |
| Tgene | ITGB3BP | chr1:51267303 | chr1:63974241 | ENST00000371092 | - | 1 | 10 | 9_13 | 40 | 283 | Motif | Note=LXXLL motif |
| Tgene | ITGB3BP | chr1:51267303 | chr1:63974241 | ENST00000371092 | - | 1 | 10 | 20_50 | 40 | 283 | Region | Note=DD1 |
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FusionGeneSequence for FAF1_ITGB3BP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FAF1_ENST00000396153_chr1_51267303_-_ITGB3BP_ENST00000371092_chr1_63974241_-_230aa MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGT CQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELENLIGISCA >In-frame_FAF1_ENST00000396153_chr1_51267303_-_ITGB3BP_ENST00000283568_chr1_63974241_-_223aa MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGT CQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELENLIGISCA >In-frame_FAF1_ENST00000371778_chr1_51267303_-_ITGB3BP_ENST00000271002_chr1_63974241_-_53aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FAF1_ENST00000396153_chr1_51267303_-_ITGB3BP_ENST00000371092_chr1_63974241_-_690nt ATGGCGTCCAACATGGACCGGGAGATGATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGCTT GAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGTTAAAAGATCACTGAAG TTGGATGGTCTGTTAGAAGAAAATTCATTTGATCCTTCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAACT TGTCAAATGAGTCTATTTGCTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCAAATGAAAAGAGAAAAAAATTGAAT CACCCCAGTTTAACTGAAAGCAAAGAATCTACAACAAAAGACAATGATGAATTCATGATGTTGCTATCAAAAGTTGAGAAATTGTCAGAA GAAATCATGGAGATAATGCAAAATTTAAGTAGTATACAGGCTTTGGAGGGCAGTAGAGAGCTTGAAAATCTCATTGGAATCTCCTGTGCA TCACATTTCTTAAAAAGAGAAATGCAGAAAACCAAAGAACTAATGACAAAAGTGAATAAACAAAAACTGTTTGAAAAGAGTACAGGACTT >In-frame_FAF1_ENST00000396153_chr1_51267303_-_ITGB3BP_ENST00000283568_chr1_63974241_-_669nt ATGGCGTCCAACATGGACCGGGAGATGATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGCTT GAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGTTAAAAGATCACTGAAG TTGGATGGTCTGTTAGAAGAAAATTCATTTGATCCTTCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAACT TGTCAAATGAGTCTATTTGCTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCAAATGAAAAGAGAAAAAAATTGAAT CACCCCAGTTTAACTGAAAGCAAAGAATCTACAACAAAAGACAATGATGAATTCATGATGTTGCTATCAAAAGTTGAGAAATTGTCAGAA GAAATCATGGAGATAATGCAAAATTTAAGTAGTATACAGGCTTTGGAGGGCAGTAGAGAGCTTGAAAATCTCATTGGAATCTCCTGTGCA TCACATTTCTTAAAAAGAGAAATGCAGAAAACCAAAGAACTAATGACAAAAGTGAATAAACAAAAACTGTTTGAAAAGAGTACAGGACTT >In-frame_FAF1_ENST00000371778_chr1_51267303_-_ITGB3BP_ENST00000271002_chr1_63974241_-_161nt ATGGCGTCCAACATGGACCGGGAGATGATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FAF1_ENST00000396153_chr1_51267303_-_ITGB3BP_ENST00000371092_chr1_63974241_-_1474nt AGGGGCGGAGGCGGCGGCCAGGGAGGAAGCGGAGGAGGCGGAGGCGGCCGCGGCGTTCGCCCGCCCGCTCGCTCGCTCGGTTTCCCCGCC CCCGCCGGGCTTAACGCCGCTGAAGGTATCCGGGTGCGCGCTGTCGCAACCTGCCCTCATCCTGGCCCGCGACTGTAAGACCGGACCCAC ATCCAGACCAATCTTCCTGTCCGGGCTGCTGCGACGCGGGCTCCGCAGGTTGCAGGCGGGCGGCCGGGGCGCCTGAAGGTTACCGAGTGC ATGAGCGCCTAGCGCTTCCCGCGCTGCCCCGCCCGCTGGCCCGCCGACCCGCCCGCCGGCTCGCCCGCCAGCCCCTCGGCGCCCGGCGGC GGCGGCGGCGGTGGCGGCGACGGTCGCAGGAGGTGCCGTCTGCCTCCCAGGTGCGCGCTTCGCTCCCGGAGCCGCGGAACTCGGCGGCCG CCATGGCGTCCAACATGGACCGGGAGATGATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGC TTGAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGTTAAAAGATCACTGA AGTTGGATGGTCTGTTAGAAGAAAATTCATTTGATCCTTCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAA CTTGTCAAATGAGTCTATTTGCTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCAAATGAAAAGAGAAAAAAATTGA ATCACCCCAGTTTAACTGAAAGCAAAGAATCTACAACAAAAGACAATGATGAATTCATGATGTTGCTATCAAAAGTTGAGAAATTGTCAG AAGAAATCATGGAGATAATGCAAAATTTAAGTAGTATACAGGCTTTGGAGGGCAGTAGAGAGCTTGAAAATCTCATTGGAATCTCCTGTG CATCACATTTCTTAAAAAGAGAAATGCAGAAAACCAAAGAACTAATGACAAAAGTGAATAAACAAAAACTGTTTGAAAAGAGTACAGGAC TTCCTCACAAAGCATCACGTCATCTTGACAGCTATGAATTCCTTAAAGCCATTTTAAACTGAGGCATTAAGAAGAAATGCACTCACCATG AGCACCAACTTCTGCATCTGCCTGATCATATTTAAAGGAACAGAGAAATATTTGTAATTAATCTGCCCAGTAAATACCAGCTCGTAGCAG TTGGCAGGTGCATGTCTAGATAAAATTTCTTGCAGCTAATTTAAACTTTCTACACGCACCAGTAGATAATCTCAATGTAAATAATACATT TCTTCTTGGCTCTTTAATGTAAGCCAACATGGAGAGGAAGATCTTGACTTATATTCTGTACCACATACACTTCTGTGGACTTTTAGCATT >In-frame_FAF1_ENST00000396153_chr1_51267303_-_ITGB3BP_ENST00000283568_chr1_63974241_-_1121nt AGGGGCGGAGGCGGCGGCCAGGGAGGAAGCGGAGGAGGCGGAGGCGGCCGCGGCGTTCGCCCGCCCGCTCGCTCGCTCGGTTTCCCCGCC CCCGCCGGGCTTAACGCCGCTGAAGGTATCCGGGTGCGCGCTGTCGCAACCTGCCCTCATCCTGGCCCGCGACTGTAAGACCGGACCCAC ATCCAGACCAATCTTCCTGTCCGGGCTGCTGCGACGCGGGCTCCGCAGGTTGCAGGCGGGCGGCCGGGGCGCCTGAAGGTTACCGAGTGC ATGAGCGCCTAGCGCTTCCCGCGCTGCCCCGCCCGCTGGCCCGCCGACCCGCCCGCCGGCTCGCCCGCCAGCCCCTCGGCGCCCGGCGGC GGCGGCGGCGGTGGCGGCGACGGTCGCAGGAGGTGCCGTCTGCCTCCCAGGTGCGCGCTTCGCTCCCGGAGCCGCGGAACTCGGCGGCCG CCATGGCGTCCAACATGGACCGGGAGATGATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGC TTGAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGTTAAAAGATCACTGA AGTTGGATGGTCTGTTAGAAGAAAATTCATTTGATCCTTCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAA CTTGTCAAATGAGTCTATTTGCTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCAAATGAAAAGAGAAAAAAATTGA ATCACCCCAGTTTAACTGAAAGCAAAGAATCTACAACAAAAGACAATGATGAATTCATGATGTTGCTATCAAAAGTTGAGAAATTGTCAG AAGAAATCATGGAGATAATGCAAAATTTAAGTAGTATACAGGCTTTGGAGGGCAGTAGAGAGCTTGAAAATCTCATTGGAATCTCCTGTG CATCACATTTCTTAAAAAGAGAAATGCAGAAAACCAAAGAACTAATGACAAAAGTGAATAAACAAAAACTGTTTGAAAAGAGTACAGGAC >In-frame_FAF1_ENST00000371778_chr1_51267303_-_ITGB3BP_ENST00000271002_chr1_63974241_-_1085nt AACGCCGCTGAAGGTATCCGGGTGCGCGCTTCGCTCCCGGAGCCGCGGAACTCGGCGGCCGCCATGGCGTCCAACATGGACCGGGAGATG ATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGCTTGAACAAAATAATTGGGACTTAGTGGCA GCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGTTAAAAGATCACTGAAGTTGGATGGTCTGTTAGAAGAAAATTCA TTTGATCCTTCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAACTTGTCAAATGAGTCTATTTGCTTCTCCC ACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCAAATGAAAAGAGAAAAAAATTGAATCACCCCAGTTTAACTGAAAGCAAAGAA TCTACAACAAAAGACAATGATGAATTCATGATGTTGCTATCAAAAGTTGAGAAATTGTCAGAAGAAATCATGGAGATAATGCAAAATTTA AGTAGTATACAGGCTTTGGAGGGCAGTAGAGAGCTTGAAAATCTCATTGGAATCTCCTGTGCATCACATTTCTTAAAAAGAGAAATGCAG AAAACCAAAGAACTAATGACAAAAGTGAATAAACAAAAACTGTTTGAAAAGAGTACAGGACTTCCTCACAAAGCATCACGTCATCTTGAC AGCTATGAATTCCTTAAAGCCATTTTAAACTGAGGCATTAAGAAGAAATGCACTCACCATGAGCACCAACTTCTGCATCTGCCTGATCAT ATTTAAAGGAACAGAGAAATATTTGTAATTAATCTGCCCAGTAAATACCAGCTCGTAGCAGTTGGCAGGTGCATGTCTAGATAAAATTTC TTGCAGCTAATTTAAACTTTCTACACGCACCAGTAGATAATCTCAATGTAAATAATACATTTCTTCTTGGCTCTTTAATGTAAGCCAACA TGGAGAGGAAGATCTTGACTTATATTCTGTACCACATACACTTCTGTGGACTTTTAGCATTTGTGGGTAGACTTAATAAAGCATGTATAA |
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FusionGenePPI for FAF1_ITGB3BP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FAF1 | ASCC2, FAS, CSNK2B, G3BP1, RAE1, CASP8, CTNNB1, VCP, NPLOC4, UFD1L, CUL1, CUL2, CUL3, UBR1, HIF1A, ALPP, VCPIP1, SKP1, FBXW11, KLHL22, KBTBD7, WDR26, AMFR, UBR2, UBR4, PJA2, CDC73, TAF1D, RAP1B, UROD, TK1, ANXA1, DNAJB11, CDKN1A, TNNT1, SIRT6, HSD17B10, RCC1, NR1H2, ANXA7, TSC22D1, NR4A1, ITGB1BP1, IGF2, RAD23A, BTRC, NGLY1, UBC, HSPA4, RELA, HSPA8, FADD, IKBKB, NLRP3, NLRP2, NLRP7, NLRP12, NUDT21, SKIL, CARM1, CARS, FAM114A1, FARSB, GART, HIRIP3, HIST1H4A, HSPH1, ILK, PLOD2, PPM1G, PPP2R5C, PRMT3, PUF60, RANBP3, RPL24, SAMHD1, SEC23A, SET, SF1, SWAP70, TLN1, TROVE2, UGP2, XPO7, VAPA, VAPB, UBL4A, ASNA1, GET4, BAG6, RPN2, DDOST, FAF1, CD40, MAGIX, TCEAL1, CBX3, DNAJA1, ZC3H15, NTRK1, RAP1A, CDT1, IPO5, WDR24, YTHDF1, CDC5L, KCTD10, YTHDF3, WDR59, MMAB, NUP98, MYCBP2, USP11, NSFL1C, UBXN7, UBXN1, ASPSCR1, HSPA2, MIOS, UBXN6, BTBD9, KCTD13, TNFAIP1, UBXN2B, BHLHA15, CHCHD10, CLEC3A, PRCC, TRIM25, XIAP | ITGB3BP | COL4A3BP, ARFIP2, DDX24, RECQL5, THRA, RXRG, ITGB3BP, ITGB3, NFKB1, RELA, CCNA2, RXRA, ITGB5, MTA1, ACTN2, MAPK6, SVIL, CENPO, CENPP, APP, KDM1A, KIFC3, UBR7, PIH1D2, CENPU, CENPQ, ATP5J, FANCD2, FLNB, CENPI, MCM5, COG1, ATP5J2, C2CD5, COBLL1, PKN3, SDF4, PPHLN1, CENPN, UBE2O, CENPK, CENPT, DGCR8, CNBP, MECP2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAF1_ITGB3BP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAF1_ITGB3BP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ITGB3BP | C0014175 | Endometriosis | 1 | CTD_human |
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