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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12428

FusionGeneSummary for FAF1_HCRTR1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAF1_HCRTR1
Fusion gene ID: 12428
HgeneTgene
Gene symbol

FAF1

HCRTR1

Gene ID

11124

3061

Gene nameFas associated factor 1hypocretin receptor 1
SynonymsCGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1OX1R
Cytomap

1p32.3

1p35.2

Type of geneprotein-codingprotein-coding
DescriptionFAS-associated factor 1Fas (TNFRSF6) associated factor 1TNFRSF6-associated factor 1UBX domain protein 3AUBX domain-containing protein 12UBX domain-containing protein 3Aorexin receptor type 1hypocretin (orexin) receptor 1hypocretin receptor type 1orexin receptor 1ox-1-Rox1-R
Modification date2018052220180523
UniProtAcc

Q9UNN5

O43613

Ensembl transtripts involved in fusion geneENST00000396153, ENST00000371778, 
ENST00000545823, ENST00000472808, 
ENST00000468521, ENST00000403528, 
ENST00000373706, ENST00000373705, 
Fusion gene scores* DoF score15 X 10 X 8=12002 X 2 X 2=8
# samples 212
** MAII scorelog2(21/1200*10)=-2.51457317282976
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: FAF1 [Title/Abstract] AND HCRTR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAF1

GO:0010942

positive regulation of cell death

15596450

TgeneHCRTR1

GO:0007218

neuropeptide signaling pathway

26950369

TgeneHCRTR1

GO:0051480

regulation of cytosolic calcium ion concentration

26950369


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A1R7-01AFAF1chr1

50956260

-HCRTR1chr1

32098037

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000396153ENST00000468521FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000396153ENST00000403528FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000396153ENST00000373706FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000396153ENST00000373705FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000371778ENST00000468521FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000371778ENST00000403528FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000371778ENST00000373706FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000371778ENST00000373705FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000545823ENST00000468521FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000545823ENST00000403528FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000545823ENST00000373706FAF1chr1

50956260

-HCRTR1chr1

32098037

+
5CDS-intronENST00000545823ENST00000373705FAF1chr1

50956260

-HCRTR1chr1

32098037

+
intron-intronENST00000472808ENST00000468521FAF1chr1

50956260

-HCRTR1chr1

32098037

+
intron-intronENST00000472808ENST00000403528FAF1chr1

50956260

-HCRTR1chr1

32098037

+
intron-intronENST00000472808ENST00000373706FAF1chr1

50956260

-HCRTR1chr1

32098037

+
intron-intronENST00000472808ENST00000373705FAF1chr1

50956260

-HCRTR1chr1

32098037

+

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FusionProtFeatures for FAF1_HCRTR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAF1

Q9UNN5

HCRTR1

O43613

Ubiquitin-binding protein (PubMed:19722279). Requiredfor the progression of DNA replication forks by targeting DNAreplication licensing factor CDT1 for degradation(PubMed:26842564). Potentiates but cannot initiate FAS-inducedapoptosis (By similarity). {ECO:0000250|UniProtKB:P54731,ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}. Moderately selective excitatory receptor for orexin-Aand, with a lower affinity, for orexin-B neuropeptide(PubMed:9491897, PubMed:26950369). Triggers an increase incytoplasmic Ca(2+) levels in response to orexin-A binding(PubMed:9491897, PubMed:26950369). {ECO:0000269|PubMed:26950369,ECO:0000269|PubMed:9491897}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAF1_HCRTR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAF1_HCRTR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAF1ASCC2, FAS, CSNK2B, G3BP1, RAE1, CASP8, CTNNB1, VCP, NPLOC4, UFD1L, CUL1, CUL2, CUL3, UBR1, HIF1A, ALPP, VCPIP1, SKP1, FBXW11, KLHL22, KBTBD7, WDR26, AMFR, UBR2, UBR4, PJA2, CDC73, TAF1D, RAP1B, UROD, TK1, ANXA1, DNAJB11, CDKN1A, TNNT1, SIRT6, HSD17B10, RCC1, NR1H2, ANXA7, TSC22D1, NR4A1, ITGB1BP1, IGF2, RAD23A, BTRC, NGLY1, UBC, HSPA4, RELA, HSPA8, FADD, IKBKB, NLRP3, NLRP2, NLRP7, NLRP12, NUDT21, SKIL, CARM1, CARS, FAM114A1, FARSB, GART, HIRIP3, HIST1H4A, HSPH1, ILK, PLOD2, PPM1G, PPP2R5C, PRMT3, PUF60, RANBP3, RPL24, SAMHD1, SEC23A, SET, SF1, SWAP70, TLN1, TROVE2, UGP2, XPO7, VAPA, VAPB, UBL4A, ASNA1, GET4, BAG6, RPN2, DDOST, FAF1, CD40, MAGIX, TCEAL1, CBX3, DNAJA1, ZC3H15, NTRK1, RAP1A, CDT1, IPO5, WDR24, YTHDF1, CDC5L, KCTD10, YTHDF3, WDR59, MMAB, NUP98, MYCBP2, USP11, NSFL1C, UBXN7, UBXN1, ASPSCR1, HSPA2, MIOS, UBXN6, BTBD9, KCTD13, TNFAIP1, UBXN2B, BHLHA15, CHCHD10, CLEC3A, PRCC, TRIM25, XIAPHCRTR1ARRB2, ARRB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAF1_HCRTR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAF1_HCRTR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHCRTR1C0236736Cocaine-Related Disorders3CTD_human
TgeneHCRTR1C0011570Mental Depression2PSYGENET
TgeneHCRTR1C0011581Depressive disorder2PSYGENET
TgeneHCRTR1C0036341Schizophrenia2PSYGENET
TgeneHCRTR1C0038587Substance Withdrawal Syndrome1CTD_human
TgeneHCRTR1C0525045Mood Disorders1PSYGENET