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Fusion gene ID: 12414 |
FusionGeneSummary for FABP6_CRK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FABP6_CRK | Fusion gene ID: 12414 | Hgene | Tgene | Gene symbol | FABP6 | CRK | Gene ID | 2172 | 1398 |
| Gene name | fatty acid binding protein 6 | CRK proto-oncogene, adaptor protein | |
| Synonyms | I-15P|I-BABP|I-BALB|I-BAP|ILBP|ILBP3|ILLBP | CRKII|p38 | |
| Cytomap | 5q33.3 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | gastrotropinGTfatty acid binding protein 6, ilealileal bile acid binding proteinileal lipid-binding proteinilleal lipid-binding proteinintestinal 15 kDa protein | adapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like protein | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | P51161 | P46108 | |
| Ensembl transtripts involved in fusion gene | ENST00000393980, ENST00000393982, ENST00000402432, | ENST00000398970, ENST00000300574, ENST00000574295, ENST00000572145, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 8 X 2=128 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/128*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FABP6 [Title/Abstract] AND CRK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CRK | GO:0009966 | regulation of signal transduction | 17515907 |
| Tgene | CRK | GO:0032956 | regulation of actin cytoskeleton organization | 11870224 |
| Tgene | CRK | GO:0043087 | regulation of GTPase activity | 11870224 |
| Tgene | CRK | GO:0048013 | ephrin receptor signaling pathway | 11870224 |
| Tgene | CRK | GO:0061045 | negative regulation of wound healing | 17515907 |
| Tgene | CRK | GO:0071538 | SH2 domain-mediated complex assembly | 12384576 |
| Tgene | CRK | GO:2000146 | negative regulation of cell motility | 17515907 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB067617 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000393980 | ENST00000398970 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| Frame-shift | ENST00000393980 | ENST00000300574 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| Frame-shift | ENST00000393980 | ENST00000574295 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| 5CDS-5UTR | ENST00000393980 | ENST00000572145 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| Frame-shift | ENST00000393982 | ENST00000398970 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| Frame-shift | ENST00000393982 | ENST00000300574 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| Frame-shift | ENST00000393982 | ENST00000574295 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| 5CDS-5UTR | ENST00000393982 | ENST00000572145 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| intron-3CDS | ENST00000402432 | ENST00000398970 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| intron-3CDS | ENST00000402432 | ENST00000300574 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| intron-3CDS | ENST00000402432 | ENST00000574295 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
| intron-5UTR | ENST00000402432 | ENST00000572145 | FABP6 | chr5 | 159640827 | + | CRK | chr17 | 1340451 | - |
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FusionProtFeatures for FABP6_CRK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FABP6 | CRK |
| Binds to bile acids and is involved in enterohepaticbile acid metabolism. Required for efficient apical to basolateraltransport of conjugated bile acids in ileal enterocytes (Bysimilarity). In vitro binds to bile acids in the order:deoxycholic acid > cholic acid > chenodeoxycholic acid andrespective BA conjugation modifies affinities in the ordertaurine-conjugated > glycine-conjugated > unconjugated bile acids.Stimulates gastric acid and pepsinogen secretion (By similarity).{ECO:0000250|UniProtKB:P10289, ECO:0000250|UniProtKB:P51162,ECO:0000269|PubMed:12486725, ECO:0000269|PubMed:7588781}. Isoform 2: Essential for the survival of colon cancercells to bile acid-induced apoptosis.{ECO:0000269|PubMed:17909007}. | Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FABP6_CRK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FABP6_CRK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FABP6 | CRK | PLSCR1, DPPA4, BUB1, PSMC6, EGFR, ERBB4, BCAR1, SRCIN1, ARHGAP32, DOCK1, SRC, PTK2, MAP4K1, EPHA3, SH3KBP1, SOCS1, IRS4, MAPK8, KHDRBS1, ASAP1, PDGFRA, AVIL, GRB2, ARHGAP17, RET, PXN, PDGFRB, NEDD9, EPHB3, FRS2, MAP4K5, EPHB2, RAPGEF1, SH3BP1, SOS1, XPO1, WEE1, SHB, ZAP70, EPS15, CBL, PTPN1, CBLC, MICAL1, SYN1, PPP1CA, BCR, CSE1L, PIK3R1, TERF2IP, POT1, FASLG, EFS, ATXN1, KIT, ABL1, UBASH3B, PIK3R2, SHC1, PIK3CB, KRT1, PIK3CA, KRT2, KRT9, KRT10, HSPA8, KRT14, KRT5, KRT16, KRT6A, HSPA1B, KRT6B, PIK3C2B, TUBB, TUBB4B, CASS4, PTPN11, INPPL1, KRT17, ACTB, TUBB2A, SOS2, NCKIPSD, EDC4, HSPA1L, TUBB3, TUBA1A, CBLB, ABL2, HSPA9, RPS19, PIK3R3, PEAK1, GAB2, HSPA6, KRT3, KRT19, KRT15, HSPA5, AP2A1, KRT76, KRT77, PIK3CD, GAB1, KRT73, KRT8, AGO2, YWHAG, KRT79, KRT78, UBC, EEF1A1, YWHAQ, CORO1C, AP2B1, RPS5, DDX3X, DDX6, UBASH3A, KRT24, RPS25, SFN, ASAP3, KRT12, KRT4, AGO1, DNAJA3, RNGTT, RPL23, HSP90AB1, TUBA4B, LYZ, DDX5, RPS3, SERPINB6, HSPBP1, DSC1, AP2M1, GGA3, FUBP1, ATIC, SERPINH1, NANS, DHX9, HSPB1, SPR, DOK1, ERBB2, ERBB3, PPFIBP2, LMNA, BAG3, PTPN4, MAPK4, MET, SPRR2A, HUWE1, FAM154A, CAST, GFPT1, SRM, BEX5, RTCB, CHTF18, CNDP2, DOK2, DOK3, DOK7, ELK1, EPYC, EYA3, GAREM, FSTL1, GABPB2, HSH2D, KCTD13, KLHL20, LASP1, MAGEC3, MPG, MYLIP, MYOZ2, NUFIP2, OFCC1, PAFAH1B2, PHC2, PRKACA, PRRG2, RAB2B, SEMA4D, SH2D2A, SOCS6, STAT4, TCAP, TM4SF19, VAC14, ANKZF1, ANLN, ASB9, ASCL4, PRRC2B, BATF3, C4orf17, SETD9, C6orf141, CORO6, ESD, HABP4, IFT140, INO80E, ISL1, KCTD17, KLF15, LHX8, MNDA, PSMC1, PTTG1, RYBP, SEPT6, STRN4, TDG, TP53, TUBA1C, TWIST2, WDR83, ZKSCAN7, ZNF557, ATF3, FER, CLNK, RIN3, CCP110, CEP128, CEP89, ODF2, CEP19, COX6C, HIST1H1D, PPP1R12A, NUMA1, KAT6A, MPDZ, ARPC1B, SLC25A13, C10orf12, MRPL48, INF2, FLNA, STAT5A, FGFR1, TRIM15, TSG101, CDH1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FABP6_CRK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | FABP6 | P51161 | DB02659 | Cholic Acid | Gastrotropin | small molecule | approved |
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RelatedDiseases for FABP6_CRK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CRK | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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