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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12414

FusionGeneSummary for FABP6_CRK

check button Fusion gene summary
Fusion gene informationFusion gene name: FABP6_CRK
Fusion gene ID: 12414
HgeneTgene
Gene symbol

FABP6

CRK

Gene ID

2172

1398

Gene namefatty acid binding protein 6CRK proto-oncogene, adaptor protein
SynonymsI-15P|I-BABP|I-BALB|I-BAP|ILBP|ILBP3|ILLBPCRKII|p38
Cytomap

5q33.3

17p13.3

Type of geneprotein-codingprotein-coding
DescriptiongastrotropinGTfatty acid binding protein 6, ilealileal bile acid binding proteinileal lipid-binding proteinilleal lipid-binding proteinintestinal 15 kDa proteinadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like protein
Modification date2018052220180522
UniProtAcc

P51161

P46108

Ensembl transtripts involved in fusion geneENST00000393980, ENST00000393982, 
ENST00000402432, 
ENST00000398970, 
ENST00000300574, ENST00000574295, 
ENST00000572145, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 8 X 2=128
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/128*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FABP6 [Title/Abstract] AND CRK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCRK

GO:0009966

regulation of signal transduction

17515907

TgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

TgeneCRK

GO:0043087

regulation of GTPase activity

11870224

TgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

TgeneCRK

GO:0061045

negative regulation of wound healing

17515907

TgeneCRK

GO:0071538

SH2 domain-mediated complex assembly

12384576

TgeneCRK

GO:2000146

negative regulation of cell motility

17515907


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB067617FABP6chr5

159640827

+CRKchr17

1340451

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000393980ENST00000398970FABP6chr5

159640827

+CRKchr17

1340451

-
Frame-shitENST00000393980ENST00000300574FABP6chr5

159640827

+CRKchr17

1340451

-
Frame-shitENST00000393980ENST00000574295FABP6chr5

159640827

+CRKchr17

1340451

-
5CDS-5UTRENST00000393980ENST00000572145FABP6chr5

159640827

+CRKchr17

1340451

-
Frame-shitENST00000393982ENST00000398970FABP6chr5

159640827

+CRKchr17

1340451

-
Frame-shitENST00000393982ENST00000300574FABP6chr5

159640827

+CRKchr17

1340451

-
Frame-shitENST00000393982ENST00000574295FABP6chr5

159640827

+CRKchr17

1340451

-
5CDS-5UTRENST00000393982ENST00000572145FABP6chr5

159640827

+CRKchr17

1340451

-
intron-3CDSENST00000402432ENST00000398970FABP6chr5

159640827

+CRKchr17

1340451

-
intron-3CDSENST00000402432ENST00000300574FABP6chr5

159640827

+CRKchr17

1340451

-
intron-3CDSENST00000402432ENST00000574295FABP6chr5

159640827

+CRKchr17

1340451

-
intron-5UTRENST00000402432ENST00000572145FABP6chr5

159640827

+CRKchr17

1340451

-

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FusionProtFeatures for FABP6_CRK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FABP6

P51161

CRK

P46108

Binds to bile acids and is involved in enterohepaticbile acid metabolism. Required for efficient apical to basolateraltransport of conjugated bile acids in ileal enterocytes (Bysimilarity). In vitro binds to bile acids in the order:deoxycholic acid > cholic acid > chenodeoxycholic acid andrespective BA conjugation modifies affinities in the ordertaurine-conjugated > glycine-conjugated > unconjugated bile acids.Stimulates gastric acid and pepsinogen secretion (By similarity).{ECO:0000250|UniProtKB:P10289, ECO:0000250|UniProtKB:P51162,ECO:0000269|PubMed:12486725, ECO:0000269|PubMed:7588781}. Isoform 2: Essential for the survival of colon cancercells to bile acid-induced apoptosis.{ECO:0000269|PubMed:17909007}. Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FABP6_CRK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FABP6_CRK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FABP6CRKPLSCR1, DPPA4, BUB1, PSMC6, EGFR, ERBB4, BCAR1, SRCIN1, ARHGAP32, DOCK1, SRC, PTK2, MAP4K1, EPHA3, SH3KBP1, SOCS1, IRS4, MAPK8, KHDRBS1, ASAP1, PDGFRA, AVIL, GRB2, ARHGAP17, RET, PXN, PDGFRB, NEDD9, EPHB3, FRS2, MAP4K5, EPHB2, RAPGEF1, SH3BP1, SOS1, XPO1, WEE1, SHB, ZAP70, EPS15, CBL, PTPN1, CBLC, MICAL1, SYN1, PPP1CA, BCR, CSE1L, PIK3R1, TERF2IP, POT1, FASLG, EFS, ATXN1, KIT, ABL1, UBASH3B, PIK3R2, SHC1, PIK3CB, KRT1, PIK3CA, KRT2, KRT9, KRT10, HSPA8, KRT14, KRT5, KRT16, KRT6A, HSPA1B, KRT6B, PIK3C2B, TUBB, TUBB4B, CASS4, PTPN11, INPPL1, KRT17, ACTB, TUBB2A, SOS2, NCKIPSD, EDC4, HSPA1L, TUBB3, TUBA1A, CBLB, ABL2, HSPA9, RPS19, PIK3R3, PEAK1, GAB2, HSPA6, KRT3, KRT19, KRT15, HSPA5, AP2A1, KRT76, KRT77, PIK3CD, GAB1, KRT73, KRT8, AGO2, YWHAG, KRT79, KRT78, UBC, EEF1A1, YWHAQ, CORO1C, AP2B1, RPS5, DDX3X, DDX6, UBASH3A, KRT24, RPS25, SFN, ASAP3, KRT12, KRT4, AGO1, DNAJA3, RNGTT, RPL23, HSP90AB1, TUBA4B, LYZ, DDX5, RPS3, SERPINB6, HSPBP1, DSC1, AP2M1, GGA3, FUBP1, ATIC, SERPINH1, NANS, DHX9, HSPB1, SPR, DOK1, ERBB2, ERBB3, PPFIBP2, LMNA, BAG3, PTPN4, MAPK4, MET, SPRR2A, HUWE1, FAM154A, CAST, GFPT1, SRM, BEX5, RTCB, CHTF18, CNDP2, DOK2, DOK3, DOK7, ELK1, EPYC, EYA3, GAREM, FSTL1, GABPB2, HSH2D, KCTD13, KLHL20, LASP1, MAGEC3, MPG, MYLIP, MYOZ2, NUFIP2, OFCC1, PAFAH1B2, PHC2, PRKACA, PRRG2, RAB2B, SEMA4D, SH2D2A, SOCS6, STAT4, TCAP, TM4SF19, VAC14, ANKZF1, ANLN, ASB9, ASCL4, PRRC2B, BATF3, C4orf17, SETD9, C6orf141, CORO6, ESD, HABP4, IFT140, INO80E, ISL1, KCTD17, KLF15, LHX8, MNDA, PSMC1, PTTG1, RYBP, SEPT6, STRN4, TDG, TP53, TUBA1C, TWIST2, WDR83, ZKSCAN7, ZNF557, ATF3, FER, CLNK, RIN3, CCP110, CEP128, CEP89, ODF2, CEP19, COX6C, HIST1H1D, PPP1R12A, NUMA1, KAT6A, MPDZ, ARPC1B, SLC25A13, C10orf12, MRPL48, INF2, FLNA, STAT5A, FGFR1, TRIM15, TSG101, CDH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FABP6_CRK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFABP6P51161DB02659Cholic AcidGastrotropinsmall moleculeapproved

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RelatedDiseases for FABP6_CRK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCRKC0151744Myocardial Ischemia1CTD_human