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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12398

FusionGeneSummary for F2R_SERINC3

check button Fusion gene summary
Fusion gene informationFusion gene name: F2R_SERINC3
Fusion gene ID: 12398
HgeneTgene
Gene symbol

F2R

SERINC3

Gene ID

2149

10955

Gene namecoagulation factor II thrombin receptorserine incorporator 3
SynonymsCF2R|HTR|PAR-1|PAR1|TRAIGP1|DIFF33|SBBI99|TDE|TDE1|TMS-1
Cytomap

5q13.3

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionproteinase-activated receptor 1protease-activated receptor 1serine incorporator 3tumor differentially expressed protein 1
Modification date2018052320180523
UniProtAcc

P25116

Q13530

Ensembl transtripts involved in fusion geneENST00000319211, ENST00000505600, 
ENST00000255175, ENST00000342374, 
ENST00000541235, ENST00000468234, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 8 X 3=192
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: F2R [Title/Abstract] AND SERINC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneF2R

GO:0002248

connective tissue replacement involved in inflammatory response wound healing

9639571

HgeneF2R

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

10692450

HgeneF2R

GO:0007200

phospholipase C-activating G-protein coupled receptor signaling pathway

20164183

HgeneF2R

GO:0008285

negative regulation of cell proliferation

10692450

HgeneF2R

GO:0009611

response to wounding

9639571

HgeneF2R

GO:0030168

platelet activation

9038223

HgeneF2R

GO:0030193

regulation of blood coagulation

17848177

HgeneF2R

GO:0030194

positive regulation of blood coagulation

9038223

HgeneF2R

GO:0032967

positive regulation of collagen biosynthetic process

9639571

HgeneF2R

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

10692450

HgeneF2R

GO:0043410

positive regulation of MAPK cascade

17848177

HgeneF2R

GO:0045893

positive regulation of transcription, DNA-templated

17848177

HgeneF2R

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

1672265

HgeneF2R

GO:2000484

positive regulation of interleukin-8 secretion

17404307

HgeneF2R

GO:2000778

positive regulation of interleukin-6 secretion

11447194

TgeneSERINC3

GO:0009597

detection of virus

26416733|26416734

TgeneSERINC3

GO:0045087

innate immune response

26416733|26416734

TgeneSERINC3

GO:0051607

defense response to virus

26416733|26416734


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE221242F2Rchr5

76031267

-SERINC3chr20

43127276

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000319211ENST00000255175F2Rchr5

76031267

-SERINC3chr20

43127276

+
3UTR-3UTRENST00000319211ENST00000342374F2Rchr5

76031267

-SERINC3chr20

43127276

+
3UTR-intronENST00000319211ENST00000541235F2Rchr5

76031267

-SERINC3chr20

43127276

+
3UTR-intronENST00000319211ENST00000468234F2Rchr5

76031267

-SERINC3chr20

43127276

+
intron-intronENST00000505600ENST00000255175F2Rchr5

76031267

-SERINC3chr20

43127276

+
intron-3UTRENST00000505600ENST00000342374F2Rchr5

76031267

-SERINC3chr20

43127276

+
intron-intronENST00000505600ENST00000541235F2Rchr5

76031267

-SERINC3chr20

43127276

+
intron-intronENST00000505600ENST00000468234F2Rchr5

76031267

-SERINC3chr20

43127276

+

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FusionProtFeatures for F2R_SERINC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
F2R

P25116

SERINC3

Q13530

High affinity receptor for activated thrombin coupled toG proteins that stimulate phosphoinositide hydrolysis. May play arole in platelets activation and in vascular development.{ECO:0000269|PubMed:10079109}. Restriction factor required to restrict infectivity oflentiviruses, such as HIV-1: acts by inhibiting an early step ofviral infection. Impairs the penetration of the viral particleinto the cytoplasm (PubMed:26416733, PubMed:26416734).{ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for F2R_SERINC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for F2R_SERINC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for F2R_SERINC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneF2RP25116DB09030VorapaxarProteinase-activated receptor 1small moleculeapproved
HgeneF2RP25116DB00086StreptokinaseProteinase-activated receptor 1biotechapproved|investigational
HgeneF2RP25116DB11300ThrombinProteinase-activated receptor 1small moleculeapproved|investigational

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RelatedDiseases for F2R_SERINC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneF2RC0015695Fatty Liver3CTD_human
HgeneF2RC0019158Hepatitis1CTD_human
HgeneF2RC0021368Inflammation1CTD_human
HgeneF2RC0023890Liver Cirrhosis1CTD_human
HgeneF2RC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneF2RC0027659Neoplasms, Experimental1CTD_human
HgeneF2RC0038356Stomach Neoplasms1CTD_human
TgeneSERINC3C0033578Prostatic Neoplasms1CTD_human