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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12388

FusionGeneSummary for F11R_F11R

check button Fusion gene summary
Fusion gene informationFusion gene name: F11R_F11R
Fusion gene ID: 12388
HgeneTgene
Gene symbol

F11R

F11R

Gene ID

50848

50848

Gene nameF11 receptorF11 receptor
SynonymsCD321|JAM|JAM1|JAMA|JCAM|KAT|PAM-1CD321|JAM|JAM1|JAMA|JCAM|KAT|PAM-1
Cytomap

1q23.3

1q23.3

Type of geneprotein-codingprotein-coding
Descriptionjunctional adhesion molecule Ajunctional adhesion molecule 1platelet F11 receptorplatelet adhesion molecule 1junctional adhesion molecule Ajunctional adhesion molecule 1platelet F11 receptorplatelet adhesion molecule 1
Modification date2018052320180523
UniProtAcc

Q9Y624

Q9Y624

Ensembl transtripts involved in fusion geneENST00000368026, ENST00000289779, 
ENST00000537746, ENST00000472573, 
ENST00000368026, ENST00000289779, 
ENST00000537746, ENST00000472573, 
Fusion gene scores* DoF score8 X 6 X 5=2404 X 5 X 2=40
# samples 106
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: F11R [Title/Abstract] AND F11R [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1C06030F11Rchr1

160967433

+F11Rchr1

160967268

-
ChiTaRS3.1AA662651F11Rchr1

160967812

+F11Rchr1

160967521

+
ChiTaRS3.1AW006412F11Rchr1

160967812

+F11Rchr1

160967521

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000368026ENST00000368026F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000368026ENST00000289779F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000368026ENST00000537746F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000368026ENST00000472573F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-3UTRENST00000289779ENST00000368026F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000289779ENST00000289779F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000289779ENST00000537746F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000289779ENST00000472573F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-3UTRENST00000537746ENST00000368026F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000537746ENST00000289779F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000537746ENST00000537746F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000537746ENST00000472573F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-3UTRENST00000472573ENST00000368026F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000472573ENST00000289779F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000472573ENST00000537746F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-intronENST00000472573ENST00000472573F11Rchr1

160967433

+F11Rchr1

160967268

-
intron-3UTRENST00000368026ENST00000368026F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000368026ENST00000289779F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000368026ENST00000537746F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000368026ENST00000472573F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-3UTRENST00000289779ENST00000368026F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000289779ENST00000289779F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000289779ENST00000537746F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000289779ENST00000472573F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-3UTRENST00000537746ENST00000368026F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000537746ENST00000289779F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000537746ENST00000537746F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000537746ENST00000472573F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-3UTRENST00000472573ENST00000368026F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000472573ENST00000289779F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000472573ENST00000537746F11Rchr1

160967812

+F11Rchr1

160967521

+
intron-intronENST00000472573ENST00000472573F11Rchr1

160967812

+F11Rchr1

160967521

+

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FusionProtFeatures for F11R_F11R


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
F11R

Q9Y624

F11R

Q9Y624

Seems to play a role in epithelial tight junctionformation. Appears early in primordial forms of cell junctions andrecruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1,thereby preventing tight junction assembly (By similarity). Playsa role in regulating monocyte transmigration involved in integrityof epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration(PubMed:11812992). Involved in platelet activation(PubMed:10753840). {ECO:0000250|UniProtKB:O88792,ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913,ECO:0000269|PubMed:11812992}. (Microbial infection) Acts as a receptor for Mammalianreovirus sigma-1. {ECO:0000269|PubMed:11239401}. (Microbial infection) Acts as a receptor for HumanRotavirus strain Wa. {ECO:0000269|PubMed:25481868}. Seems to play a role in epithelial tight junctionformation. Appears early in primordial forms of cell junctions andrecruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1,thereby preventing tight junction assembly (By similarity). Playsa role in regulating monocyte transmigration involved in integrityof epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration(PubMed:11812992). Involved in platelet activation(PubMed:10753840). {ECO:0000250|UniProtKB:O88792,ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913,ECO:0000269|PubMed:11812992}. (Microbial infection) Acts as a receptor for Mammalianreovirus sigma-1. {ECO:0000269|PubMed:11239401}. (Microbial infection) Acts as a receptor for HumanRotavirus strain Wa. {ECO:0000269|PubMed:25481868}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for F11R_F11R


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for F11R_F11R


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for F11R_F11R


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for F11R_F11R


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource