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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12385

FusionGeneSummary for F11-AS1_ULK4

check button Fusion gene summary
Fusion gene informationFusion gene name: F11-AS1_ULK4
Fusion gene ID: 12385
HgeneTgene
Gene symbol

F11-AS1

ULK4

Gene ID

285441

54986

Gene nameF11 antisense RNA 1unc-51 like kinase 4
Synonyms-FAM7C1|REC01035
Cytomap

4q35.2

3p22.1

Type of genencRNAprotein-coding
Description-serine/threonine-protein kinase ULK4
Modification date2018032920180519
UniProtAcc

Q96C45

Ensembl transtripts involved in fusion geneENST00000505103, ENST00000510172, 
ENST00000508110, ENST00000508287, 
ENST00000301831, ENST00000420927, 
ENST00000489118, ENST00000414606, 
Fusion gene scores* DoF score2 X 2 X 1=49 X 9 X 4=324
# samples 210
** MAII scorelog2(2/4*10)=2.32192809488736log2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: F11-AS1 [Title/Abstract] AND ULK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB094943F11-AS1chr4

187421998

-ULK4chr3

41961312

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000505103ENST00000301831F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-3CDSENST00000505103ENST00000420927F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-intronENST00000505103ENST00000489118F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-intronENST00000505103ENST00000414606F11-AS1chr4

187421998

-ULK4chr3

41961312

-
intron-3CDSENST00000510172ENST00000301831F11-AS1chr4

187421998

-ULK4chr3

41961312

-
intron-3CDSENST00000510172ENST00000420927F11-AS1chr4

187421998

-ULK4chr3

41961312

-
intron-intronENST00000510172ENST00000489118F11-AS1chr4

187421998

-ULK4chr3

41961312

-
intron-intronENST00000510172ENST00000414606F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-3CDSENST00000508110ENST00000301831F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-3CDSENST00000508110ENST00000420927F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-intronENST00000508110ENST00000489118F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-intronENST00000508110ENST00000414606F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-3CDSENST00000508287ENST00000301831F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-3CDSENST00000508287ENST00000420927F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-intronENST00000508287ENST00000489118F11-AS1chr4

187421998

-ULK4chr3

41961312

-
5UTR-intronENST00000508287ENST00000414606F11-AS1chr4

187421998

-ULK4chr3

41961312

-

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FusionProtFeatures for F11-AS1_ULK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
F11-AS1

ULK4

Q96C45

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. May be involved in the remodeling of cytoskeletalcomponents, such as alpha-tubulin, and in this way regulatesneurite branching and elongation, as well as cell motility.{ECO:0000269|PubMed:24284070}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for F11-AS1_ULK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for F11-AS1_ULK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
F11-AS1ULK4APP, UBE2V1, SULT1A4, YWHAQ, ANKRD40


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for F11-AS1_ULK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for F11-AS1_ULK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneULK4C0005586Bipolar Disorder1PSYGENET
TgeneULK4C0026764Multiple Myeloma1CTD_human
TgeneULK4C0036341Schizophrenia1PSYGENET