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Fusion gene ID: 12311 |
FusionGeneSummary for EXOSC4_NEIL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EXOSC4_NEIL2 | Fusion gene ID: 12311 | Hgene | Tgene | Gene symbol | EXOSC4 | NEIL2 | Gene ID | 54512 | 252969 |
| Gene name | exosome component 4 | nei like DNA glycosylase 2 | |
| Synonyms | RRP41|RRP41A|Rrp41p|SKI6|Ski6p|hRrp41p|p12A | NEH2|NEI2 | |
| Cytomap | 8q24.3 | 8p23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exosome complex component RRP41exosome complex exonuclease RRP41exosome component Rrp41ribosomal RNA-processing protein 41 | endonuclease 8-like 2DNA glycosylase/AP lyase Neil2DNA-(apurinic or apyrimidinic site) lyase Neil2nei endonuclease VIII-like 2nei homolog 2nei-like protein 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NPD3 | Q969S2 | |
| Ensembl transtripts involved in fusion gene | ENST00000316052, ENST00000525936, | ENST00000436750, ENST00000455213, ENST00000403422, ENST00000528323, ENST00000284503, | |
| Fusion gene scores | * DoF score | 1 X 2 X 1=2 | 2 X 3 X 3=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/2*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EXOSC4 [Title/Abstract] AND NEIL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EXOSC4 | GO:0045006 | DNA deamination | 21255825 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-UD-AAC4-01A | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| TCGA | LD | MESO | TCGA-UD-AAC4-01A | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000316052 | ENST00000436750 | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| In-frame | ENST00000316052 | ENST00000455213 | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| 5CDS-5UTR | ENST00000316052 | ENST00000403422 | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| 5CDS-intron | ENST00000316052 | ENST00000528323 | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| 5CDS-intron | ENST00000316052 | ENST00000284503 | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| In-frame | ENST00000525936 | ENST00000436750 | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| In-frame | ENST00000525936 | ENST00000455213 | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| 5CDS-5UTR | ENST00000525936 | ENST00000403422 | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| 5CDS-intron | ENST00000525936 | ENST00000528323 | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| 5CDS-intron | ENST00000525936 | ENST00000284503 | EXOSC4 | chr8 | 145133802 | + | NEIL2 | chr8 | 11637107 | + |
| In-frame | ENST00000316052 | ENST00000436750 | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
| In-frame | ENST00000316052 | ENST00000455213 | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
| 5CDS-5UTR | ENST00000316052 | ENST00000403422 | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
| 5CDS-intron | ENST00000316052 | ENST00000528323 | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
| 5CDS-intron | ENST00000316052 | ENST00000284503 | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
| In-frame | ENST00000525936 | ENST00000436750 | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
| In-frame | ENST00000525936 | ENST00000455213 | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
| 5CDS-5UTR | ENST00000525936 | ENST00000403422 | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
| 5CDS-intron | ENST00000525936 | ENST00000528323 | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
| 5CDS-intron | ENST00000525936 | ENST00000284503 | EXOSC4 | chr8 | 145133803 | + | NEIL2 | chr8 | 11637108 | + |
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FusionProtFeatures for EXOSC4_NEIL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EXOSC4 | NEIL2 |
| Non-catalytic component of the RNA exosome complex whichhas 3'->5' exoribonuclease activity and participates in amultitude of cellular RNA processing and degradation events. Inthe nucleus, the RNA exosome complex is involved in propermaturation of stable RNA species such as rRNA, snRNA and snoRNA,in the elimination of RNA processing by-products and non-coding'pervasive' transcripts, such as antisense RNA species andpromoter-upstream transcripts (PROMPTs), and of mRNAs withprocessing defects, thereby limiting or excluding their export tothe cytoplasm. The RNA exosome may be involved in Ig class switchrecombination (CSR) and/or Ig variable region somatichypermutation (SHM) by targeting AICDA deamination activity totranscribed dsDNA substrates. In the cytoplasm, the RNA exosomecomplex is involved in general mRNA turnover and specificallydegrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNAsurveillance pathways, preventing translation of aberrant mRNAs.It seems to be involved in degradation of histone mRNA. Thecatalytic inactive RNA exosome core complex of 9 subunits (Exo-9)is proposed to play a pivotal role in the binding and presentationof RNA for ribonucleolysis, and to serve as a scaffold for theassociation with catalytic subunits and accessory proteins orcomplexes. EXOSC4 binds to ARE-containing RNAs.{ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563,ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20368444,ECO:0000269|PubMed:21255825}. | Involved in base excision repair of DNA damaged byoxidation or by mutagenic agents. Has DNA glycosylase activitytowards 5-hydroxyuracil and other oxidized derivatives of cytosinewith a preference for mismatched double-stranded DNA (DNAbubbles). Has low or no DNA glycosylase activity towards thymineglycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP(apurinic/apyrimidinic) lyase activity and introduces nicks in theDNA strand. Cleaves the DNA backbone by beta-delta elimination togenerate a single-strand break at the site of the removed basewith both 3'- and 5'-phosphates. {ECO:0000269|PubMed:12097317,ECO:0000269|PubMed:14522990, ECO:0000269|PubMed:15175427,ECO:0000269|PubMed:15339932}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >NEIL2 | chr8:145133802 | chr8:11637107 | ENST00000284503 | + | 1 | 5 | 284_320 | 46 | 333 | Zinc finger | FPG-type |
| Tgene | >NEIL2 | chr8:145133802 | chr8:11637107 | ENST00000403422 | + | 0 | 4 | 284_320 | -15 | 272 | Zinc finger | FPG-type |
| Tgene | >NEIL2 | chr8:145133802 | chr8:11637107 | ENST00000436750 | + | 1 | 5 | 284_320 | 46 | 333 | Zinc finger | FPG-type |
| Tgene | >NEIL2 | chr8:145133802 | chr8:11637107 | ENST00000455213 | + | 2 | 6 | 284_320 | 46 | 333 | Zinc finger | FPG-type |
| Tgene | >NEIL2 | chr8:145133802 | chr8:11637107 | ENST00000528323 | + | 0 | 5 | 284_320 | -82 | 217 | Zinc finger | FPG-type |
| Tgene | >NEIL2 | chr8:145133803 | chr8:11637108 | ENST00000284503 | + | 1 | 5 | 284_320 | 46 | 333 | Zinc finger | FPG-type |
| Tgene | >NEIL2 | chr8:145133803 | chr8:11637108 | ENST00000403422 | + | 0 | 4 | 284_320 | -15 | 272 | Zinc finger | FPG-type |
| Tgene | >NEIL2 | chr8:145133803 | chr8:11637108 | ENST00000436750 | + | 1 | 5 | 284_320 | 46 | 333 | Zinc finger | FPG-type |
| Tgene | >NEIL2 | chr8:145133803 | chr8:11637108 | ENST00000455213 | + | 2 | 6 | 284_320 | 46 | 333 | Zinc finger | FPG-type |
| Tgene | >NEIL2 | chr8:145133803 | chr8:11637108 | ENST00000528323 | + | 0 | 5 | 284_320 | -82 | 217 | Zinc finger | FPG-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EXOSC4_NEIL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EXOSC4_ENST00000316052_chr8_145133802_+_NEIL2_ENST00000436750_chr8_11637107_+_344aa MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV >In-frame_EXOSC4_ENST00000316052_chr8_145133802_+_NEIL2_ENST00000455213_chr8_11637107_+_344aa MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV >In-frame_EXOSC4_ENST00000525936_chr8_145133802_+_NEIL2_ENST00000436750_chr8_11637107_+_344aa MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV >In-frame_EXOSC4_ENST00000525936_chr8_145133802_+_NEIL2_ENST00000455213_chr8_11637107_+_344aa MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV >In-frame_EXOSC4_ENST00000316052_chr8_145133803_+_NEIL2_ENST00000436750_chr8_11637108_+_344aa MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV >In-frame_EXOSC4_ENST00000316052_chr8_145133803_+_NEIL2_ENST00000455213_chr8_11637108_+_344aa MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV >In-frame_EXOSC4_ENST00000525936_chr8_145133803_+_NEIL2_ENST00000436750_chr8_11637108_+_344aa MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV >In-frame_EXOSC4_ENST00000525936_chr8_145133803_+_NEIL2_ENST00000455213_chr8_11637108_+_344aa MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQ KEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHF GGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EXOSC4_ENST00000316052_chr8_145133802_+_NEIL2_ENST00000436750_chr8_11637107_+_1032nt ATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGC GTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGA AAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAG AAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCC CAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGC AGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTT GGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAG AAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTA GGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTC CTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAA CAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAG >In-frame_EXOSC4_ENST00000316052_chr8_145133802_+_NEIL2_ENST00000455213_chr8_11637107_+_1032nt ATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGC GTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGA AAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAG AAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCC CAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGC AGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTT GGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAG AAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTA GGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTC CTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAA CAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAG >In-frame_EXOSC4_ENST00000525936_chr8_145133802_+_NEIL2_ENST00000436750_chr8_11637107_+_1032nt ATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGC GTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGA AAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAG AAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCC CAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGC AGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTT GGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAG AAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTA GGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTC CTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAA CAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAG >In-frame_EXOSC4_ENST00000525936_chr8_145133802_+_NEIL2_ENST00000455213_chr8_11637107_+_1032nt ATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGC GTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGA AAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAG AAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCC CAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGC AGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTT GGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAG AAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTA GGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTC CTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAA CAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAG >In-frame_EXOSC4_ENST00000316052_chr8_145133803_+_NEIL2_ENST00000436750_chr8_11637108_+_1032nt ATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGC GTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGA AAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAG AAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCC CAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGC AGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTT GGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAG AAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTA GGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTC CTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAA CAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAG >In-frame_EXOSC4_ENST00000316052_chr8_145133803_+_NEIL2_ENST00000455213_chr8_11637108_+_1032nt ATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGC GTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGA AAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAG AAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCC CAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGC AGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTT GGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAG AAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTA GGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTC CTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAA CAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAG >In-frame_EXOSC4_ENST00000525936_chr8_145133803_+_NEIL2_ENST00000436750_chr8_11637108_+_1032nt ATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGC GTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGA AAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAG AAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCC CAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGC AGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTT GGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAG AAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTA GGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTC CTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAA CAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAG >In-frame_EXOSC4_ENST00000525936_chr8_145133803_+_NEIL2_ENST00000455213_chr8_11637108_+_1032nt ATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGC GTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGA AAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAG AAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCC CAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGC AGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTT GGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAG AAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTA GGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTC CTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAA CAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EXOSC4_ENST00000316052_chr8_145133802_+_NEIL2_ENST00000436750_chr8_11637107_+_2207nt ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG >In-frame_EXOSC4_ENST00000316052_chr8_145133802_+_NEIL2_ENST00000455213_chr8_11637107_+_2202nt ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG >In-frame_EXOSC4_ENST00000525936_chr8_145133802_+_NEIL2_ENST00000436750_chr8_11637107_+_2185nt GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT >In-frame_EXOSC4_ENST00000525936_chr8_145133802_+_NEIL2_ENST00000455213_chr8_11637107_+_2180nt GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT >In-frame_EXOSC4_ENST00000316052_chr8_145133803_+_NEIL2_ENST00000436750_chr8_11637108_+_2207nt ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG >In-frame_EXOSC4_ENST00000316052_chr8_145133803_+_NEIL2_ENST00000455213_chr8_11637108_+_2202nt ACCTCCGGAAACCGTAGATTCCGGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTG GCGGCCGGGCAGCATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCA GGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCA CGAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACA AAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGC AGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTT TGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTT GGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGA CATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATA CTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTC GCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGT CTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTG CCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCT TGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTAT AATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTG TTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAA GCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCC TCCAGAGTAGCTGGGACTACAGGCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGC TAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT TATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGA TACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCT TAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTG >In-frame_EXOSC4_ENST00000525936_chr8_145133803_+_NEIL2_ENST00000436750_chr8_11637108_+_2185nt GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT >In-frame_EXOSC4_ENST00000525936_chr8_145133803_+_NEIL2_ENST00000455213_chr8_11637108_+_2180nt GGGCGGTCGGAGCCGCCGGGAGCTGTAGTTCTCCCGCGGCTCAGAGAAGTAGGCAGAGAGCGGACCTGGCGGCCGGGCAGCATGGCGGGG CTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCG CAGGCTGACGGCTCGGCCTACATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGGTCCATGGAAAGAAATTA TTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGG GCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAG GATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGG GTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGT GGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCAT CGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATC ATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGAT CACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCT GCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTG TCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTG TCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTA TGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAG ATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCT CCCAACATAGCTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTCTTGCTCTGTCTCCCTGGCTAGG GTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCCTCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAG GCATGTGATATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCCAGGCTGGTTTGAACTCCTACAA CTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTGGGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTG TTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCC AGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCG TGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTG TTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACAT |
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FusionGenePPI for EXOSC4_NEIL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EXOSC4 | EEF1A1, UPF1, UPF2, UPF3A, EXOSC2, EXOSC4, EXOSC7, EXOSC1, EXOSC9, EXOSC3, EXOSC5, EXOSC8, SKIV2L2, EXOSC10, EXOSC6, DIS3L, DIS3, DDX47, PSIP1, ESR2, AICDA, SMPD4, TSEN15, FAHD1, NEK1, AKR1A1, GTF2IRD1, LRRC8D, MPZL1, GADD45GIP1, HNRNPD, SKIV2L, DXO, H1FX, HIST1H1E, NMI, TOM1, EED, ABCE1, COMMD4, HMGB3, KPNA6, MPHOSPH6, NOP56, PSMA1, PSMA3, PSMA4, PSMA5, PSMA6, TTC37, NTRK1, TP53, KRAS, IFI16, ADAR, ETFA, HNRNPA1, HNRNPU, LIG3, MECP2, PHF1, RPL13, RPL18A, RPL37A, RPS3, RPS4X, RPS10, RPS29, EIF2B4, EIF2S2, MED17, IVNS1ABP, MRPL48, GAR1, CBX8, SHQ1, LRRC59, UTP3, WDR18, TXNDC16, SPATA5L1, MTDH, CHAMP1, FBXW7, HBS1L, C1D, PTPN2, DHPS, LUM, RSRC1, SLIT2, LRRC47, NCL, FOXA1 | NEIL2 | KEAP1, ELAVL1, MEOX1, REL, TRIM27, EP300 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EXOSC4_NEIL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | NEIL2 | Q969S2 | DB01592 | Iron | Endonuclease 8-like 2 | small molecule | approved |
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RelatedDiseases for EXOSC4_NEIL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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