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Fusion gene ID: 1231 |
FusionGeneSummary for AHNAK_RPS6KA4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AHNAK_RPS6KA4 | Fusion gene ID: 1231 | Hgene | Tgene | Gene symbol | AHNAK | RPS6KA4 | Gene ID | 79026 | 8986 |
| Gene name | AHNAK nucleoprotein | ribosomal protein S6 kinase A4 | |
| Synonyms | AHNAKRS|PM227 | MSK2|RSK-B|S6K-alpha-4 | |
| Cytomap | 11q12.3 | 11q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neuroblast differentiation-associated protein AHNAKAHNAK-relateddesmoyokin | ribosomal protein S6 kinase alpha-490 kDa ribosomal protein S6 kinase 4mitogen- and stress-activated protein kinase 2nuclear mitogen- and stress-activated protein kinase 2ribosomal protein S6 kinase, 90kDa, polypeptide 4ribosomal protein kinase B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q09666 | O75676 | |
| Ensembl transtripts involved in fusion gene | ENST00000530124, ENST00000257247, ENST00000525875, ENST00000378024, | ENST00000528057, ENST00000334205, ENST00000294261, | |
| Fusion gene scores | * DoF score | 20 X 15 X 9=2700 | 2 X 1 X 2=4 |
| # samples | 22 | 2 | |
| ** MAII score | log2(22/2700*10)=-3.61738397841353 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: AHNAK [Title/Abstract] AND RPS6KA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RPS6KA4 | GO:0006355 | regulation of transcription, DNA-templated | 9792677 |
| Tgene | RPS6KA4 | GO:0006468 | protein phosphorylation | 9792677 |
| Tgene | RPS6KA4 | GO:0035556 | intracellular signal transduction | 9792677 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A09E-01A | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000530124 | ENST00000528057 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| intron-3CDS | ENST00000530124 | ENST00000334205 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| intron-3CDS | ENST00000530124 | ENST00000294261 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| In-frame | ENST00000257247 | ENST00000528057 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| In-frame | ENST00000257247 | ENST00000334205 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| In-frame | ENST00000257247 | ENST00000294261 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| 5UTR-3CDS | ENST00000525875 | ENST00000528057 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| 5UTR-3CDS | ENST00000525875 | ENST00000334205 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| 5UTR-3CDS | ENST00000525875 | ENST00000294261 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| intron-3CDS | ENST00000378024 | ENST00000528057 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| intron-3CDS | ENST00000378024 | ENST00000334205 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
| intron-3CDS | ENST00000378024 | ENST00000294261 | AHNAK | chr11 | 62259204 | - | RPS6KA4 | chr11 | 64132773 | + |
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FusionProtFeatures for AHNAK_RPS6KA4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AHNAK | RPS6KA4 |
| May be required for neuronal cell differentiation. | Serine/threonine-protein kinase that is required for themitogen or stress-induced phosphorylation of the transcriptionfactors CREB1 and ATF1 and for the regulation of the transcriptionfactor RELA, and that contributes to gene activation by histonephosphorylation and functions in the regulation of inflammatorygenes. Phosphorylates CREB1 and ATF1 in response to mitogenic orstress stimuli such as UV-C irradiation, epidermal growth factor(EGF) and anisomycin. Plays an essential role in the control ofRELA transcriptional activity in response to TNF. Phosphorylates'Ser-10' of histone H3 in response to mitogenics, stress stimuliand EGF, which results in the transcriptional activation ofseveral immediate early genes, including proto-oncogenes c-fos/FOSand c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3.Mediates the mitogen- and stress-induced phosphorylation of highmobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-likereceptor TLR4 to limit the production of pro-inflammatorycytokines. Functions probably by inducing transcription of the MAPkinase phosphatase DUSP1 and the anti-inflammatory cytokineinterleukin 10 (IL10), via CREB1 and ATF1 transcription factors.{ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393,ECO:0000269|PubMed:9792677}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AHNAK_RPS6KA4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AHNAK_ENST00000257247_chr11_62259204_-_RPS6KA4_ENST00000528057_chr11_64132773_+_464aa GLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAA VARSAMMQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGG ELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPE LLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLR GSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASK >In-frame_AHNAK_ENST00000257247_chr11_62259204_-_RPS6KA4_ENST00000334205_chr11_64132773_+_471aa GLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAA VARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLV LELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFT LQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKR LKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPG >In-frame_AHNAK_ENST00000257247_chr11_62259204_-_RPS6KA4_ENST00000294261_chr11_64132773_+_223aa GLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAAEIMCKIREGRFSLDGEAW QGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AHNAK_ENST00000257247_chr11_62259204_-_RPS6KA4_ENST00000528057_chr11_64132773_+_1392nt GGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCG GAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTG GCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCG GTGGCCAGGAGCGCTATGATGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGC CAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTG TGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGG GAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTC ATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATC ATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAG CTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTC CAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCC TGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGG GGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGC TCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAG CGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAA >In-frame_AHNAK_ENST00000257247_chr11_62259204_-_RPS6KA4_ENST00000334205_chr11_64132773_+_1413nt GGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCG GAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTG GCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCG GTGGCCAGGAGCGCTATGATGCAGGACTCGCCCTTCTTCCAGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTT TCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGC GAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTC CTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGC CTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACG CCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACG CTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATG CTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGC TTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGG CTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAG TCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTG GAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGC >In-frame_AHNAK_ENST00000257247_chr11_62259204_-_RPS6KA4_ENST00000294261_chr11_64132773_+_669nt GGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCG GAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTG GCACCCTCCATTCTCTTTGACCACAACAACGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGG CAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGC AGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCG GGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGG CGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AHNAK_ENST00000257247_chr11_62259204_-_RPS6KA4_ENST00000528057_chr11_64132773_+_2805nt AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCC CCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGC AGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACC GATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCGCTATGATGCAGTACGAGCTGGACCTGCGG GAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGT CGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCAT CACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAG TCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCG GAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGG GTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGG AGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAG ATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGG CTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCC CCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAG CGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGG GGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAA TCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGAT CCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTA CCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGC CCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCC TACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAG ACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGG GGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGG TGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGACTTTAAAATAAAAGTCCACCCA >In-frame_AHNAK_ENST00000257247_chr11_62259204_-_RPS6KA4_ENST00000334205_chr11_64132773_+_2826nt AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCC CCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGC AGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACC GATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCGCTATGATGCAGGACTCGCCCTTCTTCCAG CAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAG TTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTG GTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGC AAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTG GTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGG TTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTAC GACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGC GGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAA GCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGAC GGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTC ATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGG AGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAAC GGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCC TCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAG CAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACAC TGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCT AACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCT GTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGT CATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGC ACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGAC >In-frame_AHNAK_ENST00000257247_chr11_62259204_-_RPS6KA4_ENST00000294261_chr11_64132773_+_2081nt AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCC CCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGC AGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGCCGAGATC ATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTC CTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCG CTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGG GAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGC TCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCC CCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCC CAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCA GATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCC TCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTAC CCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACC CGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGC TAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGG GGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGACTTTAAAATAAAAGTCCACCCAGTG |
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FusionGenePPI for AHNAK_RPS6KA4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AHNAK | EZR, S100B, EGFR, SIRT7, ISG15, POT1, CDK2, GRB2, HNRNPD, ESR1, DMD, FMNL1, FN1, ATF2, ATP4A, TARDBP, BAG2, RPA1, RPA2, RPA3, KLHL40, AHNAK, NOL9, NXF1, CUL7, OBSL1, CCDC8, SUMO2, JSRP1, S100A10, ACTN4, ASNS, C14orf166, CDC42, EEF1B2, EEF1D, GORASP2, GRPEL1, HSPA9, HSPB1, LASP1, MYL6, OXCT1, STMN1, TARS, ARHGDIA, CCT5, EEF1A1, EEF2, FLNB, HNRNPAB, HNRNPDL, HNRNPH1, PSME3, RUVBL1, SEC16A, STIP1, VARS, YARS, MED4, CAPZA2, HSPA5, MYH9, STRN, LIMA1, MYO19, TUBA1C, SKI, MCM2, SNW1, CDC5L, U2AF2, ZNF131, CDH1, PPP3CB, HSD17B3, PMS1, ING2, GJB7, ALPPL2, PCK2, GPR141, PYCR2, SDC1, POLH, USP14, ZNF517, RFPL2, PCDHGC3, GALK2, PLEC, PPIP5K2, CYLD, TRIM25, BRCA1, YAP1, TXNIP | RPS6KA4 | MAPK14, MAPK3, CREB1, FOS, NEDD4, MAPK1, SH3KBP1, DDX42, HECW2, RNF2, MYLK2, DLG3, MESDC2, CDC37, KLHDC3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AHNAK_RPS6KA4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AHNAK_RPS6KA4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AHNAK | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | AHNAK | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | AHNAK | C0263454 | Chloracne | 1 | CTD_human |
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