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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12292

FusionGeneSummary for EXOC6_DTNB

check button Fusion gene summary
Fusion gene informationFusion gene name: EXOC6_DTNB
Fusion gene ID: 12292
HgeneTgene
Gene symbol

EXOC6

DTNB

Gene ID

54536

1838

Gene nameexocyst complex component 6dystrobrevin beta
SynonymsEXOC6A|SEC15|SEC15L|SEC15L1|SEC15L3|Sec15p-
Cytomap

10q23.33

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionexocyst complex component 6SEC15-like 1SEC15-like protein 3exocyst complex component Sec15Arsec15-like proteindystrobrevin betaDTN-Bbeta-dystrobrevin
Modification date2018052320180522
UniProtAcc

Q8TAG9

O60941

Ensembl transtripts involved in fusion geneENST00000371547, ENST00000371552, 
ENST00000371543, ENST00000443748, 
ENST00000260762, ENST00000497262, 
ENST00000496972, ENST00000405222, 
ENST00000407661, ENST00000406818, 
ENST00000407038, ENST00000404103, 
ENST00000407186, ENST00000288642, 
ENST00000545439, ENST00000472690, 
Fusion gene scores* DoF score3 X 3 X 3=278 X 7 X 7=392
# samples 39
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EXOC6 [Title/Abstract] AND DTNB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-BB-7861-01AEXOC6chr10

94608391

+DTNBchr2

25611230

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000371547ENST00000496972EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371547ENST00000405222EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371547ENST00000407661EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371547ENST00000406818EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371547ENST00000407038EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371547ENST00000404103EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371547ENST00000407186EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371547ENST00000288642EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371547ENST00000545439EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-intronENST00000371547ENST00000472690EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371552ENST00000496972EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371552ENST00000405222EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371552ENST00000407661EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371552ENST00000406818EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371552ENST00000407038EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371552ENST00000404103EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371552ENST00000407186EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371552ENST00000288642EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000371552ENST00000545439EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-intronENST00000371552ENST00000472690EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000371543ENST00000496972EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000371543ENST00000405222EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000371543ENST00000407661EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000371543ENST00000406818EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000371543ENST00000407038EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000371543ENST00000404103EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000371543ENST00000407186EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000371543ENST00000288642EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000371543ENST00000545439EXOC6chr10

94608391

+DTNBchr2

25611230

-
5CDS-intronENST00000371543ENST00000472690EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000443748ENST00000496972EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000443748ENST00000405222EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000443748ENST00000407661EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000443748ENST00000406818EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000443748ENST00000407038EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000443748ENST00000404103EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000443748ENST00000407186EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000443748ENST00000288642EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000443748ENST00000545439EXOC6chr10

94608391

+DTNBchr2

25611230

-
5CDS-intronENST00000443748ENST00000472690EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000260762ENST00000496972EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000260762ENST00000405222EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000260762ENST00000407661EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000260762ENST00000406818EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000260762ENST00000407038EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000260762ENST00000404103EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000260762ENST00000407186EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000260762ENST00000288642EXOC6chr10

94608391

+DTNBchr2

25611230

-
Frame-shiftENST00000260762ENST00000545439EXOC6chr10

94608391

+DTNBchr2

25611230

-
5CDS-intronENST00000260762ENST00000472690EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000497262ENST00000496972EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000497262ENST00000405222EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000497262ENST00000407661EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000497262ENST00000406818EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000497262ENST00000407038EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000497262ENST00000404103EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000497262ENST00000407186EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000497262ENST00000288642EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-3CDSENST00000497262ENST00000545439EXOC6chr10

94608391

+DTNBchr2

25611230

-
intron-intronENST00000497262ENST00000472690EXOC6chr10

94608391

+DTNBchr2

25611230

-

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FusionProtFeatures for EXOC6_DTNB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EXOC6

Q8TAG9

DTNB

O60941

Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane.Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42and DNMBP promotes transcytosis of PODXL to the apical membraneinitiation sites (AMIS), apical surface formation andlumenogenesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EXOC6_DTNB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EXOC6_DTNB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EXOC6MYO5A, ECSIT, NOS3, APP, EXOSC1, GCDH, LOXL4, PRDX2, EXOC6, MAST1, PSEN2, CYP2C8, RNF32, EXOC3, EXOC2, ALB, EGFR, CA14, DTNBP1, DSN1, SCN2B, EXOC4, EXOC5, EXOC7, EXOC8, NAE1, NTRK1, XRCC3, RAB8A, RAB11A, MYO5B, STX3, TBC1D30, EXOC1, IL1R2, C9orf89, RAP1A, STX11, NPY2R, SIGLECL1, VPS53, CD70, GNAQ, CHRM4, APLNR, IMMT, EXOC6BDTNBKIF5A, TSACC, NUP62, TRAF2, CCDC85B, PRTFDC1, BEGAIN, HMG20A, PPFIBP2, KIF5B, MLC1, DMD, DTNB, KRT31, VCP, PPFIA1, ABI2, MTUS2, GGA1, ABI3, CEP55, CEP63, NDEL1, USHBP1, DTNBP1, SPZ1, KRT40, TXLNA, ZBTB9, CASK, CCDC101, GAPDH, CEP128, TNS1, TNS3, SNTG2, CPNE5, RHPN1, COG6, OLFM2, TENC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EXOC6_DTNB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EXOC6_DTNB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource