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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12291

FusionGeneSummary for EXOC6B_SLC4A5

check button Fusion gene summary
Fusion gene informationFusion gene name: EXOC6B_SLC4A5
Fusion gene ID: 12291
HgeneTgene
Gene symbol

EXOC6B

SLC4A5

Gene ID

23233

57835

Gene nameexocyst complex component 6Bsolute carrier family 4 member 5
SynonymsSEC15B|SEC15L2NBC4|NBCe2
Cytomap

2p13.2

2p13.1

Type of geneprotein-codingprotein-coding
Descriptionexocyst complex component 6BSEC15 homolog BSEC15-like protein 2exocyst complex component Sec15Belectrogenic sodium bicarbonate cotransporter 4solute carrier family 4 (sodium bicarbonate cotransporter), member 5
Modification date2018052320180523
UniProtAcc

Q9Y2D4

Q9BY07

Ensembl transtripts involved in fusion geneENST00000272427, ENST00000490919, 
ENST00000410104, 
ENST00000483195, 
ENST00000394019, ENST00000423644, 
ENST00000346834, ENST00000359484, 
ENST00000357822, ENST00000358683, 
ENST00000377632, ENST00000377634, 
Fusion gene scores* DoF score6 X 4 X 7=1687 X 8 X 2=112
# samples 88
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EXOC6B [Title/Abstract] AND SLC4A5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-LN-A7HV-01AEXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000272427ENST00000483195EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000272427ENST00000394019EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000272427ENST00000423644EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000272427ENST00000346834EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000272427ENST00000359484EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000272427ENST00000357822EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000272427ENST00000358683EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000272427ENST00000377632EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000272427ENST00000377634EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
intron-5UTRENST00000490919ENST00000483195EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
intron-5UTRENST00000490919ENST00000394019EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
intron-5UTRENST00000490919ENST00000423644EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
intron-5UTRENST00000490919ENST00000346834EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
intron-5UTRENST00000490919ENST00000359484EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
intron-5UTRENST00000490919ENST00000357822EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
intron-5UTRENST00000490919ENST00000358683EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
intron-5UTRENST00000490919ENST00000377632EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
intron-5UTRENST00000490919ENST00000377634EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000410104ENST00000483195EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000410104ENST00000394019EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000410104ENST00000423644EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000410104ENST00000346834EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000410104ENST00000359484EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000410104ENST00000357822EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000410104ENST00000358683EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000410104ENST00000377632EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-
5CDS-5UTRENST00000410104ENST00000377634EXOC6Bchr2

72945232

-SLC4A5chr2

74460690

-

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FusionProtFeatures for EXOC6B_SLC4A5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EXOC6B

Q9Y2D4

SLC4A5

Q9BY07

Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane. Mediates sodium- and bicarbonate-dependent electrogenicsodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometryof 2:1. May have a housekeeping function in regulating the pH oftissues in which it is expressed. May play a role in mediatingNa(+):HCO3(-) cotransport in hepatocytes and intrahepaticcholangiocytes. Also may be important in protecting the renalparanchyma from alterations in urine pH.{ECO:0000250|UniProtKB:Q6RI88, ECO:0000269|PubMed:11788353,ECO:0000269|PubMed:11997242, ECO:0000269|PubMed:12388414}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EXOC6B_SLC4A5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EXOC6B_SLC4A5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EXOC6BEGFR, MTERF1, CA14, DTNBP1, SCN2B, EXOC5, EXOC7, EXOC8, NTRK1, IL1R2, EXOC3, EXOC1, EPHA1, EXOC4, EXOC2, EXOC6, TRIM25SLC4A5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EXOC6B_SLC4A5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EXOC6B_SLC4A5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource