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Fusion gene ID: 12276 |
FusionGeneSummary for EXOC4_RAB4B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EXOC4_RAB4B | Fusion gene ID: 12276 | Hgene | Tgene | Gene symbol | EXOC4 | RAB4B | Gene ID | 60412 | 53916 |
| Gene name | exocyst complex component 4 | RAB4B, member RAS oncogene family | |
| Synonyms | SEC8|SEC8L1|Sec8p | - | |
| Cytomap | 7q33 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exocyst complex component 4SEC8-like 1exocyst complex component Sec8 | ras-related protein Rab-4Bras-related GTP-binding protein 4bsmall GTP binding protein RAB4B | |
| Modification date | 20180523 | 20180526 | |
| UniProtAcc | Q96A65 | P61018 | |
| Ensembl transtripts involved in fusion gene | ENST00000253861, ENST00000539845, ENST00000393161, ENST00000545148, ENST00000460346, ENST00000541309, | ENST00000594800, ENST00000602069, ENST00000357052, | |
| Fusion gene scores | * DoF score | 17 X 13 X 8=1768 | 1 X 1 X 1=1 |
| # samples | 16 | 1 | |
| ** MAII score | log2(16/1768*10)=-3.46597446450407 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: EXOC4 [Title/Abstract] AND RAB4B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-19-0957-02A | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000253861 | ENST00000594800 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| 5CDS-3UTR | ENST00000253861 | ENST00000602069 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| 5CDS-3UTR | ENST00000253861 | ENST00000357052 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| In-frame | ENST00000539845 | ENST00000594800 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| 5CDS-3UTR | ENST00000539845 | ENST00000602069 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| 5CDS-3UTR | ENST00000539845 | ENST00000357052 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| In-frame | ENST00000393161 | ENST00000594800 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| 5CDS-3UTR | ENST00000393161 | ENST00000602069 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| 5CDS-3UTR | ENST00000393161 | ENST00000357052 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| intron-3CDS | ENST00000545148 | ENST00000594800 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| intron-3UTR | ENST00000545148 | ENST00000602069 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| intron-3UTR | ENST00000545148 | ENST00000357052 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| intron-3CDS | ENST00000460346 | ENST00000594800 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| intron-3UTR | ENST00000460346 | ENST00000602069 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| intron-3UTR | ENST00000460346 | ENST00000357052 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| intron-3CDS | ENST00000541309 | ENST00000594800 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| intron-3UTR | ENST00000541309 | ENST00000602069 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
| intron-3UTR | ENST00000541309 | ENST00000357052 | EXOC4 | chr7 | 133002144 | + | RAB4B | chr19 | 41285924 | + |
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FusionProtFeatures for EXOC4_RAB4B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EXOC4 | RAB4B |
| Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane.{ECO:0000250}. | Protein transport. Probably involved in vesiculartraffic (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EXOC4 | chr7:133002144 | chr19:41285924 | ENST00000253861 | + | 5 | 18 | 32_114 | 254 | 975 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | EXOC4 | chr7:133002144 | chr19:41285924 | ENST00000393161 | + | 5 | 10 | 32_114 | 254 | 474 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >RAB4B | chr7:133002144 | chr19:41285924 | ENST00000357052 | + | 0 | 8 | 37_45 | 5 | 296 | Motif | Effector region |
| Tgene | >RAB4B | chr7:133002144 | chr19:41285924 | ENST00000594800 | + | 0 | 8 | 37_45 | 5 | 274 | Motif | Effector region |
| Tgene | >RAB4B | chr7:133002144 | chr19:41285924 | ENST00000357052 | + | 0 | 8 | 121_124 | 5 | 296 | Nucleotide binding | GTP |
| Tgene | >RAB4B | chr7:133002144 | chr19:41285924 | ENST00000357052 | + | 0 | 8 | 151_153 | 5 | 296 | Nucleotide binding | GTP |
| Tgene | >RAB4B | chr7:133002144 | chr19:41285924 | ENST00000357052 | + | 0 | 8 | 15_23 | 5 | 296 | Nucleotide binding | GTP |
| Tgene | >RAB4B | chr7:133002144 | chr19:41285924 | ENST00000357052 | + | 0 | 8 | 63_67 | 5 | 296 | Nucleotide binding | GTP |
| Tgene | >RAB4B | chr7:133002144 | chr19:41285924 | ENST00000594800 | + | 0 | 8 | 121_124 | 5 | 274 | Nucleotide binding | GTP |
| Tgene | >RAB4B | chr7:133002144 | chr19:41285924 | ENST00000594800 | + | 0 | 8 | 151_153 | 5 | 274 | Nucleotide binding | GTP |
| Tgene | >RAB4B | chr7:133002144 | chr19:41285924 | ENST00000594800 | + | 0 | 8 | 15_23 | 5 | 274 | Nucleotide binding | GTP |
| Tgene | >RAB4B | chr7:133002144 | chr19:41285924 | ENST00000594800 | + | 0 | 8 | 63_67 | 5 | 274 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EXOC4_RAB4B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EXOC4_ENST00000253861_chr7_133002144_+_RAB4B_ENST00000594800_chr19_41285924_+_463aa MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKI KQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLE LHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSDFLFKFLVIGSAGTGK SCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLAS PNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPR >In-frame_EXOC4_ENST00000539845_chr7_133002144_+_RAB4B_ENST00000594800_chr19_41285924_+_362aa MLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLELHSKKMNLHLV LIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSDFLFKFLVIGSAGTGKSCLLHQFIENK FKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNK KDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPRSAQAVAPQPCG >In-frame_EXOC4_ENST00000393161_chr7_133002144_+_RAB4B_ENST00000594800_chr19_41285924_+_463aa MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKI KQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLE LHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSDFLFKFLVIGSAGTGK SCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLAS PNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EXOC4_ENST00000253861_chr7_133002144_+_RAB4B_ENST00000594800_chr19_41285924_+_1389nt ATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCCTCGGGGCTGCTCATCTCTGTGATCAGGACT CTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAAGAAGCCTACGAGAAATGTGACCGTGACCTGGATGAA TTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACAGAGCGCATCACTAACTCCCGAAATAAAATA AAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGGGATGAGCTTCGGAAACTGTGGATTGAAGGAATTGAG CATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAGCTGGAACAGTGCATGGCCAGCAAGCACTAT CTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTGCTCCAGGTGGAAGGACTGAGTGACCTTCGACTAGAG CTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTGTACATCAAATCGACTAGCCGAGTTGTGCAG CGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTGATGTTACAAACCTCCCTACTCCTCGAAAA TTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGACTTCCTCTTCAAATTCCTGGTGATTGGCAGTGCAGGAACTGGCAAA TCATGTCTCCTTCATCAGTTCATTGAGAATAAGTTCAAACAGGACTCCAACCACACAATCGGCGTGGAGTTTGGATCCCGGGTGGTCAAC GTGGGTGGGAAGACTGTGAAGCTACAGATTTGGGACACGGCTGGCCAGGAGCGGTTTCGGTCAGTGACGCGGAGTTATTACCGAGGGGCG GCTGGAGCCCTGCTGGTGTACGACATCACCAGCCGGGAGACATACAACTCACTGGCTGCCTGGCTGACGGATGCCCGCACCCTGGCCAGC CCCAACATCGTGGTCATCCTCTGTGGCAACAAGAAGGACCTGGACCCTGAGCGGGAGGTCACTTTCCTGGAGGCCTCCCGCTTTGCCCAG GAGAATGAGCTGATGTTCCTGGAGACCAGCGCTCTCACAGGCGAGAACGTGGAGGAGGCGTTCCTCAAGTGTGCCCGCACTATCCTCAAC AAGATTGACTCAGGCGAGCTAGACCCGGAGAGGATGGGCTCTGGCATTCAGTACGGGGATGCGTCCCTCCGCCAGCTTCGGCAGCCTCGG >In-frame_EXOC4_ENST00000539845_chr7_133002144_+_RAB4B_ENST00000594800_chr19_41285924_+_1086nt ATGCTGCTGCACTGCAAACGGGATGAGCTTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATT GAGAATATCAAGCAAGTGCCTCAAAAGCTGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTT GAGTCTTTGGAGGGCCCCCTGCTCCAGGTGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTT CTCATAGATGAACTACACCGGCACCTGTACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTC GTGAAAGATGCTTCTGTTCCTCTGATTGATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGA AGCTCAAGTGACTTCCTCTTCAAATTCCTGGTGATTGGCAGTGCAGGAACTGGCAAATCATGTCTCCTTCATCAGTTCATTGAGAATAAG TTCAAACAGGACTCCAACCACACAATCGGCGTGGAGTTTGGATCCCGGGTGGTCAACGTGGGTGGGAAGACTGTGAAGCTACAGATTTGG GACACGGCTGGCCAGGAGCGGTTTCGGTCAGTGACGCGGAGTTATTACCGAGGGGCGGCTGGAGCCCTGCTGGTGTACGACATCACCAGC CGGGAGACATACAACTCACTGGCTGCCTGGCTGACGGATGCCCGCACCCTGGCCAGCCCCAACATCGTGGTCATCCTCTGTGGCAACAAG AAGGACCTGGACCCTGAGCGGGAGGTCACTTTCCTGGAGGCCTCCCGCTTTGCCCAGGAGAATGAGCTGATGTTCCTGGAGACCAGCGCT CTCACAGGCGAGAACGTGGAGGAGGCGTTCCTCAAGTGTGCCCGCACTATCCTCAACAAGATTGACTCAGGCGAGCTAGACCCGGAGAGG ATGGGCTCTGGCATTCAGTACGGGGATGCGTCCCTCCGCCAGCTTCGGCAGCCTCGGAGTGCCCAGGCCGTGGCCCCTCAGCCGTGTGGC >In-frame_EXOC4_ENST00000393161_chr7_133002144_+_RAB4B_ENST00000594800_chr19_41285924_+_1389nt ATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCCTCGGGGCTGCTCATCTCTGTGATCAGGACT CTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAAGAAGCCTACGAGAAATGTGACCGTGACCTGGATGAA TTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACAGAGCGCATCACTAACTCCCGAAATAAAATA AAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGGGATGAGCTTCGGAAACTGTGGATTGAAGGAATTGAG CATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAGCTGGAACAGTGCATGGCCAGCAAGCACTAT CTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTGCTCCAGGTGGAAGGACTGAGTGACCTTCGACTAGAG CTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTGTACATCAAATCGACTAGCCGAGTTGTGCAG CGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTGATGTTACAAACCTCCCTACTCCTCGAAAA TTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGACTTCCTCTTCAAATTCCTGGTGATTGGCAGTGCAGGAACTGGCAAA TCATGTCTCCTTCATCAGTTCATTGAGAATAAGTTCAAACAGGACTCCAACCACACAATCGGCGTGGAGTTTGGATCCCGGGTGGTCAAC GTGGGTGGGAAGACTGTGAAGCTACAGATTTGGGACACGGCTGGCCAGGAGCGGTTTCGGTCAGTGACGCGGAGTTATTACCGAGGGGCG GCTGGAGCCCTGCTGGTGTACGACATCACCAGCCGGGAGACATACAACTCACTGGCTGCCTGGCTGACGGATGCCCGCACCCTGGCCAGC CCCAACATCGTGGTCATCCTCTGTGGCAACAAGAAGGACCTGGACCCTGAGCGGGAGGTCACTTTCCTGGAGGCCTCCCGCTTTGCCCAG GAGAATGAGCTGATGTTCCTGGAGACCAGCGCTCTCACAGGCGAGAACGTGGAGGAGGCGTTCCTCAAGTGTGCCCGCACTATCCTCAAC AAGATTGACTCAGGCGAGCTAGACCCGGAGAGGATGGGCTCTGGCATTCAGTACGGGGATGCGTCCCTCCGCCAGCTTCGGCAGCCTCGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EXOC4_ENST00000253861_chr7_133002144_+_RAB4B_ENST00000594800_chr19_41285924_+_1789nt GGAGCCTAGCGGCTCTCCCCGCGTCCAAGATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCCT CGGGGCTGCTCATCTCTGTGATCAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAAGAAGCCT ACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACAG AGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGGGATGAGC TTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAGC TGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTGCTCCAGG TGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTGT ACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTG ATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGACTTCCTCTTCAAATTCC TGGTGATTGGCAGTGCAGGAACTGGCAAATCATGTCTCCTTCATCAGTTCATTGAGAATAAGTTCAAACAGGACTCCAACCACACAATCG GCGTGGAGTTTGGATCCCGGGTGGTCAACGTGGGTGGGAAGACTGTGAAGCTACAGATTTGGGACACGGCTGGCCAGGAGCGGTTTCGGT CAGTGACGCGGAGTTATTACCGAGGGGCGGCTGGAGCCCTGCTGGTGTACGACATCACCAGCCGGGAGACATACAACTCACTGGCTGCCT GGCTGACGGATGCCCGCACCCTGGCCAGCCCCAACATCGTGGTCATCCTCTGTGGCAACAAGAAGGACCTGGACCCTGAGCGGGAGGTCA CTTTCCTGGAGGCCTCCCGCTTTGCCCAGGAGAATGAGCTGATGTTCCTGGAGACCAGCGCTCTCACAGGCGAGAACGTGGAGGAGGCGT TCCTCAAGTGTGCCCGCACTATCCTCAACAAGATTGACTCAGGCGAGCTAGACCCGGAGAGGATGGGCTCTGGCATTCAGTACGGGGATG CGTCCCTCCGCCAGCTTCGGCAGCCTCGGAGTGCCCAGGCCGTGGCCCCTCAGCCGTGTGGCTGCTGAGCTCTGTGGAGCCAGGACTTTG CACCTGCTGTGCCTGAGCCTAAGTTTGCTCATCTGTAAAATGAGGCTAATAATAGCACCTGCTTCTATAGATGTTGAGAAGAAGAAATAC ATTAATTCACGAAAGTGCTCAGAATGGGGCCTGATGGTCAAGACTTGATCGATGAGGGCTGTTTTTAAAGTTTTCTTCTTATCCATCTTT GGGCTGAGCTCAAATGAATGGGTGTGTCTTCTTCACCTCAGGGCTTAGCAGAGACTCTGTCCTAGAGAGTTTGCCCTCAGTAGGTGAAAT >In-frame_EXOC4_ENST00000539845_chr7_133002144_+_RAB4B_ENST00000594800_chr19_41285924_+_1796nt GGGGTTAGCTATAGAGAGAGGAGCCCCGCCTCAGTCTTTTCTTTAGGGGCAGCACCTTCTATTACAGTCTCGGGACCCCAAAGCACGCTA TTTGGGTTTGGTAGAGAAAACCAGGTGTAAAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAA GAAGCCTACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGC ATCACAGAGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGG GATGAGCTTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCT CAAAAGCTGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTG CTCCAGGTGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGG CACCTGTACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCT CTGATTGATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGACTTCCTCTTC AAATTCCTGGTGATTGGCAGTGCAGGAACTGGCAAATCATGTCTCCTTCATCAGTTCATTGAGAATAAGTTCAAACAGGACTCCAACCAC ACAATCGGCGTGGAGTTTGGATCCCGGGTGGTCAACGTGGGTGGGAAGACTGTGAAGCTACAGATTTGGGACACGGCTGGCCAGGAGCGG TTTCGGTCAGTGACGCGGAGTTATTACCGAGGGGCGGCTGGAGCCCTGCTGGTGTACGACATCACCAGCCGGGAGACATACAACTCACTG GCTGCCTGGCTGACGGATGCCCGCACCCTGGCCAGCCCCAACATCGTGGTCATCCTCTGTGGCAACAAGAAGGACCTGGACCCTGAGCGG GAGGTCACTTTCCTGGAGGCCTCCCGCTTTGCCCAGGAGAATGAGCTGATGTTCCTGGAGACCAGCGCTCTCACAGGCGAGAACGTGGAG GAGGCGTTCCTCAAGTGTGCCCGCACTATCCTCAACAAGATTGACTCAGGCGAGCTAGACCCGGAGAGGATGGGCTCTGGCATTCAGTAC GGGGATGCGTCCCTCCGCCAGCTTCGGCAGCCTCGGAGTGCCCAGGCCGTGGCCCCTCAGCCGTGTGGCTGCTGAGCTCTGTGGAGCCAG GACTTTGCACCTGCTGTGCCTGAGCCTAAGTTTGCTCATCTGTAAAATGAGGCTAATAATAGCACCTGCTTCTATAGATGTTGAGAAGAA GAAATACATTAATTCACGAAAGTGCTCAGAATGGGGCCTGATGGTCAAGACTTGATCGATGAGGGCTGTTTTTAAAGTTTTCTTCTTATC CATCTTTGGGCTGAGCTCAAATGAATGGGTGTGTCTTCTTCACCTCAGGGCTTAGCAGAGACTCTGTCCTAGAGAGTTTGCCCTCAGTAG >In-frame_EXOC4_ENST00000393161_chr7_133002144_+_RAB4B_ENST00000594800_chr19_41285924_+_1789nt GGAGCCTAGCGGCTCTCCCCGCGTCCAAGATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCCT CGGGGCTGCTCATCTCTGTGATCAGGACTCTGTCTACTAGTGACGATGTCGAAGACAGGGAAAATGAAAAGGGTCGCCTTGAAGAAGCCT ACGAGAAATGTGACCGTGACCTGGATGAATTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACAG AGCGCATCACTAACTCCCGAAATAAAATAAAGCAGGTAAAAGAGAACCTGCTTTCATGCAAGATGCTGCTGCACTGCAAACGGGATGAGC TTCGGAAACTGTGGATTGAAGGAATTGAGCATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAGC TGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTGGTGTCAGCAGTTGAGTCTTTGGAGGGCCCCCTGCTCCAGG TGGAAGGACTGAGTGACCTTCGACTAGAGCTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTGT ACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAGCTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTG ATGTTACAAACCTCCCTACTCCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGACTTCCTCTTCAAATTCC TGGTGATTGGCAGTGCAGGAACTGGCAAATCATGTCTCCTTCATCAGTTCATTGAGAATAAGTTCAAACAGGACTCCAACCACACAATCG GCGTGGAGTTTGGATCCCGGGTGGTCAACGTGGGTGGGAAGACTGTGAAGCTACAGATTTGGGACACGGCTGGCCAGGAGCGGTTTCGGT CAGTGACGCGGAGTTATTACCGAGGGGCGGCTGGAGCCCTGCTGGTGTACGACATCACCAGCCGGGAGACATACAACTCACTGGCTGCCT GGCTGACGGATGCCCGCACCCTGGCCAGCCCCAACATCGTGGTCATCCTCTGTGGCAACAAGAAGGACCTGGACCCTGAGCGGGAGGTCA CTTTCCTGGAGGCCTCCCGCTTTGCCCAGGAGAATGAGCTGATGTTCCTGGAGACCAGCGCTCTCACAGGCGAGAACGTGGAGGAGGCGT TCCTCAAGTGTGCCCGCACTATCCTCAACAAGATTGACTCAGGCGAGCTAGACCCGGAGAGGATGGGCTCTGGCATTCAGTACGGGGATG CGTCCCTCCGCCAGCTTCGGCAGCCTCGGAGTGCCCAGGCCGTGGCCCCTCAGCCGTGTGGCTGCTGAGCTCTGTGGAGCCAGGACTTTG CACCTGCTGTGCCTGAGCCTAAGTTTGCTCATCTGTAAAATGAGGCTAATAATAGCACCTGCTTCTATAGATGTTGAGAAGAAGAAATAC ATTAATTCACGAAAGTGCTCAGAATGGGGCCTGATGGTCAAGACTTGATCGATGAGGGCTGTTTTTAAAGTTTTCTTCTTATCCATCTTT GGGCTGAGCTCAAATGAATGGGTGTGTCTTCTTCACCTCAGGGCTTAGCAGAGACTCTGTCCTAGAGAGTTTGCCCTCAGTAGGTGAAAT |
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FusionGenePPI for EXOC4_RAB4B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EXOC4 | MYC, DLG3, EXOC3, GRIN2B, DLG4, EXOC7, GTF2E2, DISC1, DTNBP1, CEP63, EXOC1, MYO5A, EXOC2, EXOC8, EXOC5, IQCB1, EGFR, ATG5, ATG12, BECN1, SNAP29, BSG, TPM1, SETDB1, EXOC6, NTRK1, MED4, SCLT1, OFD1, PCM1, CNTROB, FGFR1OP, CEP128, CEP44, CNTRL, ODF2, DYNLT1, TMEM17, SNW1, CDC5L, PTAR1, MTMR4, STX11, IKBIP, IL1R2, GGA1, APLNR, EXOC3L2, EXOC6B, TSSC1, RABEP2, VPS51, RABEP1, RALB, TRIM25 | RAB4B | RAB7A, EXOC5, FBXW7, NSF, PRDX1, SKIV2L, TAF11, PRPF3, SNRNP200, PRPF6, NECAP1, RAB14, CHD8, TFB2M, ARHGAP39, RNF170, SFXN3, LCOR, DAB2IP, GDI1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EXOC4_RAB4B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EXOC4_RAB4B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | RAB4B | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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