|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 12265 |
FusionGeneSummary for EXOC3_TRIP13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EXOC3_TRIP13 | Fusion gene ID: 12265 | Hgene | Tgene | Gene symbol | EXOC3 | TRIP13 | Gene ID | 11336 | 9319 |
| Gene name | exocyst complex component 3 | thyroid hormone receptor interactor 13 | |
| Synonyms | SEC6|SEC6L1|Sec6p | 16E1BP|MVA3 | |
| Cytomap | 5p15.33 | 5p15.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exocyst complex component 3SEC6-like 1Sec 6 homologexocyst complex component Sec6 | pachytene checkpoint protein 2 homolog16E1-BPHPV16 E1 protein binding proteinSH3TC1/TRIP13 fusionTR-interacting protein 13TRIP-13human papillomavirus type 16 E1 protein-binding proteinthyroid receptor-interacting protein 13 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O60645 | Q15645 | |
| Ensembl transtripts involved in fusion gene | ENST00000512944, ENST00000510441, ENST00000315013, | ENST00000166345, ENST00000510412, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: EXOC3 [Title/Abstract] AND TRIP13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-FR-A8YE-06A | EXOC3 | chr5 | 447867 | + | TRIP13 | chr5 | 894902 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000512944 | ENST00000166345 | EXOC3 | chr5 | 447867 | + | TRIP13 | chr5 | 894902 | + |
| 5CDS-intron | ENST00000512944 | ENST00000510412 | EXOC3 | chr5 | 447867 | + | TRIP13 | chr5 | 894902 | + |
| intron-3CDS | ENST00000510441 | ENST00000166345 | EXOC3 | chr5 | 447867 | + | TRIP13 | chr5 | 894902 | + |
| intron-intron | ENST00000510441 | ENST00000510412 | EXOC3 | chr5 | 447867 | + | TRIP13 | chr5 | 894902 | + |
| Frame-shift | ENST00000315013 | ENST00000166345 | EXOC3 | chr5 | 447867 | + | TRIP13 | chr5 | 894902 | + |
| 5CDS-intron | ENST00000315013 | ENST00000510412 | EXOC3 | chr5 | 447867 | + | TRIP13 | chr5 | 894902 | + |
Top |
FusionProtFeatures for EXOC3_TRIP13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EXOC3 | TRIP13 |
| Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane. | Plays a key role in chromosome recombination andchromosome structure development during meiosis. Required at earlysteps in meiotic recombination that leads to non-crossoverspathways. Also needed for efficient completion of homologoussynapsis by influencing crossover distribution along thechromosomes affecting both crossovers and non-crossovers pathways.Also required for development of higher-order chromosomestructures and is needed for synaptonemal-complex formation. Inmales, required for efficient synapsis of the sex chromosomes andfor sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly ofRAD51 complexes. Required for depletion of HORMAD1 and HORMAD2from synapsed chromosomes (By similarity). Plays a role in mitoticspindle assembly checkpoint (SAC) activation (PubMed:28553959).{ECO:0000250|UniProtKB:Q3UA06, ECO:0000269|PubMed:28553959}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for EXOC3_TRIP13 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for EXOC3_TRIP13 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EXOC3 | EXOC5, EXOC4, DLG3, GRIN2B, MYO5A, APP, EXOC2, EXOC8, EXOC6, MLH1, EGFR, BUB3, PRPF19, KIAA0907, CCDC8, VAMP2, BSG, DTNBP1, EXOC1, EXOC7, METAP1, TRMT2A, NTRK1, TMEM17, MKNK2, KIF2A, SNW1, CDH1, PTPRA, PTPRH, GCC2, TRIP11, SCLT1, EXOC6B, KIZ, KLC2, IL1R2, IFT20, KIF3A, CCDC136, PIBF1, PKD2, KXD1, KLC1, RGPD2, MACROD1, RGPD5, SDC2, TMED1, RALB, TRIM32, TULP3, TRIM25 | TRIP13 | C11orf54, GPRIN2, LASP1, COMT, PPP2CA, TEX37, ASB13, TRIP13, MAD2L1BP, CYB5R2, STAMBPL1, HDHD3, GPSM1, CARD14, ZNF655, NME4, TLDC1, LNX1, RBPMS, DTX2, PLSCR4, SELENBP1, PARK2, GLYCTK, ADAM15, DDAH2, LOXL4, SEC24A, SMUG1, SIGLEC5, PLAC8, PBLD, NIF3L1, GALT, SEMA4G, PLSCR3, CPSF3L, WDYHV1, KRTAP3-2, PLK3, ARL11, CRMP1, USP32, MEPCE, CLN3, FBXW8, MYC, FBXO25, CUL3, CD99, UBA1, RAB9A, ALYREF, TTC37, ECT2, MDC1, MPPED2, CRYBA2, STAMBP, PARP11, RHOXF2, MAD2L2, LRRC61, MMS19, FBXO6, AASDHPPT, HIST1H2AB, S100A4, SGTA, ZC3HC1, DCP1A, MVP, BUB1B, MAD2L1, MAD1L1, ARSA, CCBL1, QARS, SCP2, TPT1, DPYSL4, DIP2A, TNRC6A, AMDHD2, PCMTD2, PELI1, SPRYD7, TINAGL1, FNDC3B, ZNF34, LRR1, M1AP, C4orf33, MGAT5B, METTL15, MORN3, KRTAP12-2, KRTAP12-1, KRTAP26-1, CCDC8, MSH2, TARDBP, TTC4, NTRK1, UBE2I, NCSTN, ELMSAN1, ARMC6, CDC20, SNW1, CDC5L, DPPA4, POU5F1, MTG1, METTL8, PUSL1, ADAT3, CRYZ, PI4K2B, AARSD1, PTPN1, TRIM25, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for EXOC3_TRIP13 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for EXOC3_TRIP13 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|