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Fusion gene ID: 12255 |
FusionGeneSummary for EXOC1_NUP107 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EXOC1_NUP107 | Fusion gene ID: 12255 | Hgene | Tgene | Gene symbol | EXOC1 | NUP107 | Gene ID | 55763 | 57122 |
| Gene name | exocyst complex component 1 | nucleoporin 107 | |
| Synonyms | BM-102|SEC3|SEC3L1|SEC3P | NPHS11|NUP84 | |
| Cytomap | 4q12 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exocyst complex component 1SEC3-like 1exocyst complex component Sec3 | nuclear pore complex protein Nup107nucleoporin 107kDa | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NV70 | P57740 | |
| Ensembl transtripts involved in fusion gene | ENST00000381295, ENST00000346134, ENST00000349598, | ENST00000229179, ENST00000378905, ENST00000539906, ENST00000401003, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 23 X 12 X 9=2484 |
| # samples | 4 | 26 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/2484*10)=-3.25608164519203 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EXOC1 [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EXOC1 | GO:0048015 | phosphatidylinositol-mediated signaling | 25591774 |
| Tgene | NUP107 | GO:0006406 | mRNA export from nucleus | 11684705 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-26-5135-01A | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000381295 | ENST00000229179 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| In-frame | ENST00000381295 | ENST00000378905 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| In-frame | ENST00000381295 | ENST00000539906 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| 5CDS-intron | ENST00000381295 | ENST00000401003 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| In-frame | ENST00000346134 | ENST00000229179 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| In-frame | ENST00000346134 | ENST00000378905 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| In-frame | ENST00000346134 | ENST00000539906 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| 5CDS-intron | ENST00000346134 | ENST00000401003 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| In-frame | ENST00000349598 | ENST00000229179 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| In-frame | ENST00000349598 | ENST00000378905 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| In-frame | ENST00000349598 | ENST00000539906 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
| 5CDS-intron | ENST00000349598 | ENST00000401003 | EXOC1 | chr4 | 56726707 | + | NUP107 | chr12 | 69135593 | + |
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FusionProtFeatures for EXOC1_NUP107 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EXOC1 | NUP107 |
| Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane. (Microbial infection) Has an antiviral effect againstflaviviruses by affecting viral RNA transcription and translationthrough the sequestration of elongation factor 1-alpha (EEF1A1).This results in decreased viral RNA synthesis and decreased viralprotein translation. {ECO:0000269|PubMed:19889084}. | Plays a role in the nuclear pore complex (NPC) assemblyand/or maintenance (PubMed:12552102, PubMed:15229283). Requiredfor the assembly of peripheral proteins into the NPC(PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC(PubMed:15229283). {ECO:0000269|PubMed:12552102,ECO:0000269|PubMed:15229283}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >EXOC1 | chr4:56726707 | chr12:69135593 | ENST00000346134 | + | 3 | 19 | 152_174 | 85 | 895 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >EXOC1 | chr4:56726707 | chr12:69135593 | ENST00000346134 | + | 3 | 19 | 205_259 | 85 | 895 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >EXOC1 | chr4:56726707 | chr12:69135593 | ENST00000349598 | + | 3 | 18 | 152_174 | 85 | 880 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >EXOC1 | chr4:56726707 | chr12:69135593 | ENST00000349598 | + | 3 | 18 | 205_259 | 85 | 880 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >EXOC1 | chr4:56726707 | chr12:69135593 | ENST00000381295 | + | 3 | 19 | 152_174 | 85 | 895 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >EXOC1 | chr4:56726707 | chr12:69135593 | ENST00000381295 | + | 3 | 19 | 205_259 | 85 | 895 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for EXOC1_NUP107 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EXOC1_ENST00000381295_chr4_56726707_+_NUP107_ENST00000229179_chr12_69135593_+_177aa MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKDAKED >In-frame_EXOC1_ENST00000381295_chr4_56726707_+_NUP107_ENST00000378905_chr12_69135593_+_177aa MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKDAKED >In-frame_EXOC1_ENST00000381295_chr4_56726707_+_NUP107_ENST00000539906_chr12_69135593_+_177aa MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKDAKED >In-frame_EXOC1_ENST00000346134_chr4_56726707_+_NUP107_ENST00000229179_chr12_69135593_+_177aa MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKDAKED >In-frame_EXOC1_ENST00000346134_chr4_56726707_+_NUP107_ENST00000378905_chr12_69135593_+_177aa MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKDAKED >In-frame_EXOC1_ENST00000346134_chr4_56726707_+_NUP107_ENST00000539906_chr12_69135593_+_177aa MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKDAKED >In-frame_EXOC1_ENST00000349598_chr4_56726707_+_NUP107_ENST00000229179_chr12_69135593_+_177aa MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKDAKED >In-frame_EXOC1_ENST00000349598_chr4_56726707_+_NUP107_ENST00000378905_chr12_69135593_+_177aa MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKDAKED >In-frame_EXOC1_ENST00000349598_chr4_56726707_+_NUP107_ENST00000539906_chr12_69135593_+_177aa MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKDAKED |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EXOC1_ENST00000381295_chr4_56726707_+_NUP107_ENST00000229179_chr12_69135593_+_531nt ATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGA AAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAG GGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGAC CATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGT CAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAG >In-frame_EXOC1_ENST00000381295_chr4_56726707_+_NUP107_ENST00000378905_chr12_69135593_+_531nt ATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGA AAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAG GGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGAC CATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGT CAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAG >In-frame_EXOC1_ENST00000381295_chr4_56726707_+_NUP107_ENST00000539906_chr12_69135593_+_531nt ATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGA AAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAG GGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGAC CATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGT CAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAG >In-frame_EXOC1_ENST00000346134_chr4_56726707_+_NUP107_ENST00000229179_chr12_69135593_+_531nt ATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGA AAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAG GGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGAC CATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGT CAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAG >In-frame_EXOC1_ENST00000346134_chr4_56726707_+_NUP107_ENST00000378905_chr12_69135593_+_531nt ATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGA AAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAG GGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGAC CATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGT CAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAG >In-frame_EXOC1_ENST00000346134_chr4_56726707_+_NUP107_ENST00000539906_chr12_69135593_+_531nt ATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGA AAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAG GGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGAC CATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGT CAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAG >In-frame_EXOC1_ENST00000349598_chr4_56726707_+_NUP107_ENST00000229179_chr12_69135593_+_531nt ATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGA AAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAG GGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGAC CATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGT CAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAG >In-frame_EXOC1_ENST00000349598_chr4_56726707_+_NUP107_ENST00000378905_chr12_69135593_+_531nt ATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGA AAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAG GGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGAC CATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGT CAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAG >In-frame_EXOC1_ENST00000349598_chr4_56726707_+_NUP107_ENST00000539906_chr12_69135593_+_531nt ATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGA AAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAG GGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGAC CATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGT CAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EXOC1_ENST00000381295_chr4_56726707_+_NUP107_ENST00000229179_chr12_69135593_+_1422nt CTTCCTTCTCTACGCGGTCAACTTCCGGCGCGGAGTTTGTCACGTGCCCGGATATAGGAAGTGTTGGGGGAACGGCCGCTTCCCGTTCAA CGCTTTATTGAGGGGCGTATCCTAGTGGCCCCCATCCGGTCTCCGTTTTGGAAGACCCGCCTCGGCACAGCCAGGCTCAGTCCGGCCTTG CGGTAAGCCTTCGGCCGCGGCTGCCCGGTAGTCCCGGCGGCGGCGGACAGACGAGCTGACAGGCACCAGGGTCTAAGGCGGCTCCTCAGT CCGGCTGCTGTCTCCACGCCTGGGGTCGGGCACCGCTCCTTCTGACCTTCCTTTCCCCGTTTGTCCCGCTGAGAAAAGATGACAGCAATC AAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGAAAAAAGAAAAAG AACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAGGGAGATTTCTAC AAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGACCATGAAAGAACA CATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAA TGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAG CTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACT AATTTTCATGATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGA ATTTTGTACTTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAA AATTAAAATTTTCTGTTTTTACAAATTCCAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAA TCATAAGCATTCTGATATTTTAAAATCATAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAA ATTTAGTATTTTTGAATATTAAAATTAAGAAGATGACTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGA >In-frame_EXOC1_ENST00000381295_chr4_56726707_+_NUP107_ENST00000378905_chr12_69135593_+_1100nt CTTCCTTCTCTACGCGGTCAACTTCCGGCGCGGAGTTTGTCACGTGCCCGGATATAGGAAGTGTTGGGGGAACGGCCGCTTCCCGTTCAA CGCTTTATTGAGGGGCGTATCCTAGTGGCCCCCATCCGGTCTCCGTTTTGGAAGACCCGCCTCGGCACAGCCAGGCTCAGTCCGGCCTTG CGGTAAGCCTTCGGCCGCGGCTGCCCGGTAGTCCCGGCGGCGGCGGACAGACGAGCTGACAGGCACCAGGGTCTAAGGCGGCTCCTCAGT CCGGCTGCTGTCTCCACGCCTGGGGTCGGGCACCGCTCCTTCTGACCTTCCTTTCCCCGTTTGTCCCGCTGAGAAAAGATGACAGCAATC AAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGAAAAAAGAAAAAG AACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAGGGAGATTTCTAC AAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGACCATGAAAGAACA CATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAA TGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAG CTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACT AATTTTCATGATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGA ATTTTGTACTTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAA >In-frame_EXOC1_ENST00000381295_chr4_56726707_+_NUP107_ENST00000539906_chr12_69135593_+_948nt CTTCCTTCTCTACGCGGTCAACTTCCGGCGCGGAGTTTGTCACGTGCCCGGATATAGGAAGTGTTGGGGGAACGGCCGCTTCCCGTTCAA CGCTTTATTGAGGGGCGTATCCTAGTGGCCCCCATCCGGTCTCCGTTTTGGAAGACCCGCCTCGGCACAGCCAGGCTCAGTCCGGCCTTG CGGTAAGCCTTCGGCCGCGGCTGCCCGGTAGTCCCGGCGGCGGCGGACAGACGAGCTGACAGGCACCAGGGTCTAAGGCGGCTCCTCAGT CCGGCTGCTGTCTCCACGCCTGGGGTCGGGCACCGCTCCTTCTGACCTTCCTTTCCCCGTTTGTCCCGCTGAGAAAAGATGACAGCAATC AAGCATGCATTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGAAAAAAGAAAAAG AACTGTTTTTTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAGGGAGATTTCTAC AAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGACCATGAAAGAACA CATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAA TGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAG CTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACT >In-frame_EXOC1_ENST00000346134_chr4_56726707_+_NUP107_ENST00000229179_chr12_69135593_+_1207nt AGTGTTGGGGGAACGGCCGCTTCCCGTTCAACGCTTTATTGAGGGGCGTATCCTAGTGGCCCCCATCCGGTCTCCGTTTTGGAAGACCCG CCTCGGCACAGCCAGGCTCAGTCCGGCCTTGCGCTGAGAAAAGATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAA TGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGAAAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACG CCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAGGGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGC TGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCC AATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCG CCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGG ACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATAT ACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTGACACTTT CAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAATTTTCTGTTTTTACAAATTCCAGGGTT GTCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCATTCTGATATTTTAAAATCATAAAGAT GATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTATTTTTGAATATTAAAATTAAGAAGATG ACTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTCTAGTTTAACTTTCATTTAGCAAACTT >In-frame_EXOC1_ENST00000346134_chr4_56726707_+_NUP107_ENST00000378905_chr12_69135593_+_885nt AGTGTTGGGGGAACGGCCGCTTCCCGTTCAACGCTTTATTGAGGGGCGTATCCTAGTGGCCCCCATCCGGTCTCCGTTTTGGAAGACCCG CCTCGGCACAGCCAGGCTCAGTCCGGCCTTGCGCTGAGAAAAGATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAA TGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGAAAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACG CCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAGGGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGC TGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCC AATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCG CCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGG ACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATAT ACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTGACACTTT >In-frame_EXOC1_ENST00000346134_chr4_56726707_+_NUP107_ENST00000539906_chr12_69135593_+_733nt AGTGTTGGGGGAACGGCCGCTTCCCGTTCAACGCTTTATTGAGGGGCGTATCCTAGTGGCCCCCATCCGGTCTCCGTTTTGGAAGACCCG CCTCGGCACAGCCAGGCTCAGTCCGGCCTTGCGCTGAGAAAAGATGACAGCAATCAAGCATGCATTACAAAGAGACATTTTTACACCAAA TGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGAAAAAAGAAAAAGAACTGTTTTTTATGTGCCACAGTGACAACTGAACG CCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAGGGAGATTTCTACAAAAGGCAGATTGCATGGGCCCTTCGAGATCTTGC TGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCC AATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCG CCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGG ACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATAT >In-frame_EXOC1_ENST00000349598_chr4_56726707_+_NUP107_ENST00000229179_chr12_69135593_+_1143nt ATCCGGTCTCCGTTTTGGAAGACCCGCCTCGGCACAGCCAGGCTCAGTCCGGCCTTGCGCTGAGAAAAGATGACAGCAATCAAGCATGCA TTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGAAAAAAGAAAAAGAACTGTTTT TTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAGGGAGATTTCTACAAAAGGCAG ATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGACCATGAAAGAACACATCAAATG GTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAG TTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAG TCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCAT GATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTAC TTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAAT TTTCTGTTTTTACAAATTCCAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCA TTCTGATATTTTAAAATCATAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTAT TTTTGAATATTAAAATTAAGAAGATGACTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTC >In-frame_EXOC1_ENST00000349598_chr4_56726707_+_NUP107_ENST00000378905_chr12_69135593_+_821nt ATCCGGTCTCCGTTTTGGAAGACCCGCCTCGGCACAGCCAGGCTCAGTCCGGCCTTGCGCTGAGAAAAGATGACAGCAATCAAGCATGCA TTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGAAAAAAGAAAAAGAACTGTTTT TTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAGGGAGATTTCTACAAAAGGCAG ATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGACCATGAAAGAACACATCAAATG GTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAG TTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAG TCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCAT GATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTAC TTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAAT >In-frame_EXOC1_ENST00000349598_chr4_56726707_+_NUP107_ENST00000539906_chr12_69135593_+_669nt ATCCGGTCTCCGTTTTGGAAGACCCGCCTCGGCACAGCCAGGCTCAGTCCGGCCTTGCGCTGAGAAAAGATGACAGCAATCAAGCATGCA TTACAAAGAGACATTTTTACACCAAATGATGAACGCCTGCTGAGCATTGTGAATGTCTGCAAAGCAGGAAAAAAGAAAAAGAACTGTTTT TTATGTGCCACAGTGACAACTGAACGCCCTGTGCAGGTTAAGGTGGTCAAAGTCAAGAAATCCGATAAGGGAGATTTCTACAAAAGGCAG ATTGCATGGGCCCTTCGAGATCTTGCTGTGGTAGATGCCAAAGATGCTATCAAAGATGCCAAAGAAGACCATGAAAGAACACATCAAATG GTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAG TTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAG TCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCAT |
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FusionGenePPI for EXOC1_NUP107 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EXOC1 | CDC5L, DISC1, TRAF3IP1, TRIO, DST, LUC7L2, EXOC4, SYBU, SPTAN1, SFR1, CCSER2, CCDC93, CCDC88A, KDM1A, NUF2, MACF1, SRGAP2, GOLGA4, SH3BP5, CEP295, KIAA1551, KIF5A, TRIM9, KANSL1, COLEC12, IQCB1, KIAA0226, RB1CC1, ATG14, SNAP29, BSG, CD274, THAP7, KIR2DS2, CA14, DTNBP1, TMEFF1, SCN2B, EXOC2, EXOC3, NTRK1, MED4, SNW1, EXOC6, NCKAP5L, TUFT1, GRIPAP1, CLOCK, FKBP15, PTRF, BLOC1S4, IKBIP, RABEP2, RABGAP1L, NDC80, PHF21A, IL1R2, EXOC6B, EXOC8, VPS53, RABGEF1, CCDC6, CCDC132, TRIM32, EXOC5, KXD1, GIT2, POTEE, ARHGEF7, SNAPIN, VPS51, BLOC1S2, EXOC7, USP4, THAP11, TSKS, JUN, TSSC1, TNFRSF8, CCHCR1, SIKE1, GIT1, KIF5B, RABEP1, NUP54, TNIP1, GOLGA5, COG6, KIF5C, STRN3, STRN, APLNR, PCNT, CCDC122, EDNRB, ZWINT, VTI1B, TMED1, RALB, MTNR1A | NUP107 | SEH1L, NUP133, NUP85, NUP160, NUP43, NUP37, SEC13, TPR, NUP214, KPNB1, SIRT7, NUP98, WRNIP1, CUL3, CENPF, NUP153, TP53BP1, PNPT1, EIF4B, CORO1B, MYL1, C1QBP, CPSF6, VCP, PYCARD, CUL7, OBSL1, SUZ12, EED, PNKD, NTRK1, IFI16, SYNE1, APC, PRKDC, RRP1B, NALCN, CD1E, ACTBL2, HSP90AB1, XPO1, SENP1, SENP2, AHCTF1, RANGAP1, H2AFV, NUP50, RANBP2, B9D2, ACLY, RCC1, GLE1, ITPR2, KPNA4, NUP88, RAN, UBE2I, SUMO1, AAAS, RAE1, NUP155, NUP93, NUPL1, WDR1, NXF1, IPO7, NUPL2, NUP205, NUP210, NUP188, NUP62, NXT1, SEC61A1, NUP54, TMEM214, SMPD4, NDC1, KRAS, IP6K3, TMEM209, NUP35, RPUSD3, RGPD8, POM121C, FOXA3, FOXI2, FOXK2, FOXL1, FOXP3, FOXQ1, CDC5L, ZNF746, DUSP13, SPAST, UXS1, SIGLECL1, CD70, RAF1, PDHA1, TRIM25, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EXOC1_NUP107 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EXOC1_NUP107 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NUP107 | C4225228 | NEPHROTIC SYNDROME, TYPE 11 | 1 | UNIPROT |
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