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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12235

FusionGeneSummary for EWSR1_MED15

check button Fusion gene summary
Fusion gene informationFusion gene name: EWSR1_MED15
Fusion gene ID: 12235
HgeneTgene
Gene symbol

EWSR1

MED15

Gene ID

2130

51586

Gene nameEWS RNA binding protein 1mediator complex subunit 15
SynonymsEWS|EWS-FLI1|bK984G1.4ARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7
Cytomap

22q12.2

22q11.21

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogenemediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible ge
Modification date2018052720180523
UniProtAcc

Q01844

Q96RN5

Ensembl transtripts involved in fusion geneENST00000332050, ENST00000397938, 
ENST00000406548, ENST00000331029, 
ENST00000414183, ENST00000333395, 
ENST00000332035, 
ENST00000425759, 
ENST00000292733, ENST00000542773, 
ENST00000263205, ENST00000406969, 
ENST00000382974, ENST00000541476, 
ENST00000478831, 
Fusion gene scores* DoF score17 X 31 X 5=263513 X 9 X 7=819
# samples 5315
** MAII scorelog2(53/2635*10)=-2.31373869707402
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/819*10)=-2.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EWSR1 [Title/Abstract] AND MED15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG003281EWSR1chr22

29695746

+MED15chr22

20928982

+
ChiTaRS3.1BG003287EWSR1chr22

29695746

+MED15chr22

20928982

+
ChiTaRS3.1BG003288EWSR1chr22

29695746

+MED15chr22

20928982

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000332050ENST00000425759EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332050ENST00000292733EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332050ENST00000542773EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332050ENST00000263205EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332050ENST00000406969EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332050ENST00000382974EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332050ENST00000541476EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332050ENST00000478831EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000397938ENST00000425759EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000397938ENST00000292733EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000397938ENST00000542773EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000397938ENST00000263205EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000397938ENST00000406969EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000397938ENST00000382974EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000397938ENST00000541476EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000397938ENST00000478831EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000406548ENST00000425759EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000406548ENST00000292733EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000406548ENST00000542773EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000406548ENST00000263205EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000406548ENST00000406969EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000406548ENST00000382974EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000406548ENST00000541476EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000406548ENST00000478831EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000331029ENST00000425759EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000331029ENST00000292733EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000331029ENST00000542773EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000331029ENST00000263205EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000331029ENST00000406969EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000331029ENST00000382974EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000331029ENST00000541476EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000331029ENST00000478831EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000414183ENST00000425759EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000414183ENST00000292733EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000414183ENST00000542773EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000414183ENST00000263205EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000414183ENST00000406969EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000414183ENST00000382974EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000414183ENST00000541476EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000414183ENST00000478831EWSR1chr22

29695746

+MED15chr22

20928982

+
intron-intronENST00000333395ENST00000425759EWSR1chr22

29695746

+MED15chr22

20928982

+
intron-intronENST00000333395ENST00000292733EWSR1chr22

29695746

+MED15chr22

20928982

+
intron-intronENST00000333395ENST00000542773EWSR1chr22

29695746

+MED15chr22

20928982

+
intron-intronENST00000333395ENST00000263205EWSR1chr22

29695746

+MED15chr22

20928982

+
intron-intronENST00000333395ENST00000406969EWSR1chr22

29695746

+MED15chr22

20928982

+
intron-intronENST00000333395ENST00000382974EWSR1chr22

29695746

+MED15chr22

20928982

+
intron-intronENST00000333395ENST00000541476EWSR1chr22

29695746

+MED15chr22

20928982

+
intron-intronENST00000333395ENST00000478831EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332035ENST00000425759EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332035ENST00000292733EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332035ENST00000542773EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332035ENST00000263205EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332035ENST00000406969EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332035ENST00000382974EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332035ENST00000541476EWSR1chr22

29695746

+MED15chr22

20928982

+
5CDS-intronENST00000332035ENST00000478831EWSR1chr22

29695746

+MED15chr22

20928982

+

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FusionProtFeatures for EWSR1_MED15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EWSR1

Q01844

MED15

Q96RN5

Might normally function as a transcriptional repressor.EWS-fusion-proteins (EFPS) may play a role in the tumorigenicprocess. They may disturb gene expression by mimicking, orinterfering with the normal function of CTD-POLII within thetranscription initiation complex. They may also contribute to anaberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EWSR1_MED15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EWSR1_MED15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EWSR1_MED15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EWSR1_MED15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEWSR1C0553580Ewings sarcoma3CTD_human;HPO;ORPHANET
HgeneEWSR1C0206663Neuroectodermal Tumor, Primitive1CTD_human
TgeneMED15C0036341Schizophrenia2PSYGENET
TgeneMED15C0036337Schizoaffective Disorder1PSYGENET