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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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RelatedDiseases

Fusion gene ID: 12232

FusionGeneSummary for EWSR1_EWSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: EWSR1_EWSR1
Fusion gene ID: 12232
HgeneTgene
Gene symbol

EWSR1

EWSR1

Gene ID

2130

2130

Gene nameEWS RNA binding protein 1EWS RNA binding protein 1
SynonymsEWS|EWS-FLI1|bK984G1.4EWS|EWS-FLI1|bK984G1.4
Cytomap

22q12.2

22q12.2

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogeneRNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene
Modification date2018052720180527
UniProtAcc

Q01844

Q01844

Ensembl transtripts involved in fusion geneENST00000332050, ENST00000397938, 
ENST00000406548, ENST00000331029, 
ENST00000414183, ENST00000333395, 
ENST00000332035, 
ENST00000332050, 
ENST00000397938, ENST00000406548, 
ENST00000331029, ENST00000414183, 
ENST00000333395, ENST00000332035, 
Fusion gene scores* DoF score17 X 31 X 5=26358 X 20 X 7=1120
# samples 5321
** MAII scorelog2(53/2635*10)=-2.31373869707402
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(21/1120*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EWSR1 [Title/Abstract] AND EWSR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW983579EWSR1chr22

29688590

+EWSR1chr22

29692252

-
ChiTaRS3.1AJ229257EWSR1chr22

29684475

+EWSR1chr22

29684542

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000332050ENST00000332050EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000332050ENST00000397938EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000332050ENST00000406548EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000332050ENST00000331029EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000332050ENST00000414183EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000332050ENST00000333395EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000332050ENST00000332035EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000397938ENST00000332050EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000397938ENST00000397938EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000397938ENST00000406548EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000397938ENST00000331029EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000397938ENST00000414183EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000397938ENST00000333395EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000397938ENST00000332035EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000406548ENST00000332050EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000406548ENST00000397938EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000406548ENST00000406548EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000406548ENST00000331029EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000406548ENST00000414183EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000406548ENST00000333395EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000406548ENST00000332035EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000331029ENST00000332050EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000331029ENST00000397938EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000331029ENST00000406548EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000331029ENST00000331029EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000331029ENST00000414183EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000331029ENST00000333395EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000331029ENST00000332035EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000414183ENST00000332050EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000414183ENST00000397938EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000414183ENST00000406548EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000414183ENST00000331029EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000414183ENST00000414183EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000414183ENST00000333395EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000414183ENST00000332035EWSR1chr22

29688590

+EWSR1chr22

29692252

-
intron-3CDSENST00000333395ENST00000332050EWSR1chr22

29688590

+EWSR1chr22

29692252

-
intron-3CDSENST00000333395ENST00000397938EWSR1chr22

29688590

+EWSR1chr22

29692252

-
intron-3CDSENST00000333395ENST00000406548EWSR1chr22

29688590

+EWSR1chr22

29692252

-
intron-3CDSENST00000333395ENST00000331029EWSR1chr22

29688590

+EWSR1chr22

29692252

-
intron-3CDSENST00000333395ENST00000414183EWSR1chr22

29688590

+EWSR1chr22

29692252

-
intron-intronENST00000333395ENST00000333395EWSR1chr22

29688590

+EWSR1chr22

29692252

-
intron-intronENST00000333395ENST00000332035EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000332035ENST00000332050EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000332035ENST00000397938EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000332035ENST00000406548EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000332035ENST00000331029EWSR1chr22

29688590

+EWSR1chr22

29692252

-
In-frameENST00000332035ENST00000414183EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000332035ENST00000333395EWSR1chr22

29688590

+EWSR1chr22

29692252

-
5CDS-intronENST00000332035ENST00000332035EWSR1chr22

29688590

+EWSR1chr22

29692252

-
intron-intronENST00000332050ENST00000332050EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332050ENST00000397938EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332050ENST00000406548EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332050ENST00000331029EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332050ENST00000414183EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332050ENST00000333395EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332050ENST00000332035EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000397938ENST00000332050EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000397938ENST00000397938EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000397938ENST00000406548EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000397938ENST00000331029EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000397938ENST00000414183EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000397938ENST00000333395EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000397938ENST00000332035EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000406548ENST00000332050EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000406548ENST00000397938EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000406548ENST00000406548EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000406548ENST00000331029EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000406548ENST00000414183EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000406548ENST00000333395EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000406548ENST00000332035EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000331029ENST00000332050EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000331029ENST00000397938EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000331029ENST00000406548EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000331029ENST00000331029EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000331029ENST00000414183EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000331029ENST00000333395EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000331029ENST00000332035EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000414183ENST00000332050EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000414183ENST00000397938EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000414183ENST00000406548EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000414183ENST00000331029EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000414183ENST00000414183EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000414183ENST00000333395EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000414183ENST00000332035EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000333395ENST00000332050EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000333395ENST00000397938EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000333395ENST00000406548EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000333395ENST00000331029EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000333395ENST00000414183EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000333395ENST00000333395EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000333395ENST00000332035EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332035ENST00000332050EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332035ENST00000397938EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332035ENST00000406548EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332035ENST00000331029EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332035ENST00000414183EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332035ENST00000333395EWSR1chr22

29684475

+EWSR1chr22

29684542

-
intron-intronENST00000332035ENST00000332035EWSR1chr22

29684475

+EWSR1chr22

29684542

-

Top

FusionProtFeatures for EWSR1_EWSR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EWSR1

Q01844

EWSR1

Q01844

Might normally function as a transcriptional repressor.EWS-fusion-proteins (EFPS) may play a role in the tumorigenicprocess. They may disturb gene expression by mimicking, orinterfering with the normal function of CTD-POLII within thetranscription initiation complex. They may also contribute to anaberrant activation of the fusion protein target genes. Might normally function as a transcriptional repressor.EWS-fusion-proteins (EFPS) may play a role in the tumorigenicprocess. They may disturb gene expression by mimicking, orinterfering with the normal function of CTD-POLII within thetranscription initiation complex. They may also contribute to anaberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117300_340388657Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117300_340387656Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218300_340393662Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016256_285332601DomainNote=IQ
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117256_285388657DomainNote=IQ
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117256_285387656DomainNote=IQ
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218256_285393662DomainNote=IQ
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+10161_285332601RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+10168_285332601RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+11171_285388657RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+11178_285388657RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+11171_285387656RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+11178_285387656RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+12181_285393662RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+12188_285393662RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016111_116332601RepeatNote=12
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016117_125332601RepeatNote=13
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016126_156332601RepeatNote=14
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016157_163332601RepeatNote=15
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016164_170332601RepeatNote=16
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016171_177332601RepeatNote=17
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016178_188332601RepeatNote=18
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+101617_27332601RepeatNote=2
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016189_193332601RepeatNote=19
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016194_201332601RepeatNote=20
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016202_206332601RepeatNote=21
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016207_212332601RepeatNote=22
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016213_218332601RepeatNote=23
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016219_224332601RepeatNote=24
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016225_230332601RepeatNote=25
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016231_238332601RepeatNote=26
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016239_245332601RepeatNote=27
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016246_252332601RepeatNote=28
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016253_259332601RepeatNote=29
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016260_276332601RepeatNote=30
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016277_285332601RepeatNote=31
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+101628_34332601RepeatNote=3
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+101635_42332601RepeatNote=4
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+101643_50332601RepeatNote=5
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+101651_59332601RepeatNote=6
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+101660_68332601RepeatNote=7
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+101669_75332601RepeatNote=8
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+101676_84332601RepeatNote=9
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+101685_91332601RepeatNote=10
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+10168_16332601RepeatNote=1
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+101692_110332601RepeatNote=11
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117111_116388657RepeatNote=12
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117117_125388657RepeatNote=13
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117126_156388657RepeatNote=14
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117157_163388657RepeatNote=15
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117164_170388657RepeatNote=16
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117171_177388657RepeatNote=17
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117178_188388657RepeatNote=18
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+111717_27388657RepeatNote=2
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117189_193388657RepeatNote=19
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117194_201388657RepeatNote=20
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117202_206388657RepeatNote=21
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117207_212388657RepeatNote=22
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117213_218388657RepeatNote=23
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117219_224388657RepeatNote=24
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117225_230388657RepeatNote=25
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117231_238388657RepeatNote=26
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117239_245388657RepeatNote=27
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117246_252388657RepeatNote=28
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117253_259388657RepeatNote=29
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117260_276388657RepeatNote=30
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117277_285388657RepeatNote=31
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+111728_34388657RepeatNote=3
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+111735_42388657RepeatNote=4
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+111743_50388657RepeatNote=5
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+111751_59388657RepeatNote=6
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+111760_68388657RepeatNote=7
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+111769_75388657RepeatNote=8
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+111776_84388657RepeatNote=9
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+111785_91388657RepeatNote=10
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+11178_16388657RepeatNote=1
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+111792_110388657RepeatNote=11
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117111_116387656RepeatNote=12
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117117_125387656RepeatNote=13
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117126_156387656RepeatNote=14
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117157_163387656RepeatNote=15
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117164_170387656RepeatNote=16
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117171_177387656RepeatNote=17
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117178_188387656RepeatNote=18
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+111717_27387656RepeatNote=2
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117189_193387656RepeatNote=19
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117194_201387656RepeatNote=20
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117202_206387656RepeatNote=21
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117207_212387656RepeatNote=22
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117213_218387656RepeatNote=23
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117219_224387656RepeatNote=24
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117225_230387656RepeatNote=25
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117231_238387656RepeatNote=26
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117239_245387656RepeatNote=27
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117246_252387656RepeatNote=28
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117253_259387656RepeatNote=29
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117260_276387656RepeatNote=30
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117277_285387656RepeatNote=31
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+111728_34387656RepeatNote=3
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+111735_42387656RepeatNote=4
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+111743_50387656RepeatNote=5
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+111751_59387656RepeatNote=6
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+111760_68387656RepeatNote=7
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+111769_75387656RepeatNote=8
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+111776_84387656RepeatNote=9
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+111785_91387656RepeatNote=10
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+11178_16387656RepeatNote=1
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+111792_110387656RepeatNote=11
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218111_116393662RepeatNote=12
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218117_125393662RepeatNote=13
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218126_156393662RepeatNote=14
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218157_163393662RepeatNote=15
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218164_170393662RepeatNote=16
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218171_177393662RepeatNote=17
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218178_188393662RepeatNote=18
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+121817_27393662RepeatNote=2
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218189_193393662RepeatNote=19
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218194_201393662RepeatNote=20
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218202_206393662RepeatNote=21
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218207_212393662RepeatNote=22
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218213_218393662RepeatNote=23
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218219_224393662RepeatNote=24
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218225_230393662RepeatNote=25
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218231_238393662RepeatNote=26
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218239_245393662RepeatNote=27
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218246_252393662RepeatNote=28
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218253_259393662RepeatNote=29
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218260_276393662RepeatNote=30
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218277_285393662RepeatNote=31
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+121828_34393662RepeatNote=3
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+121835_42393662RepeatNote=4
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+121843_50393662RepeatNote=5
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+121851_59393662RepeatNote=6
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+121860_68393662RepeatNote=7
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+121869_75393662RepeatNote=8
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+121876_84393662RepeatNote=9
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+121885_91393662RepeatNote=10
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+12188_16393662RepeatNote=1
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+121892_110393662RepeatNote=11

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016300_340332601Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016454_513332601Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016559_640332601Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19300_340-7355Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19454_513-7355Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19559_640-7355Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117454_513388657Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117559_640388657Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117454_513387656Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117559_640387656Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218454_513393662Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218559_640393662Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016361_447332601DomainRRM
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19256_285-7355DomainNote=IQ
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19361_447-7355DomainRRM
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117361_447388657DomainRRM
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117361_447387656DomainRRM
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218361_447393662DomainRRM
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016639_656332601MotifNuclear localization signal
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19639_656-7355MotifNuclear localization signal
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117639_656388657MotifNuclear localization signal
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117639_656387656MotifNuclear localization signal
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218639_656393662MotifNuclear localization signal
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+191_285-7355RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+198_285-7355RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19111_116-7355RepeatNote=12
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19117_125-7355RepeatNote=13
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19126_156-7355RepeatNote=14
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19157_163-7355RepeatNote=15
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19164_170-7355RepeatNote=16
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19171_177-7355RepeatNote=17
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19178_188-7355RepeatNote=18
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+1917_27-7355RepeatNote=2
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19189_193-7355RepeatNote=19
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19194_201-7355RepeatNote=20
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19202_206-7355RepeatNote=21
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19207_212-7355RepeatNote=22
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19213_218-7355RepeatNote=23
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19219_224-7355RepeatNote=24
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19225_230-7355RepeatNote=25
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19231_238-7355RepeatNote=26
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19239_245-7355RepeatNote=27
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19246_252-7355RepeatNote=28
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19253_259-7355RepeatNote=29
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19260_276-7355RepeatNote=30
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19277_285-7355RepeatNote=31
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+1928_34-7355RepeatNote=3
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+1935_42-7355RepeatNote=4
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+1943_50-7355RepeatNote=5
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+1951_59-7355RepeatNote=6
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+1960_68-7355RepeatNote=7
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+1969_75-7355RepeatNote=8
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+1976_84-7355RepeatNote=9
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+1985_91-7355RepeatNote=10
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+198_16-7355RepeatNote=1
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+1992_110-7355RepeatNote=11
HgeneEWSR1chr22:29688590chr22:29692252ENST00000332035+1016518_549332601Zinc fingerRanBP2-type
HgeneEWSR1chr22:29688590chr22:29692252ENST00000333395+19518_549-7355Zinc fingerRanBP2-type
HgeneEWSR1chr22:29688590chr22:29692252ENST00000397938+1117518_549388657Zinc fingerRanBP2-type
HgeneEWSR1chr22:29688590chr22:29692252ENST00000406548+1117518_549387656Zinc fingerRanBP2-type
HgeneEWSR1chr22:29688590chr22:29692252ENST00000414183+1218518_549393662Zinc fingerRanBP2-type


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FusionGeneSequence for EWSR1_EWSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EWSR1_EWSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EWSR1_EWSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EWSR1_EWSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEWSR1C0553580Ewings sarcoma3CTD_human;HPO;ORPHANET
HgeneEWSR1C0206663Neuroectodermal Tumor, Primitive1CTD_human
TgeneEWSR1C0553580Ewings sarcoma3CTD_human;HPO;ORPHANET
TgeneEWSR1C0206663Neuroectodermal Tumor, Primitive1CTD_human