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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1223

FusionGeneSummary for AHNAK_EEF1G

check button Fusion gene summary
Fusion gene informationFusion gene name: AHNAK_EEF1G
Fusion gene ID: 1223
HgeneTgene
Gene symbol

AHNAK

EEF1G

Gene ID

79026

1937

Gene nameAHNAK nucleoproteineukaryotic translation elongation factor 1 gamma
SynonymsAHNAKRS|PM227EF1G|GIG35
Cytomap

11q12.3

11q12.3

Type of geneprotein-codingprotein-coding
Descriptionneuroblast differentiation-associated protein AHNAKAHNAK-relateddesmoyokinelongation factor 1-gammaEF-1-gammaPRO1608eEF-1B gammapancreatic tumor-related proteintranslation elongation factor eEF-1 gamma chain
Modification date2018052320180523
UniProtAcc

Q09666

P26641

Ensembl transtripts involved in fusion geneENST00000530124, ENST00000257247, 
ENST00000525875, ENST00000378024, 
ENST00000329251, ENST00000378019, 
ENST00000532986, 
Fusion gene scores* DoF score20 X 15 X 9=27003 X 4 X 4=48
# samples 224
** MAII scorelog2(22/2700*10)=-3.61738397841353
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AHNAK [Title/Abstract] AND EEF1G [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-77-7142-01AAHNAKchr11

62301133

-EEF1Gchr11

62335000

-
TCGALDOVTCGA-59-2363-01AAHNAKchr11

62301133

-EEF1Gchr11

62327926

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000530124ENST00000329251AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-3CDSENST00000530124ENST00000378019AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-intronENST00000530124ENST00000532986AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-3CDSENST00000257247ENST00000329251AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-3CDSENST00000257247ENST00000378019AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-intronENST00000257247ENST00000532986AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-3CDSENST00000525875ENST00000329251AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-3CDSENST00000525875ENST00000378019AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-intronENST00000525875ENST00000532986AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-3CDSENST00000378024ENST00000329251AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-3CDSENST00000378024ENST00000378019AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-intronENST00000378024ENST00000532986AHNAKchr11

62301133

-EEF1Gchr11

62335000

-
intron-3CDSENST00000530124ENST00000329251AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-3CDSENST00000530124ENST00000378019AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-intronENST00000530124ENST00000532986AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-3CDSENST00000257247ENST00000329251AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-3CDSENST00000257247ENST00000378019AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-intronENST00000257247ENST00000532986AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-3CDSENST00000525875ENST00000329251AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-3CDSENST00000525875ENST00000378019AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-intronENST00000525875ENST00000532986AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-3CDSENST00000378024ENST00000329251AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-3CDSENST00000378024ENST00000378019AHNAKchr11

62301133

-EEF1Gchr11

62327926

-
intron-intronENST00000378024ENST00000532986AHNAKchr11

62301133

-EEF1Gchr11

62327926

-

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FusionProtFeatures for AHNAK_EEF1G


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AHNAK

Q09666

EEF1G

P26641

May be required for neuronal cell differentiation. Probably plays a role in anchoring the complex to othercellular components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AHNAK_EEF1G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AHNAK_EEF1G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AHNAKEZR, S100B, EGFR, SIRT7, ISG15, POT1, CDK2, GRB2, HNRNPD, ESR1, DMD, FMNL1, FN1, ATF2, ATP4A, TARDBP, BAG2, RPA1, RPA2, RPA3, KLHL40, AHNAK, NOL9, NXF1, CUL7, OBSL1, CCDC8, SUMO2, JSRP1, S100A10, ACTN4, ASNS, C14orf166, CDC42, EEF1B2, EEF1D, GORASP2, GRPEL1, HSPA9, HSPB1, LASP1, MYL6, OXCT1, STMN1, TARS, ARHGDIA, CCT5, EEF1A1, EEF2, FLNB, HNRNPAB, HNRNPDL, HNRNPH1, PSME3, RUVBL1, SEC16A, STIP1, VARS, YARS, MED4, CAPZA2, HSPA5, MYH9, STRN, LIMA1, MYO19, TUBA1C, SKI, MCM2, SNW1, CDC5L, U2AF2, ZNF131, CDH1, PPP3CB, HSD17B3, PMS1, ING2, GJB7, ALPPL2, PCK2, GPR141, PYCR2, SDC1, POLH, USP14, ZNF517, RFPL2, PCDHGC3, GALK2, PLEC, PPIP5K2, CYLD, TRIM25, BRCA1, YAP1, TXNIPEEF1GEEF1DP3, EEF1D, EEF1B2, ILF2, ABCC9, EEF1G, ADAP2, CHFR, CXCL13, HDAC5, FAM195A, MVD, EFNA1, OGFOD2, FOXG1, C1orf174, NUP85, PLEKHA4, PHACTR3, ARF1, CBX8, CRELD1, DKC1, FEN1, ENOX1, NADK, NCK2, RPS28, SNAPIN, SNRPD2, TP53I3, TRIB3, GET4, MED31, ECH1, RECQL5, GSTO1, HMOX2, KARS, RPL4P5, PDCD5, PSMD11, RGL2, WDR33, ARIH2, CCT7, CDC42, CDK5RAP2, CSTF2, DLEU1, HNRNPH3, CCDC106, PTPN4, PTPRS, SAT1, TUBB3, ZNF24, VARS, LZTS1, CARS, LARS, HARS, EGFR, MYC, UCHL5, SNW1, AGO4, YWHAG, SIRT1, NUDT21, GSK3B, ZBED8, NUDT3, PTK2, TNNT1, AKT1, CDK2AP2, GADD45A, C11orf58, NDRG1, ISG15, CUL3, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, GADD45G, GRB2, EEF1A1, RPL5, RPL8, HNRNPA3, SNRPA1, SRSF9, PLOD3, FLNC, STRIP1, SMURF1, YWHAE, FN1, VCAM1, MTNR1A, SKIL, MLH1, PAN2, IGSF8, NPM1, RAD52, ADRB2, FBXO6, TARDBP, TRAP1, CCT3, SHFM1, STAU1, TRIM63, TRIM55, FUS, RBM6, KLHL18, PLGRKT, ZDHHC17, CUL7, OBSL1, CCDC8, EED, SUMO2, SIRT6, ABL1, KTN1, INPPL1, EEF1A2, MKKS, RPS6KB2, HNRNPA1, ATL3, GTF2E1, GTF2E2, NACA, NPM3, PABPC1, RANGAP1, RPL38, IPO4, PRPF38B, NTRK1, ERBB2, EXOSC9, PKN2, SLC33A1, KIF20B, CHMP4B, MCM2, CDC73, WWP2, CDH1, CYLD, DLD, DLST, DNM1L, HSD17B10, PARK7, PDHA1, SDHA, SOAT1, SOD1, VDAC1, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AHNAK_EEF1G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AHNAK_EEF1G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAHNAKC0007134Renal Cell Carcinoma1CTD_human
HgeneAHNAKC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneAHNAKC0263454Chloracne1CTD_human