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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12166

FusionGeneSummary for ETV4_CHID1

check button Fusion gene summary
Fusion gene informationFusion gene name: ETV4_CHID1
Fusion gene ID: 12166
HgeneTgene
Gene symbol

ETV4

CHID1

Gene ID

2118

66005

Gene nameETS variant 4chitinase domain containing 1
SynonymsE1A-F|E1AF|PEA3|PEAS3GL008|SI-CLP|SICLP
Cytomap

17q21.31

11p15.5

Type of geneprotein-codingprotein-coding
DescriptionETS translocation variant 4EWS protein/E1A enhancer binding protein chimeraadenovirus E1A enhancer-binding proteinets variant gene 4 (E1A enhancer-binding protein, E1AF)polyomavirus enhancer activator 3 homologchitinase domain-containing protein 1stabilin-1 interacting chitinase-like protein
Modification date2018052320180523
UniProtAcc

P43268

Q9BWS9

Ensembl transtripts involved in fusion geneENST00000319349, ENST00000393664, 
ENST00000538265, ENST00000545954, 
ENST00000545089, ENST00000591713, 
ENST00000586826, 
ENST00000323541, 
ENST00000454838, ENST00000449825, 
ENST00000323578, ENST00000429789, 
ENST00000336845, ENST00000528581, 
ENST00000436108, ENST00000526714, 
Fusion gene scores* DoF score5 X 3 X 4=605 X 4 X 4=80
# samples 55
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ETV4 [Title/Abstract] AND CHID1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV4

GO:0045944

positive regulation of transcription by RNA polymerase II

24983502

TgeneCHID1

GO:1900016

negative regulation of cytokine production involved in inflammatory response

20724479


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A8PE-01AETV4chr17

41622343

-CHID1chr11

870499

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000319349ENST00000323541ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000319349ENST00000454838ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000319349ENST00000449825ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000319349ENST00000323578ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000319349ENST00000429789ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000319349ENST00000336845ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000319349ENST00000528581ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000319349ENST00000436108ETV4chr17

41622343

-CHID1chr11

870499

-
5CDS-intronENST00000319349ENST00000526714ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000393664ENST00000323541ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000393664ENST00000454838ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000393664ENST00000449825ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000393664ENST00000323578ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000393664ENST00000429789ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000393664ENST00000336845ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000393664ENST00000528581ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000393664ENST00000436108ETV4chr17

41622343

-CHID1chr11

870499

-
5CDS-intronENST00000393664ENST00000526714ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000538265ENST00000323541ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000538265ENST00000454838ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000538265ENST00000449825ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000538265ENST00000323578ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000538265ENST00000429789ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000538265ENST00000336845ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000538265ENST00000528581ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000538265ENST00000436108ETV4chr17

41622343

-CHID1chr11

870499

-
5CDS-intronENST00000538265ENST00000526714ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545954ENST00000323541ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545954ENST00000454838ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545954ENST00000449825ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545954ENST00000323578ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545954ENST00000429789ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545954ENST00000336845ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545954ENST00000528581ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545954ENST00000436108ETV4chr17

41622343

-CHID1chr11

870499

-
5CDS-intronENST00000545954ENST00000526714ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545089ENST00000323541ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545089ENST00000454838ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545089ENST00000449825ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545089ENST00000323578ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545089ENST00000429789ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545089ENST00000336845ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545089ENST00000528581ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000545089ENST00000436108ETV4chr17

41622343

-CHID1chr11

870499

-
5CDS-intronENST00000545089ENST00000526714ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000591713ENST00000323541ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000591713ENST00000454838ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000591713ENST00000449825ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000591713ENST00000323578ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000591713ENST00000429789ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000591713ENST00000336845ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000591713ENST00000528581ETV4chr17

41622343

-CHID1chr11

870499

-
Frame-shiftENST00000591713ENST00000436108ETV4chr17

41622343

-CHID1chr11

870499

-
5CDS-intronENST00000591713ENST00000526714ETV4chr17

41622343

-CHID1chr11

870499

-
intron-3CDSENST00000586826ENST00000323541ETV4chr17

41622343

-CHID1chr11

870499

-
intron-3CDSENST00000586826ENST00000454838ETV4chr17

41622343

-CHID1chr11

870499

-
intron-3CDSENST00000586826ENST00000449825ETV4chr17

41622343

-CHID1chr11

870499

-
intron-3CDSENST00000586826ENST00000323578ETV4chr17

41622343

-CHID1chr11

870499

-
intron-3CDSENST00000586826ENST00000429789ETV4chr17

41622343

-CHID1chr11

870499

-
intron-3CDSENST00000586826ENST00000336845ETV4chr17

41622343

-CHID1chr11

870499

-
intron-3CDSENST00000586826ENST00000528581ETV4chr17

41622343

-CHID1chr11

870499

-
intron-3CDSENST00000586826ENST00000436108ETV4chr17

41622343

-CHID1chr11

870499

-
intron-intronENST00000586826ENST00000526714ETV4chr17

41622343

-CHID1chr11

870499

-

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FusionProtFeatures for ETV4_CHID1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV4

P43268

CHID1

Q9BWS9

Transcriptional activator that binds to the enhancer ofthe adenovirus E1A gene; the core-binding sequence is5'[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:19307308}. Saccharide- and LPS-binding protein with possible rolesin pathogen sensing and endotoxin neutralization. Ligand-bindingspecificity relates to the length of the oligosaccharides, withpreference for chitotetraose (in vitro).{ECO:0000269|PubMed:20724479}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ETV4_CHID1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ETV4_CHID1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ETV4HOXD4, RFWD2, SAE1, UBA2, SMAD2, APP, HTT, ATXN1, STK11, TP63, JUN, CARM1, TRIM25CHID1APP, TMEM25, PAFAH1B1, GAA, MAN2B1, TCTN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ETV4_CHID1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ETV4_CHID1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETV4C0027627Neoplasm Metastasis1CTD_human
HgeneETV4C0033578Prostatic Neoplasms1CTD_human
HgeneETV4C1458155Mammary Neoplasms1CTD_human