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Fusion gene ID: 12140 |
FusionGeneSummary for ETHE1_PLAUR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ETHE1_PLAUR | Fusion gene ID: 12140 | Hgene | Tgene | Gene symbol | ETHE1 | PLAUR | Gene ID | 23474 | 5329 |
| Gene name | ETHE1, persulfide dioxygenase | plasminogen activator, urokinase receptor | |
| Synonyms | HSCO|YF13H12 | CD87|U-PAR|UPAR|URKR | |
| Cytomap | 19q13.31 | 19q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | persulfide dioxygenase ETHE1, mitochondrialethylmalonic encephalopathy 1hepatoma subtracted clone one proteinprotein ETHE1, mitochondrialsulfur dioxygenase ETHE1 | urokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95571 | Q03405 | |
| Ensembl transtripts involved in fusion gene | ENST00000292147, ENST00000600651, | ENST00000339082, ENST00000601723, ENST00000340093, ENST00000221264, | |
| Fusion gene scores | * DoF score | 8 X 5 X 7=280 | 4 X 2 X 4=32 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ETHE1 [Title/Abstract] AND PLAUR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ETHE1 | GO:0006749 | glutathione metabolic process | 23144459 |
| Hgene | ETHE1 | GO:0070813 | hydrogen sulfide metabolic process | 23144459 |
| Tgene | PLAUR | GO:0043388 | positive regulation of DNA binding | 22984561 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-L5-A8NI-01A | ETHE1 | chr19 | 44030667 | - | PLAUR | chr19 | 44159725 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000292147 | ENST00000339082 | ETHE1 | chr19 | 44030667 | - | PLAUR | chr19 | 44159725 | - |
| In-frame | ENST00000292147 | ENST00000601723 | ETHE1 | chr19 | 44030667 | - | PLAUR | chr19 | 44159725 | - |
| In-frame | ENST00000292147 | ENST00000340093 | ETHE1 | chr19 | 44030667 | - | PLAUR | chr19 | 44159725 | - |
| 5CDS-intron | ENST00000292147 | ENST00000221264 | ETHE1 | chr19 | 44030667 | - | PLAUR | chr19 | 44159725 | - |
| In-frame | ENST00000600651 | ENST00000339082 | ETHE1 | chr19 | 44030667 | - | PLAUR | chr19 | 44159725 | - |
| In-frame | ENST00000600651 | ENST00000601723 | ETHE1 | chr19 | 44030667 | - | PLAUR | chr19 | 44159725 | - |
| In-frame | ENST00000600651 | ENST00000340093 | ETHE1 | chr19 | 44030667 | - | PLAUR | chr19 | 44159725 | - |
| 5CDS-intron | ENST00000600651 | ENST00000221264 | ETHE1 | chr19 | 44030667 | - | PLAUR | chr19 | 44159725 | - |
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FusionProtFeatures for ETHE1_PLAUR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ETHE1 | PLAUR |
| Sulfur dioxygenase that plays an essential role inhydrogen sulfide catabolism in the mitochondrial matrix. Hydrogensulfide (H(2)S) is first oxidized by SQRDL, giving rise tocysteine persulfide residues. ETHE1 consumes molecular oxygen tocatalyze the oxidation of the persulfide, once it has beentransferred to a thiophilic acceptor, such as glutathione (R-SSH).Plays an important role in metabolic homeostasis in mitochondriaby metabolizing hydrogen sulfide and preventing the accumulationof supraphysiological H(2)S levels that have toxic effects, due tothe inhibition of cytochrome c oxidase. First described as aprotein that can shuttle between the nucleus and the cytoplasm andsuppress p53-induced apoptosis by sequestering the transcriptionfactor RELA/NFKB3 in the cytoplasm and preventing its accumulationin the nucleus (PubMed:12398897). {ECO:0000269|PubMed:12398897,ECO:0000269|PubMed:14732903, ECO:0000269|PubMed:19136963,ECO:0000269|PubMed:23144459}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PLAUR | chr19:44030667 | chr19:44159725 | ENST00000221264 | - | 0 | 6 | 115_213 | -143 | 291 | Domain | Note=UPAR/Ly6 2 |
| Tgene | >PLAUR | chr19:44030667 | chr19:44159725 | ENST00000221264 | - | 0 | 6 | 214_305 | -143 | 291 | Domain | Note=UPAR/Ly6 3 |
| Tgene | >PLAUR | chr19:44030667 | chr19:44159725 | ENST00000221264 | - | 0 | 6 | 23_114 | -143 | 291 | Domain | Note=UPAR/Ly6 1 |
| Tgene | >PLAUR | chr19:44030667 | chr19:44159725 | ENST00000339082 | - | 3 | 7 | 214_305 | 157 | 282 | Domain | Note=UPAR/Ly6 3 |
| Tgene | >PLAUR | chr19:44030667 | chr19:44159725 | ENST00000340093 | - | 3 | 7 | 214_305 | 157 | 336 | Domain | Note=UPAR/Ly6 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PLAUR | chr19:44030667 | chr19:44159725 | ENST00000339082 | - | 3 | 7 | 115_213 | 157 | 282 | Domain | Note=UPAR/Ly6 2 |
| Tgene | PLAUR | chr19:44030667 | chr19:44159725 | ENST00000339082 | - | 3 | 7 | 23_114 | 157 | 282 | Domain | Note=UPAR/Ly6 1 |
| Tgene | PLAUR | chr19:44030667 | chr19:44159725 | ENST00000340093 | - | 3 | 7 | 115_213 | 157 | 336 | Domain | Note=UPAR/Ly6 2 |
| Tgene | PLAUR | chr19:44030667 | chr19:44159725 | ENST00000340093 | - | 3 | 7 | 23_114 | 157 | 336 | Domain | Note=UPAR/Ly6 1 |
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FusionGeneSequence for ETHE1_PLAUR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ETHE1_ENST00000292147_chr19_44030667_-_PLAUR_ENST00000339082_chr19_44159725_-_200aa MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAGRPKDDRHLRGCGYL PGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHERSLWGSWLPC >In-frame_ETHE1_ENST00000292147_chr19_44030667_-_PLAUR_ENST00000601723_chr19_44159725_-_205aa MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAGRPKDDRHLRGCGYL PGCPGSNGFHNNDTFHFLKCCNTTKCNEGPKPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPG >In-frame_ETHE1_ENST00000292147_chr19_44030667_-_PLAUR_ENST00000340093_chr19_44159725_-_254aa MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAGRPKDDRHLRGCGYL PGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRG >In-frame_ETHE1_ENST00000600651_chr19_44030667_-_PLAUR_ENST00000339082_chr19_44159725_-_200aa MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAGRPKDDRHLRGCGYL PGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHERSLWGSWLPC >In-frame_ETHE1_ENST00000600651_chr19_44030667_-_PLAUR_ENST00000601723_chr19_44159725_-_205aa MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAGRPKDDRHLRGCGYL PGCPGSNGFHNNDTFHFLKCCNTTKCNEGPKPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPG >In-frame_ETHE1_ENST00000600651_chr19_44030667_-_PLAUR_ENST00000340093_chr19_44159725_-_254aa MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAGRPKDDRHLRGCGYL PGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ETHE1_ENST00000292147_chr19_44030667_-_PLAUR_ENST00000339082_chr19_44159725_-_600nt ATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAG CCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGG GATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTT CCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAGGGCCCA ATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCATGGATGCTCCTCTGAAGAGACT TTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACGCTCACTCTGGGGAAGCTGGTTGCCATGT >In-frame_ETHE1_ENST00000292147_chr19_44030667_-_PLAUR_ENST00000601723_chr19_44159725_-_615nt ATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAG CCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGG GATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTT CCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAGGGCCCA AAACCGAAAAACCAAAGCTATATGGTAAGAGGCTGTGCAACCGCCTCAATGTGCCAACATGCCCACCTGGGTGACGCCTTCAGCATGAAC CACATTGATGTCTCCTGCTGTACTAAAAGTGGCTGTAACCACCCAGACCTGGATGTCCAGTACCGCAGTGGGGCTGCTCCTCAGCCTGGC >In-frame_ETHE1_ENST00000292147_chr19_44030667_-_PLAUR_ENST00000340093_chr19_44159725_-_762nt ATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAG CCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGG GATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTT CCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAGGGCCCA ATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCATGGATGCTCCTCTGAAGAGACT TTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACCGAAAAACCAAAGCTATATGGTAAGAGGC TGTGCAACCGCCTCAATGTGCCAACATGCCCACCTGGGTGACGCCTTCAGCATGAACCACATTGATGTCTCCTGCTGTACTAAAAGTGGC TGTAACCACCCAGACCTGGATGTCCAGTACCGCAGTGGGGCTGCTCCTCAGCCTGGCCCTGCCCATCTCAGCCTCACCATCACCCTGCTA >In-frame_ETHE1_ENST00000600651_chr19_44030667_-_PLAUR_ENST00000339082_chr19_44159725_-_600nt ATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAG CCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGG GATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTT CCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAGGGCCCA ATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCATGGATGCTCCTCTGAAGAGACT TTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACGCTCACTCTGGGGAAGCTGGTTGCCATGT >In-frame_ETHE1_ENST00000600651_chr19_44030667_-_PLAUR_ENST00000601723_chr19_44159725_-_615nt ATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAG CCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGG GATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTT CCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAGGGCCCA AAACCGAAAAACCAAAGCTATATGGTAAGAGGCTGTGCAACCGCCTCAATGTGCCAACATGCCCACCTGGGTGACGCCTTCAGCATGAAC CACATTGATGTCTCCTGCTGTACTAAAAGTGGCTGTAACCACCCAGACCTGGATGTCCAGTACCGCAGTGGGGCTGCTCCTCAGCCTGGC >In-frame_ETHE1_ENST00000600651_chr19_44030667_-_PLAUR_ENST00000340093_chr19_44159725_-_762nt ATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAG CCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGG GATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTT CCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAGGGCCCA ATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCATGGATGCTCCTCTGAAGAGACT TTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACCGAAAAACCAAAGCTATATGGTAAGAGGC TGTGCAACCGCCTCAATGTGCCAACATGCCCACCTGGGTGACGCCTTCAGCATGAACCACATTGATGTCTCCTGCTGTACTAAAAGTGGC TGTAACCACCCAGACCTGGATGTCCAGTACCGCAGTGGGGCTGCTCCTCAGCCTGGCCCTGCCCATCTCAGCCTCACCATCACCCTGCTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ETHE1_ENST00000292147_chr19_44030667_-_PLAUR_ENST00000339082_chr19_44159725_-_1029nt AGTGCCGTAGCGCCCGGCTCCTGCAGGCGCTCGGCCTCCGCTCATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGT CGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTA CCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCT GGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGG TTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCC GCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCC CATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACGCTCACTCTGGGGAAGCTGGTTGCCATGTAAAAGTACTACTGCCCTGAGACC ACCATGCTGTGAGGAAGCCCAAGCTACTCATGTATAAATGCCATGTGGAGATAGAGCCCCAGATGTTTCAGCCATCTCAGCCCAGGCACC AGACAAGTGGGTGAAGAAGCCACCTTGGACATGTAGCCCCAGCAGATGTGATATAGAGAAGAAACAGGAAACTTGGCTATATTAGTTTCC TAGGGCTGCCTGTGATAAATTATTACAAACTTTATAAACTAACACATTGTGTGCCTATATCAAAACATCATGGAAGGACAGGCACAGTGG CTCATGCCTGTAGTCCTAGCACTTTGGGAGGGTGAGAAAGGAAGATCTCTTGAGCTCAGGAGTTCAAGATCAGCCTGGGCAACACAGTGA >In-frame_ETHE1_ENST00000292147_chr19_44030667_-_PLAUR_ENST00000601723_chr19_44159725_-_993nt AGTGCCGTAGCGCCCGGCTCCTGCAGGCGCTCGGCCTCCGCTCATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGT CGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTA CCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCT GGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGG TTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAGGGCCCAAAACCGAAAAACCAAAGCTATAT GGTAAGAGGCTGTGCAACCGCCTCAATGTGCCAACATGCCCACCTGGGTGACGCCTTCAGCATGAACCACATTGATGTCTCCTGCTGTAC TAAAAGTGGCTGTAACCACCCAGACCTGGATGTCCAGTACCGCAGTGGGGCTGCTCCTCAGCCTGGCCCTGCCCATCTCAGCCTCACCAT CACCCTGCTAATGACTGCCAGACTGTGGGGAGGCACTCTCCTCTGGACCTAAACCTGAAATCCCCCTCTCTGCCCTGGCTGGATCCGGGG GACCCCTTTGCCCTTCCCTCGGCTCCCAGCCCTACAGACTTGCTGTGTGACCTCAGGCCAGTGTGCCGACCTCTCTGGGCCTCAGTTTTC CCAGCTATGAAAACAGCTATCTCACAAAGTTGTGTGAAGCAGAAGAGAAAAGCTGGAGGAAGGCCGTGGGCCAATGGGAGAGCTCTTGTT ATTATTAATATTGTTGCCGCTGTTGTGTTGTTGTTATTAATTAATATTCATATTATTTATTTTATACTTACATAAAGATTTTGTACCAGT >In-frame_ETHE1_ENST00000292147_chr19_44030667_-_PLAUR_ENST00000340093_chr19_44159725_-_1139nt AGTGCCGTAGCGCCCGGCTCCTGCAGGCGCTCGGCCTCCGCTCATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGT CGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTA CCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCT GGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGG TTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCC GCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCC CATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACCGAAAAACCAAAGCTATATGGTAAGAGGCTGTGCAACCGCCTCAATGTGCCA ACATGCCCACCTGGGTGACGCCTTCAGCATGAACCACATTGATGTCTCCTGCTGTACTAAAAGTGGCTGTAACCACCCAGACCTGGATGT CCAGTACCGCAGTGGGGCTGCTCCTCAGCCTGGCCCTGCCCATCTCAGCCTCACCATCACCCTGCTAATGACTGCCAGACTGTGGGGAGG CACTCTCCTCTGGACCTAAACCTGAAATCCCCCTCTCTGCCCTGGCTGGATCCGGGGGACCCCTTTGCCCTTCCCTCGGCTCCCAGCCCT ACAGACTTGCTGTGTGACCTCAGGCCAGTGTGCCGACCTCTCTGGGCCTCAGTTTTCCCAGCTATGAAAACAGCTATCTCACAAAGTTGT GTGAAGCAGAAGAGAAAAGCTGGAGGAAGGCCGTGGGCCAATGGGAGAGCTCTTGTTATTATTAATATTGTTGCCGCTGTTGTGTTGTTG >In-frame_ETHE1_ENST00000600651_chr19_44030667_-_PLAUR_ENST00000339082_chr19_44159725_-_986nt ATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCC ATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGAC CCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGC CACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAAC ACCACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACC CATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACGCTCA CTCTGGGGAAGCTGGTTGCCATGTAAAAGTACTACTGCCCTGAGACCACCATGCTGTGAGGAAGCCCAAGCTACTCATGTATAAATGCCA TGTGGAGATAGAGCCCCAGATGTTTCAGCCATCTCAGCCCAGGCACCAGACAAGTGGGTGAAGAAGCCACCTTGGACATGTAGCCCCAGC AGATGTGATATAGAGAAGAAACAGGAAACTTGGCTATATTAGTTTCCTAGGGCTGCCTGTGATAAATTATTACAAACTTTATAAACTAAC ACATTGTGTGCCTATATCAAAACATCATGGAAGGACAGGCACAGTGGCTCATGCCTGTAGTCCTAGCACTTTGGGAGGGTGAGAAAGGAA >In-frame_ETHE1_ENST00000600651_chr19_44030667_-_PLAUR_ENST00000601723_chr19_44159725_-_950nt ATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCC ATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGAC CCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGC CACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAAC ACCACCAAATGCAACGAGGGCCCAAAACCGAAAAACCAAAGCTATATGGTAAGAGGCTGTGCAACCGCCTCAATGTGCCAACATGCCCAC CTGGGTGACGCCTTCAGCATGAACCACATTGATGTCTCCTGCTGTACTAAAAGTGGCTGTAACCACCCAGACCTGGATGTCCAGTACCGC AGTGGGGCTGCTCCTCAGCCTGGCCCTGCCCATCTCAGCCTCACCATCACCCTGCTAATGACTGCCAGACTGTGGGGAGGCACTCTCCTC TGGACCTAAACCTGAAATCCCCCTCTCTGCCCTGGCTGGATCCGGGGGACCCCTTTGCCCTTCCCTCGGCTCCCAGCCCTACAGACTTGC TGTGTGACCTCAGGCCAGTGTGCCGACCTCTCTGGGCCTCAGTTTTCCCAGCTATGAAAACAGCTATCTCACAAAGTTGTGTGAAGCAGA AGAGAAAAGCTGGAGGAAGGCCGTGGGCCAATGGGAGAGCTCTTGTTATTATTAATATTGTTGCCGCTGTTGTGTTGTTGTTATTAATTA >In-frame_ETHE1_ENST00000600651_chr19_44030667_-_PLAUR_ENST00000340093_chr19_44159725_-_1096nt ATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCC ATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGAC CCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGGGCGTCCAAAGGATGACCGC CACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAAC ACCACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACC CATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACCGAAA AACCAAAGCTATATGGTAAGAGGCTGTGCAACCGCCTCAATGTGCCAACATGCCCACCTGGGTGACGCCTTCAGCATGAACCACATTGAT GTCTCCTGCTGTACTAAAAGTGGCTGTAACCACCCAGACCTGGATGTCCAGTACCGCAGTGGGGCTGCTCCTCAGCCTGGCCCTGCCCAT CTCAGCCTCACCATCACCCTGCTAATGACTGCCAGACTGTGGGGAGGCACTCTCCTCTGGACCTAAACCTGAAATCCCCCTCTCTGCCCT GGCTGGATCCGGGGGACCCCTTTGCCCTTCCCTCGGCTCCCAGCCCTACAGACTTGCTGTGTGACCTCAGGCCAGTGTGCCGACCTCTCT GGGCCTCAGTTTTCCCAGCTATGAAAACAGCTATCTCACAAAGTTGTGTGAAGCAGAAGAGAAAAGCTGGAGGAAGGCCGTGGGCCAATG GGAGAGCTCTTGTTATTATTAATATTGTTGCCGCTGTTGTGTTGTTGTTATTAATTAATATTCATATTATTTATTTTATACTTACATAAA |
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FusionGenePPI for ETHE1_PLAUR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ETHE1 | IGSF21, LRIF1, RELA, TP53, HDAC1, APP, FGL1, IDH1, NDUFS7 | PLAUR | ITGB2, KNG1, EEF1A1, PFN2, FAP, ITGAM, PLAU, IGF2R, LRP1, JAK1, TYK2, PSAP, OXCT1, CTSA, CTTN, SELENBP1, SCAF4, VMA21, HDLBP, SDHAF2, UBQLN2, WDHD1, NOTCH2, TXNDC17, TBCA, ELAVL1, LYN, TEX101, TUBB3, GYLTL1B, LARGE, PKN1, PXDN, ZNF146, MBTPS1, DNA2, TAZ, LAMB2, POGLUT1, POMGNT2, ARSA, GALNS, EXT1, CHSY1, CHSY3, DDX11, DDX11L8, TUBA1A, LOXL2, ADCK1, MAN2A1, SPCS2, EOGT, NAGLU, DNAJB9, NDST2, NDST1, SGSH, ARSK, FUT11, DARS2, CNTNAP3B, MAN1A1, MGAT4B, PI4K2B, PCYOX1, FASTKD3, PCSK5, CDYL, MGAT5, LEPREL2, RPUSD3, GCLM, GALNT18, ARSB, HUS1, MELK, EMILIN3, TATDN2, CERCAM, DHFRL1, TRMT11, KIAA0391, HOXD13, DHRS4, MANEA, CCRN4L, PLTP, NR2F2, ST3GAL4, UBE3A, PPOX, MAN2A2, NEK4, EGFL7, PCYOX1L, XRCC3, MCM9, TOP2B, GLB1, TUBA4A, BMP8B, TXNDC16 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ETHE1_PLAUR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PLAUR | Q03405 | DB00009 | Alteplase | Urokinase plasminogen activator surface receptor | biotech | approved |
| Tgene | PLAUR | Q03405 | DB00029 | Anistreplase | Urokinase plasminogen activator surface receptor | biotech | approved |
| Tgene | PLAUR | Q03405 | DB00031 | Tenecteplase | Urokinase plasminogen activator surface receptor | biotech | approved |
| Tgene | PLAUR | Q03405 | DB00015 | Reteplase | Urokinase plasminogen activator surface receptor | biotech | approved|investigational |
| Tgene | PLAUR | Q03405 | DB00013 | Urokinase | Urokinase plasminogen activator surface receptor | biotech | approved|investigational|withdrawn |
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RelatedDiseases for ETHE1_PLAUR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ETHE1 | C1865349 | Ethylmalonic encephalopathy | 2 | CTD_human;ORPHANET;UNIPROT |
| Tgene | PLAUR | C0004352 | Autistic Disorder | 2 | CTD_human |
| Tgene | PLAUR | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | PLAUR | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | PLAUR | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | PLAUR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | PLAUR | C3495559 | Juvenile arthritis | 1 | CTD_human |
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