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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12130

FusionGeneSummary for ETF1_TRAPPC13

check button Fusion gene summary
Fusion gene informationFusion gene name: ETF1_TRAPPC13
Fusion gene ID: 12130
HgeneTgene
Gene symbol

ETF1

TRAPPC13

Gene ID

2107

80006

Gene nameeukaryotic translation termination factor 1trafficking protein particle complex 13
SynonymsD5S1995|ERF|ERF1|RF1|SUP45L1|TB3-1C5orf44
Cytomap

5q31.2

5q12.3

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic peptide chain release factor subunit 1polypeptide chain release factor 1protein Cl1sup45 (yeast omnipotent suppressor 45) homolog-like 1trafficking protein particle complex subunit 13Trs65-relatedUPF0533 protein C5orf44
Modification date2018052320180519
UniProtAcc

P62495

A5PLN9

Ensembl transtripts involved in fusion geneENST00000499810, ENST00000360541, 
ENST00000503014, ENST00000514005, 
ENST00000399438, ENST00000438419, 
ENST00000231526, ENST00000505553, 
ENST00000545191, 
Fusion gene scores* DoF score2 X 1 X 2=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ETF1 [Title/Abstract] AND TRAPPC13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETF1

GO:0006479

protein methylation

18539146


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-8259-01AETF1chr5

137878522

-TRAPPC13chr5

64954195

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000499810ENST00000399438ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000499810ENST00000438419ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000499810ENST00000231526ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000499810ENST00000505553ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000499810ENST00000545191ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
Frame-shiftENST00000360541ENST00000399438ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
Frame-shiftENST00000360541ENST00000438419ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
Frame-shiftENST00000360541ENST00000231526ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
Frame-shiftENST00000360541ENST00000505553ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
Frame-shiftENST00000360541ENST00000545191ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000503014ENST00000399438ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000503014ENST00000438419ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000503014ENST00000231526ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000503014ENST00000505553ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000503014ENST00000545191ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000514005ENST00000399438ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000514005ENST00000438419ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000514005ENST00000231526ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000514005ENST00000505553ETF1chr5

137878522

-TRAPPC13chr5

64954195

+
intron-3CDSENST00000514005ENST00000545191ETF1chr5

137878522

-TRAPPC13chr5

64954195

+

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FusionProtFeatures for ETF1_TRAPPC13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETF1

P62495

TRAPPC13

A5PLN9

Directs the termination of nascent peptide synthesis(translation) in response to the termination codons UAA, UAG andUGA. Component of the transient SURF complex which recruits UPF1to stalled ribosomes in the context of nonsense-mediated decay(NMD) of mRNAs containing premature stop codons.{ECO:0000269|PubMed:7990965}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ETF1_TRAPPC13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ETF1_TRAPPC13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ETF1KEAP1, PABPC1, PPP2CA, GSPT2, GSPT1, UPF1, LIG4, ALB, HECW2, CORO1B, CORO1C, NUDC, RTF1, VPS26A, TSN, EGFR, ABCE1, MBD5, FSD1, ACTL6A, RNF26, CYP1A1, EIF2S1, EIF2S2, BZW1, DNAJB1, DNAJB4, HYOU1, LARS, NCKAP1, PDCD4, PSMA1, RPS7, SYAP1, ZPR1, XPO1, KPNB1, FGFR1OP, GEMIN5, SGTB, BAG6, SNRNP27, GTF2E2, FGB, USP47, MRPS11, SLC38A7, DLD, G3BP1, CCND2TRAPPC13TRAPPC3, TRAPPC8, TRAPPC2L, UBB, COG6, TRAPPC12, PRKCD, PRKCI, SAMD9, CDT1, PPP4R2, FOS, C10orf76, GOSR1, PTAR1, RAB1A, RAB1B, TSSC1, TRAPPC5, TRAPPC1, TRAPPC2, TBC1D14, DNAJC10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ETF1_TRAPPC13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ETF1_TRAPPC13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource