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Fusion gene ID: 12128 |
FusionGeneSummary for ESYT3_RPN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ESYT3_RPN1 | Fusion gene ID: 12128 | Hgene | Tgene | Gene symbol | ESYT3 | RPN1 | Gene ID | 83850 | 6184 |
| Gene name | extended synaptotagmin 3 | ribophorin I | |
| Synonyms | CHR3SYT|E-Syt3|FAM62C | OST1|RBPH1 | |
| Cytomap | 3q22.3 | 3q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | extended synaptotagmin-3chr3 synaptotagminextended synaptotagmin protein 3family with sequence similarity 62 (C2 domain containing), member C | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1RPN-Idolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunitoligosaccharyltransferase 1 homologoligosaccharyltransferase complex subunit (non-catalytic)ribop | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | A0FGR9 | P04843 | |
| Ensembl transtripts involved in fusion gene | ENST00000389567, ENST00000289135, ENST00000460133, | ENST00000296255, ENST00000497289, ENST00000490166, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 7 X 5 X 5=175 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ESYT3 [Title/Abstract] AND RPN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-66-2756-01A | ESYT3 | chr3 | 138153967 | + | RPN1 | chr3 | 128363826 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000389567 | ENST00000296255 | ESYT3 | chr3 | 138153967 | + | RPN1 | chr3 | 128363826 | - |
| 5CDS-5UTR | ENST00000389567 | ENST00000497289 | ESYT3 | chr3 | 138153967 | + | RPN1 | chr3 | 128363826 | - |
| 5CDS-intron | ENST00000389567 | ENST00000490166 | ESYT3 | chr3 | 138153967 | + | RPN1 | chr3 | 128363826 | - |
| In-frame | ENST00000289135 | ENST00000296255 | ESYT3 | chr3 | 138153967 | + | RPN1 | chr3 | 128363826 | - |
| 5CDS-5UTR | ENST00000289135 | ENST00000497289 | ESYT3 | chr3 | 138153967 | + | RPN1 | chr3 | 128363826 | - |
| 5CDS-intron | ENST00000289135 | ENST00000490166 | ESYT3 | chr3 | 138153967 | + | RPN1 | chr3 | 128363826 | - |
| intron-3CDS | ENST00000460133 | ENST00000296255 | ESYT3 | chr3 | 138153967 | + | RPN1 | chr3 | 128363826 | - |
| intron-5UTR | ENST00000460133 | ENST00000497289 | ESYT3 | chr3 | 138153967 | + | RPN1 | chr3 | 128363826 | - |
| intron-intron | ENST00000460133 | ENST00000490166 | ESYT3 | chr3 | 138153967 | + | RPN1 | chr3 | 128363826 | - |
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FusionProtFeatures for ESYT3_RPN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ESYT3 | RPN1 |
| Binds glycerophospholipids in a barrel-like domain andmay play a role in cellular lipid transport (By similarity).Tethers the endoplasmic reticulum to the cell membrane andpromotes the formation of appositions between the endoplasmicreticulum and the cell membrane. {ECO:0000250,ECO:0000269|PubMed:23791178}. | Essential subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. {ECO:0000250|UniProtKB:E2RQ08,ECO:0000250|UniProtKB:Q9GMB0, ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ESYT3 | chr3:138153967 | chr3:128363826 | ENST00000389567 | + | 1 | 23 | 1_29 | 109 | 887 | Topological domain | Cytoplasmic |
| Hgene | ESYT3 | chr3:138153967 | chr3:128363826 | ENST00000389567 | + | 1 | 23 | 30_50 | 109 | 887 | Transmembrane | Helical |
| Hgene | ESYT3 | chr3:138153967 | chr3:128363826 | ENST00000389567 | + | 1 | 23 | 51_71 | 109 | 887 | Transmembrane | Helical |
| Tgene | >RPN1 | chr3:138153967 | chr3:128363826 | ENST00000296255 | - | 0 | 10 | 458_607 | 87 | 608 | Topological domain | Cytoplasmic |
| Tgene | >RPN1 | chr3:138153967 | chr3:128363826 | ENST00000296255 | - | 0 | 10 | 439_457 | 87 | 608 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ESYT3 | chr3:138153967 | chr3:128363826 | ENST00000389567 | + | 1 | 23 | 114_291 | 109 | 887 | Domain | SMP-LTD |
| Hgene | >ESYT3 | chr3:138153967 | chr3:128363826 | ENST00000389567 | + | 1 | 23 | 293_392 | 109 | 887 | Domain | C2 1 |
| Hgene | >ESYT3 | chr3:138153967 | chr3:128363826 | ENST00000389567 | + | 1 | 23 | 430_544 | 109 | 887 | Domain | C2 2 |
| Hgene | >ESYT3 | chr3:138153967 | chr3:128363826 | ENST00000389567 | + | 1 | 23 | 756_860 | 109 | 887 | Domain | C2 3 |
| Hgene | >ESYT3 | chr3:138153967 | chr3:128363826 | ENST00000389567 | + | 1 | 23 | 801_808 | 109 | 887 | Region | Required for phosphatidylinositol 4%2C5-bisphosphate-dependent location at the cell membrane |
| Hgene | >ESYT3 | chr3:138153967 | chr3:128363826 | ENST00000389567 | + | 1 | 23 | 72_886 | 109 | 887 | Topological domain | Cytoplasmic |
| Tgene | RPN1 | chr3:138153967 | chr3:128363826 | ENST00000296255 | - | 0 | 10 | 24_438 | 87 | 608 | Topological domain | Lumenal |
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FusionGeneSequence for ESYT3_RPN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ESYT3_ENST00000389567_chr3_138153967_+_RPN1_ENST00000296255_chr3_128363826_-_630aa MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSITWLLLGALLWMWWRRNRRGKLGRLAAAFEFL DNEREFISRELRGQHLPAWVKGEDEEENNLEVRETKIKGKSGRFFTVKLPVALDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEG NHYFYSPYPTKTQTMRVKLASRNVESYTKLGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENV DLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPS YEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHY TFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKS LETEHKALTSEIALLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLISGKRQELVTKIDHILDALX >In-frame_ESYT3_ENST00000289135_chr3_138153967_+_RPN1_ENST00000296255_chr3_128363826_-_630aa MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSITWLLLGALLWMWWRRNRRGKLGRLAAAFEFL DNEREFISRELRGQHLPAWVKGEDEEENNLEVRETKIKGKSGRFFTVKLPVALDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEG NHYFYSPYPTKTQTMRVKLASRNVESYTKLGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENV DLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPS YEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHY TFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKS LETEHKALTSEIALLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLISGKRQELVTKIDHILDALX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ESYT3_ENST00000389567_chr3_138153967_+_RPN1_ENST00000296255_chr3_128363826_-_1890nt ATGCGAGCAGAGGAGCCCTGCGCCCCCGGGGCCCCCAGCGCCCTGGGAGCCCAGCGCACGCCGGGCCCCGAGCTGCGCCTGTCCAGCCAG CTGCTGCCCGAGCTCTGTACCTTCGTGGTGCGCGTGCTGTTCTACCTGGGGCCTGTCTACCTAGCTGGCTACCTGGGGCTCAGCATAACC TGGTTGCTGCTCGGCGCCCTGCTGTGGATGTGGTGGCGCAGGAACCGCCGCGGGAAGCTTGGGCGCCTGGCCGCCGCCTTCGAATTCCTT GACAATGAACGCGAGTTCATCAGCCGCGAGCTGCGGGGCCAGCACCTGCCAGCCTGGGTAAAGGGAGAAGATGAGGAAGAGAACAATTTG GAAGTACGTGAAACCAAAATTAAGGGTAAAAGTGGGAGATTCTTCACAGTCAAGCTCCCAGTTGCTCTTGATCCTGGGGCCAAGATTTCA GTCATTGTGGAAACAGTCTACACCCATGTGCTTCATCCGTATCCAACCCAGATCACCCAGTCAGAGAAACAGTTTGTGGTGTTTGAGGGG AACCATTATTTCTACTCTCCCTATCCAACGAAGACACAAACCATGCGTGTGAAGCTTGCCTCTCGAAATGTGGAGAGCTACACCAAGCTG GGGAACCCCACGCGCTCTGAGGACCTACTGGATTATGGGCCTTTCAGAGATGTGCCTGCCTATAGTCAGGATACTTTTAAAGTACATTAT GAGAACAACAGCCCTTTCCTGACCATCACCAGCATGACCCGAGTCATTGAAGTCTCTCACTGGGGTAATATTGCTGTGGAAGAAAATGTG GACTTAAAGCACACAGGAGCTGTGCTTAAGGGGCCTTTCTCACGCTATGATTACCAGAGACAGCCAGATAGTGGAATATCCTCCATCCGT TCTTTTAAGACCATCCTTCCTGCTGCTGCCCAGGATGTTTATTACCGGGATGAGATTGGCAATGTTTCTACCAGCCACCTCCTTATTTTG GATGACTCTGTAGAGATGGAAATCCGGCCTCGCTTCCCTCTCTTTGGCGGGTGGAAGACCCATTACATCGTTGGCTACAACCTCCCAAGC TATGAGTACCTCTATAATTTGGGTGACCAGTATGCACTGAAGATGAGGTTTGTGGACCATGTGTTTGATGAACAAGTGATAGATTCTCTG ACTGTGAAGATCATCCTGCCTGAAGGAGCCAAGAACATTGAAATTGATAGTCCCTATGAAATCAGCCGTGCCCCAGATGAGCTGCACTAC ACCTATCTGGACACATTTGGCCGCCCTGTGATTGTTGCCTACAAGAAAAATCTGGTAGAACAGCACATTCAGGACATTGTGGTCCACTAC ACGTTCAACAAGGTGCTCATGCTGCAGGAGCCCCTGCTGGTGGTGGCGGCCTTCTACATCCTGTTCTTCACCGTTATCATCTATGTTCGG CTGGACTTCTCCATCACCAAGGATCCAGCCGCAGAAGCCAGGATGAAGGTAGCCTGCATCACAGAGCAGGTCTTGACCCTGGTCAACAAG AGAATAGGCCTTTACCGTCACTTTGACGAGACCGTCAATAGGTACAAGCAATCCCGGGACATCTCCACCCTCAACAGTGGCAAGAAGAGC CTGGAGACTGAACACAAGGCCTTGACCAGTGAGATTGCACTGCTGCAGTCCAGGCTGAAGACAGAGGGCTCTGATCTGTGCGACAGAGTG AGCGAAATGCAGAAGCTGGATGCACAGGTCAAGGAGCTGGTGCTGAAGTCGGCGGTGGAGGCTGAGCGCCTGGTGGCTGGCAAGCTCAAG AAAGACACGTACATTGAGAATGAGAAGCTCATCTCAGGAAAGCGCCAGGAGCTGGTCACCAAGATCGACCACATCCTGGATGCCCTGTAG >In-frame_ESYT3_ENST00000289135_chr3_138153967_+_RPN1_ENST00000296255_chr3_128363826_-_1890nt ATGCGAGCAGAGGAGCCCTGCGCCCCCGGGGCCCCCAGCGCCCTGGGAGCCCAGCGCACGCCGGGCCCCGAGCTGCGCCTGTCCAGCCAG CTGCTGCCCGAGCTCTGTACCTTCGTGGTGCGCGTGCTGTTCTACCTGGGGCCTGTCTACCTAGCTGGCTACCTGGGGCTCAGCATAACC TGGTTGCTGCTCGGCGCCCTGCTGTGGATGTGGTGGCGCAGGAACCGCCGCGGGAAGCTTGGGCGCCTGGCCGCCGCCTTCGAATTCCTT GACAATGAACGCGAGTTCATCAGCCGCGAGCTGCGGGGCCAGCACCTGCCAGCCTGGGTAAAGGGAGAAGATGAGGAAGAGAACAATTTG GAAGTACGTGAAACCAAAATTAAGGGTAAAAGTGGGAGATTCTTCACAGTCAAGCTCCCAGTTGCTCTTGATCCTGGGGCCAAGATTTCA GTCATTGTGGAAACAGTCTACACCCATGTGCTTCATCCGTATCCAACCCAGATCACCCAGTCAGAGAAACAGTTTGTGGTGTTTGAGGGG AACCATTATTTCTACTCTCCCTATCCAACGAAGACACAAACCATGCGTGTGAAGCTTGCCTCTCGAAATGTGGAGAGCTACACCAAGCTG GGGAACCCCACGCGCTCTGAGGACCTACTGGATTATGGGCCTTTCAGAGATGTGCCTGCCTATAGTCAGGATACTTTTAAAGTACATTAT GAGAACAACAGCCCTTTCCTGACCATCACCAGCATGACCCGAGTCATTGAAGTCTCTCACTGGGGTAATATTGCTGTGGAAGAAAATGTG GACTTAAAGCACACAGGAGCTGTGCTTAAGGGGCCTTTCTCACGCTATGATTACCAGAGACAGCCAGATAGTGGAATATCCTCCATCCGT TCTTTTAAGACCATCCTTCCTGCTGCTGCCCAGGATGTTTATTACCGGGATGAGATTGGCAATGTTTCTACCAGCCACCTCCTTATTTTG GATGACTCTGTAGAGATGGAAATCCGGCCTCGCTTCCCTCTCTTTGGCGGGTGGAAGACCCATTACATCGTTGGCTACAACCTCCCAAGC TATGAGTACCTCTATAATTTGGGTGACCAGTATGCACTGAAGATGAGGTTTGTGGACCATGTGTTTGATGAACAAGTGATAGATTCTCTG ACTGTGAAGATCATCCTGCCTGAAGGAGCCAAGAACATTGAAATTGATAGTCCCTATGAAATCAGCCGTGCCCCAGATGAGCTGCACTAC ACCTATCTGGACACATTTGGCCGCCCTGTGATTGTTGCCTACAAGAAAAATCTGGTAGAACAGCACATTCAGGACATTGTGGTCCACTAC ACGTTCAACAAGGTGCTCATGCTGCAGGAGCCCCTGCTGGTGGTGGCGGCCTTCTACATCCTGTTCTTCACCGTTATCATCTATGTTCGG CTGGACTTCTCCATCACCAAGGATCCAGCCGCAGAAGCCAGGATGAAGGTAGCCTGCATCACAGAGCAGGTCTTGACCCTGGTCAACAAG AGAATAGGCCTTTACCGTCACTTTGACGAGACCGTCAATAGGTACAAGCAATCCCGGGACATCTCCACCCTCAACAGTGGCAAGAAGAGC CTGGAGACTGAACACAAGGCCTTGACCAGTGAGATTGCACTGCTGCAGTCCAGGCTGAAGACAGAGGGCTCTGATCTGTGCGACAGAGTG AGCGAAATGCAGAAGCTGGATGCACAGGTCAAGGAGCTGGTGCTGAAGTCGGCGGTGGAGGCTGAGCGCCTGGTGGCTGGCAAGCTCAAG AAAGACACGTACATTGAGAATGAGAAGCTCATCTCAGGAAAGCGCCAGGAGCTGGTCACCAAGATCGACCACATCCTGGATGCCCTGTAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ESYT3_ENST00000389567_chr3_138153967_+_RPN1_ENST00000296255_chr3_128363826_-_2513nt GGTGCATTTCCAGGCGCTGCTCTCCGTCGCAGAGAACCCTGAGCTCGGCGCGCCGAGAGTCCCAGCAGGGCAAGGGGGCGCGGCGTCCTG GTCCTCGAGCTTGGGAGACAGATGCGCATGGGCGTGGGGGCATGCGGACCTAAGCTCGGGTGAAGCTCTCGGGAAGGGCAAGACTGCGGC GACGAGATGCGAGCAGAGGAGCCCTGCGCCCCCGGGGCCCCCAGCGCCCTGGGAGCCCAGCGCACGCCGGGCCCCGAGCTGCGCCTGTCC AGCCAGCTGCTGCCCGAGCTCTGTACCTTCGTGGTGCGCGTGCTGTTCTACCTGGGGCCTGTCTACCTAGCTGGCTACCTGGGGCTCAGC ATAACCTGGTTGCTGCTCGGCGCCCTGCTGTGGATGTGGTGGCGCAGGAACCGCCGCGGGAAGCTTGGGCGCCTGGCCGCCGCCTTCGAA TTCCTTGACAATGAACGCGAGTTCATCAGCCGCGAGCTGCGGGGCCAGCACCTGCCAGCCTGGGTAAAGGGAGAAGATGAGGAAGAGAAC AATTTGGAAGTACGTGAAACCAAAATTAAGGGTAAAAGTGGGAGATTCTTCACAGTCAAGCTCCCAGTTGCTCTTGATCCTGGGGCCAAG ATTTCAGTCATTGTGGAAACAGTCTACACCCATGTGCTTCATCCGTATCCAACCCAGATCACCCAGTCAGAGAAACAGTTTGTGGTGTTT GAGGGGAACCATTATTTCTACTCTCCCTATCCAACGAAGACACAAACCATGCGTGTGAAGCTTGCCTCTCGAAATGTGGAGAGCTACACC AAGCTGGGGAACCCCACGCGCTCTGAGGACCTACTGGATTATGGGCCTTTCAGAGATGTGCCTGCCTATAGTCAGGATACTTTTAAAGTA CATTATGAGAACAACAGCCCTTTCCTGACCATCACCAGCATGACCCGAGTCATTGAAGTCTCTCACTGGGGTAATATTGCTGTGGAAGAA AATGTGGACTTAAAGCACACAGGAGCTGTGCTTAAGGGGCCTTTCTCACGCTATGATTACCAGAGACAGCCAGATAGTGGAATATCCTCC ATCCGTTCTTTTAAGACCATCCTTCCTGCTGCTGCCCAGGATGTTTATTACCGGGATGAGATTGGCAATGTTTCTACCAGCCACCTCCTT ATTTTGGATGACTCTGTAGAGATGGAAATCCGGCCTCGCTTCCCTCTCTTTGGCGGGTGGAAGACCCATTACATCGTTGGCTACAACCTC CCAAGCTATGAGTACCTCTATAATTTGGGTGACCAGTATGCACTGAAGATGAGGTTTGTGGACCATGTGTTTGATGAACAAGTGATAGAT TCTCTGACTGTGAAGATCATCCTGCCTGAAGGAGCCAAGAACATTGAAATTGATAGTCCCTATGAAATCAGCCGTGCCCCAGATGAGCTG CACTACACCTATCTGGACACATTTGGCCGCCCTGTGATTGTTGCCTACAAGAAAAATCTGGTAGAACAGCACATTCAGGACATTGTGGTC CACTACACGTTCAACAAGGTGCTCATGCTGCAGGAGCCCCTGCTGGTGGTGGCGGCCTTCTACATCCTGTTCTTCACCGTTATCATCTAT GTTCGGCTGGACTTCTCCATCACCAAGGATCCAGCCGCAGAAGCCAGGATGAAGGTAGCCTGCATCACAGAGCAGGTCTTGACCCTGGTC AACAAGAGAATAGGCCTTTACCGTCACTTTGACGAGACCGTCAATAGGTACAAGCAATCCCGGGACATCTCCACCCTCAACAGTGGCAAG AAGAGCCTGGAGACTGAACACAAGGCCTTGACCAGTGAGATTGCACTGCTGCAGTCCAGGCTGAAGACAGAGGGCTCTGATCTGTGCGAC AGAGTGAGCGAAATGCAGAAGCTGGATGCACAGGTCAAGGAGCTGGTGCTGAAGTCGGCGGTGGAGGCTGAGCGCCTGGTGGCTGGCAAG CTCAAGAAAGACACGTACATTGAGAATGAGAAGCTCATCTCAGGAAAGCGCCAGGAGCTGGTCACCAAGATCGACCACATCCTGGATGCC CTGTAGCCCCTGCCCGCATCCTCCAGGGGGCCCAGGGTGCCTGCACTTTGCTGTGGCAGGCAGATTGGGTGGTAGTGGGAGGTTGTGCAT GGAGGCCAGTGAAAGCTGACATCTGTAAAAGGCCTTCAAGGAAGAGAAACCAGGCCCTGCGTCAGGCAGTGTGAGTTTGCCGTTTGTCCT TAACTTTCTTTTTTTTTTTTTTTAAAAAAAGAAAACTTTAAAAAAACTCCCATTAAAAACAAAACATCTTTGTGTTTTGAACAAAGGAAT TTTCAATATTTGATTGGTATTCTGTTCTGAAGTCTAAGATATTTTTCAGCCTATAAAGCCCCCTGTTTTATGCCCTTCTAATTCTGATGT >In-frame_ESYT3_ENST00000289135_chr3_138153967_+_RPN1_ENST00000296255_chr3_128363826_-_2501nt GGCGCTGCTCTCCGTCGCAGAGAACCCTGAGCTCGGCGCGCCGAGAGTCCCAGCAGGGCAAGGGGGCGCGGCGTCCTGGTCCTCGAGCTT GGGAGACAGATGCGCATGGGCGTGGGGGCATGCGGACCTAAGCTCGGGTGAAGCTCTCGGGAAGGGCAAGACTGCGGCGACGAGATGCGA GCAGAGGAGCCCTGCGCCCCCGGGGCCCCCAGCGCCCTGGGAGCCCAGCGCACGCCGGGCCCCGAGCTGCGCCTGTCCAGCCAGCTGCTG CCCGAGCTCTGTACCTTCGTGGTGCGCGTGCTGTTCTACCTGGGGCCTGTCTACCTAGCTGGCTACCTGGGGCTCAGCATAACCTGGTTG CTGCTCGGCGCCCTGCTGTGGATGTGGTGGCGCAGGAACCGCCGCGGGAAGCTTGGGCGCCTGGCCGCCGCCTTCGAATTCCTTGACAAT GAACGCGAGTTCATCAGCCGCGAGCTGCGGGGCCAGCACCTGCCAGCCTGGGTAAAGGGAGAAGATGAGGAAGAGAACAATTTGGAAGTA CGTGAAACCAAAATTAAGGGTAAAAGTGGGAGATTCTTCACAGTCAAGCTCCCAGTTGCTCTTGATCCTGGGGCCAAGATTTCAGTCATT GTGGAAACAGTCTACACCCATGTGCTTCATCCGTATCCAACCCAGATCACCCAGTCAGAGAAACAGTTTGTGGTGTTTGAGGGGAACCAT TATTTCTACTCTCCCTATCCAACGAAGACACAAACCATGCGTGTGAAGCTTGCCTCTCGAAATGTGGAGAGCTACACCAAGCTGGGGAAC CCCACGCGCTCTGAGGACCTACTGGATTATGGGCCTTTCAGAGATGTGCCTGCCTATAGTCAGGATACTTTTAAAGTACATTATGAGAAC AACAGCCCTTTCCTGACCATCACCAGCATGACCCGAGTCATTGAAGTCTCTCACTGGGGTAATATTGCTGTGGAAGAAAATGTGGACTTA AAGCACACAGGAGCTGTGCTTAAGGGGCCTTTCTCACGCTATGATTACCAGAGACAGCCAGATAGTGGAATATCCTCCATCCGTTCTTTT AAGACCATCCTTCCTGCTGCTGCCCAGGATGTTTATTACCGGGATGAGATTGGCAATGTTTCTACCAGCCACCTCCTTATTTTGGATGAC TCTGTAGAGATGGAAATCCGGCCTCGCTTCCCTCTCTTTGGCGGGTGGAAGACCCATTACATCGTTGGCTACAACCTCCCAAGCTATGAG TACCTCTATAATTTGGGTGACCAGTATGCACTGAAGATGAGGTTTGTGGACCATGTGTTTGATGAACAAGTGATAGATTCTCTGACTGTG AAGATCATCCTGCCTGAAGGAGCCAAGAACATTGAAATTGATAGTCCCTATGAAATCAGCCGTGCCCCAGATGAGCTGCACTACACCTAT CTGGACACATTTGGCCGCCCTGTGATTGTTGCCTACAAGAAAAATCTGGTAGAACAGCACATTCAGGACATTGTGGTCCACTACACGTTC AACAAGGTGCTCATGCTGCAGGAGCCCCTGCTGGTGGTGGCGGCCTTCTACATCCTGTTCTTCACCGTTATCATCTATGTTCGGCTGGAC TTCTCCATCACCAAGGATCCAGCCGCAGAAGCCAGGATGAAGGTAGCCTGCATCACAGAGCAGGTCTTGACCCTGGTCAACAAGAGAATA GGCCTTTACCGTCACTTTGACGAGACCGTCAATAGGTACAAGCAATCCCGGGACATCTCCACCCTCAACAGTGGCAAGAAGAGCCTGGAG ACTGAACACAAGGCCTTGACCAGTGAGATTGCACTGCTGCAGTCCAGGCTGAAGACAGAGGGCTCTGATCTGTGCGACAGAGTGAGCGAA ATGCAGAAGCTGGATGCACAGGTCAAGGAGCTGGTGCTGAAGTCGGCGGTGGAGGCTGAGCGCCTGGTGGCTGGCAAGCTCAAGAAAGAC ACGTACATTGAGAATGAGAAGCTCATCTCAGGAAAGCGCCAGGAGCTGGTCACCAAGATCGACCACATCCTGGATGCCCTGTAGCCCCTG CCCGCATCCTCCAGGGGGCCCAGGGTGCCTGCACTTTGCTGTGGCAGGCAGATTGGGTGGTAGTGGGAGGTTGTGCATGGAGGCCAGTGA AAGCTGACATCTGTAAAAGGCCTTCAAGGAAGAGAAACCAGGCCCTGCGTCAGGCAGTGTGAGTTTGCCGTTTGTCCTTAACTTTCTTTT TTTTTTTTTTTAAAAAAAGAAAACTTTAAAAAAACTCCCATTAAAAACAAAACATCTTTGTGTTTTGAACAAAGGAATTTTCAATATTTG ATTGGTATTCTGTTCTGAAGTCTAAGATATTTTTCAGCCTATAAAGCCCCCTGTTTTATGCCCTTCTAATTCTGATGTTTGGGTATTGTG |
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FusionGenePPI for ESYT3_RPN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ESYT3 | EWSR1 | RPN1 | GSTK1, USP49, SLX4IP, ERBB3, FOXRED2, SEL1L, RNF185, MYC, HDAC5, INSIG2, CDK9, NELFB, ELAVL1, OS9, FBXO25, CUL3, COPS5, UBQLN4, NHS, HSPA5, FBXO6, STT3B, RPN2, SSR3, RPSA, TECR, ILF3, SLC25A5, VDAC2, SYNCRIP, SND1, ESR1, ECT2, VCP, FN1, VCAM1, ATF2, UBL4A, MMS19, OST4, CLN3, CLN5, ADRB2, EGFR, ASB5, ASB11, LGR4, STAU1, SGTA, UBQLN1, EED, RNF2, BMI1, ILK, SCCPDH, RPS6KB2, ATP5C1, CANX, CCDC47, CLGN, CYC1, IDH3A, COX2, NDUFA12, NDUFB8, PC, PPIB, RAB2A, RPL35, ABCB7, ACADM, AFG3L2, ATAD3A, ATAD3B, ATP1A1, ATP5A1, ATP5L, ATP6V0D1, ATP6V1A, BCAP29, CCT3, CCT6A, CCT7, CCT8, CDC5L, CLTC, DDOST, DDX39A, DDX39B, EIF2S1, EIF3M, HNRNPU, HSD17B12, HSP90B1, IPO5, IPO9, KDSR, MTCH1, MTCH2, NDUFB9, NOMO1, NOMO2, PDIA6, PKM, PPP2R1A, PPP2R1B, PRPF19, PSMC1, PSMC2, PSMC3, PSMC5, RAB1A, RAB1B, RAB5A, RAB5B, RAB5C, RDH13, SCAMP2, SLC25A3, SSR2, SUCLG2, TCP1, TMCO1, UQCRC2, VDAC1, VDAC3, SSR1, SSR4, TUFM, NTRK1, SCARNA22, BAG6, TCTN2, TCTN3, EVC2, TCTN1, TMEM67, TUBG1, TMEM63B, TUBA1C, CRY2, MCM2, U2AF2, RC3H1, UBC, TMEM258, CDC73, DERL1, ZNF746, NCDN, COX15, DLST, PDHA1, SDHA, EDEM3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ESYT3_RPN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ESYT3_RPN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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