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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12122

FusionGeneSummary for ESYT2_PPIA

check button Fusion gene summary
Fusion gene informationFusion gene name: ESYT2_PPIA
Fusion gene ID: 12122
HgeneTgene
Gene symbol

ESYT2

PPIA

Gene ID

57488

5478

Gene nameextended synaptotagmin 2peptidylprolyl isomerase A
SynonymsCHR2SYT|E-Syt2|FAM62BCYPA|CYPH|HEL-S-69p
Cytomap

7q36.3

7p13

Type of geneprotein-codingprotein-coding
Descriptionextended synaptotagmin-2chr2 synaptotagminextended synaptotagmin like protein 2extended synaptotagmin protein 2family with sequence similarity 62 (C2 domain containing), member Bpeptidyl-prolyl cis-trans isomerase APPIase AT cell cyclophilincyclosporin A-binding proteinepididymis secretory sperm binding protein Li 69ppeptidylprolyl isomerase A (cyclophilin A)rotamase A
Modification date2018052320180523
UniProtAcc

A0FGR8

P62937

Ensembl transtripts involved in fusion geneENST00000251527, ENST00000497111, 
ENST00000435514, 
ENST00000451562, 
ENST00000468812, ENST00000489459, 
ENST00000355968, ENST00000480603, 
Fusion gene scores* DoF score10 X 8 X 7=5606 X 6 X 2=72
# samples 107
** MAII scorelog2(10/560*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ESYT2 [Title/Abstract] AND PPIA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPIA

GO:0000413

protein peptidyl-prolyl isomerization

14993672|20676357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC001224ESYT2chr7

158622163

+PPIAchr7

44839045

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000251527ENST00000451562ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-3CDSENST00000251527ENST00000468812ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-5UTRENST00000251527ENST00000489459ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-5UTRENST00000251527ENST00000355968ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-3UTRENST00000251527ENST00000480603ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-3CDSENST00000497111ENST00000451562ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-3CDSENST00000497111ENST00000468812ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-5UTRENST00000497111ENST00000489459ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-5UTRENST00000497111ENST00000355968ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-3UTRENST00000497111ENST00000480603ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-3CDSENST00000435514ENST00000451562ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-3CDSENST00000435514ENST00000468812ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-5UTRENST00000435514ENST00000489459ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-5UTRENST00000435514ENST00000355968ESYT2chr7

158622163

+PPIAchr7

44839045

+
intron-3UTRENST00000435514ENST00000480603ESYT2chr7

158622163

+PPIAchr7

44839045

+

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FusionProtFeatures for ESYT2_PPIA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESYT2

A0FGR8

PPIA

P62937


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ESYT2_PPIA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ESYT2_PPIA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ESYT2_PPIA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePPIAP62937DB11638ArtenimolPeptidyl-prolyl cis-trans isomerase Asmall moleculeapproved|investigational
TgenePPIAP62937DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Asmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for ESYT2_PPIA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePPIAC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgenePPIAC0007137Squamous cell carcinoma1CTD_human
TgenePPIAC0026640Mouth Neoplasms1CTD_human
TgenePPIAC0027627Neoplasm Metastasis1CTD_human
TgenePPIAC0036341Schizophrenia1PSYGENET
TgenePPIAC0038356Stomach Neoplasms1CTD_human