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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12087

FusionGeneSummary for ESPNP_NECAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ESPNP_NECAP2
Fusion gene ID: 12087
HgeneTgene
Gene symbol

ESPNP

NECAP2

Gene ID

284729

55707

Gene nameespin pseudogeneNECAP endocytosis associated 2
SynonymsdJ1182A14.1-
Cytomap

1p36.13

1p36.13

Type of genepseudoprotein-coding
Description-adaptin ear-binding coat-associated protein 2adaptin-ear-binding coat-associated protein 2
Modification date2018032920180523
UniProtAcc

Q9NVZ3

Ensembl transtripts involved in fusion geneENST00000492551, ENST00000337132, 
ENST00000504551, ENST00000457722, 
ENST00000406746, ENST00000443980, 
ENST00000486390, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 4 X 2=24
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ESPNP [Title/Abstract] AND NECAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A13D-01AESPNPchr1

17023274

-NECAP2chr1

16782313

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000492551ENST00000337132ESPNPchr1

17023274

-NECAP2chr1

16782313

+
5UTR-3CDSENST00000492551ENST00000504551ESPNPchr1

17023274

-NECAP2chr1

16782313

+
5UTR-3CDSENST00000492551ENST00000457722ESPNPchr1

17023274

-NECAP2chr1

16782313

+
5UTR-3CDSENST00000492551ENST00000406746ESPNPchr1

17023274

-NECAP2chr1

16782313

+
5UTR-intronENST00000492551ENST00000443980ESPNPchr1

17023274

-NECAP2chr1

16782313

+
5UTR-intronENST00000492551ENST00000486390ESPNPchr1

17023274

-NECAP2chr1

16782313

+

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FusionProtFeatures for ESPNP_NECAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESPNP

NECAP2

Q9NVZ3

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Involved in endocytosis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ESPNP_NECAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ESPNP_NECAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ESPNPNECAP2TRAF2, PLSCR1, AP2B1, NMI, AP1G1, GGA1, GGA2, EPS15, AP2M1, APP, HSPA8, FN1, AP2S1, CARM1, AP2A2, AP2A1, AP1B1, ZYG11B, FBXO11, NECAP1, TES, AP1M1, ITSN1, ANKRD28, MPI, UFC1, CEP170, CEP128, SCLT1, RUNDC3A, SPATA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ESPNP_NECAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ESPNP_NECAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource