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Fusion gene ID: 12079 |
FusionGeneSummary for ESCO2_EPHX2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ESCO2_EPHX2 | Fusion gene ID: 12079 | Hgene | Tgene | Gene symbol | ESCO2 | EPHX2 | Gene ID | 157570 | 2053 |
| Gene name | establishment of sister chromatid cohesion N-acetyltransferase 2 | epoxide hydrolase 2 | |
| Synonyms | 2410004I17Rik|EFO2|RBS | CEH|SEH | |
| Cytomap | 8p21.1 | 8p21.2-p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-acetyltransferase ESCO2ECO1 homolog 2 | bifunctional epoxide hydrolase 2epoxide hydrataseepoxide hydrolase 2, cytoplasmicepoxide hydrolase 2, cytosolicepoxide hydrolase, soluble | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q56NI9 | P34913 | |
| Ensembl transtripts involved in fusion gene | ENST00000305188, ENST00000397418, ENST00000523910, | ENST00000521400, ENST00000517536, ENST00000521780, ENST00000380476, ENST00000518379, ENST00000520666, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ESCO2 [Title/Abstract] AND EPHX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | EPHX2 | GO:0010628 | positive regulation of gene expression | 18974052 |
| Tgene | EPHX2 | GO:0016311 | dephosphorylation | 12574508 |
| Tgene | EPHX2 | GO:0042632 | cholesterol homeostasis | 18974052 |
| Tgene | EPHX2 | GO:0046272 | stilbene catabolic process | 8342951 |
| Tgene | EPHX2 | GO:0046839 | phospholipid dephosphorylation | 12574510 |
| Tgene | EPHX2 | GO:0097176 | epoxide metabolic process | 22798687 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-23-1027-01A | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000305188 | ENST00000521400 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| In-frame | ENST00000305188 | ENST00000517536 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| In-frame | ENST00000305188 | ENST00000521780 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| In-frame | ENST00000305188 | ENST00000380476 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| In-frame | ENST00000305188 | ENST00000518379 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| 5CDS-intron | ENST00000305188 | ENST00000520666 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| In-frame | ENST00000397418 | ENST00000521400 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| In-frame | ENST00000397418 | ENST00000517536 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| In-frame | ENST00000397418 | ENST00000521780 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| In-frame | ENST00000397418 | ENST00000380476 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| In-frame | ENST00000397418 | ENST00000518379 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| 5CDS-intron | ENST00000397418 | ENST00000520666 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| intron-3CDS | ENST00000523910 | ENST00000521400 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| intron-3CDS | ENST00000523910 | ENST00000517536 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| intron-3CDS | ENST00000523910 | ENST00000521780 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| intron-3CDS | ENST00000523910 | ENST00000380476 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| intron-3CDS | ENST00000523910 | ENST00000518379 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
| intron-intron | ENST00000523910 | ENST00000520666 | ESCO2 | chr8 | 27646495 | + | EPHX2 | chr8 | 27394301 | + |
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FusionProtFeatures for ESCO2_EPHX2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ESCO2 | EPHX2 |
| Acetyltransferase required for the establishment ofsister chromatid cohesion (PubMed:15821733, PubMed:15958495).Couples the processes of cohesion and DNA replication to ensurethat only sister chromatids become paired together. In contrast tothe structural cohesins, the deposition and establishment factorsare required only during the S phase. Acetylates the cohesincomponent SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733,ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496,ECO:0000269|PubMed:21111234}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ESCO2 | chr8:27646495 | chr8:27394301 | ENST00000305188 | + | 7 | 11 | 387_411 | 421 | 602 | Zinc finger | Note=CCHH-type |
| Tgene | >EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000380476 | + | 11 | 19 | 553_555 | 337 | 503 | Motif | Microbody targeting signal |
| Tgene | >EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521400 | + | 11 | 19 | 553_555 | 390 | 556 | Motif | Microbody targeting signal |
| Tgene | >EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521780 | + | 10 | 18 | 553_555 | 324 | 490 | Motif | Microbody targeting signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000380476 | + | 11 | 19 | 259_531 | 337 | 503 | Domain | AB hydrolase-1 |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521400 | + | 11 | 19 | 259_531 | 390 | 556 | Domain | AB hydrolase-1 |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521780 | + | 10 | 18 | 259_531 | 324 | 490 | Domain | AB hydrolase-1 |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000380476 | + | 11 | 19 | 123_124 | 337 | 503 | Region | Phosphate binding |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000380476 | + | 11 | 19 | 1_224 | 337 | 503 | Region | Note=Phosphatase |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000380476 | + | 11 | 19 | 235_555 | 337 | 503 | Region | Note=Epoxide hydrolase |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521400 | + | 11 | 19 | 123_124 | 390 | 556 | Region | Phosphate binding |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521400 | + | 11 | 19 | 1_224 | 390 | 556 | Region | Note=Phosphatase |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521400 | + | 11 | 19 | 235_555 | 390 | 556 | Region | Note=Epoxide hydrolase |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521780 | + | 10 | 18 | 123_124 | 324 | 490 | Region | Phosphate binding |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521780 | + | 10 | 18 | 1_224 | 324 | 490 | Region | Note=Phosphatase |
| Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521780 | + | 10 | 18 | 235_555 | 324 | 490 | Region | Note=Epoxide hydrolase |
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FusionGeneSequence for ESCO2_EPHX2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000521400_chr8_27394301_+_587aa MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQN KWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKEN NCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKL KIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQK NTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSM HKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMED >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000517536_chr8_27394301_+_587aa MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQN KWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKEN NCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKL KIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQK NTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSM HKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMED >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000521780_chr8_27394301_+_587aa MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQN KWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKEN NCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKL KIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQK NTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSM HKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMED >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000380476_chr8_27394301_+_587aa MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQN KWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKEN NCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKL KIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQK NTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSM HKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMED >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000518379_chr8_27394301_+_587aa MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQN KWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKEN NCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKL KIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQK NTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSM HKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMED >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000521400_chr8_27394301_+_235aa MKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRA SDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVP >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000517536_chr8_27394301_+_235aa MKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRA SDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVP >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000521780_chr8_27394301_+_235aa MKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRA SDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVP >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000380476_chr8_27394301_+_235aa MKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRA SDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVP >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000518379_chr8_27394301_+_235aa MKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRA SDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000521400_chr8_27394301_+_1761nt ATGGCAGCTCTTACTCCAAGGAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCT AATAAAAAGCACTGTTTTTATCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTC AAAACAACTGAAATAAATAGACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAAT AAGTGGTACCTCAATCCACTGGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCC ATTGTGACAGAAAAAATGCAAGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCA AAGTATAGACACATCAAGCCTGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAAT AATTGTCATTCAGCTGAAAATAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCA TTTTTTGTTAGAAAAAAATCTTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTC ATTGAAGATTCTGATGTAGAGACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTG AAAATTGGACTACTGAGTGCAAGCAGTAAAAATAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAA GTTGATAAAAATGAGGCTTTTTCTTCAGAGGATTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGT GCATCTTCAGTCAATTCAAAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAA AATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAG TCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATAT GTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATG CATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTC TATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGC TTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGAC TGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATT >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000517536_chr8_27394301_+_1761nt ATGGCAGCTCTTACTCCAAGGAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCT AATAAAAAGCACTGTTTTTATCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTC AAAACAACTGAAATAAATAGACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAAT AAGTGGTACCTCAATCCACTGGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCC ATTGTGACAGAAAAAATGCAAGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCA AAGTATAGACACATCAAGCCTGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAAT AATTGTCATTCAGCTGAAAATAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCA TTTTTTGTTAGAAAAAAATCTTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTC ATTGAAGATTCTGATGTAGAGACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTG AAAATTGGACTACTGAGTGCAAGCAGTAAAAATAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAA GTTGATAAAAATGAGGCTTTTTCTTCAGAGGATTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGT GCATCTTCAGTCAATTCAAAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAA AATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAG TCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATAT GTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATG CATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTC TATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGC TTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGAC TGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATT >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000521780_chr8_27394301_+_1761nt ATGGCAGCTCTTACTCCAAGGAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCT AATAAAAAGCACTGTTTTTATCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTC AAAACAACTGAAATAAATAGACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAAT AAGTGGTACCTCAATCCACTGGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCC ATTGTGACAGAAAAAATGCAAGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCA AAGTATAGACACATCAAGCCTGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAAT AATTGTCATTCAGCTGAAAATAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCA TTTTTTGTTAGAAAAAAATCTTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTC ATTGAAGATTCTGATGTAGAGACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTG AAAATTGGACTACTGAGTGCAAGCAGTAAAAATAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAA GTTGATAAAAATGAGGCTTTTTCTTCAGAGGATTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGT GCATCTTCAGTCAATTCAAAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAA AATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAG TCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATAT GTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATG CATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTC TATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGC TTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGAC TGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATT >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000380476_chr8_27394301_+_1761nt ATGGCAGCTCTTACTCCAAGGAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCT AATAAAAAGCACTGTTTTTATCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTC AAAACAACTGAAATAAATAGACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAAT AAGTGGTACCTCAATCCACTGGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCC ATTGTGACAGAAAAAATGCAAGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCA AAGTATAGACACATCAAGCCTGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAAT AATTGTCATTCAGCTGAAAATAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCA TTTTTTGTTAGAAAAAAATCTTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTC ATTGAAGATTCTGATGTAGAGACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTG AAAATTGGACTACTGAGTGCAAGCAGTAAAAATAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAA GTTGATAAAAATGAGGCTTTTTCTTCAGAGGATTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGT GCATCTTCAGTCAATTCAAAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAA AATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAG TCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATAT GTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATG CATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTC TATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGC TTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGAC TGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATT >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000518379_chr8_27394301_+_1761nt ATGGCAGCTCTTACTCCAAGGAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCT AATAAAAAGCACTGTTTTTATCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTC AAAACAACTGAAATAAATAGACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAAT AAGTGGTACCTCAATCCACTGGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCC ATTGTGACAGAAAAAATGCAAGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCA AAGTATAGACACATCAAGCCTGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAAT AATTGTCATTCAGCTGAAAATAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCA TTTTTTGTTAGAAAAAAATCTTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTC ATTGAAGATTCTGATGTAGAGACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTG AAAATTGGACTACTGAGTGCAAGCAGTAAAAATAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAA GTTGATAAAAATGAGGCTTTTTCTTCAGAGGATTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGT GCATCTTCAGTCAATTCAAAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAA AATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAG TCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATAT GTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATG CATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTC TATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGC TTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGAC TGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATT >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000521400_chr8_27394301_+_705nt ATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAA CATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCAC AGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCA AGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATG GTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGG AACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCT CAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCA >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000517536_chr8_27394301_+_705nt ATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAA CATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCAC AGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCA AGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATG GTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGG AACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCT CAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCA >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000521780_chr8_27394301_+_705nt ATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAA CATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCAC AGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCA AGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATG GTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGG AACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCT CAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCA >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000380476_chr8_27394301_+_705nt ATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAA CATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCAC AGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCA AGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATG GTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGG AACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCT CAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCA >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000518379_chr8_27394301_+_705nt ATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAA CATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCAC AGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCA AGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATG GTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGG AACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCT CAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000521400_chr8_27394301_+_3041nt AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT AGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATGACTATGCTGCTGGCTGTCTTTGTTCTTGGAGAGGTGGAGT GACTGTTCACGGAGAATGCACGGCATGGGGATGAACCCTTTCCCTCTGCTTTTGAGCCCTGTTCTGGGCTCCAAGGTGCTGTATGATCTA GGCCGTGCTGGCCAGGAGACAATCCTATGGGGATGGCAGTGGTGTCTTGTGCTCTGTCCCCTAGAGCAGTCACTGGCCACAGGTAGCCAC CTGCCTTTCTCCCGGCTTCCCTAGCAGAGTTTGCTCAGGCACAAATGTGCACCTGGAGCATTTGAAATGTGCTAGTGAGGCTGAGGAAGA GAATTTTAAATTTCATTGAATTGTAATCAGTTTAAAGTTAAATAGCAGCAGCTGCCATGAGGCTCAGGCAGATCCAGCTCATCTTCCCCT CTGCCCCCTCCTCCCTATCTTCCCCTCTACCCTCTCCTGCCTCCTGTCACATCCGGTTAGGCTCCCATCTCACTGATGTGTCTCCTGCAG TGGTCTCTCCCCTGCCCTGCTTCCAGCCCCAGAGTCCTGGAGCAGCAGCCTCCTCACGGGTCTTGCCGCCCACATGGTTGGATCCTGAAA >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000517536_chr8_27394301_+_2396nt AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000521780_chr8_27394301_+_2396nt AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000380476_chr8_27394301_+_2390nt AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT >In-frame_ESCO2_ENST00000305188_chr8_27646495_+_EPHX2_ENST00000518379_chr8_27394301_+_2369nt AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000521400_chr8_27394301_+_2721nt GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG ACTATGCTGCTGGCTGTCTTTGTTCTTGGAGAGGTGGAGTGACTGTTCACGGAGAATGCACGGCATGGGGATGAACCCTTTCCCTCTGCT TTTGAGCCCTGTTCTGGGCTCCAAGGTGCTGTATGATCTAGGCCGTGCTGGCCAGGAGACAATCCTATGGGGATGGCAGTGGTGTCTTGT GCTCTGTCCCCTAGAGCAGTCACTGGCCACAGGTAGCCACCTGCCTTTCTCCCGGCTTCCCTAGCAGAGTTTGCTCAGGCACAAATGTGC ACCTGGAGCATTTGAAATGTGCTAGTGAGGCTGAGGAAGAGAATTTTAAATTTCATTGAATTGTAATCAGTTTAAAGTTAAATAGCAGCA GCTGCCATGAGGCTCAGGCAGATCCAGCTCATCTTCCCCTCTGCCCCCTCCTCCCTATCTTCCCCTCTACCCTCTCCTGCCTCCTGTCAC ATCCGGTTAGGCTCCCATCTCACTGATGTGTCTCCTGCAGTGGTCTCTCCCCTGCCCTGCTTCCAGCCCCAGAGTCCTGGAGCAGCAGCC TCCTCACGGGTCTTGCCGCCCACATGGTTGGATCCTGAAACTCGCAGGGCCTCCCCCAACTGCCCCTGCCCACCCCCAGCCCGGCCCCAT >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000517536_chr8_27394301_+_2076nt GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000521780_chr8_27394301_+_2076nt GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000380476_chr8_27394301_+_2070nt GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG >In-frame_ESCO2_ENST00000397418_chr8_27646495_+_EPHX2_ENST00000518379_chr8_27394301_+_2049nt GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT |
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FusionGenePPI for ESCO2_EPHX2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ESCO2 | RCOR1, KDM1A, HDAC1, HDAC2, HDAC4, PHF21A, SUV39H1, SETDB1, EHMT2, CBX8, MOV10, NXF1, HIST1H2BG, RPGRIP1L, S100A4, YEATS4, MATR3, NCAPD3, USF1 | EPHX2 | TERF1, PEX5, EPHX2, MVP, HDHD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ESCO2_EPHX2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ESCO2_EPHX2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ESCO2 | C0392475 | Roberts-SC phocomelia syndrome | 4 | CTD_human;ORPHANET;UNIPROT |
| Tgene | EPHX2 | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | EPHX2 | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
| Tgene | EPHX2 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| Tgene | EPHX2 | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human |
| Tgene | EPHX2 | C2609414 | Acute kidney injury | 1 | CTD_human |
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