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Fusion gene ID: 12042 |
FusionGeneSummary for ERLIN2_FGFR1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ERLIN2_FGFR1 | Fusion gene ID: 12042 | Hgene | Tgene | Gene symbol | ERLIN2 | FGFR1 | Gene ID | 11160 | 2260 |
Gene name | ER lipid raft associated 2 | fibroblast growth factor receptor 1 | |
Synonyms | C8orf2|Erlin-2|NET32|SPFH2|SPG18 | BFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1 | |
Cytomap | 8p11.23 | 8p11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | erlin-2SPFH domain family, member 2endoplasmic reticulum lipid raft-associated protein 2spastic paraplegia 18 (autosomal dominant)stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 | fibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | O94905 | P11362 | |
Ensembl transtripts involved in fusion gene | ENST00000397228, ENST00000523887, ENST00000276461, ENST00000518586, ENST00000335171, ENST00000523107, ENST00000519638, | ENST00000425967, ENST00000397091, ENST00000447712, ENST00000341462, ENST00000532791, ENST00000397113, ENST00000356207, ENST00000335922, ENST00000326324, ENST00000397103, ENST00000397108, ENST00000496629, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 9 X 8 X 4=288 |
# samples | 3 | 12 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/288*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ERLIN2 [Title/Abstract] AND FGFR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ERLIN2 | GO:0030433 | ubiquitin-dependent ERAD pathway | 19240031 |
Tgene | FGFR1 | GO:0008284 | positive regulation of cell proliferation | 8663044 |
Tgene | FGFR1 | GO:0008543 | fibroblast growth factor receptor signaling pathway | 8663044 |
Tgene | FGFR1 | GO:0010863 | positive regulation of phospholipase C activity | 18480409 |
Tgene | FGFR1 | GO:0018108 | peptidyl-tyrosine phosphorylation | 8622701|18480409 |
Tgene | FGFR1 | GO:0043406 | positive regulation of MAP kinase activity | 8622701|18480409 |
Tgene | FGFR1 | GO:0046777 | protein autophosphorylation | 8622701 |
Tgene | FGFR1 | GO:2000546 | positive regulation of endothelial cell chemotaxis to fibroblast growth factor | 21885851 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-D8-A1JC-01A | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000397228 | ENST00000425967 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000397228 | ENST00000397091 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000397228 | ENST00000447712 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000397228 | ENST00000341462 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000397228 | ENST00000532791 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000397228 | ENST00000397113 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000397228 | ENST00000356207 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000397228 | ENST00000335922 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000397228 | ENST00000326324 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-intron | ENST00000397228 | ENST00000397103 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000397228 | ENST00000397108 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-intron | ENST00000397228 | ENST00000496629 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-3CDS | ENST00000523887 | ENST00000425967 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523887 | ENST00000397091 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523887 | ENST00000447712 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523887 | ENST00000341462 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523887 | ENST00000532791 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523887 | ENST00000397113 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523887 | ENST00000356207 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523887 | ENST00000335922 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523887 | ENST00000326324 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-intron | ENST00000523887 | ENST00000397103 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523887 | ENST00000397108 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-intron | ENST00000523887 | ENST00000496629 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
In-frame | ENST00000276461 | ENST00000425967 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000276461 | ENST00000397091 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000276461 | ENST00000447712 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000276461 | ENST00000341462 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000276461 | ENST00000532791 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000276461 | ENST00000397113 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000276461 | ENST00000356207 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000276461 | ENST00000335922 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000276461 | ENST00000326324 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000276461 | ENST00000397103 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000276461 | ENST00000397108 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000276461 | ENST00000496629 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-3CDS | ENST00000518586 | ENST00000425967 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000518586 | ENST00000397091 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000518586 | ENST00000447712 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000518586 | ENST00000341462 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000518586 | ENST00000532791 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000518586 | ENST00000397113 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000518586 | ENST00000356207 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000518586 | ENST00000335922 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000518586 | ENST00000326324 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-intron | ENST00000518586 | ENST00000397103 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000518586 | ENST00000397108 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-intron | ENST00000518586 | ENST00000496629 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-3CDS | ENST00000335171 | ENST00000425967 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000335171 | ENST00000397091 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000335171 | ENST00000447712 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000335171 | ENST00000341462 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000335171 | ENST00000532791 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000335171 | ENST00000397113 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000335171 | ENST00000356207 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000335171 | ENST00000335922 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000335171 | ENST00000326324 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-intron | ENST00000335171 | ENST00000397103 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000335171 | ENST00000397108 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-intron | ENST00000335171 | ENST00000496629 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-3CDS | ENST00000523107 | ENST00000425967 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523107 | ENST00000397091 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523107 | ENST00000447712 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523107 | ENST00000341462 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523107 | ENST00000532791 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523107 | ENST00000397113 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523107 | ENST00000356207 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523107 | ENST00000335922 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523107 | ENST00000326324 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-intron | ENST00000523107 | ENST00000397103 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-5UTR | ENST00000523107 | ENST00000397108 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
intron-intron | ENST00000523107 | ENST00000496629 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
In-frame | ENST00000519638 | ENST00000425967 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000519638 | ENST00000397091 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000519638 | ENST00000447712 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000519638 | ENST00000341462 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000519638 | ENST00000532791 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000519638 | ENST00000397113 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000519638 | ENST00000356207 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000519638 | ENST00000335922 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000519638 | ENST00000326324 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000519638 | ENST00000397103 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000519638 | ENST00000397108 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000519638 | ENST00000496629 | ERLIN2 | chr8 | 37607370 | + | FGFR1 | chr8 | 38315052 | - |
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FusionProtFeatures for ERLIN2_FGFR1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ERLIN2 | FGFR1 |
Component of the ERLIN1/ERLIN2 complex which mediatesthe endoplasmic reticulum-associated degradation (ERAD) ofinositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1(PubMed:19240031, PubMed:17502376). Promotes sterol-acceleratedERAD of HMGCR probably implicating an AMFR/gp78-containingubiquitin ligase complex (PubMed:21343306). Involved in regulationof cellular cholesterol homeostasis by regulation the SREBPsignaling pathway. May promote ER retention of the SCAP-SREBFcomplex (PubMed:24217618). {ECO:0000269|PubMed:17502376,ECO:0000269|PubMed:19240031, ECO:0000269|PubMed:21343306,ECO:0000269|PubMed:24217618}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ERLIN2_FGFR1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ERLIN2_ENST00000276461_chr8_37607370_+_FGFR1_ENST00000425967_chr8_38315052_-_1036aa MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIE VVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIR RNYELMVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRC RLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTK PNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYG SINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLH LRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKL AKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG VLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYS >In-frame_ERLIN2_ENST00000519638_chr8_37607370_+_FGFR1_ENST00000425967_chr8_38315052_-_1036aa MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIE VVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIR RNYELMVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRC RLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTK PNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYG SINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLH LRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKL AKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG VLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ERLIN2_ENST00000276461_chr8_37607370_+_FGFR1_ENST00000425967_chr8_38315052_-_3108nt ATGGCTCAGTTGGGAGCAGTTGTGGCTGTGGCTTCCAGTTTCTTTTGTGCATCTCTCTTCTCAGCTGTGCACAAGATAGAAGAGGGACAT ATTGGGGTATATTACAGAGGCGGTGCCCTGCTGACTTCGACCAGCGGCCCTGGTTTCCATCTCATGCTCCCTTTCATCACATCATATAAG TCTGTGCAGACCACACTCCAGACAGATGAGGTGAAGAATGTACCTTGTGGGACTAGTGGTGGTGTGATGATCTACTTTGACAGAATTGAA GTGGTGAACTTCCTGGTCCCGAACGCAGTGTATGATATAGTGAAGAACTATACTGCTGACTATGACAAGGCCCTCATCTTCAACAAGATC CACCACGAACTGAACCAGTTCTGCAGTGTGCACACGCTTCAAGAGGTCTACATTGAGCTGTTTGATCAGATTGATGAAAATCTCAAACTG GCTTTGCAACAGGACCTGACCTCCATGGCCCCTGGGCTGGTCATTCAAGCTGTGCGGGTAACAAAGCCCAACATACCAGAGGCAATCCGC AGAAACTACGAGTTGATGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCT AACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCG ACCTTGCCTGAACAAGCCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCCCGGTGACCTGCTGCAGCTTCGCTGT CGGCTGCGGGACGATGTGCAGAGCATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAGGGGAGGAG GTGGAGGTGCAGGACTCCGTGCCCGCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCC GTCAATGTTTCAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAAACAGATAACACCAAA CCAAACCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAA TGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAG GTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGC AGCATCAACCACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTG GCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGG AGCAAGATTGGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCAC TTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACGTGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACC GTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGTACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATC TCCTGCATGGTGGGGTCGGTCATCGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTG GCCAAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAACTCTGGGGTTCTTCTGGTTCGGCCATCA CGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGA CTGGTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCGT GTGACCAAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATG ATCGGGAAGCATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGGGC AACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCC AAGGACCTGGTGTCCTGCGCCTACCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGG AATGTCCTGGTGACAGAGGACAATGTGATGAAGATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACA ACCAACGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCATTATTTGACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGG GTGCTCCTGTGGGAGATCTTCACTCTGGGCGGCTCCCCATACCCCGGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCAC CGCATGGACAAGCCCAGTAACTGCACCAACGAGCTGTACATGATGATGCGGGACTGCTGGCATGCAGTGCCCTCACAGAGACCCACCTTC AAGCAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTCCAACCAGGAGTACCTGGACCTGTCCATGCCCCTGGACCAGTACTCC CCCAGCTTTCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCTG >In-frame_ERLIN2_ENST00000519638_chr8_37607370_+_FGFR1_ENST00000425967_chr8_38315052_-_3108nt ATGGCTCAGTTGGGAGCAGTTGTGGCTGTGGCTTCCAGTTTCTTTTGTGCATCTCTCTTCTCAGCTGTGCACAAGATAGAAGAGGGACAT ATTGGGGTATATTACAGAGGCGGTGCCCTGCTGACTTCGACCAGCGGCCCTGGTTTCCATCTCATGCTCCCTTTCATCACATCATATAAG TCTGTGCAGACCACACTCCAGACAGATGAGGTGAAGAATGTACCTTGTGGGACTAGTGGTGGTGTGATGATCTACTTTGACAGAATTGAA GTGGTGAACTTCCTGGTCCCGAACGCAGTGTATGATATAGTGAAGAACTATACTGCTGACTATGACAAGGCCCTCATCTTCAACAAGATC CACCACGAACTGAACCAGTTCTGCAGTGTGCACACGCTTCAAGAGGTCTACATTGAGCTGTTTGATCAGATTGATGAAAATCTCAAACTG GCTTTGCAACAGGACCTGACCTCCATGGCCCCTGGGCTGGTCATTCAAGCTGTGCGGGTAACAAAGCCCAACATACCAGAGGCAATCCGC AGAAACTACGAGTTGATGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCT AACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCG ACCTTGCCTGAACAAGCCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCCCGGTGACCTGCTGCAGCTTCGCTGT CGGCTGCGGGACGATGTGCAGAGCATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAGGGGAGGAG GTGGAGGTGCAGGACTCCGTGCCCGCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCC GTCAATGTTTCAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAAACAGATAACACCAAA CCAAACCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAA TGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAG GTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGC AGCATCAACCACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTG GCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGG AGCAAGATTGGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCAC TTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACGTGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACC GTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGTACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATC TCCTGCATGGTGGGGTCGGTCATCGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTG GCCAAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAACTCTGGGGTTCTTCTGGTTCGGCCATCA CGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGA CTGGTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCGT GTGACCAAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATG ATCGGGAAGCATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGGGC AACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCC AAGGACCTGGTGTCCTGCGCCTACCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGG AATGTCCTGGTGACAGAGGACAATGTGATGAAGATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACA ACCAACGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCATTATTTGACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGG GTGCTCCTGTGGGAGATCTTCACTCTGGGCGGCTCCCCATACCCCGGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCAC CGCATGGACAAGCCCAGTAACTGCACCAACGAGCTGTACATGATGATGCGGGACTGCTGGCATGCAGTGCCCTCACAGAGACCCACCTTC AAGCAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTCCAACCAGGAGTACCTGGACCTGTCCATGCCCCTGGACCAGTACTCC CCCAGCTTTCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCTG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ERLIN2_ENST00000276461_chr8_37607370_+_FGFR1_ENST00000425967_chr8_38315052_-_5665nt TTTTCTTGCTCGTGGGCTCGGACGAGTACGGAGCGCCTGCAGGGACAGCCTGGATAAAGGCTCACTGATGGCTCAGTTGGGAGCAGTTGT GGCTGTGGCTTCCAGTTTCTTTTGTGCATCTCTCTTCTCAGCTGTGCACAAGATAGAAGAGGGACATATTGGGGTATATTACAGAGGCGG TGCCCTGCTGACTTCGACCAGCGGCCCTGGTTTCCATCTCATGCTCCCTTTCATCACATCATATAAGTCTGTGCAGACCACACTCCAGAC AGATGAGGTGAAGAATGTACCTTGTGGGACTAGTGGTGGTGTGATGATCTACTTTGACAGAATTGAAGTGGTGAACTTCCTGGTCCCGAA CGCAGTGTATGATATAGTGAAGAACTATACTGCTGACTATGACAAGGCCCTCATCTTCAACAAGATCCACCACGAACTGAACCAGTTCTG CAGTGTGCACACGCTTCAAGAGGTCTACATTGAGCTGTTTGATCAGATTGATGAAAATCTCAAACTGGCTTTGCAACAGGACCTGACCTC CATGGCCCCTGGGCTGGTCATTCAAGCTGTGCGGGTAACAAAGCCCAACATACCAGAGGCAATCCGCAGAAACTACGAGTTGATGGTCAG TTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAG CTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGCCCAGCC CTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCCCGGTGACCTGCTGCAGCTTCGCTGTCGGCTGCGGGACGATGTGCAGAG CATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAGGGGAGGAGGTGGAGGTGCAGGACTCCGTGCC CGCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCCGTCAATGTTTCAGATGCTCTCCC CTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAAACAGATAACACCAAACCAAACCCCGTAGCTCCATATTG GACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAA CCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAGGTCCGTTATGCCACCTGGAGCAT CATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAACCACACATACCAGCT GGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTT CATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCT GCCTTATGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCACTTAAGAAATGTCTCCTTTGAGGA CGCAGGGGAGTATACGTGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGAAGCCCTGGAAGAGAG GCCGGCAGTGATGACCTCGCCCCTGTACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCAT CGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTGGCCAAGAGCATCCCTCTGCGCAG ACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAACTCTGGGGTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTCC CATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGACTGGTCTTAGGCAAACCCCTGGG AGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCGTGTGACCAAAGTGGCTGTGAAGAT GTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATCGGGAAGCATAAGAATATCAT CAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGGGCAACCTGCGGGAGTACCTGCAGGC CCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCTGCGCCTA CCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGGAATGTCCTGGTGACAGAGGACAA TGTGATGAAGATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACAACCAACGGCCGACTGCCTGTGAA GTGGATGGCACCCGAGGCATTATTTGACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCAC TCTGGGCGGCTCCCCATACCCCGGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATGGACAAGCCCAGTAACTG CACCAACGAGCTGTACATGATGATGCGGGACTGCTGGCATGCAGTGCCCTCACAGAGACCCACCTTCAAGCAGCTGGTGGAAGACCTGGA CCGCATCGTGGCCTTGACCTCCAACCAGGAGTACCTGGACCTGTCCATGCCCCTGGACCAGTACTCCCCCAGCTTTCCCGACACCCGGAG CTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCTGCCCCGACACCCAGCCCAGCTTGC CAATGGCGGACTCAAACGCCGCTGACTGCCACCCACACGCCCTCCCCAGACTCCACCGTCAGCTGTAACCCTCACCCACAGCCCCTGCTG GGCCCACCACCTGTCCGTCCCTGTCCCCTTTCCTGCTGGCAGGAGCCGGCTGCCTACCAGGGGCCTTCCTGTGTGGCCTGCCTTCACCCC ACTCAGCTCACCTCTCCCTCCACCTCCTCTCCACCTGCTGGTGAGAGGTGCAAAGAGGCAGATCTTTGCTGCCAGCCACTTCATCCCCTC CCAGATGTTGGACCAACACCCCTCCCTGCCACCAGGCACTGCCTGGAGGGCAGGGAGTGGGAGCCAATGAACAGGCATGCAAGTGAGAGC TTCCTGAGCTTTCTCCTGTCGGTTTGGTCTGTTTTGCCTTCACCCATAAGCCCCTCGCACTCTGGTGGCAGGTGCCTTGTCCTCAGGGCT ACAGCAGTAGGGAGGTCAGTGCTTCGTGCCTCGATTGAAGGTGACCTCTGCCCCAGATAGGTGGTGCCAGTGGCTTATTAATTCCGATAC TAGTTTGCTTTGCTGACCAAATGCCTGGTACCAGAGGATGGTGAGGCGAAGGCCAGGTTGGGGGCAGTGTTGTGGCCCTGGGGCCCAGCC CCAAACTGGGGGCTCTGTATATAGCTATGAAGAAAACACAAAGTGTATAAATCTGAGTATATATTTACATGTCTTTTTAAAAGGGTCGTT ACCAGAGATTTACCCATCGGGTAAGATGCTCCTGGTGGCTGGGAGGCATCAGTTGCTATATATTAAAAACAAAAAAGAAAAAAAAGGAAA ATGTTTTTAAAAAGGTCATATATTTTTTGCTACTTTTGCTGTTTTATTTTTTTAAATTATGTTCTAAACCTATTTTCAGTTTAGGTCCCT CAATAAAAATTGCTGCTGCTTCATTTATCTATGGGCTGTATGAAAAGGGTGGGAATGTCCACTGGAAAGAAGGGACACCCACGGGCCCTG GGGCTAGGTCTGTCCCGAGGGCACCGCATGCTCCCGGCGCAGGTTCCTTGTAACCTCTTCTTCCTAGGTCCTGCACCCAGACCTCACGAC GCACCTCCTGCCTCTCCGCTGCTTTTGGAAAGTCAGAAAAAGAAGATGTCTGCTTCGAGGGCAGGAACCCCATCCATGCAGTAGAGGCGC TGGGCAGAGAGTCAAGGCCCAGCAGCCATCGACCATGGATGGTTTCCTCCAAGGAAACCGGTGGGGTTGGGCTGGGGAGGGGGCACCTAC CTAGGAATAGCCACGGGGTAGAGCTACAGTGATTAAGAGGAAAGCAAGGGCGCGGTTGCTCACGCCTGTAATCCCAGCACTTTGGGACAC CGAGGTGGGCAGATCACTTCAGGTCAGGAGTTTGAGACCAGCCTGGCCAACTTAGTGAAACCCCATCTCTACTAAAAATGCAAAAATTAT CCAGGCATGGTGGCACACGCCTGTAATCCCAGCTCCACAGGAGGCTGAGGCAGAATCCCTTGAAGCTGGGAGGCGGAGGTTGCAGTGAGC CGAGATTGCGCCATTGCACTCCAGCCTGGGCAACAGAGAAAACAAAAAGGAAAACAAATGATGAAGGTCTGCAGAAACTGAAACCCAGAC ATGTGTCTGCCCCCTCTATGTGGGCATGGTTTTGCCAGTGCTTCTAAGTGCAGGAGAACATGTCACCTGAGGCTAGTTTTGCATTCAGGT CCCTGGCTTCGTTTCTTGTTGGTATGCCTCCCCAGATCGTCCTTCCTGTATCCATGTGACCAGACTGTATTTGTTGGGACTGTCGCAGAT CTTGGCTTCTTACAGTTCTTCCTGTCCAAACTCCATCCTGTCCCTCAGGAACGGGGGGAAAATTCTCCGAATGTTTTTGGTTTTTTGGCT GCTTGGAATTTACTTCTGCCACCTGCTGGTCATCACTGTCCTCACTAAGTGGATTCTGGCTCCCCCGTACCTCATGGCTCAAACTACCAC TCCTCAGTCGCTATATTAAAGCTTATATTTTGCTGGATTACTGCTAAATACAAAAGAAAGTTCAATATGTTTTCATTTCTGTAGGGAAAA TGGGATTGCTGCTTTAAATTTCTGAGCTAGGGATTTTTTGGCAGCTGCAGTGTTGGCGACTATTGTAAAATTCTCTTTGTTTCTCTCTGT AAATAGCACCTGCTAACATTACAATTTGTATTTATGTTTAAAGAAGGCATCATTTGGTGAACAGAACTAGGAAATGAATTTTTAGCTCTT AAAAGCATTTGCTTTGAGACCGCACAGGAGTGTCTTTCCTTGTAAAACAGTGATGATAATTTCTGCCTTGGCCCTACCTTGAAGCAATGT TGTGTGAAGGGATGAAGAATCTAAAAGTCTTCATAAGTCCTTGGGAGAGGTGCTAGAAAAATATAAGGCACTATCATAATTACAGTGATG >In-frame_ERLIN2_ENST00000519638_chr8_37607370_+_FGFR1_ENST00000425967_chr8_38315052_-_5955nt TACTGGTAGGAAAGGTTCAGTGACAGCACATTCGTGTTCACAGGAAGACAAGGCTGTGTTCTGAACCCTACCCAGCTGGCACGGGTTCTC CCTTGAGCAACGGCTGTATCCGGAGCCAGTGCTTCCTCAGTGCGGTGGGGGCTCTAATTTTACAGTTAAAGAAAGGGGAACGTTGACTGA GAACGAGGAGGAAGCGAGTTGTAGATCTAGCCTTGTGTTCACACGACACCAGGCTGGATATGAGTCACTCGCAGGGAGCTCAGCTTGGTG AGGTCCTCTCGCTGTTGTGGCCTTTTCTCCTGCACGTTGGACCACACACATTTTCCCGTGTCTTTTCCCTAGGATAAAGGCTCACTGATG GCTCAGTTGGGAGCAGTTGTGGCTGTGGCTTCCAGTTTCTTTTGTGCATCTCTCTTCTCAGCTGTGCACAAGATAGAAGAGGGACATATT GGGGTATATTACAGAGGCGGTGCCCTGCTGACTTCGACCAGCGGCCCTGGTTTCCATCTCATGCTCCCTTTCATCACATCATATAAGTCT GTGCAGACCACACTCCAGACAGATGAGGTGAAGAATGTACCTTGTGGGACTAGTGGTGGTGTGATGATCTACTTTGACAGAATTGAAGTG GTGAACTTCCTGGTCCCGAACGCAGTGTATGATATAGTGAAGAACTATACTGCTGACTATGACAAGGCCCTCATCTTCAACAAGATCCAC CACGAACTGAACCAGTTCTGCAGTGTGCACACGCTTCAAGAGGTCTACATTGAGCTGTTTGATCAGATTGATGAAAATCTCAAACTGGCT TTGCAACAGGACCTGACCTCCATGGCCCCTGGGCTGGTCATTCAAGCTGTGCGGGTAACAAAGCCCAACATACCAGAGGCAATCCGCAGA AACTACGAGTTGATGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAAC TGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACC TTGCCTGAACAAGCCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCCCGGTGACCTGCTGCAGCTTCGCTGTCGG CTGCGGGACGATGTGCAGAGCATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAGGGGAGGAGGTG GAGGTGCAGGACTCCGTGCCCGCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCCGTC AATGTTTCAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAAACAGATAACACCAAACCA AACCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATGC CCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAGGTC CGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGC ATCAACCACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCC CTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGC AAGATTGGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCACTTA AGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACGTGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACCGTT CTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGTACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCC TGCATGGTGGGGTCGGTCATCGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTGGCC AAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAACTCTGGGGTTCTTCTGGTTCGGCCATCACGG CTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGACTG GTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCGTGTG ACCAAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATC GGGAAGCATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGGGCAAC CTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAG GACCTGGTGTCCTGCGCCTACCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGGAAT GTCCTGGTGACAGAGGACAATGTGATGAAGATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACAACC AACGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCATTATTTGACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGGGTG CTCCTGTGGGAGATCTTCACTCTGGGCGGCTCCCCATACCCCGGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGC ATGGACAAGCCCAGTAACTGCACCAACGAGCTGTACATGATGATGCGGGACTGCTGGCATGCAGTGCCCTCACAGAGACCCACCTTCAAG CAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTCCAACCAGGAGTACCTGGACCTGTCCATGCCCCTGGACCAGTACTCCCCC AGCTTTCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCTGCCC CGACACCCAGCCCAGCTTGCCAATGGCGGACTCAAACGCCGCTGACTGCCACCCACACGCCCTCCCCAGACTCCACCGTCAGCTGTAACC CTCACCCACAGCCCCTGCTGGGCCCACCACCTGTCCGTCCCTGTCCCCTTTCCTGCTGGCAGGAGCCGGCTGCCTACCAGGGGCCTTCCT GTGTGGCCTGCCTTCACCCCACTCAGCTCACCTCTCCCTCCACCTCCTCTCCACCTGCTGGTGAGAGGTGCAAAGAGGCAGATCTTTGCT GCCAGCCACTTCATCCCCTCCCAGATGTTGGACCAACACCCCTCCCTGCCACCAGGCACTGCCTGGAGGGCAGGGAGTGGGAGCCAATGA ACAGGCATGCAAGTGAGAGCTTCCTGAGCTTTCTCCTGTCGGTTTGGTCTGTTTTGCCTTCACCCATAAGCCCCTCGCACTCTGGTGGCA GGTGCCTTGTCCTCAGGGCTACAGCAGTAGGGAGGTCAGTGCTTCGTGCCTCGATTGAAGGTGACCTCTGCCCCAGATAGGTGGTGCCAG TGGCTTATTAATTCCGATACTAGTTTGCTTTGCTGACCAAATGCCTGGTACCAGAGGATGGTGAGGCGAAGGCCAGGTTGGGGGCAGTGT TGTGGCCCTGGGGCCCAGCCCCAAACTGGGGGCTCTGTATATAGCTATGAAGAAAACACAAAGTGTATAAATCTGAGTATATATTTACAT GTCTTTTTAAAAGGGTCGTTACCAGAGATTTACCCATCGGGTAAGATGCTCCTGGTGGCTGGGAGGCATCAGTTGCTATATATTAAAAAC AAAAAAGAAAAAAAAGGAAAATGTTTTTAAAAAGGTCATATATTTTTTGCTACTTTTGCTGTTTTATTTTTTTAAATTATGTTCTAAACC TATTTTCAGTTTAGGTCCCTCAATAAAAATTGCTGCTGCTTCATTTATCTATGGGCTGTATGAAAAGGGTGGGAATGTCCACTGGAAAGA AGGGACACCCACGGGCCCTGGGGCTAGGTCTGTCCCGAGGGCACCGCATGCTCCCGGCGCAGGTTCCTTGTAACCTCTTCTTCCTAGGTC CTGCACCCAGACCTCACGACGCACCTCCTGCCTCTCCGCTGCTTTTGGAAAGTCAGAAAAAGAAGATGTCTGCTTCGAGGGCAGGAACCC CATCCATGCAGTAGAGGCGCTGGGCAGAGAGTCAAGGCCCAGCAGCCATCGACCATGGATGGTTTCCTCCAAGGAAACCGGTGGGGTTGG GCTGGGGAGGGGGCACCTACCTAGGAATAGCCACGGGGTAGAGCTACAGTGATTAAGAGGAAAGCAAGGGCGCGGTTGCTCACGCCTGTA ATCCCAGCACTTTGGGACACCGAGGTGGGCAGATCACTTCAGGTCAGGAGTTTGAGACCAGCCTGGCCAACTTAGTGAAACCCCATCTCT ACTAAAAATGCAAAAATTATCCAGGCATGGTGGCACACGCCTGTAATCCCAGCTCCACAGGAGGCTGAGGCAGAATCCCTTGAAGCTGGG AGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCATTGCACTCCAGCCTGGGCAACAGAGAAAACAAAAAGGAAAACAAATGATGAAGGTCT GCAGAAACTGAAACCCAGACATGTGTCTGCCCCCTCTATGTGGGCATGGTTTTGCCAGTGCTTCTAAGTGCAGGAGAACATGTCACCTGA GGCTAGTTTTGCATTCAGGTCCCTGGCTTCGTTTCTTGTTGGTATGCCTCCCCAGATCGTCCTTCCTGTATCCATGTGACCAGACTGTAT TTGTTGGGACTGTCGCAGATCTTGGCTTCTTACAGTTCTTCCTGTCCAAACTCCATCCTGTCCCTCAGGAACGGGGGGAAAATTCTCCGA ATGTTTTTGGTTTTTTGGCTGCTTGGAATTTACTTCTGCCACCTGCTGGTCATCACTGTCCTCACTAAGTGGATTCTGGCTCCCCCGTAC CTCATGGCTCAAACTACCACTCCTCAGTCGCTATATTAAAGCTTATATTTTGCTGGATTACTGCTAAATACAAAAGAAAGTTCAATATGT TTTCATTTCTGTAGGGAAAATGGGATTGCTGCTTTAAATTTCTGAGCTAGGGATTTTTTGGCAGCTGCAGTGTTGGCGACTATTGTAAAA TTCTCTTTGTTTCTCTCTGTAAATAGCACCTGCTAACATTACAATTTGTATTTATGTTTAAAGAAGGCATCATTTGGTGAACAGAACTAG GAAATGAATTTTTAGCTCTTAAAAGCATTTGCTTTGAGACCGCACAGGAGTGTCTTTCCTTGTAAAACAGTGATGATAATTTCTGCCTTG GCCCTACCTTGAAGCAATGTTGTGTGAAGGGATGAAGAATCTAAAAGTCTTCATAAGTCCTTGGGAGAGGTGCTAGAAAAATATAAGGCA CTATCATAATTACAGTGATGTCCTTGCTGTTACTACTCAAATCACCCACAAATTTCCCCAAAGACTGCGCTAGCTGTCAAATAAAAGACA 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FusionGenePPI for ERLIN2_FGFR1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ERLIN2 | RNF185, UBC, ICT1, ITPR1, ERLIN1, AMFR, RNF139, SYVN1, HMGCR, INSIG1, TMUB1, ELAVL1, PSMD2, UFD1L, DERL1, CD3D, TCF3, FBXO6, FLOT1, KRT7, RAB2A, EEF2, FLOT2, HNRNPUL2, PDCD6, MCU, CCT2, FN1, UBL4A, CFTR, MMS19, CLN3, HDAC11, ADRB2, ADRA1D, PPP6R3, STK3, SCAP, PSEN1, NCSTN, APH1A, PSENEN, SREBF1, SREBF2, SRPRB, CASP8, CANX, TCP1, CCDC47, ATP2A2, SEC61B, HSP90B1, HSPA5, HSPA4, CSE1L, TRIM28, HAX1, RHOT1, TIMM50, HNRNPM, TMEM259, DUSP3, TUBB, UBAC2, FAF2, TUBA8, RIC3, ARSK, TUBA1A, FKBP14, GSTM5, AMIGO1, CD109, CACNA2D1, NTRK1, FAP, EWSR1, CEP128, CNTRL, RPGRIP1L, SCLT1, DCTN1, TCTN1, TMEM67, RAB7A, VAPA, GOLT1B, TMEM63B, NF2, RNF170, RNF5, GALNS, TMUB2, STOM, CYLD, COX15, SOAT1, VDAC1, EDEM3 | FGFR1 | FDPS, FRS3, NCAM1, FGF1, FGFR1, FRS2, PLCG1, FGF2, SHB, GRB14, BNIP2, KPNB1, CREBBP, STAT3, JAK2, SRC, NEDD4, PPP2R1B, FGF23, PTK6, ITK, NCK1, VAV1, HSP90AA1, ERBB3, CTPS2, CDK9, RPS6KA3, CDC20, TSPAN3, CEACAM21, IL20RB, LGALS8, TGFBR2, GINM1, DLK1, LTBR, TNFRSF10B, EVI2A, MREG, HEPACAM2, GOLGA7B, LDLRAD4, CRK, CTNNB1, CDH1, FGF8, SOS1, PIK3R1, PKM, FGF3, FGF5, FGF6, FGF9, FGF10, FGF17, CD44, RPS6KA1, SLA, PIK3R2, SH3BP2, NCK2, TENC1, RTN1, RTN3, PVRL1, EPHA4, YES1, L1CAM, TNK2, AKT1, PDP1, FGFR2, FAM8A1, TMEM30B, LRRN2, LITAF, C16orf58, ZDHHC11, IFNGR1, GAD1, FCGRT, IL27RA, RAET1E, SLC1A1, C14orf37, MANSC1, TPCN2, CD79B, SCN3B, C19orf45, HTR1A, FLRT1, KAL1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ERLIN2_FGFR1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | FGFR1 | P11362 | DB00039 | Palifermin | Fibroblast growth factor receptor 1 | biotech | approved |
Tgene | FGFR1 | P11362 | DB08896 | Regorafenib | Fibroblast growth factor receptor 1 | small molecule | approved |
Tgene | FGFR1 | P11362 | DB09079 | Nintedanib | Fibroblast growth factor receptor 1 | small molecule | approved |
Tgene | FGFR1 | P11362 | DB00398 | Sorafenib | Fibroblast growth factor receptor 1 | small molecule | approved|investigational |
Tgene | FGFR1 | P11362 | DB01109 | Heparin | Fibroblast growth factor receptor 1 | small molecule | approved|investigational |
Tgene | FGFR1 | P11362 | DB08901 | Ponatinib | Fibroblast growth factor receptor 1 | small molecule | approved|investigational |
Tgene | FGFR1 | P11362 | DB09078 | Lenvatinib | Fibroblast growth factor receptor 1 | small molecule | approved|investigational |
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RelatedDiseases for ERLIN2_FGFR1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ERLIN2 | C3714756 | Intellectual Disability | 1 | CTD_human |
Tgene | FGFR1 | C1563720 | Kallmann Syndrome 2 (disorder) | 14 | ORPHANET;UNIPROT |
Tgene | FGFR1 | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | FGFR1 | C0011581 | Depressive disorder | 5 | CTD_human;HPO;PSYGENET |
Tgene | FGFR1 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
Tgene | FGFR1 | C0041696 | Unipolar Depression | 3 | PSYGENET |
Tgene | FGFR1 | C1269683 | Major Depressive Disorder | 3 | PSYGENET |
Tgene | FGFR1 | C0027022 | Myeloproliferative disease | 2 | CTD_human |
Tgene | FGFR1 | C0220658 | Pfeiffer Syndrome | 2 | UNIPROT |
Tgene | FGFR1 | C0406612 | Encephalocraniocutaneous lipomatosis | 2 | ORPHANET;UNIPROT |
Tgene | FGFR1 | C0432283 | Osteoglophonic dwarfism | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | FGFR1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Tgene | FGFR1 | C1845146 | Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate | 2 | ORPHANET;UNIPROT |
Tgene | FGFR1 | C0004114 | Astrocytoma | 1 | CTD_human |
Tgene | FGFR1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | FGFR1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | FGFR1 | C0008924 | Cleft Lip | 1 | CTD_human;HPO |
Tgene | FGFR1 | C0008925 | Cleft Palate | 1 | CTD_human;HPO |
Tgene | FGFR1 | C0017638 | Glioma | 1 | CTD_human |
Tgene | FGFR1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | FGFR1 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | FGFR1 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
Tgene | FGFR1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Tgene | FGFR1 | C0432122 | Interfrontal craniofaciosynostosis | 1 | CTD_human;UNIPROT |