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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12017

FusionGeneSummary for ERG_SRPK2

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG_SRPK2
Fusion gene ID: 12017
HgeneTgene
Gene symbol

ERG

SRPK2

Gene ID

2078

6733

Gene nameERG, ETS transcription factorSRSF protein kinase 2
Synonymserg-3|p55SFRSK2
Cytomap

21q22.2

7q22.3

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 onSRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2
Modification date2018052320180523
UniProtAcc

P11308

P78362

Ensembl transtripts involved in fusion geneENST00000398907, ENST00000398905, 
ENST00000288319, ENST00000398897, 
ENST00000398911, ENST00000398910, 
ENST00000417133, ENST00000442448, 
ENST00000453032, ENST00000398919, 
ENST00000429727, ENST00000485493, 
ENST00000393651, ENST00000357311, 
ENST00000489828, ENST00000493638, 
Fusion gene scores* DoF score15 X 4 X 3=1807 X 7 X 2=98
# samples 197
** MAII scorelog2(19/180*10)=0.0780025120012732
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND SRPK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826

TgeneSRPK2

GO:0000245

spliceosomal complex assembly

9472028

TgeneSRPK2

GO:0006468

protein phosphorylation

9472028

TgeneSRPK2

GO:0008284

positive regulation of cell proliferation

18559500

TgeneSRPK2

GO:0008380

RNA splicing

9472028

TgeneSRPK2

GO:0035556

intracellular signal transduction

9472028

TgeneSRPK2

GO:0045070

positive regulation of viral genome replication

20498328

TgeneSRPK2

GO:0045071

negative regulation of viral genome replication

12417631


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-KK-A6E6-01AERGchr21

39947586

-SRPK2chr7

105039700

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000398907ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000398907ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000398907ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000398907ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000398905ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000398905ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000398905ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000398905ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000288319ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000288319ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000288319ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000288319ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
5UTR-intronENST00000398897ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
5UTR-intronENST00000398897ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
5UTR-intronENST00000398897ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
5UTR-intronENST00000398897ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398911ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398911ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398911ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398911ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398910ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398910ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398910ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398910ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000417133ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000417133ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000417133ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000417133ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000442448ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000442448ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000442448ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000442448ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000453032ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000453032ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000453032ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000453032ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398919ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398919ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398919ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
5CDS-intronENST00000398919ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000429727ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000429727ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000429727ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
intron-intronENST00000429727ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-
5UTR-intronENST00000485493ENST00000393651ERGchr21

39947586

-SRPK2chr7

105039700

-
5UTR-intronENST00000485493ENST00000357311ERGchr21

39947586

-SRPK2chr7

105039700

-
5UTR-intronENST00000485493ENST00000489828ERGchr21

39947586

-SRPK2chr7

105039700

-
5UTR-intronENST00000485493ENST00000493638ERGchr21

39947586

-SRPK2chr7

105039700

-

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FusionProtFeatures for ERG_SRPK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

SRPK2

P78362

Transcriptional regulator. May participate intranscriptional regulation through the recruitment of SETDB1histone methyltransferase and subsequent modification of localchromatin structure. Serine/arginine-rich protein-specific kinase whichspecifically phosphorylates its substrates at serine residueslocated in regions rich in arginine/serine dipeptides, known as RSdomains and is involved in the phosphorylation of SR splicingfactors and the regulation of splicing. Promotes neuronalapoptosis by up-regulating cyclin-D1 (CCND1) expression. This isdone by the phosphorylation of SRSF2, leading to the suppressionof p53/TP53 phosphorylation thereby relieving the repressiveeffect of p53/TP53 on cyclin-D1 (CCND1) expression. PhosphorylatesACIN1, and redistributes it from the nuclear speckles to thenucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complexformation via the phosphorylation of DDX23/PRP28. Can mediatehepatitis B virus (HBV) core protein phosphorylation. Plays anegative role in the regulation of HBV replication through amechanism not involving the phosphorylation of the core proteinbut by reducing the packaging efficiency of the pregenomic RNA(pgRNA) without affecting the formation of the viral coreparticles. {ECO:0000269|PubMed:12134018,ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142,ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491,ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21157427,ECO:0000269|PubMed:9472028}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERG_SRPK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERG_SRPK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3SRPK2U2AF2, RNPS1, SRSF1, SRSF3, SRSF2, SRSF5, SRSF6, SNRNP70, LUC7L3, SRPK1, VAV2, ARRB2, CUL3, APP, ESR1, BARD1, U2AF1, DDX46, RBM23, RBM39, PRPF38A, CTNNBL1, SNIP1, ACIN1, ARGLU1, SNRNP27, YTHDC1, DDX21, LUC7L, SRRM1, PABPC4, PRPF4B, SRRM2, PNN, SRPK2, SNRPD1, EIF4A3, HNRNPM, NOP2, DHX15, SNRPA, SNRPC, PCBP1, BCLAF1, RBBP6, PABPC1, C1orf35, DROSHA, LUC7L2, SRSF8, HNRNPC, RBM8A, MAGOH, SRSF7, TJP2, ALMS1, HNRNPCL1, CLASRP, DIDO1, DDX50, SNRPB, DGCR8, THRAP3, HNRNPH2, DDX39A, DDX39B, CPSF6, SON, NUDT21, NSG1, CHTOP, CDK13, FOXN3, EIF1AY, CHD2, TNFRSF10C, CASK, AURKA, CHUK, ARPC1B, UBD, NCK2, AHCYL1, TLE4, ERN1, DNAJC8, GABARAP, ZRANB2, TDP2, PAK4, ABL1, POLB, NELFE, ERCC3, MDK, PSMA3, DDX6, PTBP1, APEX1, GTF2E1, SRI, YWHAB, RPL22, MAGEB1, CBX5, CLK1, CLK3, CDK7, ADPRH, TPD52, RWDD2B, YPEL3, FGF12, WDR5, PPIA, RPL41, TRA2B, RNF4, MRPS6, PRKAA1, SRSF9, IFIT5, MPP3, TCOF1, TRA2A, DHX8, DRAP1, BRD3, SEC23B, HMGN3, ZRSR2, ENOX2, SNRNP35, C4orf46, C17orf85, TAF7L, FAM76B, ATAT1, ARL6IP4, AMMECR1L, CSAG1, RSRC2, NPM2, CAND1, LCA5, FAM90A1, MAPKAPK5, CCDC28A, ARHGAP12, CHERP, GPR114, DAW1, CLDN19, MARCH10, LRRN4CL, DBF4B, TNIP2, MCOLN3, EPS8L3, C16orf78, SDR42E1, TRIM41, SREK1, SRSF12, TTN, RTF1, RIT1, C18orf25, EVI5L, RPL39L, CCDC97, PELI1, NGLY1, RSRC1, EGLN2, UBE2E2, ALKBH3, YPEL2, RBM15, RIT2, VRK1, VIMP, CCM2, RSRP1, HIRIP3, LCE3D, NSRP1, GABARAPL1, KCNN2, CDC42EP4, EPB41L1, OCEL1, ZMAT4, EPB41L4A, PDE7B, NXT2, APOBEC3C, HOMER3, CBLN4, NSMCE4A, SLAIN2, NUP50, BAIAP2, DRG1, NOP16, PPIL1, HBS1L, MAB21L2, SUPT16H, SNURF, CACNG2, STON1, AES, CLK2, ZSCAN9, FXR2, LUZP4, BMI1, PPM1G, PRPF8, NTRK1, C5orf42, ACTB, ACTG1, ADAMTS18, AKAP13, ALDOA, ALPL, ANK3, ANKFY1, ANKRD35, AP1M1, KIAA1244, ARSG, ASL, BAG3, BAZ1A, BCL9L, BUD13, EFCAB12, ELP6, CADPS2, CALCOCO1, CAMSAP1, CARD11, CARHSP1, MTCL1, CCDC86, CCDC88B, CDK12, CEP170, CHD1L, CHEK2, CLASP1, CLASP2, CLCNKA, CLU, CPSF7, CRTC1, YBX3, DCAF10, DDX3X, DNAH6, DNAH9, DOCK3, ECT2, EED, EIF3A, EIF4B, EIF4G1, ELAVL3, ENSA, EPB41L4B, EPM2A, EPS8L1, ERBB3, ERC1, F5, AMER1, FAM179B, FAM43A, NXPE4, FBXO24, FCHO1, FGFR3, FIP1L1, FMNL1, GBF1, GCC2, GGCX, GHR, GLRA4, GLTSCR2, GNGT2, GSE1, GTPBP4, GXYLT2, HERC3, HIST1H2BK, HIVEP1, HMCN2, HMGA1, HMGN2, HMGXB4, HNRNPA1, HNRNPA3, HNRNPK, HTATSF1, IRS2, ISLR, JMJD1C, KANK2, KHDRBS1, KIF11, KRT78, LBR, LDHC, LINC00322, LMNA, LMNB1, LMO7, LRRC34, LRRC52, MACF1, MAP1S, MAP4, MAP7, MAP7D1, MAPKAPK3, MAPRE1, MAST2, MATR3, MDC1, MFSD10, MIB2, MIPOL1, ZAK, MMP23B, MYCBP2, MYLIP, MYO18B, MYO1E, MZT2B, NADK, NAGK, NCL, NGDN, NKAP, NOLC1, NSUN5P2, NTHL1, NXF1, OTOF, PALLD, PCF11, PDCL3, PHF6, PHLDB1, PKD1L2, PLEKHA5, PNMAL2, POLDIP3, PPHLN1, PPP1R13L, PRPF38B, PRRC2A, PRRC2B, PRRC2C, PSMD13, PTPN22, RABEP1, RASGRF1, RBM15B, RBM19, RBMX, RIPK3, RNF219, RPL13, RPL34, RPL37, RPLP2, RPS26, RRM2B, RRP1, RRP1B, RSL1D1, RXFP1, S100A4, SAFB, SART1, SBK1, SCAF1, SDK2, SEC16B, SERPING1, PNISR, SGPL1, SIPA1L3, SLC13A2, SLC17A6, SLFN5, SLTM, SMCHD1, SPDEF, SPEN, SRC, SRSF11, SRXN1, SYCP2, TCEANC2, TMEM57, TMPO, TMPRSS11A, TMSB10, TNFAIP8L2, TNS3, TOP1, TRIP12, TUBA1B, TXN, UBR4, UPF3B, USP36, USP39, VAC14, VSTM2L, WDR24, WDR70, XRCC5, YRDC, YTHDC2, ZC3H13, ZC3H18, ZCCHC17, ZDHHC5, ZFC3H1, ZFHX4, ZFP91, ZMYM4, ZNF140, ZNF234, ZNF529, ZNF592, ZNF593, ZNF616, FOXK2, FOXL2, FOXQ1, YBX1, AKT1, INO80B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERG_SRPK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERG_SRPK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms5CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human