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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12016

FusionGeneSummary for ERG_SON

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG_SON
Fusion gene ID: 12016
HgeneTgene
Gene symbol

ERG

SON

Gene ID

2078

6651

Gene nameERG, ETS transcription factorSON DNA binding protein
Synonymserg-3|p55BASS1|C21orf50|DBP-5|NREBP|SON3|TOKIMS
Cytomap

21q22.2

21q22.11

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 onprotein SONBax antagonist selected in Saccharomyces 1NRE-binding proteinnegative regulatory element-binding protein
Modification date2018052320180523
UniProtAcc

P11308

P18583

Ensembl transtripts involved in fusion geneENST00000398907, ENST00000398905, 
ENST00000288319, ENST00000398897, 
ENST00000398911, ENST00000398910, 
ENST00000417133, ENST00000442448, 
ENST00000453032, ENST00000398919, 
ENST00000429727, ENST00000485493, 
ENST00000356577, ENST00000290239, 
ENST00000381692, ENST00000300278, 
ENST00000381679, ENST00000470533, 
Fusion gene scores* DoF score15 X 4 X 3=1807 X 6 X 3=126
# samples 197
** MAII scorelog2(19/180*10)=0.0780025120012732
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND SON [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826

TgeneSON

GO:0006397

mRNA processing

21504830

TgeneSON

GO:0043066

negative regulation of apoptotic process

10509013

TgeneSON

GO:0048024

regulation of mRNA splicing, via spliceosome

21504830


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7230-01AERGchr21

39947586

-SONchr21

34918519

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398907ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000398907ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000398907ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000398907ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000398907ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
intron-intronENST00000398907ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000398905ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000398905ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000398905ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000398905ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000398905ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
intron-intronENST00000398905ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000288319ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000288319ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000288319ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000288319ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000288319ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
intron-intronENST00000288319ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
5UTR-3CDSENST00000398897ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
5UTR-3CDSENST00000398897ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
5UTR-3CDSENST00000398897ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
5UTR-3CDSENST00000398897ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
5UTR-3CDSENST00000398897ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
5UTR-intronENST00000398897ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398911ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398911ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398911ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398911ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398911ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
5CDS-intronENST00000398911ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398910ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398910ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398910ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398910ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398910ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
5CDS-intronENST00000398910ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000417133ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000417133ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000417133ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000417133ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000417133ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
5CDS-intronENST00000417133ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000442448ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000442448ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000442448ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000442448ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000442448ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
5CDS-intronENST00000442448ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000453032ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000453032ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000453032ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000453032ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000453032ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
intron-intronENST00000453032ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398919ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398919ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398919ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398919ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
Frame-shitENST00000398919ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
5CDS-intronENST00000398919ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000429727ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000429727ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000429727ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000429727ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
intron-3CDSENST00000429727ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
intron-intronENST00000429727ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+
5UTR-3CDSENST00000485493ENST00000356577ERGchr21

39947586

-SONchr21

34918519

+
5UTR-3CDSENST00000485493ENST00000290239ERGchr21

39947586

-SONchr21

34918519

+
5UTR-3CDSENST00000485493ENST00000381692ERGchr21

39947586

-SONchr21

34918519

+
5UTR-3CDSENST00000485493ENST00000300278ERGchr21

39947586

-SONchr21

34918519

+
5UTR-3CDSENST00000485493ENST00000381679ERGchr21

39947586

-SONchr21

34918519

+
5UTR-intronENST00000485493ENST00000470533ERGchr21

39947586

-SONchr21

34918519

+

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FusionProtFeatures for ERG_SON


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

SON

P18583

Transcriptional regulator. May participate intranscriptional regulation through the recruitment of SETDB1histone methyltransferase and subsequent modification of localchromatin structure.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERG_SON


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERG_SON


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3SONYWHAG, YWHAB, SIRT7, TCF3, SF3B1, ILF3, PRPF6, ILF2, PRPF3, DDX21, USP39, SAFB, NONO, DHX9, NHP2L1, NFIA, PRPF19, NXF1, SF3B6, SFPQ, PUF60, S100A9, U2AF1, BUD31, HNRNPM, HP1BP3, SRRM2, PSIP1, PPP1CA, CDC5L, SEPT2, CHCHD4, USP25, TFPI, SRSF7, HSPA8, SRSF5, SRSF11, SMARCB1, DIDO1, ACIN1, TRIM26, RAN, SEPT7, NDUFAF2, PHGDH, MAGOH, EIF4A3, VCP, PRPF40A, HDAC11, VHL, SRPK2, SRPK1, CLK2, SRPK3, FAM96B, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, RBM4B, SAMD7, FBXW11, RBM17, RBM39, IFI16, KIFAP3, U2AF2, ATOH1, C11orf30, UBE2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ERG_SON


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERG_SON


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms5CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneSONC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneSONC0036095Salivary Gland Neoplasms1CTD_human