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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12013

FusionGeneSummary for ERG_PLEKHH1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG_PLEKHH1
Fusion gene ID: 12013
HgeneTgene
Gene symbol

ERG

PLEKHH1

Gene ID

2078

57475

Gene nameERG, ETS transcription factorpleckstrin homology, MyTH4 and FERM domain containing H1
Synonymserg-3|p55-
Cytomap

21q22.2

14q24.1

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 onpleckstrin homology domain-containing family H member 1PH domain-containing family H member 1pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
Modification date2018052320180519
UniProtAcc

P11308

Q9ULM0

Ensembl transtripts involved in fusion geneENST00000398907, ENST00000398905, 
ENST00000288319, ENST00000398897, 
ENST00000398911, ENST00000398910, 
ENST00000417133, ENST00000442448, 
ENST00000453032, ENST00000398919, 
ENST00000429727, ENST00000485493, 
ENST00000329153, ENST00000417684, 
ENST00000559832, 
Fusion gene scores* DoF score15 X 4 X 3=1807 X 6 X 5=210
# samples 197
** MAII scorelog2(19/180*10)=0.0780025120012732
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND PLEKHH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-CH-5739-01AERGchr21

39947586

-PLEKHH1chr14

68022542

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398907ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000398907ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000398907ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-3CDSENST00000398905ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000398905ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000398905ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-3CDSENST00000288319ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000288319ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000288319ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-3CDSENST00000398897ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-intronENST00000398897ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-intronENST00000398897ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
In-frameENST00000398911ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398911ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398911ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
Frame-shitENST00000398910ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398910ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398910ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
Frame-shitENST00000417133ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000417133ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000417133ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
Frame-shitENST00000442448ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000442448ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000442448ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-3CDSENST00000453032ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000453032ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000453032ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
In-frameENST00000398919ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398919ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398919ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-3CDSENST00000429727ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000429727ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000429727ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-3CDSENST00000485493ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-intronENST00000485493ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-intronENST00000485493ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+

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FusionProtFeatures for ERG_PLEKHH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

PLEKHH1

Q9ULM0

Transcriptional regulator. May participate intranscriptional regulation through the recruitment of SETDB1histone methyltransferase and subsequent modification of localchromatin structure.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERG_PLEKHH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ERG_ENST00000398911_chr21_39947586_-_PLEKHH1_ENST00000329153_chr14_68022542_+_1336aa
MIQTVPDPAAHIKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAE
EAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLVPPYGAAEQDSVPSEPGIQPMGQDSGSQAQ
GLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTKT
SAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELESRARSREEPEKMEMEEPPPAGKNE
ERESPKALGAELEEVELGNKPPTPPLHQFSSWESRITAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGR
ATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYST
DGLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSL
LEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYTRSHEDKRPLGCLPVRDAHIEEVDRSCDSDEDT
EAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTATEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYA
SLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLF
LPQHHFLWTVKQQLQRHADPRSETGQTATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTV
DEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRE
RLLLASQTSREIVAGRFPINKELALEMAALMAQVETGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRTRHGAPAEQLRHLADMLTTK
WATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRS

>In-frame_ERG_ENST00000398919_chr21_39947586_-_PLEKHH1_ENST00000329153_chr14_68022542_+_1336aa
MIQTVPDPAAHIKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAE
EAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLVPPYGAAEQDSVPSEPGIQPMGQDSGSQAQ
GLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTKT
SAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELESRARSREEPEKMEMEEPPPAGKNE
ERESPKALGAELEEVELGNKPPTPPLHQFSSWESRITAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGR
ATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYST
DGLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSL
LEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYTRSHEDKRPLGCLPVRDAHIEEVDRSCDSDEDT
EAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTATEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYA
SLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLF
LPQHHFLWTVKQQLQRHADPRSETGQTATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTV
DEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRE
RLLLASQTSREIVAGRFPINKELALEMAALMAQVETGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRTRHGAPAEQLRHLADMLTTK
WATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ERG_ENST00000398911_chr21_39947586_-_PLEKHH1_ENST00000329153_chr14_68022542_+_4008nt
ATGATTCAGACTGTCCCGGACCCAGCAGCTCATATCAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAAC
GCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATAC
CAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAG
GAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTG
AAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGCTATTCAGATAGCTCCTTCACGGAAGCTGCTG
GTGCCCCCCTACGGAGCTGCAGAGCAGGATTCTGTCCCTTCAGAGCCGGGAATCCAGCCTATGGGCCAGGACAGTGGCTCCCAGGCCCAG
GGTCTGAAGGCAGCTGTGCTTGCACCTTCCCCAGGTGCCCTGCAGAGCAAGGACTCTGTTTCTGAAGCAGCAAGCCCCTTGGAGGATTCT
AGTTCCAGCACGGTCCATTCTGGGGAAACAGTAGAGGCCAAGCCCCTTCAACCTCATCTGGGAAGAGAGAGCCCTCCCCACCAGCCATGC
ATGAAGCTTCTTACCTTCAGATGTAGTTCAGCTTCCTGGGGTGAGGGTCTGGTTACTGCTCAGAGAGGGATGCTCCCTGGGACAAAGACC
TCTGCCAGGGAAGGTGGTCCTGGCAGCAGTCTGACCCTACCAAAGGTGCGGGCTCCTGGCACCCCGCGGGACAGCATCCAGTTGGCCAAA
AGGCACCACAGCCAGCCCCAGGTGGGCCATGGGCACTTTGGCCGTGTGGTGAACATTGAGACTGAGGCCTTCTCAGCCCTCCACCCCTCT
GGCCTTCCTGAGCTGGAGTCCCGAGCTAGGTCCCGGGAGGAACCAGAGAAGATGGAGATGGAGGAGCCACCCCCAGCAGGGAAGAATGAG
GAAAGAGAGAGCCCAAAGGCCCTTGGAGCTGAGCTGGAGGAAGTGGAGCTGGGTAACAAGCCACCTACACCCCCGCTGCACCAGTTTTCA
TCCTGGGAGAGCCGGATCTATGCTGTGGCCACATCGGGCATGCGGCTCTCAGATATGTCTCCCAGAAGTAATACTGCATGCTGCGCTTCA
AGCCCTCCTGCCCTTGTTTCCCCTGGGTCTTTCTCTGGCCTGGTCTACAAGAATGTCACTGTGCCTGTCTACACAGCACTGAAGGGGAGA
GCTACACAGATCAGCAACATGCCCTTTATGGACGAGTCCTCTGGGTCTGACGATGACTGCAGCTCTCAGGCGAGTTTCCGAATCTCGGTC
CCCTCCTCTGAGTCCAGGAAGACCAGCGGACTAGGCAGCCCCCGGGCCATCAAGAGAGGCGTCTCCATGTCCTCACTGAGCTCCGAGGGT
GACTACGCCATCCCCCCGGACGCCTGCTCACTGGACAGTGACTACTCAGAGCCTGAGCACAAACTGCAGCGCACCTCATCCTACTCCACC
GACGGGCTGGGCCTGGGCGGGGAGTCACTGGAGAAGTCGGGCTACCTGCTGAAAATGGGGAGCCAGGTGAAGACGTGGAAGAGGCGCTGG
TTTGTCCTGAGACAGGGACAGATTATGTACTACAAGTCCCCGAGTGATGTCATCCGGAAACCTCAAGGCCAAGTGGATCTGAACTCCCGC
TGCCAAATTGTTCGAGGGGAGGGTTCACAGACGTTTCAGCTCATCTCTGAGAAGAAAACCTACTACCTGACGGCCGATTCACCCAGCCTG
CTGGAGGAGTGGATCCGAGTACTCCAGAGCCTGCTGAAGGTGCAGGCCACCGGGCCTCCAGCTCTGCTTCGGGGTGGCACCAAGCCCACC
GTGAAGGGCTGGCTGACCAAGGTAAAGCATGGCCACTCCAAGGTGGTCTGGTGCGCTCTTGTTGGGAAAATCTTCTACTACTATCGGAGC
CATGAGGACAAGCGACCCCTGGGCTGCCTGCCTGTGCGGGATGCGCACATAGAGGAAGTAGATCGATCCTGTGACTCAGACGAGGACTAT
GAGGCTGGAGGAACCAGACGGTTGCTTTCCTCCCACTGCACCCTGGTGATCCACCCCACAGAGCACAGCCCCACCTACCTCCTCATTGGC
ACCAAGCATGAAAAGGATACGTGGCTCTACCACCTCACAGTGGCTGCAGGTGGCAGCAGTGCCAAGGTGGGCACTGCCTATGAGCAGCTC
ATTGGAAAACTGATGGATGGTGAAGGAGATCCAGATTCGCCGCTCTGGAGGCACCCCATGCTGTGCTACAGCAAAGACGGCCTATACGCC
TCCCTCACCACCCTGCCCTCTGAGGCCTTGCAGACGGAGGCCCTCAAGCTCTTCAAGTCCTGCCAGCTCTTCATCAACGTGCCGGTGGAA
GCTGCCTCGGTGGACTACCATGTGTCCCTGGCCCAGACCGCACTGCAGGTCTGCCTGGTTCACCCCGAGCTGCAGAGTGAGATCTACTGC
CAACTCATGAAGCAGACCAGCTGCCGCCCACCTCAGAAGTACTCCCTCATGCAGTGCTGGCAGCTCCTCGCTCTGTGTGCTCCACTTTTC
CTGCCTCAGCATCACTTCCTCTGGTATGTCAAGCAGCAGCTCCAACGCCATGCAGATCCCAGAAGTGAAACTGGCCAGTATGCCACCTAC
TGCCAGCGGGCAGTGGAGCGGACCCTGCGGACCGGGGAGCGGGAAGCCAGGCCATCGCGCATGGAAGTGGTGTCCATCCTGCTGCGTAAC
CCCTTCCACCACTCCTTGCCCTTCAGCATCCCCGTGCACTTTACCAACGGGACTTACCATGTGGTTGGTTTTGACGGCTCTTCCACGGTT
GATGAGTTCCTCCAGCGGCTGAACCAGGAGATAGGCATGAGAAAGCCATCCCACTCTGGCTTTGCCCTCTTCACGGACGATCCCTCGGGC
AGGGACCTGGAGCACTGCCTGCAGGGAAGTGTCAAGATCTGTGATGCCATCTCCAAGTGGGAACAAGCCATGAAGGAGCTGCACCCCGGA
AAGTCTGAGGGTGGGACACGCGTCGTGAAGCTGATGTACAAGAACAGGCTGTACTTTCGCAGTCAAGTCAAAGGGGAGACGGACCGAGAA
CGGCTGCTCCTTGCCTCTCAAACCAGTAGAGAGATAGTGGCAGGGAGGTTTCCTATCAACAAGGAATTGGCTCTTGAGATGGCTGCCCTG
ATGGCCCAGGTAGAATATGGGGACTTGGAGAAGCCTGCCCTGCCAGGCCCTGGAGGCACATCCCCTGCCAAGGCTCAGCATCTTCTCCAG
CAGGTCCTAGACAGGTTCCACCCCAGGCGCTATAGACATGGGGCCCCCGCTGAACAGCTGAGGCACCTGGCAGATATGTTGACCACAAAA
TGGGCAACATTGCAAGGATGCTCCCCTCCTGAGTGCATCCGCATCTACCTGACCGTGGCCAGGAAATGGCCTTTCTTTGGTGCTAAACTT
TTTGCTGCTCAGCCTGCCCAGCTGTCTTCCAAGGAGAACGCTCTGGTGTGGATTGCTGTGAATGAGGATGGCGTCAGCATCCTGGACCAC
AACACTATGCAAGTGCACATCACTTACCCCTACTCTTCAGTGACAACGTTTGGTGGCTGCAGGGATGACTTCATGCTTGTGATTAGATCT
ATCCCAGACAAGAGCTCTGGAAAAAGCCACATTGAGAAGTTGATCTTCCGGATGGCTGCTCCCAAGATTGCAGAAGCTACCTTCATCATG
GCCAGCTATATGAACCATTGCACTACAACTGTGAACCCCCCCACCAACCCACCCGGAGCCTGCCAGCTGTGGGAACTGGATGGACGACAG

>In-frame_ERG_ENST00000398919_chr21_39947586_-_PLEKHH1_ENST00000329153_chr14_68022542_+_4008nt
ATGATTCAGACTGTCCCGGACCCAGCAGCTCATATCAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAAC
GCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATAC
CAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAG
GAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTG
AAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGCTATTCAGATAGCTCCTTCACGGAAGCTGCTG
GTGCCCCCCTACGGAGCTGCAGAGCAGGATTCTGTCCCTTCAGAGCCGGGAATCCAGCCTATGGGCCAGGACAGTGGCTCCCAGGCCCAG
GGTCTGAAGGCAGCTGTGCTTGCACCTTCCCCAGGTGCCCTGCAGAGCAAGGACTCTGTTTCTGAAGCAGCAAGCCCCTTGGAGGATTCT
AGTTCCAGCACGGTCCATTCTGGGGAAACAGTAGAGGCCAAGCCCCTTCAACCTCATCTGGGAAGAGAGAGCCCTCCCCACCAGCCATGC
ATGAAGCTTCTTACCTTCAGATGTAGTTCAGCTTCCTGGGGTGAGGGTCTGGTTACTGCTCAGAGAGGGATGCTCCCTGGGACAAAGACC
TCTGCCAGGGAAGGTGGTCCTGGCAGCAGTCTGACCCTACCAAAGGTGCGGGCTCCTGGCACCCCGCGGGACAGCATCCAGTTGGCCAAA
AGGCACCACAGCCAGCCCCAGGTGGGCCATGGGCACTTTGGCCGTGTGGTGAACATTGAGACTGAGGCCTTCTCAGCCCTCCACCCCTCT
GGCCTTCCTGAGCTGGAGTCCCGAGCTAGGTCCCGGGAGGAACCAGAGAAGATGGAGATGGAGGAGCCACCCCCAGCAGGGAAGAATGAG
GAAAGAGAGAGCCCAAAGGCCCTTGGAGCTGAGCTGGAGGAAGTGGAGCTGGGTAACAAGCCACCTACACCCCCGCTGCACCAGTTTTCA
TCCTGGGAGAGCCGGATCTATGCTGTGGCCACATCGGGCATGCGGCTCTCAGATATGTCTCCCAGAAGTAATACTGCATGCTGCGCTTCA
AGCCCTCCTGCCCTTGTTTCCCCTGGGTCTTTCTCTGGCCTGGTCTACAAGAATGTCACTGTGCCTGTCTACACAGCACTGAAGGGGAGA
GCTACACAGATCAGCAACATGCCCTTTATGGACGAGTCCTCTGGGTCTGACGATGACTGCAGCTCTCAGGCGAGTTTCCGAATCTCGGTC
CCCTCCTCTGAGTCCAGGAAGACCAGCGGACTAGGCAGCCCCCGGGCCATCAAGAGAGGCGTCTCCATGTCCTCACTGAGCTCCGAGGGT
GACTACGCCATCCCCCCGGACGCCTGCTCACTGGACAGTGACTACTCAGAGCCTGAGCACAAACTGCAGCGCACCTCATCCTACTCCACC
GACGGGCTGGGCCTGGGCGGGGAGTCACTGGAGAAGTCGGGCTACCTGCTGAAAATGGGGAGCCAGGTGAAGACGTGGAAGAGGCGCTGG
TTTGTCCTGAGACAGGGACAGATTATGTACTACAAGTCCCCGAGTGATGTCATCCGGAAACCTCAAGGCCAAGTGGATCTGAACTCCCGC
TGCCAAATTGTTCGAGGGGAGGGTTCACAGACGTTTCAGCTCATCTCTGAGAAGAAAACCTACTACCTGACGGCCGATTCACCCAGCCTG
CTGGAGGAGTGGATCCGAGTACTCCAGAGCCTGCTGAAGGTGCAGGCCACCGGGCCTCCAGCTCTGCTTCGGGGTGGCACCAAGCCCACC
GTGAAGGGCTGGCTGACCAAGGTAAAGCATGGCCACTCCAAGGTGGTCTGGTGCGCTCTTGTTGGGAAAATCTTCTACTACTATCGGAGC
CATGAGGACAAGCGACCCCTGGGCTGCCTGCCTGTGCGGGATGCGCACATAGAGGAAGTAGATCGATCCTGTGACTCAGACGAGGACTAT
GAGGCTGGAGGAACCAGACGGTTGCTTTCCTCCCACTGCACCCTGGTGATCCACCCCACAGAGCACAGCCCCACCTACCTCCTCATTGGC
ACCAAGCATGAAAAGGATACGTGGCTCTACCACCTCACAGTGGCTGCAGGTGGCAGCAGTGCCAAGGTGGGCACTGCCTATGAGCAGCTC
ATTGGAAAACTGATGGATGGTGAAGGAGATCCAGATTCGCCGCTCTGGAGGCACCCCATGCTGTGCTACAGCAAAGACGGCCTATACGCC
TCCCTCACCACCCTGCCCTCTGAGGCCTTGCAGACGGAGGCCCTCAAGCTCTTCAAGTCCTGCCAGCTCTTCATCAACGTGCCGGTGGAA
GCTGCCTCGGTGGACTACCATGTGTCCCTGGCCCAGACCGCACTGCAGGTCTGCCTGGTTCACCCCGAGCTGCAGAGTGAGATCTACTGC
CAACTCATGAAGCAGACCAGCTGCCGCCCACCTCAGAAGTACTCCCTCATGCAGTGCTGGCAGCTCCTCGCTCTGTGTGCTCCACTTTTC
CTGCCTCAGCATCACTTCCTCTGGTATGTCAAGCAGCAGCTCCAACGCCATGCAGATCCCAGAAGTGAAACTGGCCAGTATGCCACCTAC
TGCCAGCGGGCAGTGGAGCGGACCCTGCGGACCGGGGAGCGGGAAGCCAGGCCATCGCGCATGGAAGTGGTGTCCATCCTGCTGCGTAAC
CCCTTCCACCACTCCTTGCCCTTCAGCATCCCCGTGCACTTTACCAACGGGACTTACCATGTGGTTGGTTTTGACGGCTCTTCCACGGTT
GATGAGTTCCTCCAGCGGCTGAACCAGGAGATAGGCATGAGAAAGCCATCCCACTCTGGCTTTGCCCTCTTCACGGACGATCCCTCGGGC
AGGGACCTGGAGCACTGCCTGCAGGGAAGTGTCAAGATCTGTGATGCCATCTCCAAGTGGGAACAAGCCATGAAGGAGCTGCACCCCGGA
AAGTCTGAGGGTGGGACACGCGTCGTGAAGCTGATGTACAAGAACAGGCTGTACTTTCGCAGTCAAGTCAAAGGGGAGACGGACCGAGAA
CGGCTGCTCCTTGCCTCTCAAACCAGTAGAGAGATAGTGGCAGGGAGGTTTCCTATCAACAAGGAATTGGCTCTTGAGATGGCTGCCCTG
ATGGCCCAGGTAGAATATGGGGACTTGGAGAAGCCTGCCCTGCCAGGCCCTGGAGGCACATCCCCTGCCAAGGCTCAGCATCTTCTCCAG
CAGGTCCTAGACAGGTTCCACCCCAGGCGCTATAGACATGGGGCCCCCGCTGAACAGCTGAGGCACCTGGCAGATATGTTGACCACAAAA
TGGGCAACATTGCAAGGATGCTCCCCTCCTGAGTGCATCCGCATCTACCTGACCGTGGCCAGGAAATGGCCTTTCTTTGGTGCTAAACTT
TTTGCTGCTCAGCCTGCCCAGCTGTCTTCCAAGGAGAACGCTCTGGTGTGGATTGCTGTGAATGAGGATGGCGTCAGCATCCTGGACCAC
AACACTATGCAAGTGCACATCACTTACCCCTACTCTTCAGTGACAACGTTTGGTGGCTGCAGGGATGACTTCATGCTTGTGATTAGATCT
ATCCCAGACAAGAGCTCTGGAAAAAGCCACATTGAGAAGTTGATCTTCCGGATGGCTGCTCCCAAGATTGCAGAAGCTACCTTCATCATG
GCCAGCTATATGAACCATTGCACTACAACTGTGAACCCCCCCACCAACCCACCCGGAGCCTGCCAGCTGTGGGAACTGGATGGACGACAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ERG_ENST00000398911_chr21_39947586_-_PLEKHH1_ENST00000329153_chr14_68022542_+_6534nt
GTTATTCCAGGATCTTTGGAGACCCGAGGAAAGCCGTGTTGACCAAAAGCAAGACAAATGACTCACAGAGAAAAAAGATGGCAGAACCAA
GGGCAACTAAAGCCGTCAGGTTCTGAACAGCTGGTAGATGGGCTGGCTTACTGAAGGACATGATTCAGACTGTCCCGGACCCAGCAGCTC
ATATCAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGA
AGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAG
ATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAA
AGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGG
TGGGATCCCTTCAAGATGCGCTAGAAGCTATTCAGATAGCTCCTTCACGGAAGCTGCTGGTGCCCCCCTACGGAGCTGCAGAGCAGGATT
CTGTCCCTTCAGAGCCGGGAATCCAGCCTATGGGCCAGGACAGTGGCTCCCAGGCCCAGGGTCTGAAGGCAGCTGTGCTTGCACCTTCCC
CAGGTGCCCTGCAGAGCAAGGACTCTGTTTCTGAAGCAGCAAGCCCCTTGGAGGATTCTAGTTCCAGCACGGTCCATTCTGGGGAAACAG
TAGAGGCCAAGCCCCTTCAACCTCATCTGGGAAGAGAGAGCCCTCCCCACCAGCCATGCATGAAGCTTCTTACCTTCAGATGTAGTTCAG
CTTCCTGGGGTGAGGGTCTGGTTACTGCTCAGAGAGGGATGCTCCCTGGGACAAAGACCTCTGCCAGGGAAGGTGGTCCTGGCAGCAGTC
TGACCCTACCAAAGGTGCGGGCTCCTGGCACCCCGCGGGACAGCATCCAGTTGGCCAAAAGGCACCACAGCCAGCCCCAGGTGGGCCATG
GGCACTTTGGCCGTGTGGTGAACATTGAGACTGAGGCCTTCTCAGCCCTCCACCCCTCTGGCCTTCCTGAGCTGGAGTCCCGAGCTAGGT
CCCGGGAGGAACCAGAGAAGATGGAGATGGAGGAGCCACCCCCAGCAGGGAAGAATGAGGAAAGAGAGAGCCCAAAGGCCCTTGGAGCTG
AGCTGGAGGAAGTGGAGCTGGGTAACAAGCCACCTACACCCCCGCTGCACCAGTTTTCATCCTGGGAGAGCCGGATCTATGCTGTGGCCA
CATCGGGCATGCGGCTCTCAGATATGTCTCCCAGAAGTAATACTGCATGCTGCGCTTCAAGCCCTCCTGCCCTTGTTTCCCCTGGGTCTT
TCTCTGGCCTGGTCTACAAGAATGTCACTGTGCCTGTCTACACAGCACTGAAGGGGAGAGCTACACAGATCAGCAACATGCCCTTTATGG
ACGAGTCCTCTGGGTCTGACGATGACTGCAGCTCTCAGGCGAGTTTCCGAATCTCGGTCCCCTCCTCTGAGTCCAGGAAGACCAGCGGAC
TAGGCAGCCCCCGGGCCATCAAGAGAGGCGTCTCCATGTCCTCACTGAGCTCCGAGGGTGACTACGCCATCCCCCCGGACGCCTGCTCAC
TGGACAGTGACTACTCAGAGCCTGAGCACAAACTGCAGCGCACCTCATCCTACTCCACCGACGGGCTGGGCCTGGGCGGGGAGTCACTGG
AGAAGTCGGGCTACCTGCTGAAAATGGGGAGCCAGGTGAAGACGTGGAAGAGGCGCTGGTTTGTCCTGAGACAGGGACAGATTATGTACT
ACAAGTCCCCGAGTGATGTCATCCGGAAACCTCAAGGCCAAGTGGATCTGAACTCCCGCTGCCAAATTGTTCGAGGGGAGGGTTCACAGA
CGTTTCAGCTCATCTCTGAGAAGAAAACCTACTACCTGACGGCCGATTCACCCAGCCTGCTGGAGGAGTGGATCCGAGTACTCCAGAGCC
TGCTGAAGGTGCAGGCCACCGGGCCTCCAGCTCTGCTTCGGGGTGGCACCAAGCCCACCGTGAAGGGCTGGCTGACCAAGGTAAAGCATG
GCCACTCCAAGGTGGTCTGGTGCGCTCTTGTTGGGAAAATCTTCTACTACTATCGGAGCCATGAGGACAAGCGACCCCTGGGCTGCCTGC
CTGTGCGGGATGCGCACATAGAGGAAGTAGATCGATCCTGTGACTCAGACGAGGACTATGAGGCTGGAGGAACCAGACGGTTGCTTTCCT
CCCACTGCACCCTGGTGATCCACCCCACAGAGCACAGCCCCACCTACCTCCTCATTGGCACCAAGCATGAAAAGGATACGTGGCTCTACC
ACCTCACAGTGGCTGCAGGTGGCAGCAGTGCCAAGGTGGGCACTGCCTATGAGCAGCTCATTGGAAAACTGATGGATGGTGAAGGAGATC
CAGATTCGCCGCTCTGGAGGCACCCCATGCTGTGCTACAGCAAAGACGGCCTATACGCCTCCCTCACCACCCTGCCCTCTGAGGCCTTGC
AGACGGAGGCCCTCAAGCTCTTCAAGTCCTGCCAGCTCTTCATCAACGTGCCGGTGGAAGCTGCCTCGGTGGACTACCATGTGTCCCTGG
CCCAGACCGCACTGCAGGTCTGCCTGGTTCACCCCGAGCTGCAGAGTGAGATCTACTGCCAACTCATGAAGCAGACCAGCTGCCGCCCAC
CTCAGAAGTACTCCCTCATGCAGTGCTGGCAGCTCCTCGCTCTGTGTGCTCCACTTTTCCTGCCTCAGCATCACTTCCTCTGGTATGTCA
AGCAGCAGCTCCAACGCCATGCAGATCCCAGAAGTGAAACTGGCCAGTATGCCACCTACTGCCAGCGGGCAGTGGAGCGGACCCTGCGGA
CCGGGGAGCGGGAAGCCAGGCCATCGCGCATGGAAGTGGTGTCCATCCTGCTGCGTAACCCCTTCCACCACTCCTTGCCCTTCAGCATCC
CCGTGCACTTTACCAACGGGACTTACCATGTGGTTGGTTTTGACGGCTCTTCCACGGTTGATGAGTTCCTCCAGCGGCTGAACCAGGAGA
TAGGCATGAGAAAGCCATCCCACTCTGGCTTTGCCCTCTTCACGGACGATCCCTCGGGCAGGGACCTGGAGCACTGCCTGCAGGGAAGTG
TCAAGATCTGTGATGCCATCTCCAAGTGGGAACAAGCCATGAAGGAGCTGCACCCCGGAAAGTCTGAGGGTGGGACACGCGTCGTGAAGC
TGATGTACAAGAACAGGCTGTACTTTCGCAGTCAAGTCAAAGGGGAGACGGACCGAGAACGGCTGCTCCTTGCCTCTCAAACCAGTAGAG
AGATAGTGGCAGGGAGGTTTCCTATCAACAAGGAATTGGCTCTTGAGATGGCTGCCCTGATGGCCCAGGTAGAATATGGGGACTTGGAGA
AGCCTGCCCTGCCAGGCCCTGGAGGCACATCCCCTGCCAAGGCTCAGCATCTTCTCCAGCAGGTCCTAGACAGGTTCCACCCCAGGCGCT
ATAGACATGGGGCCCCCGCTGAACAGCTGAGGCACCTGGCAGATATGTTGACCACAAAATGGGCAACATTGCAAGGATGCTCCCCTCCTG
AGTGCATCCGCATCTACCTGACCGTGGCCAGGAAATGGCCTTTCTTTGGTGCTAAACTTTTTGCTGCTCAGCCTGCCCAGCTGTCTTCCA
AGGAGAACGCTCTGGTGTGGATTGCTGTGAATGAGGATGGCGTCAGCATCCTGGACCACAACACTATGCAAGTGCACATCACTTACCCCT
ACTCTTCAGTGACAACGTTTGGTGGCTGCAGGGATGACTTCATGCTTGTGATTAGATCTATCCCAGACAAGAGCTCTGGAAAAAGCCACA
TTGAGAAGTTGATCTTCCGGATGGCTGCTCCCAAGATTGCAGAAGCTACCTTCATCATGGCCAGCTATATGAACCATTGCACTACAACTG
TGAACCCCCCCACCAACCCACCCGGAGCCTGCCAGCTGTGGGAACTGGATGGACGACAGTTCTTTTCTTCTGTTTCCTGTGCTACCAAGG
GGCCAACGTTGCTGTGAATATTTCTCCTACCCGATTCCCCAACACCACTAGTGCCTCTGGATTTAGAGATATATATCCTAGGGTATGATA
CTACTGTGACGGGTCTAACAGCCCCCGGCTACTCTTGTTCTGTGAAATGTGTATTTTAGTCTCTGTGAAGCCTTTACTCTCTAGGTGCCT
TATAATGTTTCAGGGCTCAACTTTTTAAAATCCAGACCCAGTGTTAAAACCATTTATTCCTTTTTTCATAAGAATAATGACTCCAGATGC
TACCTGATTCTAGACATAGACAGGGATGATCCACTGTTACTGAGGGCATCAGTGCTATAAGTTAAGGCTTTCTGCACTGGTACTCTCAAG
GAAGCTAATTTTCTTTCTGGGGGGGGCGGGGGACACAGTGTCACTATGTCACCCAGTCCACAGGGTTCAAGCAATTCTCCTGCCTCAGCC
TTCGGAGTGGCTGGGATTACAGGTGTGCGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAG
GCTGGTCTCGAACTCCTGACCTCAGGTGATCTGCCCACTTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATCGCCCAGCCCAG
AAGCTAATTTTTTAATATTGTATATGGTCTTATTTATACTTGAAGTTTTGTGAACGTCGCTAAACAGGATAGGACTAAAATTTCCAATTC
TCCTACACTCTGTCAGAAGCCTAGAACTCACTAAACTGGGCTGCCTTTCCCAAATGGGAAAGGTGCTGACAGAGTTGGAGAAAAAAGAAT
AGACTCATTTTTCCCCATTATTGGTATGTAGGCATTGGTACAGCCCCTTCTGGGGCAGTCTTTGCAGGATAACATGCTATACCTGCTAAG
ATTCAAGCTGTTTTCCTCACACTGGACTTTAGGCCAAACCCAGTACCACGCAATGTGCAAGCAAGGGCAGGAGGTAGGTCCAATCTGACC
CCTCCCTGTCTCATTTTAATGACTGGACAGCGCTCGGTGAAGGCTGTGTTCACTGTAGTGGGCCATCATTTGTTTCCTTCTTCTTGTAAA
AGACCAAGCAAATGCACTCTGCTTTTTGCTGCTGTAAGACCACCAAAAATGAGTCAGAAACACAGAAGACTATTTCAGGCATGTGGGCCT
GGATATGCTCCTTGAGACTTCTGGCAAACTTCTGCTGGGAATTAGTTTGAGGGTGAGGGTACATATGTGACATTTGCCCTAGCCTAAGAG
TAGCAGGTAAAAAAAAGTTTCTTTCATCTTTTGCCTTACTGATAATACCATAATCCCCCTCAATTCAGACCTTCTGATTGAGTGCAGAGG
AGACTAGACAGTCTCCTCTAGACAGGTTGTAGACACACCCTCCCCTAACAAAAACAAAACGAAAGAGTTCATACTCTGATTTTCCAACAT
CTAGGAAACTGAGTTTTATTTCCTAGCTCTAAGGCAGCCTTACTATATGTCAGTAAAGTGCTGAAAACTGTATATTTAGCAGTAGCACCC
AAAACCAAGCCTTTAACCCCAACAATGTGTGTATCTTTTGCACAGCAAAAACTGCGAGGCCAGAACTAGTTTATCTGAACACCTCAGCTG
CTGTAAGCTTCTCCTCTCTCACCCCGTAAACTGACAAGCATGATGAAAAAAGAAGCACATCCAAGTTTCTGCCTCTTTTAAATGTACTTG
ACTTTGCAAGGCAAGTAGTTTTACAGCCATTTCTGTTCACACTTTTCACCCCACAACTTGGGGATCTAGCTGAGACATTTCTACCTCGAA
CAAGTCACATGTACCACAGGTTCCTGAATAATTCCTGCAGGGCTGGTGACAGACATAACAGCTCTGGTTTTATAATATCTTGGGTATCTC
TAAGGCCAATAAGGATAACATTATCTACCCAGAGAGTTTAGAAGAAAAGTAGGAGTCCAAAGGAAGAGTAAACAAGAATGGAGCTGTGTT
CACACTGAATTTGGGGTCAATCTATTTCCCCCACCCTCTCTCCTCCCCAACCCTTCAGGAACCCTTTAGTTTATTAATCTTATACAGAAG
AAACTAACTTAGAAACAAAGGATTCAATATTTGCTTATTTATTCTTTGTTAACATGAGAGTCCCATGTCTGAAAACCAAAGTCCAATTTC
TGTCTGGCCTTTTGTCTCATCCTTCTTGGCAAAAGTAGCTTTTGAACTGATATAAAAAAAAATGCTGAGTAACAGAAAAGTATTAATGTG
CTTGACACCATGACTGAAATACTATGATCTTGTTTGTCAATAAAAAGCAGCTATCTGTGAACCAGGTAACTGTGTGTTTTGGAAGATCTG

>In-frame_ERG_ENST00000398919_chr21_39947586_-_PLEKHH1_ENST00000329153_chr14_68022542_+_6680nt
GCTGAGCCCGTCGGCGCCGAGGGAGTTAGTGCGACCCGGCTCGGCGCGCACGGCCAAGGCACGCGCGCTGGCACACGCGGGCGCGGACAC
GCGCGGACACACACGTGCGGGACACGCCCTCCCCCGACGGCGGCGCTAACCTCTCGGTTATTCCAGGATCTTTGGAGACCCGAGGAAAGC
CGTGTTGACCAAAAGCAAGACAAATGACTCACAGAGAAAAAAGATGGCAGAACCAAGGGCAACTAAAGCCGTCAGGTTCTGAACAGCTGG
TAGATGGGCTGGCTTACTGAAGGACATGATTCAGACTGTCCCGGACCCAGCAGCTCATATCAAGATGCAGGAGCTGGAGCAGAGGCTGCT
GGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTC
TGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGA
GAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAA
GCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGCTATTCA
GATAGCTCCTTCACGGAAGCTGCTGGTGCCCCCCTACGGAGCTGCAGAGCAGGATTCTGTCCCTTCAGAGCCGGGAATCCAGCCTATGGG
CCAGGACAGTGGCTCCCAGGCCCAGGGTCTGAAGGCAGCTGTGCTTGCACCTTCCCCAGGTGCCCTGCAGAGCAAGGACTCTGTTTCTGA
AGCAGCAAGCCCCTTGGAGGATTCTAGTTCCAGCACGGTCCATTCTGGGGAAACAGTAGAGGCCAAGCCCCTTCAACCTCATCTGGGAAG
AGAGAGCCCTCCCCACCAGCCATGCATGAAGCTTCTTACCTTCAGATGTAGTTCAGCTTCCTGGGGTGAGGGTCTGGTTACTGCTCAGAG
AGGGATGCTCCCTGGGACAAAGACCTCTGCCAGGGAAGGTGGTCCTGGCAGCAGTCTGACCCTACCAAAGGTGCGGGCTCCTGGCACCCC
GCGGGACAGCATCCAGTTGGCCAAAAGGCACCACAGCCAGCCCCAGGTGGGCCATGGGCACTTTGGCCGTGTGGTGAACATTGAGACTGA
GGCCTTCTCAGCCCTCCACCCCTCTGGCCTTCCTGAGCTGGAGTCCCGAGCTAGGTCCCGGGAGGAACCAGAGAAGATGGAGATGGAGGA
GCCACCCCCAGCAGGGAAGAATGAGGAAAGAGAGAGCCCAAAGGCCCTTGGAGCTGAGCTGGAGGAAGTGGAGCTGGGTAACAAGCCACC
TACACCCCCGCTGCACCAGTTTTCATCCTGGGAGAGCCGGATCTATGCTGTGGCCACATCGGGCATGCGGCTCTCAGATATGTCTCCCAG
AAGTAATACTGCATGCTGCGCTTCAAGCCCTCCTGCCCTTGTTTCCCCTGGGTCTTTCTCTGGCCTGGTCTACAAGAATGTCACTGTGCC
TGTCTACACAGCACTGAAGGGGAGAGCTACACAGATCAGCAACATGCCCTTTATGGACGAGTCCTCTGGGTCTGACGATGACTGCAGCTC
TCAGGCGAGTTTCCGAATCTCGGTCCCCTCCTCTGAGTCCAGGAAGACCAGCGGACTAGGCAGCCCCCGGGCCATCAAGAGAGGCGTCTC
CATGTCCTCACTGAGCTCCGAGGGTGACTACGCCATCCCCCCGGACGCCTGCTCACTGGACAGTGACTACTCAGAGCCTGAGCACAAACT
GCAGCGCACCTCATCCTACTCCACCGACGGGCTGGGCCTGGGCGGGGAGTCACTGGAGAAGTCGGGCTACCTGCTGAAAATGGGGAGCCA
GGTGAAGACGTGGAAGAGGCGCTGGTTTGTCCTGAGACAGGGACAGATTATGTACTACAAGTCCCCGAGTGATGTCATCCGGAAACCTCA
AGGCCAAGTGGATCTGAACTCCCGCTGCCAAATTGTTCGAGGGGAGGGTTCACAGACGTTTCAGCTCATCTCTGAGAAGAAAACCTACTA
CCTGACGGCCGATTCACCCAGCCTGCTGGAGGAGTGGATCCGAGTACTCCAGAGCCTGCTGAAGGTGCAGGCCACCGGGCCTCCAGCTCT
GCTTCGGGGTGGCACCAAGCCCACCGTGAAGGGCTGGCTGACCAAGGTAAAGCATGGCCACTCCAAGGTGGTCTGGTGCGCTCTTGTTGG
GAAAATCTTCTACTACTATCGGAGCCATGAGGACAAGCGACCCCTGGGCTGCCTGCCTGTGCGGGATGCGCACATAGAGGAAGTAGATCG
ATCCTGTGACTCAGACGAGGACTATGAGGCTGGAGGAACCAGACGGTTGCTTTCCTCCCACTGCACCCTGGTGATCCACCCCACAGAGCA
CAGCCCCACCTACCTCCTCATTGGCACCAAGCATGAAAAGGATACGTGGCTCTACCACCTCACAGTGGCTGCAGGTGGCAGCAGTGCCAA
GGTGGGCACTGCCTATGAGCAGCTCATTGGAAAACTGATGGATGGTGAAGGAGATCCAGATTCGCCGCTCTGGAGGCACCCCATGCTGTG
CTACAGCAAAGACGGCCTATACGCCTCCCTCACCACCCTGCCCTCTGAGGCCTTGCAGACGGAGGCCCTCAAGCTCTTCAAGTCCTGCCA
GCTCTTCATCAACGTGCCGGTGGAAGCTGCCTCGGTGGACTACCATGTGTCCCTGGCCCAGACCGCACTGCAGGTCTGCCTGGTTCACCC
CGAGCTGCAGAGTGAGATCTACTGCCAACTCATGAAGCAGACCAGCTGCCGCCCACCTCAGAAGTACTCCCTCATGCAGTGCTGGCAGCT
CCTCGCTCTGTGTGCTCCACTTTTCCTGCCTCAGCATCACTTCCTCTGGTATGTCAAGCAGCAGCTCCAACGCCATGCAGATCCCAGAAG
TGAAACTGGCCAGTATGCCACCTACTGCCAGCGGGCAGTGGAGCGGACCCTGCGGACCGGGGAGCGGGAAGCCAGGCCATCGCGCATGGA
AGTGGTGTCCATCCTGCTGCGTAACCCCTTCCACCACTCCTTGCCCTTCAGCATCCCCGTGCACTTTACCAACGGGACTTACCATGTGGT
TGGTTTTGACGGCTCTTCCACGGTTGATGAGTTCCTCCAGCGGCTGAACCAGGAGATAGGCATGAGAAAGCCATCCCACTCTGGCTTTGC
CCTCTTCACGGACGATCCCTCGGGCAGGGACCTGGAGCACTGCCTGCAGGGAAGTGTCAAGATCTGTGATGCCATCTCCAAGTGGGAACA
AGCCATGAAGGAGCTGCACCCCGGAAAGTCTGAGGGTGGGACACGCGTCGTGAAGCTGATGTACAAGAACAGGCTGTACTTTCGCAGTCA
AGTCAAAGGGGAGACGGACCGAGAACGGCTGCTCCTTGCCTCTCAAACCAGTAGAGAGATAGTGGCAGGGAGGTTTCCTATCAACAAGGA
ATTGGCTCTTGAGATGGCTGCCCTGATGGCCCAGGTAGAATATGGGGACTTGGAGAAGCCTGCCCTGCCAGGCCCTGGAGGCACATCCCC
TGCCAAGGCTCAGCATCTTCTCCAGCAGGTCCTAGACAGGTTCCACCCCAGGCGCTATAGACATGGGGCCCCCGCTGAACAGCTGAGGCA
CCTGGCAGATATGTTGACCACAAAATGGGCAACATTGCAAGGATGCTCCCCTCCTGAGTGCATCCGCATCTACCTGACCGTGGCCAGGAA
ATGGCCTTTCTTTGGTGCTAAACTTTTTGCTGCTCAGCCTGCCCAGCTGTCTTCCAAGGAGAACGCTCTGGTGTGGATTGCTGTGAATGA
GGATGGCGTCAGCATCCTGGACCACAACACTATGCAAGTGCACATCACTTACCCCTACTCTTCAGTGACAACGTTTGGTGGCTGCAGGGA
TGACTTCATGCTTGTGATTAGATCTATCCCAGACAAGAGCTCTGGAAAAAGCCACATTGAGAAGTTGATCTTCCGGATGGCTGCTCCCAA
GATTGCAGAAGCTACCTTCATCATGGCCAGCTATATGAACCATTGCACTACAACTGTGAACCCCCCCACCAACCCACCCGGAGCCTGCCA
GCTGTGGGAACTGGATGGACGACAGTTCTTTTCTTCTGTTTCCTGTGCTACCAAGGGGCCAACGTTGCTGTGAATATTTCTCCTACCCGA
TTCCCCAACACCACTAGTGCCTCTGGATTTAGAGATATATATCCTAGGGTATGATACTACTGTGACGGGTCTAACAGCCCCCGGCTACTC
TTGTTCTGTGAAATGTGTATTTTAGTCTCTGTGAAGCCTTTACTCTCTAGGTGCCTTATAATGTTTCAGGGCTCAACTTTTTAAAATCCA
GACCCAGTGTTAAAACCATTTATTCCTTTTTTCATAAGAATAATGACTCCAGATGCTACCTGATTCTAGACATAGACAGGGATGATCCAC
TGTTACTGAGGGCATCAGTGCTATAAGTTAAGGCTTTCTGCACTGGTACTCTCAAGGAAGCTAATTTTCTTTCTGGGGGGGGCGGGGGAC
ACAGTGTCACTATGTCACCCAGTCCACAGGGTTCAAGCAATTCTCCTGCCTCAGCCTTCGGAGTGGCTGGGATTACAGGTGTGCGCCACC
ATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTGC
CCACTTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATCGCCCAGCCCAGAAGCTAATTTTTTAATATTGTATATGGTCTTATT
TATACTTGAAGTTTTGTGAACGTCGCTAAACAGGATAGGACTAAAATTTCCAATTCTCCTACACTCTGTCAGAAGCCTAGAACTCACTAA
ACTGGGCTGCCTTTCCCAAATGGGAAAGGTGCTGACAGAGTTGGAGAAAAAAGAATAGACTCATTTTTCCCCATTATTGGTATGTAGGCA
TTGGTACAGCCCCTTCTGGGGCAGTCTTTGCAGGATAACATGCTATACCTGCTAAGATTCAAGCTGTTTTCCTCACACTGGACTTTAGGC
CAAACCCAGTACCACGCAATGTGCAAGCAAGGGCAGGAGGTAGGTCCAATCTGACCCCTCCCTGTCTCATTTTAATGACTGGACAGCGCT
CGGTGAAGGCTGTGTTCACTGTAGTGGGCCATCATTTGTTTCCTTCTTCTTGTAAAAGACCAAGCAAATGCACTCTGCTTTTTGCTGCTG
TAAGACCACCAAAAATGAGTCAGAAACACAGAAGACTATTTCAGGCATGTGGGCCTGGATATGCTCCTTGAGACTTCTGGCAAACTTCTG
CTGGGAATTAGTTTGAGGGTGAGGGTACATATGTGACATTTGCCCTAGCCTAAGAGTAGCAGGTAAAAAAAAGTTTCTTTCATCTTTTGC
CTTACTGATAATACCATAATCCCCCTCAATTCAGACCTTCTGATTGAGTGCAGAGGAGACTAGACAGTCTCCTCTAGACAGGTTGTAGAC
ACACCCTCCCCTAACAAAAACAAAACGAAAGAGTTCATACTCTGATTTTCCAACATCTAGGAAACTGAGTTTTATTTCCTAGCTCTAAGG
CAGCCTTACTATATGTCAGTAAAGTGCTGAAAACTGTATATTTAGCAGTAGCACCCAAAACCAAGCCTTTAACCCCAACAATGTGTGTAT
CTTTTGCACAGCAAAAACTGCGAGGCCAGAACTAGTTTATCTGAACACCTCAGCTGCTGTAAGCTTCTCCTCTCTCACCCCGTAAACTGA
CAAGCATGATGAAAAAAGAAGCACATCCAAGTTTCTGCCTCTTTTAAATGTACTTGACTTTGCAAGGCAAGTAGTTTTACAGCCATTTCT
GTTCACACTTTTCACCCCACAACTTGGGGATCTAGCTGAGACATTTCTACCTCGAACAAGTCACATGTACCACAGGTTCCTGAATAATTC
CTGCAGGGCTGGTGACAGACATAACAGCTCTGGTTTTATAATATCTTGGGTATCTCTAAGGCCAATAAGGATAACATTATCTACCCAGAG
AGTTTAGAAGAAAAGTAGGAGTCCAAAGGAAGAGTAAACAAGAATGGAGCTGTGTTCACACTGAATTTGGGGTCAATCTATTTCCCCCAC
CCTCTCTCCTCCCCAACCCTTCAGGAACCCTTTAGTTTATTAATCTTATACAGAAGAAACTAACTTAGAAACAAAGGATTCAATATTTGC
TTATTTATTCTTTGTTAACATGAGAGTCCCATGTCTGAAAACCAAAGTCCAATTTCTGTCTGGCCTTTTGTCTCATCCTTCTTGGCAAAA
GTAGCTTTTGAACTGATATAAAAAAAAATGCTGAGTAACAGAAAAGTATTAATGTGCTTGACACCATGACTGAAATACTATGATCTTGTT
TGTCAATAAAAAGCAGCTATCTGTGAACCAGGTAACTGTGTGTTTTGGAAGATCTGTTTATTAACAGTAAATAAATAAGCCCTGTACAGA


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FusionGenePPI for ERG_PLEKHH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3PLEKHH1APBB1IP, LPXN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERG_PLEKHH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERG_PLEKHH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms5CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgenePLEKHH1C0023893Liver Cirrhosis, Experimental1CTD_human