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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12012

FusionGeneSummary for ERG_MAPK11

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG_MAPK11
Fusion gene ID: 12012
HgeneTgene
Gene symbol

ERG

MAPK11

Gene ID

2078

5600

Gene nameERG, ETS transcription factormitogen-activated protein kinase 11
Synonymserg-3|p55P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta
Cytomap

21q22.2

22q13.33

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 onmitogen-activated protein kinase 11MAP kinase 11MAP kinase p38 betamitogen-activated protein kinase p38 betamitogen-activated protein kinase p38-2stress-activated protein kinase-2stress-activated protein kinase-2b
Modification date2018052320180523
UniProtAcc

P11308

Q15759

Ensembl transtripts involved in fusion geneENST00000398907, ENST00000398905, 
ENST00000288319, ENST00000398897, 
ENST00000398911, ENST00000398910, 
ENST00000417133, ENST00000442448, 
ENST00000453032, ENST00000398919, 
ENST00000429727, ENST00000485493, 
ENST00000330651, ENST00000449719, 
ENST00000495277, 
Fusion gene scores* DoF score15 X 4 X 3=1801 X 1 X 1=1
# samples 191
** MAII scorelog2(19/180*10)=0.0780025120012732
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: ERG [Title/Abstract] AND MAPK11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826

TgeneMAPK11

GO:0051403

stress-activated MAPK cascade

8663524

TgeneMAPK11

GO:0071347

cellular response to interleukin-1

8663524


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-63-7022-01AERGchr21

39947586

-MAPK11chr22

50706378

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398907ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-5UTRENST00000398907ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-5UTRENST00000398907ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-3CDSENST00000398905ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-5UTRENST00000398905ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-5UTRENST00000398905ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-3CDSENST00000288319ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-5UTRENST00000288319ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-5UTRENST00000288319ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
5UTR-3CDSENST00000398897ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
5UTR-5UTRENST00000398897ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
5UTR-5UTRENST00000398897ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
Frame-shitENST00000398911ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
5CDS-5UTRENST00000398911ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
5CDS-5UTRENST00000398911ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
Frame-shitENST00000398910ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
5CDS-5UTRENST00000398910ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
5CDS-5UTRENST00000398910ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
Frame-shitENST00000417133ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
5CDS-5UTRENST00000417133ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
5CDS-5UTRENST00000417133ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
Frame-shitENST00000442448ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
5CDS-5UTRENST00000442448ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
5CDS-5UTRENST00000442448ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-3CDSENST00000453032ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-5UTRENST00000453032ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-5UTRENST00000453032ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
Frame-shitENST00000398919ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
5CDS-5UTRENST00000398919ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
5CDS-5UTRENST00000398919ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-3CDSENST00000429727ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-5UTRENST00000429727ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
intron-5UTRENST00000429727ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-
5UTR-3CDSENST00000485493ENST00000330651ERGchr21

39947586

-MAPK11chr22

50706378

-
5UTR-5UTRENST00000485493ENST00000449719ERGchr21

39947586

-MAPK11chr22

50706378

-
5UTR-5UTRENST00000485493ENST00000495277ERGchr21

39947586

-MAPK11chr22

50706378

-

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FusionProtFeatures for ERG_MAPK11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

MAPK11

Q15759

Transcriptional regulator. May participate intranscriptional regulation through the recruitment of SETDB1histone methyltransferase and subsequent modification of localchromatin structure.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERG_MAPK11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERG_MAPK11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3MAPK11HDAC3, PML, RPS6KA5, CCND1, POLR3D, C9orf78, CPNE6, MAPK14, SOCS3, MBP, HTRA2, APP, ATF2, SH2D1A, PKN1, NOXA1, MAPT, BAG3, MAPKAPK3, MAPKAPK2, OBSL1, MKNK1, DUSP9, VARS, CUL7, CCDC8, ARHGAP12, HDAC1, PPM1G, TAB1, DUSP2, PTPN7, PTPRR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERG_MAPK11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMAPK11Q15759DB08896RegorafenibMitogen-activated protein kinase 11small moleculeapproved

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RelatedDiseases for ERG_MAPK11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms5CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneMAPK11C0878544Cardiomyopathies1CTD_human