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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12011

FusionGeneSummary for ERG_KCNJ6

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG_KCNJ6
Fusion gene ID: 12011
HgeneTgene
Gene symbol

ERG

KCNJ6

Gene ID

2078

3763

Gene nameERG, ETS transcription factorpotassium voltage-gated channel subfamily J member 6
Synonymserg-3|p55BIR1|GIRK-2|GIRK2|KATP-2|KATP2|KCNJ7|KIR3.2|KPLBS|hiGIRK2
Cytomap

21q22.2

21q22.13

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 onG protein-activated inward rectifier potassium channel 2inward rectifier K(+) channel Kir3.2inward rectifier potassium channel KIR3.2potassium channel, inwardly rectifying subfamily J, member 6
Modification date2018052320180523
UniProtAcc

P11308

P48051

Ensembl transtripts involved in fusion geneENST00000398907, ENST00000398905, 
ENST00000288319, ENST00000398897, 
ENST00000398911, ENST00000398910, 
ENST00000417133, ENST00000442448, 
ENST00000453032, ENST00000398919, 
ENST00000429727, ENST00000485493, 
ENST00000609713, ENST00000288309, 
Fusion gene scores* DoF score15 X 4 X 3=1807 X 4 X 5=140
# samples 197
** MAII scorelog2(19/180*10)=0.0780025120012732
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND KCNJ6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A6E1-01AERGchr21

39947586

-KCNJ6chr21

38997786

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398907ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
intron-3CDSENST00000398907ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
intron-3CDSENST00000398905ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
intron-3CDSENST00000398905ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
intron-3CDSENST00000288319ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
intron-3CDSENST00000288319ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
5UTR-3CDSENST00000398897ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
5UTR-3CDSENST00000398897ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
Frame-shitENST00000398911ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
Frame-shitENST00000398911ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
Frame-shitENST00000398910ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
Frame-shitENST00000398910ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
Frame-shitENST00000417133ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
Frame-shitENST00000417133ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
Frame-shitENST00000442448ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
Frame-shitENST00000442448ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
intron-3CDSENST00000453032ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
intron-3CDSENST00000453032ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
Frame-shitENST00000398919ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
Frame-shitENST00000398919ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
intron-3CDSENST00000429727ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
intron-3CDSENST00000429727ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-
5UTR-3CDSENST00000485493ENST00000609713ERGchr21

39947586

-KCNJ6chr21

38997786

-
5UTR-3CDSENST00000485493ENST00000288309ERGchr21

39947586

-KCNJ6chr21

38997786

-

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FusionProtFeatures for ERG_KCNJ6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

KCNJ6

P48051

Transcriptional regulator. May participate intranscriptional regulation through the recruitment of SETDB1histone methyltransferase and subsequent modification of localchromatin structure. This potassium channel may be involved in the regulationof insulin secretion by glucose and/or neurotransmitters actingthrough G-protein-coupled receptors. Inward rectifier potassiumchannels are characterized by a greater tendency to allowpotassium to flow into the cell rather than out of it. Theirvoltage dependence is regulated by the concentration ofextracellular potassium; as external potassium is raised, thevoltage range of the channel opening shifts to more positivevoltages. The inward rectification is mainly due to the blockageof outward current by internal magnesium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERG_KCNJ6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERG_KCNJ6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3KCNJ6DLG1, KCNJ9, DRD2, BIRC5, GABBR1, MB21D2, C4orf27, FAM118B, RARG, C1orf43, UFSP2, LRRC1, HSDL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERG_KCNJ6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneKCNJ6P48051DB00898EthanolG protein-activated inward rectifier potassium channel 2small moleculeapproved
TgeneKCNJ6P48051DB11633IsavuconazoleG protein-activated inward rectifier potassium channel 2small moleculeapproved|investigational
TgeneKCNJ6P48051DB01159HalothaneG protein-activated inward rectifier potassium channel 2small moleculeapproved|vet_approved

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RelatedDiseases for ERG_KCNJ6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms5CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneKCNJ6C0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneKCNJ6C0011570Mental Depression2PSYGENET
TgeneKCNJ6C0011581Depressive disorder2PSYGENET
TgeneKCNJ6C0027746Nerve Degeneration1CTD_human
TgeneKCNJ6C3279800KEPPEN-LUBINSKY SYNDROME1ORPHANET;UNIPROT