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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12010

FusionGeneSummary for ERG_EWSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG_EWSR1
Fusion gene ID: 12010
HgeneTgene
Gene symbol

ERG

EWSR1

Gene ID

2078

2130

Gene nameERG, ETS transcription factorEWS RNA binding protein 1
Synonymserg-3|p55EWS|EWS-FLI1|bK984G1.4
Cytomap

21q22.2

22q12.2

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 onRNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene
Modification date2018052320180527
UniProtAcc

P11308

Q01844

Ensembl transtripts involved in fusion geneENST00000398907, ENST00000398905, 
ENST00000288319, ENST00000398897, 
ENST00000398911, ENST00000398910, 
ENST00000417133, ENST00000442448, 
ENST00000453032, ENST00000398919, 
ENST00000429727, ENST00000485493, 
ENST00000332050, ENST00000397938, 
ENST00000406548, ENST00000331029, 
ENST00000414183, ENST00000333395, 
ENST00000332035, 
Fusion gene scores* DoF score15 X 4 X 3=1808 X 20 X 7=1120
# samples 1921
** MAII scorelog2(19/180*10)=0.0780025120012732
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(21/1120*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND EWSR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1S82338ERGchr21

39762959

-EWSR1chr22

29682948

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398907ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+

Top

FusionProtFeatures for ERG_EWSR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

EWSR1

Q01844

Transcriptional regulator. May participate intranscriptional regulation through the recruitment of SETDB1histone methyltransferase and subsequent modification of localchromatin structure. Might normally function as a transcriptional repressor.EWS-fusion-proteins (EFPS) may play a role in the tumorigenicprocess. They may disturb gene expression by mimicking, orinterfering with the normal function of CTD-POLII within thetranscription initiation complex. They may also contribute to anaberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERG_EWSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERG_EWSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ERG_EWSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERG_EWSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms5CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneEWSR1C0553580Ewings sarcoma3CTD_human;HPO;ORPHANET
TgeneEWSR1C0206663Neuroectodermal Tumor, Primitive1CTD_human