FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12009

FusionGeneSummary for ERG_CIDEC

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG_CIDEC
Fusion gene ID: 12009
HgeneTgene
Gene symbol

ERG

CIDEC

Gene ID

2078

63924

Gene nameERG, ETS transcription factorcell death inducing DFFA like effector c
Synonymserg-3|p55CIDE-3|CIDE3|FPLD5|FSP27
Cytomap

21q22.2

3p25.3

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 oncell death activator CIDE-3fat specific protein 27
Modification date2018052320180523
UniProtAcc

P11308

Q96AQ7

Ensembl transtripts involved in fusion geneENST00000398907, ENST00000398905, 
ENST00000288319, ENST00000398897, 
ENST00000398911, ENST00000398910, 
ENST00000417133, ENST00000442448, 
ENST00000453032, ENST00000398919, 
ENST00000429727, ENST00000485493, 
ENST00000455015, ENST00000336832, 
ENST00000423850, ENST00000383817, 
ENST00000430427, ENST00000443115, 
Fusion gene scores* DoF score15 X 4 X 3=1807 X 6 X 3=126
# samples 197
** MAII scorelog2(19/180*10)=0.0780025120012732
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND CIDEC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826

TgeneCIDEC

GO:0006915

apoptotic process

12429024

TgeneCIDEC

GO:0097194

execution phase of apoptosis

12429024


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI713036ERGchr21

39775430

-CIDECchr3

10048206

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000398907ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398907ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398907ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398907ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398907ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398907ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398905ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398905ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398905ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398905ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398905ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398905ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000288319ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000288319ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000288319ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000288319ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000288319ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000288319ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398897ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398897ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398897ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398897ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398897ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398897ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398911ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398911ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398911ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398911ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398911ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398911ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398910ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398910ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398910ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398910ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398910ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398910ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000417133ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000417133ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000417133ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000417133ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000417133ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000417133ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000442448ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000442448ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000442448ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000442448ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000442448ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000442448ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000453032ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000453032ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000453032ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000453032ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000453032ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000453032ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398919ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398919ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398919ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398919ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398919ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
5CDS-intronENST00000398919ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000429727ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000429727ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000429727ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000429727ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000429727ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000429727ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000485493ENST00000455015ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000485493ENST00000336832ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000485493ENST00000423850ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000485493ENST00000383817ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000485493ENST00000430427ERGchr21

39775430

-CIDECchr3

10048206

+
intron-intronENST00000485493ENST00000443115ERGchr21

39775430

-CIDECchr3

10048206

+

Top

FusionProtFeatures for ERG_CIDEC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

CIDEC

Q96AQ7

Transcriptional regulator. May participate intranscriptional regulation through the recruitment of SETDB1histone methyltransferase and subsequent modification of localchromatin structure. Binds to lipid droplets and regulates their enlargement,thereby restricting lipolysis and favoring storage. At focalcontact sites between lipid droplets, promotes directional netneutral lipid transfer from the smaller to larger lipid droplets.The transfer direction may be driven by the internal pressuredifference between the contacting lipid droplet pair. Its role inneutral lipid transfer and lipid droplet enlargement is activatedby the interaction with PLIN1. May act as a CEBPB coactivator inthe white adipose tissue to control the expression of a subset ofCEBPB downstream target genes, including SOCS1, SOCS3, TGFB1,TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, inducesapoptosis or increases cell susceptibility to apoptosis induced byserum deprivation or TGFB treatment. As mature adipocytes, thatexpress high CIDEC levels, are quite resistant to apoptoticstimuli, the physiological significance of its role in apoptosisis unclear. May play a role in the modulation of the response toosmotic stress by preventing NFAT5 to translocate into the nucleusand activate its target genes expression.{ECO:0000269|PubMed:12429024, ECO:0000269|PubMed:18334488,ECO:0000269|PubMed:19843876, ECO:0000269|PubMed:20049731,ECO:0000269|PubMed:23399566}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ERG_CIDEC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ERG_CIDEC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ERG_CIDEC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ERG_CIDEC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms5CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneCIDECC0162820Dermatitis, Allergic Contact1CTD_human